• 한국우주과학회:학술대회논문집(한국우주과학회보)
• /
• 한국우주과학회 1993년도 한국우주과학회보 제2권2호
• /
• pp.17-17
• /
• 1993

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70${\pm}$1.32mmHg/min)compared to CF dialyzers(4.32${\pm}$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500,550,570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500,550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100,300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3,000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.

• Molecules and Cells
• /
• 제27권5호
• /
• pp.591-599
• /
• 2009

Nicotinic acetylcholine receptors (nAChRs) play important roles in nervous system functions and are involved in a variety of diseases. We previously demonstrated that ginsenosides, the active ingredients of Panax ginseng, inhibit subsets of nAChR channel currents, but not ${\alpha}7$, expressed in Xenopus laevis oocytes. Mutation of the highly conserved Leu247 to Thr247 in the transmembrane domain 2 (TM2) channel pore region of ${\alpha}7$ nAChR induces alterations in channel gating properties and converts ${\alpha}7$ nAChR antagonists into agonists. In the present study, we assessed how point mutations in the Leu247 residue leading to various amino acids affect 20(S)-ginsenoside $Rg_3$ ($Rg_3$) activity against the ${\alpha}7$ nAChR. Mutation of L247 to L247A, L247D, L247E, L247I, L247S, and L247T, but not L247K, rendered mutant receptors sensitive to $Rg_3$. We further characterized $Rg_3$ regulation of L247T receptors. We found that $Rg_3$ inhibition of mutant ${\alpha}7$ nAChR channel currents was reversible and concentration-dependent. $Rg_3$ inhibition was strongly voltage-dependent and noncompetitive manner. These results indicate that the interaction between $Rg_3$ and mutant receptors might differ from its interaction with the wild-type receptor. To identify differences in $Rg_3$ interactions between wild-type and L247T receptors, we utilized docked modeling. This modeling revealed that $Rg_3$ forms hydrogen bonds with amino acids, such as Ser240 of subunit I and Thr244 of subunit II and V at the channel pore, whereas $Rg_3$ localizes at the interface of the two wild-type receptor subunits. These results indicate that mutation of Leu247 to Thr247 induces conformational changes in the wild-type receptor and provides a binding pocket for $Rg_3$ at the channel pore.

• 한국조경학회지
• /
• 제37권5호
• /
• pp.98-108
• /
• 2009

본 연구는 저토심형 옥상녹화 시스템 개발을 위하여 제안된 공법의 특징, 경제성, 자생 및 도입 지피식물류의 생육상태를 분석하여 생육 적정성을 파악하고자 하였다. 저토심 인공지반 녹화공법은 세립토양필터가 붙은 1cm 롤형 배수판 위에 7.5cm 두께의 암면매트를 설치, 그 위에 4.5cm의 상토층을 조성하여 배수판을 포함한 전체 토심은 13cm이었다. 설계가 기준으로 공법별 토양층 공사비를 살펴보면 세덤블럭공법이 89,433원/$m^2$이었고, 저배수공법이 92,550원/$m^2$이 소요되는 것과 비교한 결과에서 저토심 인공지반 녹화공법의 토양층 조성 공사비는 45,000원/$m^2$으로 기존 저토심 옥상 녹화공법보다 경제적으로 50% 정도 원가절감 효과가 있었다. 저토심 인공지반 녹화공법의 유효성 검토를 위해 대한주택공사 2층 옥상부에 실험구를 설치하고, 초본식물 생육조사를 위해 국내에 도입되고 있는 옥상녹화 초본류 중 활용빈도가 높은 종들을 대상으로 자생종 및 도입종별 피복률, 생체중량, 건체중량을 측정하였다. 자생종인 기린초, 애기기린초, 두메부추, 돌나물, 매발톱꽃, 층꽃나무 등은 저토심 인공지반 녹화공법에서 피복률 증가와 함께 생체중량, 건체중량이 증가하는 경향을 보였다. 도입종에 있어 스프리움, 리플렉섬도 비슷한 경향을 보였으나, 일부 종에서는 잡초관리가 필요할 것으로 판단되었다. 결과적으로 저토심 인공지반 녹화공법은 저비용으로 옥상녹화가 가능한 것으로 분석되었고, 식물생육도 양호한 것으로 나타나 도심 내 옥상녹화의 보급화에 기여할 것으로 기대되었다.

