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Histologic Changes of the Immunologically Untreated Xenogenic Valved Conduit (면역학적 처리 없는 이종 심장 판막 도관의 조직학적 변화에 관한 연구)

  • Sung, Ki-Ick;Seo, Jeong-Wook;Kim, Won-Gon
    • Journal of Chest Surgery
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    • v.40 no.1 s.270
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    • pp.1-7
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    • 2007
  • Backgound: It has been shown that the endothelium of cardiac valves and adjacent great vessels have a reduced immune reaction compared to other vessels. We investigated the clinical feasibility of using immunologically untreated xenogenic valves, in a pig-to-goat pulmonary valve conduit implantation model. Material and Method: Porcine pulmonary valve conduits were prepared without specific immunologic treatment and implanted into the right ventricular outflow tract of goats while undergoing cardiopulmonary bypass. Two goats each were assigned to the following observation time intervals: one day, one week, three months, six months and twelve months. Echo-cardiographic examinations were performed prior to sacrifice of the goat to evaluate pulmonary valve function. After the xenograft specimens were retrieved, histological changes were evaluated microscopically. Result: Ten of the twelve animals survived the predetermined observation time intervals. Aneurysmal dilatations, of the anterior wall of the implanted pulmonary artery, were observed at each of three and twelve month-survival animals. A variable degree of pulmonary valve regurgitation was observed on echocardiography. However, valve stenosis, thrombotic occlusion and vegetation were not seen. Microscopically, the nuclei of the donor tissue disappeared as a result of pyknosis and karyolysis; however the three components of the implanted xenografts (the pulmonary artery, the valve and the infundibulum) were gradually replaced by host cells over time, while maintaining their structural integrity. Conclusion: Immunologically untreated xenogenic pulmonary valve conduits were replaced by host cells with few observed clinical problems in a pig to goat pulmonary valve implantation model. Therefore, they might be an alternative bioprosthesis option.

Laboratory Evaluation of the Accuracy, Precision, and Inter-instrumental Variance of a Portable Photoionization Detector (휴대용 광이온화 검출기의 정확도, 정밀도 및 기기간 차이에 대한 실험실 평가)

  • Choi, Dongmin;Choi, Youngeun;Yoon, Chungsik;Rhie, Kwangwon;Lee, Yunkeun;Lee, Ikmo;Park, Jeongim
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.22 no.3
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    • pp.200-208
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    • 2012
  • Objectives: This study investigated the performance of three separate units of a portable photoionization detector (PID, ppb-RAE 3000) for measuring volatile organic compounds (VOCs) in a laboratory. Methods: A laboratory evaluation of the accuracy, precision, and inter-instrumental variance of three separate units of a portable PID (ppb-RAE 3000) was performed. The evaluation was based on the preparation of a test air sample of known toluene or ethylacetate concentration in a Tedlar$^{(R)}$ bag. The test air sample was monitored and data were logged consecutively by the three PIDs. A certified gas of 50 ppm toluene was also monitored during the test to ensure the reliability of the generated test air sample. Four different concentrations ranging from 0.1 to 2 TLV were used and a series of five measurements for each concentration level was performed. The accuracy was evaluated using National Institute for Occupational Safety and Health (NIOSH) criteria. Results: The results from the oldest ppb-RAE3000 unit among the three test units generally fell outside the NIOSH recommended accuracy criteria of ${\pm}25%$, whereas the other two units produced results which were acceptable at, or greater than, 25 ppm of toluene, or 0.5 TLV. These units also met the NIOSH criteria for some ethylacetate measurements but the results were not consistent. Conclusions: Considering the inconsistent performance of these ppb-RAE 3000 units, this device may not be appropriate for use as an alternative to the standard measurement methods. However, it can serve good survey instruments to identify exposure sources or concentration profiles. For all applications, the ppb-RAE 3000 should be used with frequent calibration checks, additional validation using a reference material, and careful maintenance.

