• 한국재난관리표준학회지
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• 제1권2호
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• pp.53-59
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• 2008

전 세계적으로 물부족 사태는 매우 심각한 상황에 이르렀다. 우리나라도 예외는 아니어서 용수부족이 예상된다. 지하수는 이러한 문제를 일부 지역에서 해결해 주는 역할을 할 수 있으며, 특히 강변여과는 위치와 규모의 제약에도 불구하고 저수지들이 지니고 있는 문제점들을 극복할 수 있다고 알려져 있다. 강변여과 적지분석을 위해 댐건설 지연과 물부족을 겪고 있는 네 지역을 선정하여, 갈등을 해결하고 대안의 우선순위를 결정하는 분석도구인 계층분석과정 (AHP)을 적용하였다. 또한 AHP를 이용한 분석결과를 기존 연구와 비교하였다. 개발된 강변여과 적지분석 방법론은 합리적 의사결정을 위한 판단근거를 제공할 것으로 사료된다.

• 응용통계연구
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• 제19권3호
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• pp.407-419
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• 2006

본 연구에서는 최근 몇 년 동안 한국에서 사회적으로 큰 문제가 되고 있는 카드이용 고객의 연체 방지를 위해 기존 금융권을 이용하는 개인에 대한 연체 성향 분석을 수행한다. 연체 성향 분석의 대상은 현재 한국의 한 특정 은행 고객으로 하였으며, 여러 연체 가운데 신용카드 연체를 중심으로 연구하였다. 연체 성향과 요인이 분석되면 기존 은행 고객에 대한 향후 부실의 정도를 예측할 수 있으며 또한 미래의 고객에 대해서도 신용평가 시스템을 만들 수 있을 것이다. 연체 성향 분석을 위한 통계적 방법으로 연체 유/무에 대한 로지스틱 회귀모형을 적용하였고 연체가 있을시 연체금액에 대한 일반화 선형 모형을 적용하여 자료를 적합한 후, 유의한 설명변수들을 선정하여 반응변수와 설명변수들의 관계를 설명해 보았다. 분석 결과 연령, 건당 현금서비스 평균금액, 타사 현금금액, 수신잔액, 순수익이 연체 유무와 연체금액에 중요한 영향을 미치는 설명변수들임을 알 수 있었다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1259-1259
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• 2001

Meat becomes brown and rancid during storage in the refrigerator and display in the case. Color changes, metmyoglobin formation and lipid oxidation are the important problems in the transportation / distribution of meat and retail display. The freshness of meat is determined by the sense of vision and smell. Since conventional method determining lipid oxidation is time consuming and destructive (it needs to homogenize meat with reagents, filtrate, time for reaction and read optical density using spectroscopy), more rapid and nondestructive technical tools are desired. The objective of this work was to evaluate near-infrared spectroscopy as an analytical tool for determining meat color, metmyoglobin formation and lipid oxidation. in beef, pork and chicken. Semitendinosus and longissimus thoracis muscles from six beef steers, biceps femoris and longissimus thoracis muscles from twelve LWD crossbred pigs, and superficial pectoral muscles from twenty-four broilers were used. About a 5-cm diameter and 1-cm thick sample (20.0g) was cut from the muscle and placed on plastic foam, over-wrapped with PVC film, and displayed under flourescent lights at 4 degrees C. during 10 days for beef and pork or 4 days for chicken. The spectra was measured by NIR systems Model 5500 Spectrophotometer using fiber optic scan at range of 400 - 1100 nm. Data were recorded at 2 nm intervals and 10 scans / 10 sec were averaged for every sample. Data obtained were saved as log 1/Re, where Re is the reflectance energy, and then mathematically transformed to second derivatives to reduce effects of differences in particle size. $L^{*}$, $a^{*}$ and $b^{*}$, and metmyoglobin formation were determined by conventional spectrophotometer using the integrating sphere unit. 2-Thiobarbituric acid reactive substances (TBARS) were measured for lipid oxidation. A multiple linear regression was used to find the equation which would best fit the data. The number of wavelengths used in the equation was selected based on the fewer number compared to the increasing multiple correlation and Decreasing standard error. (omitted)

• 한국지하수토양환경학회지:지하수토양환경
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• 제8권4호
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• pp.36-44
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• 2003

전 세계적으로 물부족 사태는 매우 심각한 상황에 이르렀다. 우리나라도 예외는 아니어서 2011년에는 약 18억 $\textrm{m}^3$, 2020년에는 약 26억 $\textrm{m}^3$의 용수부족이 예상된다 지하수는 이러한 문제를 일부 지역에서 해결해 주는 역할을 할 수 있으며, 특히 지하댐은 위치와 규모의 제약에도 불구하고 지상댐이 지니고 있는 문제점들을 극복할 수 있다고 알려져 있다. 지하댐 적지분석을 위해 댐건설 지연과 물부족을 겪고 있는 네 지역을 선정하여, 갈등을 해결하고 대안의 우선순위를 결정하는 분석도구인 계층분석과정(AHP)을 작용하였다. 또한 AHP를 이용한 분석결과를 기존 연구와 비교하였다. 개발된 지하댐 적지분석 방법론은 중앙정부나 지방자치단체에게 합리적 의사결정을 위한 판단근거를 제공할 것으로 사료된다.

