• Maxillofacial Plastic and Reconstructive Surgery
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• v.30 no.3
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• pp.217-224
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• 2008

Angiogenesis plays an important role in bone development and postnatal bone fracture repair. Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors (VEGFRs) have been thought to be primarily involved in promoting angiogenesis. It is well known that VEGF and its receptors have been reported to play an important role in the regulation of the interaction between angiogenesis and osteogenesis during bone repair processes. Dexamethasone, a potent synthetic glucocorticoid, promotes phenotype markers of osteoblast differentiation, such as ALP and osteocalcin. It stimulates in vitro osteogenesis of human bone marrow osteogenic stromal cells. Dexamethasone has been reported to suppress VEGF gene expression in some cells. However, our previous study demonstrated VEGF quantification increased in a time-dependent manner in periosteal-derived osteogenesis under dexamethasone. So, the purpose of this study was to examine the angiogenic phenotypes in cultured human periosteal-derived cells under high-dose dexamethasone. Periosteal-derived cells were cultured using a technique previously described. After passage 3, the periosteal-derived cells were further cultured for 28 days in an osteogenic inductive culture medium containing ascorbic acid, ${\beta}$-glycerophosphate and high-dose dexamethasone, We evaluated the expression of VEGF isoforms, VEGFR-1, VEGFR-2, and neuropilin-1, ALL VEGF isoforms ($VEGF_{121},\;VEGF_{165},\;VEGF_{189}$, and $VEGF_{206}$) expression was observed by RT-PCR analysis. VEGFR-1, VEGFR-2 and neuropilin-1 expression increased up to day 14, particularly during the early stage of mineralization. Our results suggest the involvement of direct VEGFs/VEGFRs system on periosteal-derived cells during early mineralization phase under high-dose of dexamethasone. These also suggest that VEGF might act as an autocrine growth molecule during osteoblastic differentiation of cultured human periosteal-derived cells.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.6
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• pp.37-45
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• 2008

It is expected that conditions of water resources will be changed in Korea in accordance with world wide climate change. In order to deal with this problem and find a way of minimizing the effect of future climate change, the usefulness of climate model simulation information is examined in this study. The objective of this study is to assess the applicability of GCM (General Circulation Model) information for Korean water resources management through uncertainty analysis. The methods are based on probabilistic measures of the effectiveness of GCM simulations of an indicator variable for discriminating high versus low regional observations of a target variable. The formulation uses the significance probability of the Kolmogorov-Smirnov test for detecting differences between two variables. An estimator that accounts for climate model simulation and spatial association between the GCM data and observed data is used. Atmospheric general circulation model (AGCM) simulations done by ECMWF (European Centre for Medium-Range Weather Forecasts) with a resolution of $2^{\circ}{\times}2^{\circ}$, and METRI (Meteorological Research Institute, Korea) with resolutions of $2^{\circ}{\times}2^{\circ}$ and $4^{\circ}{\times}5^{\circ}$, were used for indicator variables, while observed mean areal precipitation (MAP) data, discharge data and mean areal temperature data on the seven major river basins in Korea were used for target variables. The results show that GCM simulations are useful in discriminating the high from the low of the observed precipitation, discharge, and temperature values. Temperature especially can be useful regardless of model and season.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.6
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• pp.101-111
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• 2008

Hangang Parks have been played an important role as the source of various Civilian activities by providing a natural space near Han River ever since it was developed. Due to the local-heavy rain caused by recent climate change, the Hangang Parks tends to be easily overflowed. Evacuation of the park in emergency and its controlled system should be made for the sake of Civilian's safety. In this study, various basic data and several parameters were analyzed to simulate the hydraulic effect of Hangang Parks based on the outflow in $P1/4{\div}1/4^3$ Dam. Rising effects of flood water level were investigated through the one-dimensional and twodimensional numerical hydraulic models. Relationships of water level and travel time of flood between key station and centeral part of each park were also identified. It can be used to forecast the future flood water level of each individual park in Hangang Parks. Obtained results can be used to establish the rational plan of usage, management, citizen's safety, and emergency action plan of the Hangang Parks as the flood is occurred from the outflow of Paldang dam.

