• 한국조리학회지
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• 제23권7호
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• pp.194-203
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• 2017

The data collection and questionnaire survey were conducted from July 1, 2016, to August 30, 2016, and the final analysis was conducted with 273 copies. The collected data were analyzed using SPSS (V 23.0) and AMOS (V 21.0) programs. In order to identify the characteristics of the respondents, the frequency analysis was performed, and the reliability analysis and confirmatory factor analysis were performed for each measurement item. The conceptual reliability (CR) and standard variance extraction (AVE) values were calculated to verify the validity. Correlation analysis was conducted to measure the associations among the derived factors. For the hypothesis test, a structural equation modeling was used to test the jointness and organic causality of the whole model. In addition, an alternative model with a nested relationship with the basic model was set up to test the adjustment effect of the learner's educational environment on the educational satisfaction and behavioral intention. The purpose of the study was to examine the effect of educational environment on the educational satisfaction and behavioral intention of students at a cooking education institute in Busan. The implication of this study is that the operators of educational institutions should recognize the human factors as important means of marketing for the activation of cooking education and select instructors by applying more systematic and objective criteria when hiring instructors. Also, consideration should be given to support programs such as training programs and incentives to develop instructor's abilities. In addition, the positive educational outcomes of students may have a positive impact on financial performance, such as livelihood of other students and sales of educational institutions.

• BMB Reports
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• 제53권6호
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• pp.291-298
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• 2020

Tumor angiogenesis is an essential process for growth and metastasis of cancer cells as it supplies tumors with oxygen and nutrients. During tumor angiogenesis, many pro-angiogenic factors are secreted by tumor cells to induce their own vascularization via activation of pre-existing host endothelium. However, accumulating evidence suggests that vasculogenic mimicry (VM) is a key alternative mechanism for tumor vascularization when tumors are faced with insufficient supply of oxygen and nutrients. VM is a tumor vascularization mechanism in which tumors create a blood supply system, in contrast to tumor angiogenesis mechanisms that depend on pre-existing host endothelium. VM is closely associated with tumor progression and poor prognosis in many cancers. Therefore, inhibition of VM may be a promising therapeutic strategy and may overcome the limitations of anti-angiogenesis therapy for cancer patients. In this review, we provide an overview of the current anti-angiogenic therapies for ovarian cancer and the current state of knowledge regarding the links between microRNAs and the VM process, with a focus on the mechanism that regulates associated signaling pathways in ovarian cancer. Moreover, we discuss the potential for VM as a therapeutic strategy against ovarian cancer.

• 한국중재학회지:중재연구
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• 제23권4호
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• pp.97-122
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• 2013

Vietnam has become an attractive destination for foreign investors, but confidence in the country's legal system to resolve commercial disputes remains low. Reasons include the lack of an independent judiciary, the lack of published court decisions, and a tendency to criminalize civil disputes, among others. As such, arbitration has become a preferred alternative to litigation. On June 17, 2010, the National Assembly of Vietnam passed a new act on commercial arbitration replacing the July 1, 2003 ordinance on commercial arbitration. The new act will take effect on January 1, 2011, and it is widely expected by the Vietnamese legal profession and lawmakers will create a favorable legal framework for the expansion of the arbitration service market in Vietnam. The new act is inspired by the UNCITRAL Model Arbitration Law of 1985 as are most new arbitration laws throughout the world. As opposed to the 2003 ordinance, the 2010 Act allows parties to request interim relief from the arbitrators. Also the new act eliminates the mandate that arbitrators be Vietnamese. The law has addressed the ordinance's shortcomings and reflects international standards. Commercial arbitration law is an important milestone in the improvement process of the laws on commercial arbitration in Vietnam. However, it is still too soon to affirm anything definitely because there remain many obstacles to the activation of arbitration. Rule of law and business cultural factors are important. The leading arbitral institution, VIAC, which is attached to the Vietnam Chamber of Commerce and Industry, is expected to play an important role for boosting the competitiveness of Vietnamese arbitration as an avenue to dispute settlement.