• 한국안광학회지
• /
• 제11권3호
• /
• pp.281-291
• /
• 2006

본 연구는 굴절이상을 가진 피검자의 시력 개선을 위한 Netspeg 렌즈의 임상적 검증을 하였다. 피검자는 성인 100명(남성 50인, 여성 50명; 평균 21세, 연령은 19세와 24세 사이)의 200개 눈을 대상으로 검사하였다. 피검자는 전신건강, 약물복용, 유전병, 알레르기, 전신질환 그리고 안질환을 포함하는 문진 등을 조사하였다. 굴절검사는 객관적인 방법을 사용해서 단안과 양안을 기록하였다. 시력측정은 양안에 Netspeg 렌즈와 CR-39를 착용하여 실시하였다. 입체시 검사는 Netspeg 렌즈와 CR-39를 착용해서 근거리에서 Titmus fly와 TNO를 사용해서 하였다. P-VEP 검사는 3채널의 16 pattern size(Bausch Lomb, production in U.S.A.)를 사용하였다. 피검자는 Netspeg 렌즈와 CR-39 렌즈를 사용하여 교정된 시력을 통해서 양안으로 patten 자극을 사용하였다. 역시 피검자는 Netspeg 렌즈와 CR-39 렌즈를 사용하여 교정된 시력을 통해서 양안시로 P-VEP 자극을 본다. 대비감도 검사는 대비감도 차트(Pelli-Robertson, made in USA)를 이용해서 1m 거리에서 Netspeg 렌즈와 CR-39를 장용해서 실시하였다. Netspeg 렌즈와 CR-39의 표면 미세구조는 SEM(JMS-5800, made in Japan)을 이용해서 관찰하였다. 연구의 결과는 다음과 같다. 1. Netspeg 렌즈와 CR-39를 사용한 비정상 굴절 피검자의 교정된 시력에서 Netspeg 렌즈를 착용한 피검자는 시각의 주관적 테스트에서 CR-39 착용자에 비해서 좋은 시야와 깨끗한 시력을 얻었다. 그러나 시력의 편안함은 Netspeg 렌즈와 CR-39는 비슷한 결과를 가졌다. 역시 Netspeg 렌즈 착용자의 피검자는 CR-39보다 좋은 시력을 가졌다. 한편 P-VEP 분석에서는 사용된 Netspeg 렌즈 착용자의 파의 진폭은 CR-39보다 더 증가한 모습을 가졌다(p>0.5). 또한 대비감도 검사에서 Netspeg 렌즈 착용자는 CR-39보다 좋은 결과를 가졌다. Netspeg 렌즈를 착용한 피검자의 TNO 입체시 검사 값은 그 결과가 CR-39보다 좋았다. 그러나 Titmus 입체시 검사에서는 Netspeg 렌즈와 CR 착용자는 비슷한 검사 결과를 나타내었다. 특히 초경발수 Netspeg 렌즈와 비구면 Netspeg 렌즈는 시기능 테스트에서 다소 비슷한 결과를 가졌다. 2. Netspeg 렌즈 표면의 미세구조는 CR-39보다는 매끄럽고 섬세한 구조와 선을 가졌다. 역시 Netspeg 렌즈는 미세구조에서 섬세한 선상 구조를 가졌다. 결론적으로 이 연구의 결과는 사용된 Netspeg 렌즈의 표면 미세구조는 CR-39보다는 더욱 특수한 pinhole 디자인 구조를 나타내었다. 이 연구는 사용된 Netspeg 렌즈의 시각은 비정상 굴절 눈을 위한 교정된 시력에 CR-39보다 좋은 것을 나타낸다. 따라서 저자들은 Netspeg 렌즈의 미세구조와 선 구조는 좋은 시기능과 관계되었을 것으로 추측된다. 그러나 비구면 Netspeg 렌즈와 초경발수 Netspeg 렌즈의 시기능에 대한 결과는 비슷하였다.

