• 대한화장품학회지
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• 제21권1호
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• pp.67-83
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• 1995

생체내 피부 자극은 일련의 복합적인 생리 화학적 변화를 수반한다. 이러한 생체내 현상을 보다 민감하게 반영하고, 동물 시험 경감 측면 및 정확성, 재현성을 보완하기 위하여 자극 물질 검색을 위한 대체 시험법이 필요하게 되었다. CAMVA는 이러한 필요성에 의해 고안된 방법의 하나로써 약 10일된 유정란의 복합적인 혈관이 융합된 장뇨막내에 자극 물질을 투여하고 일정 시간 후, 막 내 혈관의 충혈, 출혈, 응집현상 등의 변화를 통해 자극 정도를 평가하는 in vitro 시험계이다. 본 연구에서는 화장품 영역에서 중요한 위치를 차지하는 계면활성제의 자극 정도를 검색하여 in vitro 시험법인 CAMVA와 in vivo 시험법간의 상관성을 조사하였으며, 그 결과 매우 높은 상관성을 나타냄을 알 수 있었다. 그러므로 CAMVA는 안 자극 시험의 대체 시험법 뿐만 아니라 피부자극의 예측에도 적용 가능한 유용한 시험법이라 생각된다.

• Biomolecules & Therapeutics
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• 제23권4호
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• pp.379-385
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• 2015

The eye irritation potential of drug candidates or pharmaceutical ingredients should be evaluated if there is a possibility of ocular exposure. Traditionally, the ocular irritation has been evaluated by the rabbit Draize test. However, rabbit eyes are more sensitive to irritants than human eyes, therefore substantial level of false positives are unavoidable. To resolve this species difference, several three-dimensional human corneal epithelial (HCE) models have been developed as alternative eye irritation test methods. Recently, we introduced a new HCE model, MCTT HCE$^{TM}$ which is reconstructed with non-transformed human corneal cells from limbal tissues. Here, we examined if MCTT HCE$^{TM}$ can be employed to evaluate eye irritation potential of solid substances. Through optimization of washing method and exposure time, treatment time was established as 10 min and washing procedure was set up as 4 times of washing with 10 mL of PBS and shaking in 30 mL of PBS in a beaker. With the established eye irritation test protocol, 11 solid substances (5 non-irritants, 6 irritants) were evaluated which demonstrated an excellent predictive capacity (100% accuracy, 100% specificity and 100% sensitivity). We also compared the performance of our test method with rabbit Draize test results and in vitro cytotoxicity test with 2D human corneal epithelial cell lines.

• 한국임상수의학회지
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• 제38권3호
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• pp.120-126
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• 2021

Intradermal skin test (IDST) is generally considered a useful tool in identifying causal allergens in canine atopic dermatitis. Currently, multiple allergen simultaneous test (MAST), an in vitro testing method for allergen-specific immunoglobulin E, is being used as an alternative method. However, there are no reports comparing the IDST and MAST results in the same dogs. This study compared the results of both tests to evaluate the agreement and correlation between them. The sensitivity, specificity, and accuracy of the MAST were 76.2%, 64%, and 66.7%, respectively. Moderate positive predicted value (PPV, 50-75%) or high sensitivity (80-100%) were identified for indoor allergens, such as cat epithelia, house dust, and house dust mites. In contrast, high negative predicted value (NPV, 93.3-100%) and specificity (60-100%) were observed for environmental allergens and fungi. Although the agreement between IDST and MAST for all allergens was fair (κ = 0.301), that for each allergen was poor (κ < 0.01), except for birch (κ = 0.158). Spearman's rank correlation analysis revealed a low correlation between the MAST and IDST results (ρ = 0.308, p = 0.001). As compared to the IDST results, the MAST results did not identify the causative allergens sufficiently. IDST may not be performed for environmental allergens and fungi with high NPV and specificity if the MAST result is negative, but it may have to be performed for indoor allergens with moderate PPV and high sensitivity when the MAST result is positive.

