• 대한수의학회지
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• 제47권2호
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• pp.209-212
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• 2007

A 3-year-old female Cocker Spaniel dog acutely developed hepatopathy following ingestion of root of Cycad (Cycas revoluta). Seven hours after the ingestion, she showed acute continuous nausea, vomiting, and marked depression and was presented to the local veterinary clinic. At physical evaluation, the dog showed moderate weakness, pale mucous membrane, jaundice, and dehydration. Serum biochemical analysis revealed elevated alanine aminotransferase and aspartate aminotransferase, and mild azotemia. The dog was treated with intravenous fluid, antibiotics, and hepatic protectants for 10 days and recovered without any sequela. Although the ingestion of Cycad in dogs is rare, it can be treated successfully with appropriate supportive therapy.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2018년도 추계학술발표대회
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• pp.795-796
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• 2018

방사광은 기존 기계학적인 방법으로 분석했던 연구보다 더 정확한 관찰이 가능해 신뢰도가 높은 결과를 얻을 수 있다. 본 연구의 목적은 흰쥐 정강뼈의 미세구조를 3차원적으로 분석 가능한 방사광기반 경X선을 이용해 골다공증의 진단 및 평가에 필요한 정량화된 분석을 구축하고자 하였다. 흰 쥐의 정강뼈를 방사광을 통해 해부학 구조 및 미세내부구조를 얻은 뒤 3차원적 구조분석을 하였다. 그 후, 방사광으로 얻은 영상 데이터를 통해 뼈 내부 구조를 높은 해상도 이미지로 시각화하여 분석을 할 수 있었다. 따라서, 골다공증과 관련된 퇴행성 골격질환의 정량화된 분석방법을 제시하여 근거중심의 평가와 예방의 기초자료가 될 것으로 기대한다.

• 농촌계획
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• 제28권1호
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• pp.1-15
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• 2022

A Care farm is known to have positive effects on various people in psychological, physical, and social aspects. However, care farm services for the disabled, transportation disadvantaged, and socially disadvantaged are limited. This study conducted a demand survey in order to provide basic data for development of the Agro-Healing Virtual Reality Therapy(AVRT) system. The respondents were the ordinary person(n=127) and the disabled person(n=72), and the survey items consisted of 4 categories and 20 items, including intention to use AVRT, requirements for use, factors to be considered when developing the system, and content and program preferences. The intention to use a AVRT was found to be at a high level of 80% or more by respondent characteristics. In addition, similar results were shown in all items such as virtual reality experience, willingness to use, appropriate use time, and willingness to pay by respondent characteristics, and correlation by item was determined through correlation analysis. As for the conditions of use, both sides preferred rural types and were found to have the purpose of healing. However, there were concerns about dizziness in common between system use, and in the case of the disabled person, there were difficulties in purchasing expensive equipment. In the development of the AVRT system, the part of sensory priority, important technology level, and color preference were evaluated, and the preference of content and programs to be developed in the system was identified. Fruit, vegetables, flowers, and animals preferred mandarin, tomato, tulips, and dogs first, horticultural healing preferred harvest management for the ordinary person, plant cultivation for the disabled person, and forest healing and animal education preferred walking and dog-related programs. However, agricultural work was found to be a program with high preference for making processed foods for the ordinary person and creating an animal breeding environment for the disabled person. The result of this study is expected to provide reference data that can be suggested for the development of Agro-healing Virtual Reality Therapy system.

• 한국임상수의학회지
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• 제20권2호
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• pp.233-236
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• 2003

10년령의 중성화 되지 않은 암컷의 요크셔테리어가 건국대학교 부속 동물병원으로 진료가 의뢰되어 왔다. 환축은 얼굴과 복벽에 심각한 괴사성 피부염을 보였으며 또한 다음다뇨 및 다식증을 나타내었다. 병력청취와 신체검사, CBC, 혈액생화학 검사를 토대로 하여 부신피질기능항진증을 의심하였고, 나아가 ACTH 자극시험을 통하여 쿠싱증후 군이 확진되었다. 또한, High Dose Dexamethasone Suppression lest (HDDST)극 통하여 뇌하수체 의존성 부신피질 기능 항진증임을 알 수 있었다. Mitotane을 이용한 치료가 개시된후 심자한 피부문제와 PUPD등의 임상증상들이 개선되었다. 그 후 mitotane 처치가 적절히 이루어지고 잇는가를 검증하기 위해 ACTH의 추가적인 검사가 수행되었다. 이 임상증례는 심각한 피부문제를 가지고 있던 환축이 오진단되고 치료의 핵심을 찾지못해 1년 이상 지속된 환축이 mitotane을 이용하여 성공적으로 치료되어 유지되고 있음을 보여주는 증례이다.