• 경영정보학연구
• /
• 제15권2호
• /
• pp.1-19
• /
• 2013

아이폰3로 촉발된 스마트 혁명은 시간과 장소에 구애 받지 않고 똑똑하게 일하는 스마트워킹 시대를 열어가고 있다. 기업은 스마트워킹을 통해 정보를 실시간 처리하고, 신속한 의사결정과 적시 대응을 함으로써 기업의 생산성과 성과를 향상시킬 수 있다. 그러나 스마트워킹은 이러한 기회 이면에 취약한 보안문제를 지니고 있다. 스마트워킹 이전에는 단지 기업 내에서만 정보를 볼 수 있었다. 그러나 스마트워킹이 가능해지면서 유출, 해킹 등을 통해 정보가 종전보다 쉽게 기업 외부로 노출될 수 있게 되었다. 따라서 모바일 보안은 기업 비밀을 중시하는 사기업은 물론 사회 기반구조를 담당하는 공공기관에게 있어서 다루어야 할 매우 중요한 이슈가 되고 있다. 본 연구는 공공기관의 모바일 정보보안에 초점을 맞추고 있다. 공공기관이 스마트워크를 실행하기 위해서는 국가정보원의 모바일 정보보안규칙을 준수해야 한다. 이 보안규칙은 모바일 단말 보안, 모바일 단말과 무선망간 보안, 모바일 플랫폼과 업무망간 보안으로 구성되어 있다. 지금까지 공공기관은 이러한 보안규칙을 준수하기 위해 기업 소유의 모바일 단말기에 MDM(Mobile Device Management) 솔루션을 설치 운영해 왔다. 모바일 단말기에 MDM 솔루션이 설치되면 그 단말기는 Wi-Fi, 카메라, 화면캡쳐 등이 차단되어 이러한 기능을 사용할 수 없게 된다. 지금까지는 기업 소유의 모바일 단말기만 보안규칙을 적용하여 모바일 정보시스템을 사용해왔기 때문에 별 문제가 없었다. 그러나 기업은 스마트워킹의 효과를 높이기 위해 개인 소유의 모바일 단말기까지 모바일 정보시스템의 이용범위를 확산시키려하고 있다. 바로 이러한 상황에서 문제가 발생하고 있다. 개인 소유의 모바일 기기에 종전과 같은 보안규칙을 적용하면 개인은 기기 사용에 제한을 받기 때문이다. 즉, 개인 소유의 스마트폰에 MDM 솔루션을 설치하면 Wi-Fi, 카메라, 화면캡쳐 기능을 사용할 수 없게 되기 때문이다. 그 누구도 자신이 소유한 기기의 기능을 제한받으면서까지 모바일 정보시스템을 사용하려 하지 않기 때문에 지금까지의 모바일 정보보안 방식으로는 폭넓은 스마트워킹을 구현할 수 없게 된다. 따라서 개인 소유의 모바일 단말기에까지 스마트워킹을 구현하기 위해서는 모바일 정보시스템이 실행될 때에만 MDM 솔루션이 실행되도록 함으로써 개인의 자유로운 모바일 기기 사용을 보장해야 하고, 모바일 정보시스템 각각의 보안 요구 등급에 맞게 신축적으로 단말기 기능을 차단할 필요가 있다. 본 논문에서는 K사에서 바로 이러한 필요성을 충족시킨 구현 사례를 연구하여 제시하였다. 대부분의 정보시스템은 기업에 의해 개발되고 기업 소유의 기기에 설치되어 운영된다. 그러나 모바일 정보시스템은 이와 다르게 기업에 의해 개발되고 개인 소유의 모바일 기기에 설치되어 운영될 수 있다. 본 연구는 기업에게는 모바일 정보시스템에 대한 보안 목표를 충족시켜 주고 개인에게는 시스템 사용에 따른 제한을 최소화함으로써 BYOD(Bring Your Own Device) 시대에 최적의 해결 방안을 제시할 수 있을 것으로 기대된다. 본 연구결과는 스마트워크를 추진하고자 하는 공공기관은 물론 기업비밀에 민감한 사기업의 모바일 정보보호 문제를 해결함으로써 스마트워킹 확산에 기여할 것으로 본다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제21권8호
• /
• pp.1189-1195
• /
• 2008

