• Journal of Korean Neurosurgical Society
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• 제63권6호
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• pp.827-833
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• 2020

Objective : Spine surgery is associated with higher morbidity and mortality rates in elderly patients. The modified Frailty Index (mFI) is an evaluation tool to determine the frailty of an individual and how preoperative status may impact postoperative survival and outcomes. This study aimed to determine the usefulness of mFI in predicting postoperative complications in patients aged ≥75 years undergoing surgery with instrumentation. Methods : We retrospectively reviewed the perioperative course of 137 patients who underwent thoracolumbar-instrumentation spine surgery between 2011 and 2016. The preoperative risk factors were the 11 variables of the mFI, as well as body mass index (kg/㎠), preoperative hemoglobin, platelet, albumin, creatinine, anesthesia time, operation time, estimated blood loss, and transfusion amount. The 60-day occurrences of complication rates were used for outcome assessment. Results : Major complications after spinal instrumentation surgery occurred in 34 of 138 patients (24.6%). The mean mFI score was 0.18±0.12. When we divided patients into a pre-frail group (mFI, 0.09-0.18; n=94) and a frail group (mFI ≥0.27; n=44), only the rate of sepsis was statistically higher in the frail group than in the pre-frail group. There were significantly more major complications in patients with low albumin levels or in patients with infection or who had experienced trauma. The mFI was a more useful predictor of postoperative complications than the American Society of Anesthesiologists physical status score. Conclusion : The mFI can successfully predict postoperative morbidity and mortality in patients aged ≥75 years undergoing spine surgery. The mFI improves perioperative risk stratification that provides important information to assist in the preoperative counselling of patients and their families.

• Journal of Chest Surgery
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• 제44권1호
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• pp.44-50
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• 2011

Background: Cardiovascular complications are major causes of morbidity and mortality following non-cardiac thoracic operations. Recent studies have demonstrated that elevation of N-Terminal Pro-B-type natriuretic peptide (NT-proBNP) levels can predict cardiac complications following non-cardiac major surgery as well as cardiac surgery. However, there is little information on the correlation between lung resection surgery and NT-proBNP levels. We evaluated the role of NT-proBNP as a potential marker for the risk stratification of cardiac complications following lung resection surgery. Material and Methods: Prospectively collected data of 98 patients, who underwent elective lung resection from August 2007 to February 2008, were analyzed. Postoperative adverse cardiac events were categorized as myocardial injury, ECG evidence of ischemia or arrhythmia, heart failure, or cardiac death. Results: Postoperative cardiac complications were documented in 9 patients (9/98, 9.2%): Atrial fibrillation in 3, ECG-evidenced ischemia in 2 and heart failure in 4. Preoperative median NT-proBNP levels was significantly higher in patients who developed postoperative cardiac complications than in the rest (200.2 ng/L versus 45.0 ng/L, p=0.009). NT-proBNP levels predicted adverse cardiac events with an area under the receiver operating characteristic curve of 0.76 [95% confidence interval (CI) 0.545~0.988, p=0.01]. A preoperative NT-proBNP value of 160 ng/L was found to be the best cut-off value for detecting postoperative cardiac complication with a positive predictive value of 0.857 and a negative predictive value of 0.978. Other factors related to cardiac complications by univariate analysis were a higher American Society of Anesthesiologists grade, a higher NYHA functional class and a history of hypertension. In multivariate analysis, however, high preoperative NT-proBNP level (>160 ng/L) only remained significant. Conclusion: An elevated preoperative NT-proBNP level is identified as an independent predictor of cardiac complications following lung resection surgery.