Effect of Oyster Shell Powder on Soil pH and Growth and Yield of Apple (토양의 산도교정과 사과 생육에 대한 패화석 시용 효과)

  • Lee, Seong-Tae;Lee, Young-Han;Lee, Young-Jin;Lee, Chun-Hee
    • Korean Journal of Soil Science and Fertilizer
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    • v.37 no.6
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    • pp.383-387
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    • 2004
  • Effects of oyster shell powder as a liming material were investigated in an apple orchard. Soil texture of the apple orchard was silty clay loam (Upyeong series with 7% of slope) and topsoil pH was 5.6. Treatments of 1,590 kg oyster shell powder $ha^{-1}$ and calcium-magnesium carbonate as much as oyster shell powder were included in the experiment. With treatments of oyster shell powder and calcium-magnesium carbonate, the length, number and diameter of new branches and the diameter of main, secondary and side branches increased in comparison with control. With oyster shell powder application, soil pH increased from 5.6 to 6.8 at the harvest. In addition, it increased exchangeable Ca from 2.6 to $4.2cmol_c\;kg^{-1}$. But it didn't make any difference in chlorophyll, sugar and malic acid contents. The apple weight per fruit of oyster shell powder application was 9 g more than that of control. Apple yield was highest ($37,000kg\;ha^{-1}$) in the oyster shell powder treatment, and the yield increase was significantly different at 5% level LSD. We concluded that the oyster shell powder can be an alternative of lime and effective to restore soil nutrient balance in apple orchard soil.

Improvement of Grouting by Short-period Vibration Energy (단주기 진동에너지에 의한 그라우팅 보강효과)

  • Seo, Moonbok;Kwon, Sanghoon;Lee, Bongjik
    • Journal of the Korean GEO-environmental Society
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    • v.16 no.7
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    • pp.35-42
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    • 2015
  • Grouting method has been widely used for the ground improvement and stabilization: mostly to block or control the ground water in the early years and to improve the ground, repair the structure in recent years, ever increasing its use. Despite many advantages so far, the existing grouting method also has some shortcomings including uncertain permeation of grouting with gravity type if the voids between the soil particles are narrow, and problems due to the relaxation of the neighboring ground when injected using injection pressure. As an alternative, a vibration injection method with constant amplitude and frequency has been developed in recent years, with the vibration grouting being reported to have a permeability increasing effect of grout material compared with the positive pressure injection type. Accordingly, the purpose of this study is to investigate the improvement effect of the vibration grouting that applies short-period vibration energy by varying vibration cycle, vibration time and ground conditions to evaluate the strength enhancing effect of grouting materials, expansion effect of grouting body, ground improvement effect of the grouting and the penetration characteristics of the rock joint. The findings of this study show the improved compressive strength of grout, expansion of grouting body and increased penetration rate, according to the vibration compared with non-vibration under the loose soil condition.

Microfluidic Assisted Synthesis of Ag-ZnO Nanocomposites for Enhanced Photocatalytic Activity (광촉매 성능 강화를 위한 미세유체공정 기반 Ag-ZnO 나노복합체 합성)

  • Ko, Jae-Rak;Jun, Ho Young;Choi, Chang-Ho
    • Clean Technology
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    • v.27 no.4
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    • pp.291-296
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    • 2021
  • Recently, there has been increasing demand for advancing photocatalytic techniques that are capable of the efficient removal of organic pollutants in water. TiO2, a representative photocatalytic material, has been commonly used as an effective photocatalyst, but it is rather expensive and an alternative is required that will fulfill the requirements of both high performing photocatalytic activities and cost-effectiveness. In this work, ZnO, which is more cost effective than TiO2, was synthesized by using a microreactor-assisted nanomaterials (MAN) process. The process enabled a continuous production of ZnO nanoparticles (NPs) with a flower-like structure with high uniformity. In order to resolve the limited light absorption of ZnO arising from its large band gap, Ag NPs were uniformly decorated on the flower-like ZnO surface by using the MAN process. The plasmonic effect of Ag NPs led to a broadening of the absorption range toward visible wavelengths. Ag NPs also helped inhibit the electron-hole recombination by drawing electrons generated from the light absorption of the flower-like ZnO NPs. As a result, the Ag-ZnO nanocomposites showed improved photocatalytic activities compared with the flower-like ZnO NPs. The photocatalytic activities were evaluated through the degradation of methylene blue (MB) solution. Scanning electron microscopy (SEM), x-ray diffraction (XRD), and energy-dispersive x-ray spectroscopy (EDS) confirmed the successful synthesis of Ag-ZnO nanocomposites with high uniformity. Ag-ZnO nanocomposites synthesized via the MAN process offer the potential for cost-effective and scalable production of next-generation photocatalytic materials.