• 응용통계연구
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• 제20권1호
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• pp.147-157
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• 2007

에지검출은 컴퓨터비전과 영상처리 시스템에서 널리 사용되는 단계이다. 본 논문에서는 잡음영상에서 효율적인 에지검출을 위해 이표본 위치 문제에서 월콕슨 검정의 대안인 로버스트 순위-순서 검정에 기초한 새로운 검출법을 제안하였다. 제안된 방법은 $\delta$-에지모형하에서 $5\times5$ 윈도우의 부분 픽셀만으로 구성된 근방영역 간에 통계적으로 유의한 차이가 있는지를 조사하였다. 제안된 에지 검출법의 성능을 평가하기 위해 실제영상과 인조영상을 가지고 영상실험을 통하여 얻은 에지맵과 객관적인 척도하에서 양적으로 비교 분석하였다.

• Geomechanics and Engineering
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• 제10권5호
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• pp.689-707
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• 2016

Soil stabilization is one of the useful method of ground improvement for soil with low bearing capacity and high settlement and unrequired swelling potential. Generally, the stabilization is carried out by adding some solid materials. The main objective of this research was to investigate the feasibility of stabilization of organic soils and sewage sludge to obtain low cost alternative embankment material by the addition of two different slags. Slags were used as a replacement for weak soil at ratios of 0%, 25%, 50%, 75% and 100%, where sewage sludge and organic soil were blended with slags separately. The maximum dry unit weights and the optimum water contents for all soil mixtures were determined. In order to investigate the influence of the slags on the strength of sewage sludge and organic soil, and to obtain the optimal mix design; compaction tests, the California bearing ratio (CBR) test, unconfined compressive strength (UCS) test, hydraulic conductivity test (HCT) and pH tests were carried out on slag-soil specimens. Unconfined compressive tests were performed on non-cured samples and those cured at 7 days. The test results obtained from untreated specimens were compared to tests results obtained from soil samples treated with slag. Laboratory tests results indicated that blending slags with organic soil or sewage sludge improved the engineering properties of organic or sewage sludge. Therefore, it is concluded that slag can be potentially used as a stabilizer to improve the properties of organic soils and sewage sludge.

• 대기
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• 제33권4호
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• pp.387-398
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• 2023

The double Fourier series (DFS) spectral dynamical core is evaluated for the two idealized test cases in comparison with the spherical harmonics (SPH) spectral dynamical core. A new approach in calculating the meridional expansion coefficients of DFS, which was recently developed to alleviate a computational error but only applied to the 2D spherical shallow water equation, is also tested. In the 3D deformational tracer transport test, the difference is not conspicuous between SPH and DFS simulations, with a slight outperformance of the new DFS approach in terms of undershooting problem. In the baroclinic wave development test, the DFS-simulated wave pattern is quantitatively similar to the SPH-simulated one at high resolutions, but with a substantially lower computational cost. The new DFS approach does not offer a salient advantage compared to the original DFS while computation cost slightly increases. This result suggests that the current DFS spectral method can be a practical and alternative dynamical core for high-resolution global modeling.

• 한국환경과학회지
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• 제20권4호
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• pp.435-442
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• 2011

In this study, to investigate the effects of herb aroma components, the BDI test was performed with the 124 students of the Youngdong University and the subjects whose score was 16 or higher were selected and allocated to the herb-extracted aroma-treated group and the non-treated group, 27 and 10 students for each group. The BDI and SDS tests were carried out at each stage (before and after the treatment, 10 days later and 30 days later). The result showed that the pre-treatment BDI test result was significantly different from all those of the post-treatment test, and the tests after 10 days and 30 days in the aroma-treated group. In the SDS test, the pre-treatment test result was significantly different from the results of the post-treatment test and the test after 10 days, while it was not significantly different from the result of the test after 30 days. Additionally, to verify whether the change within the group is larger than that by natural recovery or not, ANCOVA was performed with respect to the difference in the pre-treatment test score between the groups depending on whether the treatment was given or not, having the SDS pre-treatment score as the covariate, and the result showed that the post-treatment test scores were significantly different. Thus, it was verified that, if the SDS test score is considered as the depression indicator, the effect of aromatherapy was greater than the change by natural recovery. The difference in the post-treatment test score was analyzed depending on whether the treatment was given or not, having the BDI pre-treatment test score as the control variable, and the result showed that the post-treatment test scores were not significantly different. Based on such a theoretical verification, it is assumed that the nature-friendly treatment method using herb aroma components can be a great help in suppressing depression. Therefore, it is expected that herb aroma components can provide systematic therapeutic effect on the suppression of depression.