• Journal of Dental Anesthesia and Pain Medicine
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• 제23권4호
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• pp.221-228
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• 2023

Background: We assessed the relationship between patient age and remifentanil dosing rate in patients managed under general anesthesia with spontaneous breathing using low-dose remifentanil in sevoflurane. Methods: The participants were patients with an American Society of Anesthesiologists Physical Status of 1 or 2 maintained under general anesthesia with low-dose remifentanil in 1.5-2.0% sevoflurane. The infusion rate of remifentanil was adjusted so that the spontaneous respiratory rate was half the rate prior to the induction of anesthesia, and γ^H (㎍/kg/min) was defined as the infusion rate of remifentanil under stable conditions where the respiratory rate was half the rate prior to the induction of anesthesia for ≥ 15 minutes. The relationship between γ^H and patient age was analyzed statistically by Spearman's correlation analysis. Results: During dental treatment under general anesthesia using low-dose remifentanil in sevoflurane, a significant correlation was detected between γ^H and patient age. The regression line of y = - 0.00079 x + 0.066 (y-axis; γ^H, x-axis; patient's age) was provided. The values of γ^H provide 0.064 ㎍/kg/min at 2 years and 0.0186 ㎍/kg/min at 60 years. Therefore, as age increases, the dosing rate exhibits a declining trend. Furthermore, in the dosing rate of remifentanil when the patient's respiratory rate was reduced by half from the preanesthetic respiratory rate, the dosing rate provided was around 0.88 mL/h in all ages if the remifentanil was diluted as 0.1 mg/mL. EtCO₂ showed 51.0 ± 5.7 mmHg, and SpO₂ was controlled within the normal range by this method. In addition, all dental treatments were performed without major problems, such as awakening and body movement during general anesthesia, and the post-anesthetic recovery process was stable. Conclusion: General anesthesia with spontaneous breathing provides various advantages, and the present method is appropriate for minimally invasive procedures.

• Journal of Dental Anesthesia and Pain Medicine
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• 제17권4호
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• pp.265-270
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• 2017

Background: Endotracheal intubation during anesthesia induction may increase airway resistance ($R_{aw}$) and decrease dynamic lung compliance ($C_{dyn}$). We hypothesized that prophylactic treatment with a transdermal ${\beta}2$-agonist tulobuterol patch (TP) would help to reduce the risk of bronchospasm after placement of the endotracheal tube. Methods: Eighty-two American Society of Anesthesiologists (ASA) category I or II adult patients showing obstructive patterns were divided randomly into a control and a TP group (n = 41 each). The night before surgery, a 2-mg TP was applied to patients in the TP group. Standard monitors were recorded, and target controlled infusion (TCI) with propofol and remifentanil was used for anesthesia induction and maintenance. Simultaneously, end-tidal carbon dioxide, $R_{aw}$, and $C_{dyn}$ were determined at 5, 10, and 15 min intervals after endotracheal intubation. Results: There was no significant difference in demographic data between the two groups. The TP group was associated with a lower $R_{aw}$ and a higher $C_{dyn}$, as compared to the control group. $R_{aw}$ was significantly lower at 10 min (P < 0.05) and 15 min (P < 0.01), and $C_{dyn}$ was significantly higher at 5 min (P < 0.05) and 15 min (P < 0.01) in the TP group. A trend towards a lower $R_{aw}$ was observed showing a statistically significant difference 5 min after endotracheal intubation (P < 0.01) in each group. Conclusions: Prophylactic treatment with TP showed a bronchodilatory effect through suppressing an increase in $R_{aw}$ and a decrease in $C_{dyn}$ after anesthesia induction without severe adverse effects.

• Journal of Gastric Cancer
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• 제12권1호
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• pp.26-35
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• 2012