A study was conducted with 48 weaned barrows ($28{\pm}3d$, $8.45{\pm}0.14kg$) to determine the effect of Achyranthes bidentata polysaccharide (ABPS) supplementation on pig performance, immunological, adrenal and somatotropic responses following Escherichia coli lipopolysaccharide (LPS) challenge. The experiment was a $2{\times}2$ factorial design; the main factors included diet (supplementation with 0 or 500 mg/kg ABPS) and immunological challenge (LPS or saline). On d 14 and 21 of the trial, pigs were given an intraperitoneal injection with either $100{\mu}g/kg$ BW of LPS or an equivalent amount of sterile saline. Blood samples were obtained 3 h after injection for analysis of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), prostaglandin $E_2$ ($PGE_2$), cortisol, growth hormone (GH), insulin-like growth factor (IGF)-I and immunoglobulin G (IgG). On d 2 after LPS challenge, peripheral blood lymphocyte proliferation (PBLP) was measured. LPS administration decreased average daily feed intake (ADFI) (p<0.05), had a tendency to decrease average daily gain (ADG) (p<0.10) during both the first and second challenge periods and increased (p<0.05) feed:gain ratio only during the first challenge period. ABPS tended to improve ADG (p<0.10) during the first challenge period, and improved ADG (p<0.05) and tended to improve ADFI (p<0.10) during the second challenge period. ABPS did not affect feed:gain ratio. An interaction (p<0.05) between LPS challenge and diet was observed for the plasma concentrations of TNF-${\alpha}$, $PGE_2$ and cortisol after both LPS challenges such that, among LPS-treated pigs, pigs fed the ABPS diet were lower for these indices than those receiving the control diet. In contrast, pigs fed the ABPS diet had higher IGF-I (p<0.05) compared with those fed the control diet. No effect of diet, LPS challenge or both on GH and IgG was observed after both LPS administrations. LPS challenge increased PBLP when these cells were incubated with $8{\mu}g/ml$ of LPS during both the challenge periods, and did likewise when incubated with $8{\mu}g/ml$ of concanavalin A only after the first challenge. ABPS had no effect on PBLP. These data demonstrate that ABPS alters the release of pro-inflammatory cytokines following an immunological challenge, which might enable pigs to achieve better performance.