• 한국임상수의학회지
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• 제27권2호
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• pp.175-178
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• 2010

5년령의 수컷 코커스파니엘견이 갑작스런 발작증상으로 내원하였다. 내원당시 중등도의 탈수, 과다유연이 관찰되었고, 의식이 소실된 상태였다. 신체검사상 상복부에서 복강내 종괴가 촉진되었고, 실험실 검사에서 저혈당증과 간효소 수치의 상승이 관찰되었다. 진단으로는 병력, 임상증상, 신체검사, 신경검사, 기본적 실험실 검사와 방사선 검사 및 세포검사가 이용되었다. 특히 원발성 간 선암종이 의심되어 혈청 중 alpha-fetoprotein (AFP)을 측정하였다. 혈청 중 AFP 수치는 특이적으로 정상견에 비해 매우 높은 수준이었다(1513.5 ng/ml). 이 환축은 원발성 간 선암종이 의심이 되었으며 이로 인한 저혈당으로 발작증상을 관리하기 위해 포도당투여를 포함한 약물치료가 시작되었다. 하지만, 보호자의 요청에 의해 안락사가 실시되었고 부검 후 조직 검사를 통하여 원발성 간 선암종으로 확진되었다. 결론적으로 본증례의 경우 개에서 원발성 간암의 진단에 혈청 중 AFP 측정이 진단에 유용할 수 있음을 보여주는 증례다.

• 한국임상수의학회지
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• 제30권2호
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• pp.87-94
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• 2013

본 회고 연구에서는 동맥관 개존증에 이환된 개에서 심장중재술을 통한 치료증례의 임상적 특징과 치료예후를 조사하였다. 환축의 구성을 보면, 말티스와 암컷이 차지하는 비중이 컸다. Bounding pulse와 좌심저부의 심잡음이 가장 대표적인 신체검사 소견이며, differential cyanosis은 매우 드물게 관찰되었다. 심전도상 특징은 좌심종대소견과 동성빈맥이였다. 흉부방사선상 좌심실 종대와 대동맥 확장을 동반한 triple bumps가 대표적인 소견이 였다. 심초음파상 특징은 좌심실 종대를 동반한 폐동맥 단축단면상 심각한 와류 소견이였으며, 다수의 환자에서 이첨판 역류 소견도 관찰되었다. 37증례 중 32증례에서 thromboemolic coils (TCE)이나 Amplatz canine ductal occluder (ACDO)를 이용한 심장 중제술적 치료가 실시되었다. 일시적인 혈색소뇨가 관찰되었고 장착된 코일이나 ACDO가 이탈되는 부작용이 확인되었다. 하지만 장기 관찰이 가능했던 29증례에서 특별한 부작용은 관찰되지 않았다.

• Asian-Australasian Journal of Animal Sciences
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• 제15권6호
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• pp.905-911
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• 2002

A study was carried out to assess the therapeutic effect of ascorbic acid in mastitis of dairy cows. The herd with a population of 250-275 lactating cows was screened for clinical and subclinical mastitis for a period of 5 months. Based on inclusion and exclusion criteria, eighteen animals each with clinical and subclinical mastitis in one quarter only were selected as study population. Twelve cows (group A) with normal udder and health were also selected as a healthy control. Clinical mastitis cows were grouped as B (n=12) and C (n=6). Cows of group B were treated with ascorbic acid at 25 mg/kg, subcutaneously for 5 consecutive days and intramammary infusion (Ampicillin sodium 75 mg and Cloxacillin sodium 200 mg/infusion) based on antibiotic sensitivity test, till complete recovery. Group C cows received only intramammary infusion till the complete recovery. Eighteen subclinical mastitis cows were divided in group D (n=12) and E (n=6). Cows of group D were treated with ascorbic acid at 25 mg/kg subcutaneously for 5 consecutive days while group E did not receive any treatment. California mastitis test (CMT), somatic cell count (SCC), physical changes of udder and milk were used to diagnose and classify the mastitis. Evaluation of the therapy was based on CMT score and physical changes of udder and milk. Sample size calculation was also performed but was not followed for control groups due to scarcity of cases. Adequate blinding was done when and where required to avoid the biases. Confounding variables like herd, age of the cow, stage of the lactation, season and geographical region were duly considered and adequate blocking was followed. Ascorbic acid was administered in clinical and subclinical cases even after cure considering its immunostimulatory and healing inducing effects. The recovery rate was faster in cases of clinical mastitis treated with ascorbic acid along with an intramammary infusion (group B) than the quarters of group C cows. Quarter wise the average duration/number (3.16${\pm}$0.11 days) of antimicrobial intramammary infusion was significantly (p<0.01) less in group B than that of average duration/number (5.33${\pm}$0.20 days) of group C. Subclinical mastitis cows treated with ascorbic acid showed 83.33% recovery while 16.77% did not respond to treatment till last day of study. Cows of group E (untreated) did not recovered from the mastitis. Subjective parameters viz. swelling, pain reflex of udder and physical changes in milk from quarter of ascorbic acid treated cows (group B) disappeared earlier than that of group C cows. It is concluded from this study that the ascorbic acid might be useful as an adjunct in case of clinical mastitis to get quick recovery with less number of intramammary infusions. High recovery rate in subclinical mastitis quarters of group D cows is appreciable and opens a new avenue to conduct further trials in a larger population in various field conditions. However, the pharmacology of ascorbic acid with particular reference to health of mammary gland needs to be investigated.

