• Title/Summary/Keyword: Annulation

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Synthesis and Antimicrobial Screening of Pyrimidine Annulated Dihydropyrano[2, 3-c]pyrazole Derivatives

  • Hegde, Hemant;Ahn, Chuljin;Waribam, Preeti;Shetty, Nitinkumar S.
    • Journal of the Korean Chemical Society
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    • v.62 no.2
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    • pp.87-92
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    • 2018
  • A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction medium which facilitated improved yield compared to base catalyzed reaction. Wide scope of substrates, simple workup procedure and high yield even in the absence of catalyst are the major highlights of the protocol. Dihydropyrano[2, 3-c]pyrazoles on condensation with formic acid formed pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives. All the products are characterized using FTIR, $^1H-NMR$ and $^{13}C-NMR$ spectroscopic techniques. The molecules have shown good to moderate activity as antimicrobial agents when compared to the standard drug ciprofloxacin.

Rust of Korean Azalea (Rododendron yedoense) Caused by Chrysomyxa rhododendri (Chrysomyxa rhododendri에 의한 산철쭉(Rododendron yedoense) 녹병)

  • Do, Yun-Jeong;Kim, Hyung-Moo;Lee, Kui-Jae;Lee, Wang-Hyu;Ko, Jeong-Ae
    • Research in Plant Disease
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    • v.13 no.3
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    • pp.220-222
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    • 2007
  • Rust disease on Korean Azalea (Rododendron yedoense) was occurred in Jeonju, Jeonbuk province of Korea. The typical symtoms of the disease appeared first as small yellowish spots on leaves. Uredinia were observed at hypophyllous of the leaves, yellow or dark yellow in color and globoid in shape with the size of $0.27{\sim}0.46{\times}0.31{\sim}0.61$ mm. Urediniospores were also observed in the leaves, yellow in color with globoid or ovoid in shape with the size of $17.1{\sim}29.2{\times}12.8{\sim}18.2{\mu}m$. Surface characterization of the spores revealed that these spores have papilla-like projections, which were made of $2{\sim}3$ annulation (SA; small annulate). Based on these morphological characterizations the causative fungus was identified as Chrysomyxa rhododendri.

Anatomy and Artificial Seed Propagation in Anti -cancer Plant Orostachys japonicus A. Berger (항암식물 와송의 해부 형태적 관찰과 대량 증식에 의한 인공재배연구)

  • 신동영;이영만;김학진
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.39 no.2
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    • pp.146-157
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    • 1994
  • Wasong(Orostachys japonicus A. Berger) has been used as anti-cancer medicinal plants from ancient time. This experiment was conducted to obtain some fundamental informations concerning anatomical study, germination test, soil analysis of indigenious districks, adaptaion of soil for wasong. The leaf of wasong was xerotype with spine, mesophyl chloroplast is dense surrounded vascular bundle, with a many large water storage tissue without chloroplast, and was bifacial stomata leaf type. The stem of wasong was amphicribral vascular bundle, central cylinder was cylinder type and protostele. Root was polarch type, potoxylem of it's was arranged in ring shape of annulation and metaxylem. The structure of flower was cymose, was caylyx of 5 sepals, corolla of 5 petals, roecium of 10 stames, ovules of five, placentation parietal, ovary superior, axile placenta. The optimum temperature for seed germination was $25^{\circ}C$ under light and germination percentage was 22.5%. Dormancy breaking was effective for 6-8 days at 5$^{\circ}C$ and at 100 ppm level of $GA_3$ The soil analysis of wasong local districks, content of available $P_2O_5$, Ca were higer than optimal level of upland and C.E.C., exchangeable k was not significantly different of that, but exchangeable magnesium was very low. The growth of wasong was affected draining regardless soil combination treatment.

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