• 한국산학기술학회논문지
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• 제16권4호
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• pp.2338-2343
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• 2015

본 연구에서는 범용 유한요소해석 소프트웨어인 ANSYS를 사용하여 공작기계 스핀들 시스템의 유한요소 해석 자동화를 위해서 해석 모델을 개발하고, 그것을 툴로 구현하였다. 그 구현을 위해 EXCEL의 VBA를 사용하였으며, 이로 인해서 사용자가 툴과 상호교류할 수 있도록 그래픽 인터페이스를 개발할 수 있었고, 데이터 정렬을 위해서 EXCEL의 spreadsheet를 사용할 수 있었다. ANSYS 언어를 사용하여 코드를 개발하였으며, 이는 인터페이스에 입력된 정보를 사용하여 형상 모델을 만들고, 순차적으로 해석 모델을 만들며, 마지막으로 유한요소해석 연산을 수행한다. 모델 생성과 해석의 자동화는 최소한의 시간과 노력으로 설계 중인 스핀들 시스템의 근사 최적 설계를 발견하도록 도울 수 있을 것이다.

• 분석과학
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• 제33권2호
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• pp.98-107
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• 2020

Methamphetamine (MA) is currently the most abused illicit drug in Korea. MA is produced by chemical synthesis, and the final target drug that is produced contains small amounts of the precursor chemicals, intermediates, and by-products. To identify and quantify these trace compounds in MA seizures, a practical and feasible approach for conducting chromatographic fingerprinting with a suite of traditional chemometric methods and recently introduced machine learning approaches was examined. This was achieved using gas chromatography (GC) coupled with a flame ionization detector (FID) and mass spectrometry (MS). Following appropriate examination of all the peaks in 71 samples, 166 impurities were selected as the characteristic components. Unsupervised (principal component analysis (PCA), hierarchical cluster analysis (HCA), and K-means clustering) and supervised (partial least squares-discriminant analysis (PLS-DA), orthogonal partial least squares-discriminant analysis (OPLS-DA), support vector machines (SVM), and deep neural network (DNN) with Keras) chemometric techniques were employed for classifying the 71 MA seizures. The results of the PCA, HCA, K-means clustering, PLS-DA, OPLS-DA, SVM, and DNN methods for quality evaluation were in good agreement. However, the tested MA seizures possessed distinct features, such as chirality, cutting agents, and boiling points. The study indicated that the established qualitative and semi-quantitative methods will be practical and useful analytical tools for characterizing trace compounds in illicit MA seizures. Moreover, they will provide a statistical basis for identifying the synthesis route, sources of supply, trafficking routes, and connections between seizures, which will support drug law enforcement agencies in their effort to eliminate organized MA crime.

• Bulletin of the Korean Chemical Society
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• 제30권11호
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• pp.2535-2541
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• 2009

Prebiotic isomaltooligosaccharide preparations contain $\alpha$-D-glucooligosaccharides comprising isomaltooligosaccharides (IMOs) and non-prebiotic maltooligosaccharides (MOs). They are both glucose oligosaccharides characterized by their degree of polymerization (DP) value (from 2 to $\sim$10), linkages types and positions (IMOs: $\alpha$-(1$\rightarrow$2, 3, 6 and in a lower proportion internal 1$\rightarrow$4) linkages, MOs: α-(1$\rightarrow$4) linkages). Their structure is the key factor for their prebiotic potential. In order to determine and elucidate the exact structure of unknown IMOs and MOs, unambiguous assignments of $^{13}C$ and $^1H$ chemical shifts of commercial standards, representative of IMOs and MOs diversity, have been determined using optimized standard one and two-dimensional experiments such as $^1H$ NMR, $^{13}C$ NMR, APT and ${^1}H-{^1}H$ COSY, TOCSY, NOESY and <$^1H-{^{13}}C$ heteronuclear HSQC, HSQC-TOCSY, and HMBC. Here we point out the differential effect of substitution by a glucose residue at different positions on chemical shifts of anomeric as well as ring carbons together with the effect of the reducing end configuration for low DP oligosaccharides and diasteroisotopic effect for H-6 protons. From this study, structural $^{13}C$ specific spectral features can be identified as tools for structural analysis of isomaltooligosaccharides.

• 분석과학
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• 제32권4호
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• pp.147-154
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• 2019

Ampicillin and Sulbactam (2:1, w/w) are combined in formulation to provide broader antibacterial action in treatment of many infections. The development of analytical method for simultaneouly determine these two compounds was difficult because of the differences in their chemical structures and ratio in the formulation. Current published methods still have some limitations. In this study, we developed an alternative high-performance liquid chromatography (HPLC) assay method for simultaneously determination of ampicillin sodium and sulbactam sodium in powder for injection. Method validation of HPLC method was conducted to determine linearity, precision, accuracy, system suitability, robustness. The linearity of the calibration curves in the desired concentration range was good ($r^2$> 0.9994). RSDs of intra-day and inter-day precision obtained were less than 2.00 %. Accuracy was obtained with the recoveries in range of 98.42 % and 101.36 %. As a result of system suitability, RSD of both retention time and the peak area obtained were not more than 1.0 %. The values of plate number were more than 7000 and symmetric factors obtained were 0.8. As intermediate-precision and robustness of the developed assay, it could be expected to become valuable tools for revising the Korean Pharmacopoeia (KP XI).