Purpose: Emergency operations for perforated peptic ulcer are associated with a high incidence of postoperative complications. While several studies have investigated the impact of perioperative risk factors and underlying diseases on the postoperative morbidity after abdominal surgery, only a few have analyzed their role in perforated peptic ulcer disease. The purpose of this study was to determine any possible associations between postoperative morbidity and comorbid disease or perioperative risk factors in perforated peptic ulcer. Materials and Methods: In total, 142 consecutive patients, who underwent surgery for perforated peptic ulcer, at a single institution, between January 2005 and October 2010 were included in this study. The clinical data concerning the patient characteristics, operative methods, and complications were collected retrospectively. Results: The postoperative morbidity rate associated with perforated peptic ulcer operations was 36.6% (52/142). Univariate analysis revealed that a long operating time, the open surgical method, age (${\geq}60$), sex (female), high American Society of Anesthesiologists (ASA) score and presence of preoperative shock were significant perioperative risk factors for postoperative morbidity. Significant comorbid risk factors included hypertension, diabetes mellitus and pulmonary disease. Multivariate analysis revealed a long operating time, the open surgical method, high ASA score and the presence of preoperative shock were all independent risk factors for the postoperative morbidity in perforated peptic ulcer. Conclusions: A high ASA score, preoperative shock, open surgery and long operating time of more than 150 minutes are high risk factors for morbidity. However, there is no association between postoperative morbidity and comorbid disease in patients with a perforated peptic ulcer.

• Journal of Yeungnam Medical Science
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• 제24권2호
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• pp.162-169
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• 2007

현미경 하 후두 미세 수술에서 10% lidocaine 술 전 분무가 혈역학적으로 어떠한 영향을 미치는 지를 보기 위하여 대상 환자 50명을 각 25명씩 두 군으로 나누어 대조군과 10% lidocaine 분무군으로 하였다. 마취 유도 후 대조군에서는 근이완제 투여 후 3분 30초에 기관내 삽관을 시행하였으며, 연구군은 근이완제 투여 2분 후 인후두 점막과 기관내에 lidocaine 1.5 mg/kg을 분무하였고 다시 1분 30초 후에 기관내 삽관을 시행하였다. 수축기 및 이완기 혈압과 심박수를 마취 유도 전에 측정하여 기준치(T0)로 삼았으며 기관내 삽관 후 1분(T1), 3분(T2), 5분(T3), 현수 후두경 거치 후 1분(T4), 3분(T5), 5분(T6), 10분(T7)에 각각 측정하여 기록하였다. 동맥압과 심박수가 기관내 삽관후 3분까지 그리고 현수 후두경 거치 후 3분까지 대조군에 비하여 10% lidocaine 분무군에서 유의하게 낮음을 보아 기관내 삽관 전 10% lidocaine 분무는 기관내 삽관과 현수 후두경으로 인한 심혈관계 자극을 효과적으로 완화시킴을 알 수 있다.

• 한국콘텐츠학회논문지
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• 제16권5호
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• pp.351-360
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• 2016

본 연구는 부위마취로 수술을 받는 노인환자의 간호요구를 파악하기 위한 서술적 조사연구이다. 연구대상자는 일개 종합병원과 일개 준 종합병원에 입원하고 있는 60세 이상의 척추마취, 경막외마취, 신경차단하에 수술을 받은 126명으로 구조화된 설문지를 이용하여 2012년 10월 1일부터 10월 30일까지 자료를 수집하였다. 수집된 자료는 기술통계, t-test와 ANOVA, $Scheff{\acute{e}}$ test로 분석하였으며 연구결과는 다음과 같다. 노인환자의 부위마취 수술 중 간호요구의 평균은 $3.08{\pm}0.38$점이었고, 영역별로는 교육적($3.47{\pm}0.50$점), 영적($3.37{\pm}0.78$점), 신체적($3.31{\pm}0.46$점), 정서적($2.72{\pm}0.50$점), 환경적($2.51{\pm}0.47$점) 간호요구의 순으로 나타났다. 일반적인 특성에 따른 간호 요구는 성별, 종교, 배우자 유무에서 유의한 차이를 보였고, 수술관련 특성에 따른 간호 요구는 수술과, 수술시간, ASA 신체분류에서 유의한 차이를 보였다. 본 연구결과 부위마취 수술 노인 환자에게 수술과 마취에 대한 교육을 제공하는 것이 필요하며, 연구결과를 토대로 부위마취 수술 노인환자의 간호요구를 충족시키기 위한 교육지침 및 중재프로그램을 개발하고 평가하는 연구를 제언한다.