• 한국전문물리치료학회지
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• 제19권4호
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• pp.46-54
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• 2012

Ely's test is commonly used to assess rectus femoris muscle flexibility. however, a reliability limit of this test was demonstrated by a previous study. In this study, we present an alternative method using an application for a digital horizontal level in a smartphone (DHLS) to complement the reliability limit of Ely's test. The aim of this study was to examine the reliability of Ely's test using DHLS on the pelvis, compared to using visual observation (VO) of pelvic and hip motions. Nineteen patients with lumbar extension-rotation syndrome were recruited for this study. An examiner examined the rectus femoris flexibility (both pass/fail and goniometer scoring) through Ely's test using both DHLS and VO. A retest session was completed two hours later for within-day reliability and seven days later for between-day intra-rater test-retest reliability. Results showed higher Kappa values for pass/fail scoring and higher intraclass correlation coefficient values for goniometer scoring in Ely's test using DHLS, compared to using VO. Measurement error and Bland and Altman plots further demonstrated the degree of intra-rater variance during Ely's test using DHLS in a clinical setting, compared to using VO. These results demonstrated that Ely's test using DHLS showed acceptable reliability compared to using VO. Ely's test using DHLS could be widely used for measuring the rectus femoris muscle flexibility in patients with lumbar extension-rotation syndrome, although the inter-rater reliability needs to be established first.

• 콘크리트학회논문집
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• 제23권2호
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• pp.185-193
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• 2011

이 연구에서는 FRP 전단보강 및 무보강 콘크리트 보의 전단강도를 정확하게 평가하기 위하여 통합전단설계방법을 개발하였다. 이를 위하여, FRP의 전단강도 기여분과 콘크리트의 전단강도 기여분을 각각 정의하였다. 기존의 FRP 전단강도 평가모델과 실험 결과를 비교 분석한 결과, Triantafillou의 FRP 전단강도 평가모델이 FRP의 유효변형률과 전단강도의 추정이 우수하므로 Triantafillou의 모델을 이용하여 FRP의 전단강도 기여분을 정의하였다. 콘크리트 전단강도 기여분은 선행 연구에서 제안된 변형도 기반 전단강도모델을 이용하여 정의하였다. 콘크리트 단면의 압축대에 작용하는 압축응력과 전단응력의 상관관계를 고려하기 위하여 콘크리트 재료파괴기준을 이용하여 콘크리트 전단강도 기여분을 산정하였다. 제안한 설계방법은 기존 실험 연구 결과와 비교하여 유효성을 검증하였다. 비교 결과 제안한 설계방법은 다양한 설계변수 범위에서 FRP 전단보강 및 무보강 콘크리트 보의 전단강도를 정확하게 평가하는 것으로 나타났다.

• 한국환경보건학회지
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• 제43권4호
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• pp.267-272
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• 2017

Objectives: The purposes of the study were to analyze the temporal variation of carbon dioxide ($CO_2$) and particulate matter (PM) in daycare centers and evaluate the appropriateness of the official test method of one-time measurement. Methods: Indoor air quality in 46 daycare centers in the Seoul Metropolitan Area was measured as specified in the official test method of Indoor Air Quality Management law. In addition, indoor air quality in the 46 daycare centers was measured over 37 days using a real-time monitor (AirGuard K). Results: The daily means of $CO_2$ and PM in the 46 daycare centers were $1042.74{\pm}134.45ppm$ and $67.60{\pm}18.25{\mu}g/m^3$, respectively. Indoor air quality in the daycare centers showed significant temporal fluctuation. Measurements for single days were significantly different from the 37-day average exposure. Relative error of short term exposure decreased with an increase in the number of sampling days. The noncompliance rate for $CO_2$ using the official testing method was 2.17%, and none exceeded the $PM_{10}$ standard of $100{\mu}g/m^3$. With monitoring over 37 days, the daily noncompliance rate for $CO_2$ was 50.4% and the daily noncompliance rate for PM was 13.8%. Conclusions: When the official test method evaluates the indoor air at daycare centers one day per year, the results may not represent actual indoor air quality over a longer period of time. Real-time monitoring devices could be an alternative for managing indoor air quality.