• 동서간호학연구지
• /
• 제1권1호
• /
• pp.82-98
• /
• 1997

The purpose of this study was to determine pattern of the stress perceived by stroke patients over time. The ultimate goal of the research is to provide data to help nurses to design the plan of nursing care of the stroke patients both in the hospital and at home. A total of 57 admitted stroke patients were collected from one general hospital in Seoul from June, 12 to September, la, 1993. The data were collected for three phases(within one week after leaving the hospital). The tools for this study, three scales were used ; Stress scale developed by the investigator. Constitution classifing scale designed by Kho(1984), and Self-care measuring scale by Kang(1984). Data were analyzed in four steps using statistical analysis. First, demographic data were determined by descriptive statistics. Second. the pattern of stress perceived by stroke patients across three phases was measured using repeated measures ANOVA. Third, stress of stroke patients classified by constitution, paralyzed area. and attack frequency were measured using ANOVA or t-test, and the pattern of stress by group over time was determined using paired t-test in post hoc test. Fourth. Pearson correlation coefficients were calculated to determine the relationship between the stress and self-care activities. The results of this study are ; 1. The pattern of stress across three phases ; There was a decrease of the stress across three phases. In general. psychological stress as the highest among three phases(F=36.92. P=.000). There was a statistically significant difference of the physical stress(F=34.55, p=.000), the psychological stress (F=15.49, p=.0005) and the social stress (F=24.71. p=.000) among three phases. There was a statistically significant difference of the stress between the first phase (on admission) and the second phase(before leaving the hospital) and was a decrease of the stress (t =6.36. p=.000). 2. The pattern of stress of stroke patients classified by constitution across three phases ; Stroke patients classified as So-Eum perceived the highest stress among three groups(Tae-Eum, So-Eum. So-Yang). There was no statistically significant difference of stress according to the constitution of stroke patients among three phases. Hence. stress was not influenced by the constitution of stroke patients, but there was a statistically significant difference of stress over time. 3. The pattern of stress of stroke patients classified by the paralyzed area across three phases ; Right paralyzed stroke patients perceived higher stress than left paralyzed stroke patients. There was, however, no statistically significant difference of stress between two groups except 2nd phase. There was no statistically significant difference of the perception of stress bet ween the right and left paralyzed stroke patients. 4. The pattern of stress of stroke patients classified by the frequency of the relapse of the disease across three phases ; Stress was higher in stroke patients who had the relapse of the disease twice more than the first time. There was, however, no statistically significant difference of stress between two groups. There was no statistically significant difference of stress of stroke patients according to the relapse of the disease among three phases. Hence, stress was no influenced by the relapse of the disease. 5. The relationship between the stress and self-care activities ; There was a negative relationship between the stress and self-care activities each phase(on admission, r= -.1563 ; before leaving the hospital, r= -.4030 ; after leaving the hospital, r= -.5291). Hence, the higher the self-care activities, the lower the stress. This study has three important findings. First finding was that psychological stress perceived by stroke patients was the highest among three phases. The second finding was that factors such as the constitution, the paralyzed area, and the relapse of the disease did not have an influence on the stress perceived by stroke patients across three phases(on admission, before leaving the hospital, after leaving the hospital). There was a statistically significant decrease of the stress perceived by stroke patients across three phases. The third finding was that there was a negative relationship between the self-care ability and stress. In this study, these findings have implications for nursing care for the rehabilitation of stroke patients and suggest the need of nursing intervention to promote the self-care ability and to support the psychological self-esteem of stroke patients.

• 마케팅과학연구
• /
• 제19권4호
• /
• pp.57-63
• /
• 2009

随着电子商务指数式增长(电子商务), 营销人员正试图获得通过强调服务质量和服务方面的相互作用而导致客户满意度或行为后果的竞争优势. 特别是对于服装, 服务质量是鼓励客户电子忠诚的关键因素之一, 并增加电子商务中服装零售的成功. 因此, 本研究探讨电子服务质量(电子SERVQUAL)的因素和根据Parasuraman等人(2005)的研究框架对网上服装购物的电子忠诚度的独特影响. 这项研究的具体目标是确定的基本层面的E - SERVQUAL, 分析有关在网上服装购物中电子SERVQUAL对点在忠诚度的影响的结构模型. 对于服务质量, 在网上购物方面的理论框架, 我们比较分析了有关传统和电子服务质量的因素的文献并确定了核心的两个方面和恢复服务. 这项研究的假设是电子SERVQUAL对电子忠诚度的影响. 客户满意度对电子服装网上购物服务的忠诚度有积极影响和客户满意度在电子SERVQUAL对服装网上购物电子忠诚度影响中的中介作用. 根据文献我们制成了一份自填式的问卷. 我们在美国从居住在大城市的有在网上购买服装产品的在线消费者中获得了252份有用的问卷. 通过因子分析(例如, 探索, 验证)评估了有效性和可靠性, 结构方程模型, 包括测量和结构模型, 通过线性结构8.8程序评估了包括测量和结构模型的结构方程模型. 结果显示, 网上购物网站的电子SERVQUAL的五个因素: 赔偿, 执行, 效率, 系统可用性和反应能力. 这支持在网上服装购物方面Parasuraman(2005)的E-S-QUAL包括两个方面的核心服务(如满足, 效率, 系统可用性)和恢复相关的服务(例如, 补偿, 回应). 在结构方程模型中, 有5个电子SERVQUAL因素的外生潜变量, 两个内生潜变量(例如客户满意度, 电子忠诚度). 对于测量模型, 各代表概念的因子载荷有显著的统计学意义, 比 0.60大, 内部一致性信从 0.85 至 0.8 8 不等. 在估计电子SERVEQUAL因素的结构模型, 系统的可用性对电子忠诚的直接和积极的作用, 而效率对网上服装购物的电子忠诚度有负面影响. 然而, 满足不是解释网上服装购物的电子SERVQUAL结果的重要指标. 这一发现意味着, 可被理解为系统提供服务的质量可能会增加对服装网上购物的客户满意度. 然而, 电子忠诚取决于服务质量没有被支持, 因为在网上服装购买中, 通过价值或满意度的中介作用, 服务质量对电子忠诚度(例如再购买意图)有间接影响. 此外, 获得赔偿和回应被发现对客户满意度有显著影响, 会影响网上服装购买的电子忠诚度. 因此, 获得赔偿和回应对电子忠诚度有显著的间接影响. 这表明, 恢复特定的服务因素在客户满意度最大化方面的重要作用, 以及维护客户对网上服装购物网站的忠诚度方面的重要作用. 研究结果在管理和研究方面都有启示. 时装营销者可以在建立与客户的长期关系的基础上, 不断测量顾客感知与恢复服务有关的服务质量等问题, 例如对问题和返回的迅速反应, 客户购买之后的问题赔偿. 为了保持电子忠诚, 在消费者购买服装中恢复服务对消费者第一次选择网站起到重要作用. 由于网上购物的消费者可以在任何地方购物, 提高竞争优势的营销策略是为消费者提供更好的服务质量, 最大限度地满意, 并把创造客户网上服装购买的电子忠诚度. 从研究的角度来看, 解释这些结果时, 本研究的一些局限需要被考虑. 对于未来的研究, 调查结果为这一重要主题理论和实证方面的进一步的研究提供了依据. 根据研究结果, 更全面的模型预测电子SERVQUAL的结果可以被开发和测试. 对全球时装市场, 这项研究可以扩展使用多国样本的跨文化的方法来研究服装的电子服务质量.