• 해양환경안전학회지
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• 제12권1호
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• pp.15-22
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• 2006

해양은 인류가 앞으로 풀어야 할 숙명적인 문제인 식량문제, 자원문제, 환경문제를 해결할 수 있는 마지막 보루이다. 이러한 점을 감안하여 국내 산 학 연 전문가가 참여하여 추진한 $\ulcorner$해앙과학기술(MT) 개발 계획$\lrcorner$ 이 2004년 7월 28일 대통령을 위원장으로 하는 국가과학기술위원회 심의에 통과됨으로써 우리나라에서도 본격적으로 MT 개발을 추진할 기반을 마련하게 되었다. 또한, 2005년 6월부터 $\ulcorner$MT개발기획$\lrcorner$을 효율적으로 추진하기 위한 후속조치로 해양과학기술 로드맵(MTRM) 수립을 추진하여 2005년 12월에 완료하였다. 본 연구에서는 MT의 국내외 기술개발동향과 현재 직면한 현안문제 및 MTRM수립 결과를 고찰하고, MT R&D 전문기관 설치 운영 및 예산확보 등 MT 활성화 방안을 제시하였다.

• Human Ecology Research
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• 제56권3호
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• pp.233-246
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• 2018

Korean society is experiencing an increase in multicultural families and single households. The incidence of the MERS, epidemic in 2015, and the subsequent cases of child abuse have been major shocks to Korean society. In addition, there has been a steady increase in household debt, that is in danger of causing a serious crisis in the stability of our society and the family. The current demand for increased accountability in the democratic process is becoming an important topic. There is also an increased awareness of natural disaster preparation due to local earthquakes that have caused concern. At this point, the lifelong education in the home economics education field in Korea is in line with the changes and crises of various societies. Problems related to family life that have happened in the real life of learners stand in the place of the study with preventive character. It should provide the best alternative for family, home, and society, and help to overcome the problems of life. In order for lifelong education to respond to these social changes $vis-{\grave{a}}-vis$ Home Economics Education, it is necessary to develop: 'formation and improvement education of family relationship', 'crisis prevention and management coping ability training', 'safety education', 'learning communication and consensus processes', 'consumer culture education', 'ethics education on environment and resources', 'sustainability education', 'local education of family relationship', 'crisis prevention and management coping ability training', 'safety education', 'learning communication and consensus processes', 'consumer culture education', 'ethics education on environment and resources', 'sustainability education', 'local economic activation education', and other topics of lifelong education topics related to the field of Home Economics Education are required. Consequently, various related programs should be further developed and disseminated.

• Environmental Engineering Research
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• 제23권3호
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• pp.250-257
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• 2018

We developed new composites by combining the solid waste from Low-Density Polyethylene in the form of plastic bag (PB) and biomass from rice husk (RH),in the form of $(RH)_x(PB)_{1-x}$ (x = (1, 0.9, 0.7, 0.5)), as alternative fuels for electrical energy sources, and for providing the best solution to reduce environmental pollution. Elemental compositions were obtained by using proximate analysis, ultimate analysis, and X-ray fluorescence spectroscopy, and the thermal characteristics were obtained from thermogravimetric analysis. The compositions of carbon and hydrogen from the ultimate analysis show significant increases of 20-30% with increasing PB in the composite. The activation energy for RH is 101.22 kJ/mol; for x = 0.9 and 0.7, this increases by 4 and 6 magnitude, respectively, and for x = 0.5, shows remarkable increase to 165.30 kJ/mol. The range of temperature of about $480-660^{\circ}C$ is required for combustion of the composites $(RH)_x(PB)_{1-x}$ (x = (1, 0.9, 0.7, 0.5)) to perform the complete combustion process and produce high energy. In addition, the calorific value was determined by using bomb calorimetry, and shows value for RH of 13.44 MJ/kg, which increases about 30-40% with increasing PB content, indicating that PB has a strong effect of increasing the energy realized to generate electricity.

