• Biomolecules & Therapeutics
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• v.28 no.4
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• pp.302-310
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• 2020

Botulinum toxins are neurotoxic modular proteins composed of a heavy chain and a light chain connected by a disulfide bond and are produced by Clostridium botulinum. Although lethally toxic, botulinum toxin in low doses is clinically effective in numerous medical conditions, including muscle spasticity, strabismus, hyperactive urinary bladder, excessive sweating, and migraine. Globally, several companies are now producing products containing botulinum toxin for medical and cosmetic purposes, including the reduction of facial wrinkles. To test the efficacy and toxicity of botulinum toxin, animal tests have been solely and widely used, resulting in the inevitable sacrifice of hundreds of animals. Hence, alternative methods are urgently required to replace animals in botulinum toxin testing. Here, the various alternative methods developed to test the toxicity and efficacy of botulinum toxins have been briefly reviewed and future perspectives have been detailed.

• Journal of the Korean institute of surface engineering
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• v.32 no.2
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• pp.109-124
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• 1999

A study for replacing methylene chloride for an alternative cleaning agent which can be utilized for cleaning aluminium parts of hard disk drives was carried out at Suwon factory of Samsung Electro-mechanics Co. Ltd. As a result, quite a good cleaning agent was selected through data collection of alternative cleaning agents, their analysis of environment effects and safty factors and testing of their cleaning power. As compared with methylene chloride, the selected cleaning agent has better cleaning power. It is also more environmental-friendly, less toxic and more economical. And the operating cost reduction due to adoption of this alternative cleaning agent in Samsung Electro-mechanics Co. Ltd. was more than ￦l46,000,000 annually without any capital instrument in addition to improvement of environmental and safty conditions in the plant.

• Journal of Families and Better Life
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• v.21 no.2
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• pp.75-85
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• 2003

The purpose of this study was to investigate the attitudes toward divorce of young men and women. The data were collected by questionnaire from 425 respondents who resided in Sunchon. Statistical methods for the data analysis were frequencies, one-way ANOVA, t-test. The data analysis revealed that the young men and women accepted divorce as an alternative to unhappy marriage and there were significant gender differences in the attitudes toward divorce. Women accepted divorce more positively as an alternative than men in every conditions. Men accepted divorce remarkably as an alternative to unfaithful debauchery of spouse, but women accepted divorce extremely well as an alternative to wrongdoing of spouse. Most of young men and women were worried about children, but not a few of them did not perceived themselves as child rearer. This results showed that divorce will be increased and perceived differently by gender. The young men and women who had lower conservative familism, who were younger, and who had higher education responded more positively about divorce.

• Journal of Korea Water Resources Association
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• v.41 no.1
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• pp.101-113
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• 2008

Cost-benefit analysis was conducted to propose the best alternatives for integrated watershed management. Benefits of all alternatives were estimated combining results of choice experiment method with alternative evaluation index (AEI). Choice experiment which is a kind of stated preference techniques was applied to six regions since the Anyangcheon watershed was divided into six according to spatial characteristics and conditions (potential hazard and location). Alternative of NB > 0 must be considerable since they are economically and technically feasible.

• BMB Reports
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• v.46 no.9
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• pp.439-447
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• 2013

Rice is a monocot gramineous crop, and one of the most important staple foods. Rice is considered a model species for most gramineous crops. Extensive research on rice has provided critical guidance for other crops, such as maize and wheat. In recent years, climate change and exacerbated soil degradation have resulted in a variety of abiotic stresses, such as greenhouse effects, lower temperatures, drought, floods, soil salinization and heavy metal pollution. As such, there is an extremely high demand for additional research, in order to address these negative factors. Studies have shown that the alternative splicing of many genes in rice is affected by stress conditions, suggesting that manipulation of the alternative splicing of specific genes may be an effective approach for rice to adapt to abiotic stress. With the advancement of microarrays, and more recently, next generation sequencing technology, several studies have shown that more than half of the genes in the rice genome undergo alternative splicing. This mini-review summarizes the latest progress in the research of splicing and alternative splicing in rice, compared to splicing in humans. Furthermore, we discuss how additional studies may change the landscape of investigation of rice functional genomics and genetically improved rice.