• 대한치과교정학회지
• /
• 제36권1호
• /
• pp.55-62
• /
• 2006

교정용 미니임플랜트는 작은 크기로 삽입 부위에 제한이 적어 고정원 조절에 널리 이용되고 있다. 그러나 잦은 탈락의 단점이 있어 초기 안정성을 향상시키기 위한 다양한 형태와 길이에 관한 연구가 시도되어왔다. 이 연구의 목적은 교정용 미니임플랜트의 형태와 길이에 따른 초기 안정성에 대한 기계역학적 성질을 비교 분석하는 것이다. 미니임플랜트의 직경은 1.6 mm였으며, 형태는 원통형과 원추형, 길이는 6 mm와 8 mm로 구성되어 원통형 6 mm, 원통형 8 mm, 원추형 6 mm, 원추형 8 mm군과, 중앙 1/2에서부터 상방으로 나사산이 점차적으로 작아지는 변형된 원추형 8 mm군을 포함하여 총 5군으로 구성되었다. 각 군은 10개의 미니임플랜트로 구성되었고, 균일한 밀도의 polyurethane foam에 삽입 후 제거하였다. 시간에 따른 삽입 및 제거 토크의 변화와 각각의 최대 토크 등을 측정하여 기계역학적 성질을 비교 분석하였다. 동일한 길이에서 원추형은 삽입과 제거 시 원통형보다 유의성 있게 더 큰 토크를 보여주었다 (p<0.001). 동일한 형태에서 삽입과 제거 시 긴 미니임플랜트가 짧은 미니임플랜트보다 유의성 있게 더 큰 토크를 보여주었다 (p<0.001). 원추형 6 mm는 원통형 8 mm에 비해 삽입 시 유의성 있게 낮은 토크를(p<0.001) 보여주었지만, 제거 시 비슷한 토크를 보여주었다. 변형된 원추형 8 mm에서는 최대 제거 토크 후 지속적으로 높은 제거 토크를 보여주었다. 미니임플랜트의 초기 안정성은 원추형에 의해 향상될 수 있으며, 상부 나사산의 작은 크기와 형태는 미니임플랜트의 초기 안정성에 긍정적인 영향을 미치는 것으로 보인다.$76^{\circ}$였다. Naso frontal angle (G-N'-Pn)은 남자 $142^{\circ}$, 여자 $147^{\circ}$, transverse nasal prominence (Zy(Rt)-Pn-Zy(Lt))는 남자 $112^{\circ}$, 여자 $116^{\circ}$로 남녀 간에 통계학적으로 유의차가 있었다 (p<0.05). 하안면고경 하방 2/3 (Li-Me')와 하악체길이(Go'-Me'), 입술고경(ULPm-Li)과 폭경(Ch(Rt)-Ch(Lt))의 비율은 각각 2/5로 나타났다. 관상기준평면에서 안면의 윤곽을 나타내는 계측점인 FT, Zy, Pn, ULPm, Li, Me'까지의 거리의 비는 -1/-1/1/0.5/0.5/-0.6였다. 또한 얻어진 자료를 이용하여 한국 성인 정상교합자의 3차원 안면 모델을 제작하였으며 이는 교정진단 또는 치료결과 비교 시 template로 활용될 수 있으리라 사료된다.이상의 결과로 극체 방출란만을 선별하여 $12{\sim}36$시간 사이에 분할하는 난자들만을 선별하여 배양한다면 배발생능을 가진 난자들의 비율을 높일 수 있을 것으로 사료된다. 균주(菌株)의 형태학적(形態學的) 배양학적(培養學的) 특성(特性)을 조사(調査)한 결과(結果) Candida guilliermondii var. guilliermondii 로 동정(同定)되었다. 6. CHS-13 균주(菌株)를 당화액(糖化液)에 배양(培養)시켰을 때 Lowry-protein 함량은 $0.72\;mg/m{\ell}$ 이었으며 ,