• Toxicological Research
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• 제26권3호
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• pp.203-208
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• 2010

Bronchoalveolar lavage (BAL) is a useful tool in researches and in clinical medicine of lung diseases because the BAL fluid contains biochemical and cytological indicators of the cellular response to infection, drugs, or toxicants. However, the variability among laboratories regarding the technique and the processing of the BAL material limits clinical research. The aim of this study was to determine the suction frequency and lavage fraction number necessary to reduce the variability in lavage using male Sprague-Dawley rats. We compared the total cell number and protein level of each lavage fraction and concluded that more cells and protein can be obtained by repetitive lavage with a suction frequency of 2 or 3 than by lavage with a single suction. On the basis of total cell recovery, approximately 70% of cells were obtained from fractions 1~3. The first lavage fraction should be used for evaluation of protein concentration because fractions 2~5 of lavage fluid were diluted in manifolds. These observations were confirmed in bleomycin-induced inflamed lungs of rats. We further compared the BAL data from the whole lobes with data from the right lobes and concluded that BAL data of the right lobes represented data of the whole lobes. However, this conclusion can only be applied to general lung diseases. At the end, this study provides an insight into the technical or analytical problems of lavage study in vivo.

• 대한약침학회지
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• 제19권2호
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• pp.145-154
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• 2016

Objectives: The aim of this paper is to investigate the activities of Malaysian local herbs (Clinacanthus nutans Lindau, Strobilanthes crispus, Murdannia bracteata, Elephantopus scaber Linn., Pereskia bleo, Pereskia grandifolia Haw., Vernonia amygdalina, and Swietenia macrophylla King) for anti-hypertensive and vasorelaxant activity. An infrared (IR) macro-fingerprinting technique consisting of conventional fourier transform IR (FTIR), second-derivative IR (SD-IR), and two-dimensional correlation IR (2D-correlation IR) analyses were used to determine the main constituents and the fingerprints of the Malaysian local herbs. Methods: The herbs were collected, ground into powder form, and then macerated by using three different solvents: distilled water, 50% ethanol, and 95% ethanol, respectively. The potentials of the extracts produced from these herbs for use as vasorelaxants were determined. Additionally, the fingerprints of these herbs were analyzed by using FTIR spectra, SD-IR spectra, and 2D-correlation IR spectra in order to identify their main constituents and to provide useful information for future pharmacodynamics studies. Results: Swietenia macrophylla King has the highest potential in terms of vasorelaxant activity, followed by Vernonia amygdalina, Pereskia bleo, Strobilanthes crispus, Elephantopus scaber Linn., Pereskia grandifolia Haw., Clinacanthus nutans Lindau, and Murdannia bracteata. The tri-step IR macro-fingerprint of the herbs revealed that most of them contained proteins. Pereskia bleo and Pereskia grandifolia Haw. were found to contain calcium oxalate while Swietenia macrophylla King was found to contain large amounts of flavonoids. Conclusion: The flavonoid content of the herbs affects their vasorelaxant activity, and the tri-step IR macro-fingerprint method can be used as an analytical tool to determine the activity of a herbal medicine in terms of its vasorelaxant effect.

• Structural Engineering and Mechanics
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• 제53권5호
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• pp.939-956
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• 2015