• Advances in Computational Design
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• 제4권1호
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• pp.15-32
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• 2019

One of the efficient and useful tools to achieve the optimal design of structures is employing the sensitivity analysis in the finite element model. In the numerical optimization process, often the semi-analytical method is used for estimation of derivatives of the objective function with respect to design variables. Numerical methods for calculation of sensitivities are susceptible to the step size in design parameters perturbation and this is one of the great disadvantages of these methods. This article uses complex variables method to calculate the sensitivity analysis and combine it with discrete sensitivity analysis. Finally, it provides a new method to obtain the sensitivity analysis for linear structures. The use of complex variables method for sensitivity analysis has several advantages compared to other numerical methods. Implementing the finite element to calculate first derivatives of sensitivity using this method has no complexity and only requires the change in finite element meshing in the imaginary axis. This means that the real value of coordinates does not change. Second, this method has the lower dependency on the step size. In this research, the process of sensitivity analysis calculation using a finite element model based on complex variables is explained for linear problems, and some examples that have known analytical solution are solved. Results obtained by using the presented method in comparison with exact solution and also finite difference method indicate the excellent efficiency of the proposed method, and it can predict the sustainable and accurate results with the several different step sizes, despite low dependence on step size.

• KIEE International Transactions on Power Engineering
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• 제3A권3호
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• pp.161-167
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• 2003

This paper presents a study performed to investigate the steady-state operational strategies of UPFCs in the Jeollanam-Do system in Korea. The objective of the study was to determine the UPFC operating points under normal and contingency conditions. The study consists of developing load flow models to simulate different load levels with and without UPFCs in the system, assessing the effectiveness of UPFCs by contingency analysis, and introducing optimal corrective actions for removing voltage problems caused by contingencies. The paper describes analytical tools, models and approach. It also includes analysis and discussion of the study results. The paper contributes to the area of transmission operational studies with FACTS applications.

• 대한산업공학회지
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• 제33권1호
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• pp.1-10
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• 2007

The capabilities ofBusiness Process Management Systems (BPMS's) are continuously extended to increase theeffectiveness of the management and enactment of business processes. This paper identifies the challenge ofcase prediction, which for a specific case under the control of a BPMS deals with the estimation of the remaining time until it is completed. An accurate case prediction facility is a valuable tool for the operationalcontrol of business processes, as it enables the pre-active monitoring of time violations. Little research has beencarried out in this area and few commercial tools support case prediction. This paper lists the requirements onsuch a facility and sketches sonae directions to reach a solution. To illustrate the depth of the problem, a smallaspect of the problem is treated in more detail. It involves the complex relations between tasks and resources inbusiness processes, which makes an exact analytical approach mfeasible.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1995년도 하계학술대회 논문집 C
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• pp.1152-1155
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• 1995

An analytic model for the optimum design of the power MOSFET considering the degradation of the breakdown voltage by the three dimensional effect is proposed. The proposed method gives the optimum design parameters such as the lateral radius of window curvature and the doping concentration of the epi-layer, which does not minimize the on-resistance but also maintains the required breakdown voltage. The analytical results are verified by the quasi 3D simulation tools, MEDICI, and it is found that the proposed method may be a good guideline for the design of power MOSFET.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권8호
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• pp.3689-3700
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• 2016

It is not practically feasible to apply hardware-based fault-tolerant schemes, such as hardware replication, in mobile devices. Therefore, software-based fault-tolerance techniques, such as checkpoint and rollback schemes, are required. In checkpoint and rollback schemes, the optimal checkpoint interval should be applied to obtain the best performance. Most previous studies focused on minimizing the expected execution time or response time for completing a given task. Currently, most mobile applications run in real-time environments. Therefore, it is extremely essential for mobile devices to employ optimal checkpoint intervals as determined by the real-time constraints of tasks. In this study, we tackle the problem of determining the optimal inter-checkpoint interval of checkpoint and rollback schemes to maximize the deadline meet ratio in real-time systems and to build a probabilistic cost model. From this cost model, we can numerically find the optimal checkpoint interval using mathematical tools. The performance of the proposed solution is evaluated using analytical estimates.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 1996년도 학술대회
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• pp.33-38
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• 1996

A multi-media binary DS/CDMA system with variable processing gain and coherent correlation receivers are considered under additive white Gaussian noise channels. Two types of information sources with different rates and transmitting powers are assumed to be transmitted simultaneously in the same channel. Average signal-to-noise ratios at the correlation receiver outputs for each type of information sources are analytically derived as functions of discrete partial cross-correlations between spreading code sequences. The analysis is expected to provide analytical tools for use in preliminary system design and spreading code selection.