• 한국지하수토양환경학회지:지하수토양환경
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• 제21권2호
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• pp.29-37
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• 2016

CO₂ injection well sealant is vulnerable to supercritical CO₂ (scCO₂) exposure. To develop an alternative to the conventional sealant system (class G cement/class F fly ash), the performance of slag cement (SPC) systems containing class F fly ash (FFA) or class C fly ash (CFA) was evaluated and compared with the conventional sealant under scCO₂ conditions. All sealant systems showed an immediate increase in compressive strength upon scCO₂ exposure and, at 37.6 MPa, SPC/CFA showed the highest compressive strength after 14 days, which was much higher than the 29.8 MPa of the conventional sealant system. Substantial decreases in porosity were observed in all sealant systems, which were partly responsible for the increase in strength. Carbonation reactions led to pH decreases in the tested sealants from 12.5 to 10~11.6. In particular, the greatest decrease in pH in slag cement/class C fly ash probably supported relatively sustainable alkali activation reactions and the integrity of cement hydrates in this system. XRD revealed the presence of CaCO₃ and a decrease in the content of cement hydrates in the tested sealants upon scCO₂ exposure. TGA demonstrated a greater increase of CaCO₃ and calcium-silicate-hydrate phases in SPC/CFA than in the conventional sealant upon scCO₂ exposure.

• Experimental and Molecular Medicine
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• 제50권11호
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• pp.12.1-12.12
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• 2018

Drugs targeting the epidermal growth factor receptor (EGFR), such as cetuximab and panitumumab, have been prescribed for metastatic colorectal cancer (CRC), but patients harboring KRAS mutations are insensitive to them and do not have an alternative drug to overcome the problem. The levels of ${\beta}$-catenin, EGFR, and RAS, especially mutant KRAS, are increased in CRC patient tissues due to mutations of adenomatous polyposis coli (APC), which occur in 90% of human CRCs. The increases in these proteins by APC loss synergistically promote tumorigenesis. Therefore, we tested KYA1797K, a recently identified small molecule that degrades both ${\beta}$-catenin and Ras via $GSK3{\beta}$ activation, and its capability to suppress the cetuximab resistance of KRAS-mutated CRC cells. KYA1797K suppressed the growth of tumor xenografts induced by CRC cells as well as tumor organoids derived from CRC patients having both APC and KRAS mutations. Lowering the levels of both ${\beta}$-catenin and RAS as well as EGFR via targeting the $Wnt/{\beta}$-catenin pathway is a therapeutic strategy for controlling CRC and other types of cancer with aberrantly activated the $Wnt/{\beta}$-catenin and EGFR-RAS pathways, including those with resistance to EGFR-targeting drugs attributed to KRAS mutations.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 춘계학술대회
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• pp.108-111
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• 2009

최첨단 과학 기술의 발달에 의해 영상의 영역은 타 영역간의 상호의사소통을 더욱 원활하게 만들었으며, 이러한 영역간의 교류는 영역간의 새로운 결합을 촉진시켰다. 이러한 발전과 함께 공공 디자인의 활성화로 인해 영상의 영역은 공공의 의미로 환경디자인의 영역까지 확장되고 있다. 이러한 흐름으로 국내에서도 빛을 이용한 미디어아트를 water-front의 환경에 도입하여 지역의 아이덴티티를 강화하고 관광객들에게 특별한 인상을 남기고 있다. 그러나 국내의 환경디자인 분야에서는 영상의 영역에 대한 연구는 아직 미비한 실정이며, 지속적인 표현 개발의 필요성이 절실하다. 다양한 표현 기법 개발연구를 위해 미디어아트 활용이 영상 표현 기법의 대안으로 작용하길 기대한다.

• BMB Reports
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• 제52권11호
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• pp.641-646
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• 2019

The Ron proto-oncogene is a human receptor for macrophage-stimulating protein (MSP). The exclusion of exon 11 in alternative splicing generates ${\Delta}RON$ protein that is constitutively activated. Heterogenous ribonucleaoprotein (hnRNP) $C_1/C_2$ is one of the most abundant proteins in cells. In this manuscript, we showed that both hnRNP $C_1$ and $C_2$ promoted exon 11 inclusion of Ron pre-mRNA and that hnRNP $C_1$ and hnRNP $C_2$ functioned independently but not cooperatively. Moreover, hnRNP $C_1$ stimulated exon 11 splicing through intron 10 activation but not through intron 11 splicing. Furthermore, we showed that, whereas the RRM domain was required for hnRNP $C_1$ function, the Asp/Glu domain was not. In conclusion, hnRNP $C_1/C_2$ promoted exon 11 splicing independently by stimulating intron 10 splicing through RRM but not through the Asp/Glu domain.