In this study, in order to propose an efficient model to predict the torque capacity of steel fiber reinforced concrete (SFRC) beams, the existing experimental data related to torsional response of beams is reviewed. It is observed that existing data neglects the effects of some parameters on the variation of torque capacity. Thus, an experimental research was also conducted to obtain the effects of neglected parameters. In the experimental study, a total of seventeen SFRC beams are tested against torsion. The parameters considered in the experiments are concrete compressive strength, steel fiber aspect ratio, volumetric ratio of steel fibers and longitudinal reinforcement ratio. The effect of each parameter is discussed in terms of torque versus unit angle of twist graphs. The data obtained from this experimental research is also combined with the data got from previous studies and employed in artificial neural network (ANN) analysis to estimate the ultimate torque capacity of SFRC beams. In addition to parameters considered in the experiments, aspect ratio of beam cross-section, yield strengths of both transverse and longitudinal reinforcements, and transverse reinforcement ratio are also defined as parameters in ANN analysis due to their significant effects observed in previous studies. Assessment of the accuracy of ANN analysis in estimating the ultimate torque capacity of SFRC beams is performed by comparing the analytical and experimental results. Comparisons are conducted in terms of root mean square error (RMSE), mean absolute error (MAE) and coefficient of efficiency ($E_f$). The results of this study revealed that addition of steel fibers increases the ultimate torque capacity of reinforced concrete beams. It is also found that ANN is a powerful method and a feasible tool to estimate ultimate torque capacity of both normal and high strength concrete beams within the range of input parameters considered.

• Structural Engineering and Mechanics
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• 제52권6호
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• pp.1069-1084
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• 2014

The long-term performance of plates resting on viscoelastic foundations is a major concern in the analysis of soil-structure interaction. As a powerful mathematical tool, fractional calculus may address these plate-on-foundation problems. In this paper, a fractionalized Zener model is proposed to study the time-dependent behavior of a uniformly loaded rectangular thin foundation plate. By use of the viscoelastic-elastic correspondence principle and the Laplace transforms, the analytical solutions were obtained in terms of the Mittag-Leffler function. Through the analysis of a numerical example, the calculated plate deflection, bending moment and foundation reaction were compared to those from ideal elastic and standard viscoelastic models. It is found that the upper and lower bound solutions of the plate response estimated by the proposed model can be determined using the elastic model. Based on a parametric study, the impacts of model parameters on the long-term performance of a foundation plate were systematically investigated. The results show that the two spring stiffnesses govern the upper and lower bound solutions of the plate response. By varying the values of the fractional differential order and the coefficient of viscosity, the time-dependent behavior of a foundation plate can be accurately captured. The fractional differential order seems to be dependent on the mechanical properties of the ground soil. A sandy foundation will have a small fractional differential order while in order to simulate the creeping of clay foundation, a larger fractional differential order value is needed. The fractionalized Zener model is capable of accounting for the primary and secondary consolidation processes of the foundation soil and can be used to predict the plate performance over many decades of time.

• Geomechanics and Engineering
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• 제11권4호
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• pp.493-513
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• 2016

A modified grey clustering method is presented to systematically evaluate the risk of water inrush in karst tunnels. Based on the center triangle whitenization weight function and upper and lower limit measure whitenization weight function, the modified grey evaluation model doesn't have the crossing properties of grey cluster and meets the standard well. By adsorbing and integrating the previous research results, seven influence factors are selected as evaluation indexes. A couple of evaluation indexes are modified and quantitatively graded according to four risk grades through expert evaluation method. The weights of evaluation indexes are rationally distributed by the comprehensive assignment method. It is integrated by the subjective factors and the objective factors. Subjective weight is given based on analytical hierarchy process, and objective weight obtained from simple dependent function. The modified grey evaluation model is validated by Jigongling Tunnel. Finally, the water inrush risk of Shangjiawan Tunnel is evaluated by using the established model, and the evaluation result obtained from the proposed method is agrees well with practical situation. This risk assessment methodology provides a powerful tool with which planners and engineers can systematically assess the risk of water inrush in karst tunnels.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.289-294
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• 2011

A rapid and specific high performance liquid chromatography-tandem mass (LC/MS/MS) method for the analysis of montelukast in human plasma has been developed and validated. After cold acetonitrile-induced precipitation of the plasma samples, montelukast and glipizide (internal standard, IS) were eluted on a reverse-phase $C_{18}$ column by isocratic mobile phase consisted of 10 mM ammonium formate buffer (adjusted to pH 3.5 with formic acid) and acetonitrile (3:97, v/v). Acquisition was performed with multiple reaction monitoring (MRM) mode by monitoring the transitions: m/z 587.2${\rightarrow}$ 423.2 for montelukast and m/z 446.0${\rightarrow}$321.2 for IS. Ranges of concentration for calibration curves (10-1000 ng/mL) showed correlation coefficients ($r^2$) were better than 0.9948. Precision of intra- and inter-day ranged from 3.70 to 11.68% and from 3.04 to 12.95%, accuracy of intra-day and inter-day ranged from 93.34 to 102.75% and from 100.79 to 107.63%, respectively. The described method provides a fast and sensitive analytical tool for determining montelukast levels in plasma, and was successfully applied to a pharmacokinetic study in 16 healthy human subjects after oral administration of 10mg tablet formulation of montelukast sodium under fasting conditions.