• Journal of Sensor Science and Technology
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• v.6 no.1
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• pp.35-42
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• 1997

The optical biosensor using the electrically controlled release of reactive reagent is developed for the detection of peroxide. Rapid degradation of polymer complex of PEOx and PMAA occurs as the applied current increases and thus released amount of HPA increases. The degradation velocity of polymer and the amount of HPA released are linearly proportional to the applied current. Peroxide is reacted with the released reagent by peroxidase and then the product, a fluorescent dimer DBDA, is formed. The monochromic light from light source (150W Xe arc ramp) excites the DBDA and the excited light is transmitted through an optical fiber to be detected by a photodiode array. The change of fluorescence intensity is related to the change of peroxide concentration. The peroxidase is entrapped in Ca-alginate get on the inner surface. The biosensor has the linear signal range of 0.025mM-10.mM peroxide. By applying the step function of peroxide, reproducibility of biosensor has been investigated. The mathematical model is constructed by the combination of enzyme kinetics with reactor flow model. Good agreement is obtained between the experimental result and model prediction in the sensor signal.

• Journal of Soil and Groundwater Environment
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• v.13 no.2
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• pp.12-20
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• 2008

This study was conducted to investigate the spatial distributions of chromated copper arsenate (CCA) metals in soils around three log structures and a sound barrier, all built with CCA-treated wood. Sixty-six surface and 35 profile soil samples were collected around the wood structures in addition to 13 background soil samples. The concentrations of chromium, copper, and arsenic in the soil samples collected in the vicinity of the structures were higher than those in the background samples, except in the case of one structure. The concentrations in the surface soils adjacent to the 3-year-old structures seemed to be higher than those in the soils adjacent to the 8-year-old ones. Although the lateral distributions of the metals varied with the structures, chromium and arsenic appeared to show concentration gradients within 20-60 cm and 40-100 cm, respectively. Copper seemed to be the least mobile, displaying concentration gradients only within 20 cm. Even though there were no explicit vertical concentration gradients for any of the metals according to the profile soil sample analysis, chromium and copper seemed to show concentration gradients only up to 5 and 10 cm, respectively, whereas arsenic showed gradients up to 35 cm. At study sites, it was evident that heavy metals leached into soil from CCA-treated wood were confined to neighboring areas both laterally and vertically, and that any plausible ecological impact may occur only within a small range.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.18 no.3
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• pp.115-121
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• 2008

Microstructure of glass-ceramics obtained by heat treating silicate glass containing 50 wt% electric arc furnace dust (EAF dust) and nucleation agents were observed. The crystallization temperature, $T_c$ of glassy specimen measured around $850^{\circ}C$ from different thermal analysis, so the heat treatment condition to obtain glass-ceramic specimen was selected as $950^{\circ}C/15 hr$. The nucleation agent, $TiO_2$ showed the superior effect on enhancing franklinite crystal growth which has stronger mechanical properties and more durable chemical resistance than willemite phase. Some specimens containing $TiO_2$ had the augite crystal phase and increasing $TiO_2$ amount decreased a fraction of willemite and increased a franklinite. Especially, the specimen with 5 wt% $TiO_2$ showed no willemite crystal phase and $1{\sim}2\;{\mu}m$ franklinite crystals dispersed uniformly in glassy matrix. Also, the specimens containing 5 wt% $TiO_2$ mixed with $Fe_2O_3$ showed a dendrite-shaped franklinite crystals caused by coalescence of small crystallites.

• Journal of Korean Tunnelling and Underground Space Association
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• v.10 no.2
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• pp.119-128
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• 2008

In the case of a circular shaft, it is expected that asymmetric loads should apply on the surface rather than symmetric loads due to geographical factors and the non-homogeneity of the jointed rock masses. In this study, discontinuous numerical analysis was carried in order to analyze the characteristics of asymmetric load distribution on the wall of the circular shaft due to anisotropy caused by heterogeneity of rock masses affected by the discontinuities like as a Joint. And it was also analyzed that the effect of the mechanical properties varied with the rock mass rating and horizontal stress with depth had influence in the asymmetric load on the wall of the shaft. In the case of considering the effect of the joint as variable, asymmetric load ratio $(R_p)$, which was defined as the ratio of the load subtracted minimum from maximum to minimum, was below 25% in the hard rock. As regarding the variation of the rock mass rating with depth as variable, the value of $R_p$ was below than 25% in the hard rock, and the value between 30% and 40% in the soft rock. On the other hand, the $R_p$ of fractures rock was between $45{\sim}50%$ which value was much higher than that in better rock mass rating.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.3
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• pp.319-324
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• 2008