• 대한감각통합치료학회지
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• 제2권1호
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• pp.21-32
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• 2004

Objective : Effect of treadmill exercise on hippocampal neural cell proliferation under normal conditions and alcohol intoxication conditions has been recently studied; however, this effect under sensory stimulation application has not clarified yet. In the present study, the effect of compression stimulation application on hippocampal neural cell proliferation in the dentate gyrus in normal and alcohol intoxicated rats was investigated. Methods : Experimental design: comparative investigation on number of 5-Bromo-2'-deoxyuridine(BrdU)B-positive cells in dentate gyrus 5 days after commencement. Setting: animal laboratory. Participants: male Sprague-Dawley rats of 3weeks old in age weighing $80{\pm}10gm$. Intervention: animals were randomly assigned into 4 groups; control-rest group(n=8), control-compression group(n=8), alcohol intoxication-rest group(n=8) and alcohol intoxication-compression group(n=8). Animals of the alcohol intoxicated groups were injected intraperitoneally with alcohol(2g/kg) twice per day for 3 days. All animals were injected BrdU(50mg/kg) intraperitoneally, and rats compression stimulation application groups were compressed using sphygmomanometer cuff times per day, for 5 days following alcohol administration. Measures: mean number of BrdU-positive cells in dentate gyrus was observed via immunohistochemistry. Results : Compression stimulation application significantly increased the number of BrdU-positive cells in the dentate gyrus. Also, treatment with alcohol for 3 days inhibited cell proliferation, and compression stimulation application alleviated alcohol-induced inhibition of new cell formation. Conclusion : These results suggest the possibility that compression stimulation application may help in improvement following alcohol-induced brain damaged.

• 한방재활의학과학회지
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• 제27권2호
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• pp.55-66
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• 2017

Objectives This study aimed to review studies in Korean medicine for fibromyalgia syndrome (FMS). Methods We conducted search across 3 electronic databases (Korean traditional knowledge portal, RISS, Oasis) to find studies for FMS in Korean medicine. Studies of Korean medicine for FMS were included and analysed. Results 15 studies were included. 2 studies were reviews and 13 studies were case reports. Total numbers of patients in case studies were 15. In case studies, acupuncture (100%), herbal medicine (76.9%), Korean physical therapy (69.2%), pharmacopuncture (53.8%), Chuna (46.1%) and moxibustion (30.7%) etc. were used. BL23 in acupuncture and CV12 in moxibustion were most frequently used. Gamisoyo-san in herbal medicine and visual analogue scale (VAS) in outcome measure were most frequently used. Conclusions This systematic review found encouraging but limited evidence of Korean medicine for FMS. I expect various trials such as randomized clinical trial or animal experimentation and more case reports. And systemic review for FMS in other national journals is needed.

• Journal of Ginseng Research
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• 제31권4호
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• pp.210-216
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• 2007

The backbone structure of ginsenosides, active ingredients of Panax ginseng, is similar with that of sterol, especially cholesterol. Caenorhabditis elegans (c. elegans) is one of free living nematodes and is well-established animal model for biochemical and genetic studies. C. elegans cannot synthesize de novo cholesterol, although cholesterol is essential requirement for its growth and development. In the present study, we investigated the effects of Korean red ginseng total extract (KRGE), ginseng total saponins (GTS) on life span of C. elegans in cholesterol-deprived and -fed medium. Cholesterol deprivation caused damages on life span of worms throughout F1 to F3 generations. KRGE or GTS supplement to cholesterol-deprived medium restored the life span of worms as much as cholesterol alone-fed medium. In study to identify which ginsenosides are responsible for life span restoring effects of KRGE, we found that ginsenoside Rc supplement not only restored life span of worms grown in cholesterol-deprived medium but also prolonged life span of worms grown in cholesterol-fed medium. These results show a possibility that ginsenosides could be utilized by C. elegans as a sterol substitute and further indicate that ginsenoside Rc is the effective component of Korean red ginseng that prolongs the life span of C. elegans.