Reliability-Based Design Optimization of 130m Class Fixed-Type Offshore Platform (신뢰성 기반 최적설계를 이용한 130m급 고정식 해양구조물 최적설계 개발)

  • Kim, Hyun-Seok;Kim, Hyun-Sung;Park, Byoungjae;Lee, Kangsu
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.34 no.5
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    • pp.263-270
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    • 2021
  • In this study, a reliability-based design optimization of a 130-m class fixed-type offshore platform, to be installed in the North Sea, was carried out, while considering environmental, material, and manufacturing uncertainties to enhance its structural safety and economic aspects. For the reliability analysis, and reliability-based design optimization of the structural integrity, unity check values (defined as the ratio between working and allowable stress, for axial, bending, and shear stresses), of the members of the offshore platform were considered as constraints. Weight of the supporting jacket structure was minimized to reduce the manufacturing cost of the offshore platform. Statistical characteristics of uncertainties were defined based on observed and measured data references. Reliability analysis and reliability-based design optimization of a jacket-type offshore structure were computationally burdensome due to the large number of members; therefore, we suggested a method for variable screening, based on the importance of their output responses, to reduce the dimension of the problem. Furthermore, a deterministic design optimization was carried out prior to the reliability-based design optimization, to improve overall computational efficiency. Finally, the optimal design obtained was compared with the conventional rule-based offshore platform design in terms of safety and cost.

A Needs Assessment of People with Hearing Impairment for Hearing Augmentation Technology Development: Focusing on Risk Context Awareness Communication (청각증강 기술 개발을 위한 청각장애인의 욕구조사: 위험상황 인식 및 의사소통 분야를 중심으로)

  • Lee, Jun Woo;Lee, Hyuna;Bach, Jong Mie
    • 재활복지
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    • v.22 no.3
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    • pp.225-257
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    • 2018
  • The purpose of this study is to find the application point of hearing augmentation technology development through examining the risk context experience of people with hearing impairment and the use of assistive device used as an alternative technology. Data of 355 people with hearing impairment with official disability grading was analyzed. The results of this study are first, research participants had no experience of recognizing any sound or vibration in situations highest in the order of means of transportation, material, and nature. Especially the ratio of being unable to recognize the sound and vibration of means of transportation was high, which implies the high possibility of people with hearing impairment experiencing risk. Secondly, the risk context that people with hearing impairment will most likely to experience are highest in the order of traffic accident, pedestrian accident, and daily life at home. Thirdly, the recognition of 2G phone/smart phone, vibrating digital alarm clock, light bar, vibrating wrist watch as assistive device for risk context awareness and notification was high and the satisfaction level of 2G phone/smart phone was the highest. Fourthly, the research participants had high recognition of assistive device for communication in the order of hearing aid, smart phone, videophone, cochlear implant and 2G phone and it was found that the satisfaction level and communication improvement level was the highest using the smart phone. Lastly, for the development of hearing augmentation technology the research participants recognized the importance of portable/wear convenience, price, and motion accuracy and for notification delivery means they preferred the method of using sight(text and light). Based on the results of this study policy and practical plans for hearing augmentation technology development for people with hearing impairment in risk context are proposed.