Purpose: The aim of this study was to examine the incidence, location and morphology of antral septa using radiographic exam.(Panorama, CT) in the dentate/non-atrophic and edentulous/atrophic maxillary segments. Material & methods: 232 sinuses were subdivided into two groups(group1 : 175 sinuses were classified as complete & partial dentate maxillary segments, group2 : 57 sinuses were classified as complete edentulous maxillary segments) and were investigated for the incidence, location and morphology of maxillary sinus septa. Results: A total of 80 septa were observed in 232 maxillary sinuses, which corresponded to 30.65% of the sinuses(71 of 232). 67.5% of the total septa was observed in the complete & partial dentate groups, but 32.5% of the total septa was observed in the complete edentulous group. Upon analysis of the anatomical location of the septa, it was seen that 14 septa(17.5%) were located in the P1 area, 15 septa(18.7%) were located in the P2 area, 19 septa(23.8%) were located in the M1 area and 32 septa(40%) were located in the M2 area & dista area of M2. we found 45 septa in the apical lesion of teeth, Group 1. However the remaining 9 septa were found in the edentulous area. Conclusion: CT is a better method than panoramic radiography for detecting the presence of the maxillary sinus septa. Maxillary sinus septa are more commonly detected in complete edentulous maxillary segments than in complete & partial dentate maxillary segments. Also maxillary sinus septa are more commonly detected posteriorly than anteriorly.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.3
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• pp.285-292
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• 2008

Purpose: The present study was performed to evaluate the effect of surface treatment of the cervical area of implant on bone regeneration in fresh extraction socket following implant installation. Materials and methods: The four minipigs, 18 months old and 30 kg weighted, were used. Four premolars of the left side of both the mandible and maxilla were extracted. ${\phi}$3.3 mm and 11.5 mm long US II plus implants (Osstem Implant co., Korea) with resorbable blasting media (RBM) treated surface and US II implants (Osstem Implant co., Korea) with machined surface at the top and RBM surface at lower portion were installed in the socket. Stability of the implant was measured with $Osstell^{TM}$ (Model 6 Resonance Frequency Analyser: Integration Diagnostics Ltd., Sweden). After 2 months of healing, the procedures and measurement of implant stability were repeated in the right side by same method of left side. At four months after first experiment, the animals were sacrificed after measurement of stability of all implants, and biopsies were obtained. Results: Well healed soft tissue and no mobility of the implants were observed in both groups. Histologically satisfactory osseointegration of implants was observed with RBM surface, and no foreign body reaction as well as inflammatory infiltration around implant were found. Furthermore, substantial bone formation and high degree of osseointegration were exhibited at the marginal defects around the cervical area of US II plus implants. However, healing of US II implants was characterized by the incomplete bone substitution and the presence of the connective tissue zone between the implant and newly formed bone. The distance between the implant platform (P) and the most coronal level of bone-to-implant contact (B) after 2 months of healing was $2.66{\pm}0.11$ mm at US II implants group and $1.80{\pm}0.13$mm at US II plus implant group. The P-B distance after 4 months of healing was $2.29{\pm}0.13$mm at US II implants group and $1.25{\pm}0.10$mm at US II plus implants group. The difference between both groups regarding the length of P-B distance was statistically significant(p<0.05). Concerning the resonance frequency analysis (RFA) value, the stability of US II plus implants group showed relatively higher RFA value than US II implants group. Conclusion: The current results suggest that implants with rough surface at the cervical area have an advantage in process of bone regeneration on defect around implant placed in a fresh extraction socket.

• Korean Journal of Food Science and Technology
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• v.40 no.4
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• pp.474-478
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• 2008

This study was carried out to evaluate the rheology of flour doughs containing 0.5% of hydroxypropylmethyl-cellulose (HPMC), methylcellulose (MC), and sodium alginate (SA), respectively. Farinograms, alveograms, a rapid visco analyzer (RVA), and rheofermentometer were employed in the analysis. According to the farinogram tests, the hydrocolloid additions caused changes in water absorption, dough development time, stability, and breakdown. The dough containing HPMC had the highest water absorption at $67.4{\pm}0.12%$. The HPMC dough also had the longest development time ($8.2{\pm}1.04$ min), stability ($12.7{\pm}0.42$ min), and breakdown ($7.9{\pm}1.3$ min). From the alveogram tests, P, G, and PIL values increased, whereas the L value decreased. The W values of the HPMC and SA doughs were increased, but that of the MC dough was decreased. According to the RVA results, the HPMC and SA doughs had reduced initial pasting temperatures whereas that of the MC dough was increased, but the difference was not significant. The peak viscosity of the MC dough also increased. Furthermore, all the doughs had increased breakdown times and decreases in final viscosity and setback. In the rheofermentometer tests, the HPMC dough presented the highest $H_m$, and the SA dough had the largest total volume.