• Journal of the Korean Society of Earth Science Education
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• v.7 no.2
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• pp.214-225
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• 2014

This study aimed to investigate the high school students' conceptions about the plate tectonics through visual representation. For this purpose, the subjects were 67 students in 11th-grade high schools in Chungbuk. In order to in-depth understand the students' conceptions about plate tectonics, so the investigator conducted a semi-structured interview. The conclusions were as in the following. After learning the plate tectonics, the students had the alternative conceptions associated with terminology, colors' meanings, plate-related melting, plate's movement, plates' boundaries, mantle's physical conditions, driving forces for plate movement, and they had the organic relations about colors' meanings, mantle's physical conditions, and driving forces of plate movement. Also, the visual representation used to teach plate tectonics influenced on the students' responses about terminology, plates' boundaries, plate-related melting and the mantle's physical features, also this study found the factors of visual representation causing the learners to create alternative conceptions. These results implicated the importance of teacher's role in identifying the students' interpretation process on visual representation, and it needed to improve the factors creating students' alternative conceptions about visual representation and to study the factors further.

• Journal of Industrial Convergence
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• v.20 no.10
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• pp.219-224
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• 2022

This study is to propose a alternative gem that is expressed in various ways instead of jewelry with limited output. It was investigated what materials were used in the alternative gem used in the jewelry design thesis over the past five years. In addition, as a result of a survey to understand the needs of customers, it was found that customers also use resin among resins as an alternative gem, like as research trends. Based on this, the scope of resin use as a alternative gem was expanded and applied to jewelry design rather than the existing method of using resin. As a result, it was found out a various uses of resin as an alternative gem. However, the demand and traditionality that correspond to the conditions of jewelry remain challenges to be established through various jewelry design studies in the future. Therefore, in order to utilize the popular preference of alternative gem, continuous research on applying jewelry design to alternative gem should be continued.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.17 no.1
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• pp.17-28
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• 2013

In this paper, we study the global existence of solutions for the initial value problems for Volterra-Fredholm type functional impulsive integrodifferential equations. Using the Leray-Schauder Alternative, we derive conditions under which a solution exists globally.

• Journal of The Korea Institute of Healthcare Architecture
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• v.7 no.1
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• pp.77-84
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• 2001

This study provide the planning guidelines for the existing and the new alternative. On the bases of survey and analysis, the basic data for OP-Unit have been proposed in consideration of the development of medical science and hygiene, economic conditions during the last twenty years in Germany. The results of the study were firstly, genera1 basic data, secondly, guidelines of the architectural design for OP-Unit und rooms, thirdly, new alternative OP-Unit with 2 and 3 operation rooms.

• The Korean Journal of Applied Statistics
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• v.10 no.1
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• pp.15-27
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• 1997

Randomized block design (RBD) with three replication is very frequently adopted in agricultural experiments of the Rural Development Administration of Korea. Even though it works well in field trials of traditional crops, it may not accomodate trial site conditions and/or experimental environment. In this research report, we deal with two such cases. The first case is for a crop experiment in green houses. In house conditions, RBD may not be appropriate since it cannot reflect two directions of the yield gradient. So, a Latin square design is suggested as an alternative. The second case is for local field experiments of the newly-inbred rice. RBD with three replications is used without doubt for decades, even though the site layout is not appropriately shaped for the design. In this case, we suggest the RBD in two blocks with multiple replicates for control varieties as an alternative. To improve the quality of statistical experimental designs in over one-thousand agricultural trials performed annually in the Rural Development Administration, we need to re-train agricultural researchers on the design and analysis of experiments and call for concerns of Korean statisticians.