A Study on Consumer's Perception and Preference for Providing Information of Fashion Products by Using QR Code (QR 코드를 이용한 패션제품의 정보제공에 대한 20대 소비자의 인식과 선호조사 연구)

  • Yoon, Jiwon;Yoo, Shinjung
    • Science of Emotion and Sensibility
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    • v.22 no.2
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    • pp.59-69
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    • 2019
  • The present study explored consumer's perception and preference on providing information of fashion products by using QR code and suggested the possibility for consumer-to-consumer and consumer-to-company connection. A survey was conducted on males and females in their 20s-a population among whom the rate of smart phone penetration is higher than in any other age group and who tend to exchange information online. The results showed that consumers are dissatisfied with the amount of information, terms of instructions, and ambiguous washing symbols currently provided. Therefore, the study identified the need for better methods of providing information and found that QR code, which is able to deliver high-quality information on fashion products, can be an efficient alternative. Moreover, respondents felt the need for detailed washing instructions, information on handling, and functionality of material on high-involvement fashion products such as outdoor, padding, suit, and underwear worn next to the skin. They also desire styling tips or purchasing information such as SNS OOTD (Outfit Of The Day) utilizing the product, other products that may go well with the one purchased, and similar products on casual wear and coat used on a daily basis. Therefore, QR code used as a link to information web pages or a social network can help consumers to satisfy information needs and to use the products effectively.

Suppressive effect of Senecio iscoensis Hieron. extract in Propionibacterium acnes-induced inflammatory signaling pathway (Senecio iscoensis Hieron. 추출물의 Propionibacterium acnes에 의한 염증반응 억제효과)

  • Shin, Jin Hak;Lee, Eun Hye;Kim, Seon Sook;Yi, Dong-Keun;Roh, Jin Kyung;Seo, Su Ryeon
    • Korean Journal of Microbiology
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    • v.55 no.3
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    • pp.206-212
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    • 2019
  • Propionibacterium acnes (P. acnes) lives in the hair follicles and pores, and it uses cell debris, sebum and metabolic byproducts of surrounding skin tissues as energy and nutrients. Increased production of sebum due to sebaceous hyperplasia or blockage of the follicle can cause growth and proliferation of P. acnes. The rapid growth of P. acnes in follicles produces cell damage, metabolic byproducts and bacterial chips, which can cause inflammation. In this study, we examined the possibility of Senecio iscoensis Hieron. (S. iscoensis) extract to regulate P. acnes-induced inflammatory signaling pathways. We observed that S. iscoensis extract effectively inhibited P. acnes-induced pro-inflammatory cytokine expressions such as IL-$1{\beta}$, TNF-${\alpha}$, and iNOS in mouse macrophage cell line Raw 264.7. The inhibitory effect of S. iscoensis in pro-inflammatory cytokine levels was accompanied by the inhibition of the transcription factors NF-${\kappa}B$ and NF-AT. However, S. iscoensis did not alter the P. acnes-induced MAPK signaling pathways. This study first suggests the potential of using S. iscoensis extract as an alternative agent for the treatment of acne.

Study on the Suitability of Composite Materials for Enhancement of Automotive Fuel Economy (자동차 연비향상을 위한 복합재료 적용 타당성에 관한 연구)

  • Ju, Yeon Jin;Kwon, Young-Chul;Choi, Heung Soap
    • Composites Research
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    • v.32 no.5
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    • pp.284-289
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    • 2019
  • In the present paper, the dynamic force-moment equilibrium equations, driving power and energy equations are analyzed to formulate the equation for fuel economy(km/liter) equivalent to the driving distance (km) divided by the fuel volume (liter) of the vehicle, a selected model of gasoline powered KIA K3 (1.6v). In addition, the effects of the dynamic parameters such as speed of vehicle (V), vehicle total weight(M), rolling resistance ($C_r$) between tires and road surface, inclined angle of road (${\theta}$), as well as the aerodynamic parameters such as drag coefficient ($C_d$) of vehicle, air density(${\rho}$), cross-sectional area (A) of vehicle, wind speed ($V_w$) have been analyzed. And the possibility of alternative materials such as lightweight metal alloys, fiber reinforced plastic composite materials to replace the conventional steel and casting iron materials and to reduce the weight of the vehicle has been investigated by Ashby's material index method. Through studies, the following results were obtained. The most influencing parameters on the fuel economy at high speed zone (100 km/h) were V, the aerodynamic parameters such as $C_d$, A, ${\rho}$, and $C_r$ and M. While at low speed zone (60 km/h), they are, in magnitude order, dynamic parameters such as V, M, $C_r$ and aerodynamic ones such as $C_d$, A, and ${\rho}$, respectively.