• 농촌의학ㆍ지역보건
• /
• 제38권3호
• /
• pp.182-194
• /
• 2013

본 연구는 국민건강영양조사를 이용하여 도시와 농촌지역에 거주하는 노인의 건강행태와 질병수준을 파악하고, 사회인구학적 특성을 통제한 상태에서 도시와 농촌지역의 노인의 건강수준을 비교하고자 수행하였다. 제4기 국민건강 영양조사(2007년-2009년) 자료를 이용하였으며, 65세 이상 노인으로 건강면접조사, 보건의식행태조사, 검진조사에 참여하여 분석에 필요한 변수가 모두 확보된 3,823명을 최종 연구대상으로 하였다. 지역의 분류는 행정지역과 동, 읍면으로 구분된 거주지역을 이용하여 '대도시', '도시', '농촌'으로 분류하였다. 가중치를 적용한 복합표본분석을 시행하여 지역에 따른 건강행태, 정신 건강 및 만성질환수준 증의 건강상태를 비교하였다. 연구결과, 우리나라 65세 이상 노인의 건강수준은 농촌지역이 사회경제적 여건은 도시지역에 비해 열악하지만 노인의 건강행태나 건강상태는 도시지역에 비해 더 양호함을 알 수 있었다. 농촌지역을 대도시 지역과 비교할 경우 건강행태 및 건강상태의 교차비는 독감접종 1.58(95% 신뢰구간 1.25-2.01)로 유의하게 높았고, 유연성운동 0.47(0.37-0.59), 근력운동 0.56(0.38-0.81), 비만 0.76(0.62-0.92)로 유의하게 낮았다. 질환 이환 중 관절염(0.81, 95% 신뢰구간: 0.66-0.99)과 당뇨병(0.70, 0.55-0.89)의 교차비는 농촌지역에서 대도시지역에 비해 통계적으로 유의하게 낮았다. 결론적으로 65세 이상 노인의 건강행태와 건강 수준은 이들의 거주 지역에 따라 차이가 있음을 알 수 있었다. 따라서 노인의 건강 수준의 향상을 위해서는 지역 특성과 여건에 맞는 프로그램의 개발이 필요하며, 거주 지역에 따른 차이를 설명할 수 있는 특성을 파악하고자 하는 연구가 이루어져야 할 것으로 생각된다.