• 건축역사연구
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• 제19권2호
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• pp.101-116
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• 2010

Jangan-sa is one of the Buddhist temples in the southeastern seaside district, which was restored directly after the termination of Japanese Invasion of Korea in 1592. Recently we could find out 4 records on the constructions of Daeoong - jeon in J angan-sa. These are written in the 12th year of Emperor Soonchi, written in the 8th year of Emperor Geonryung, written in 1947 Buddha Era and written in 1951 Buddha Era. Until the revelation of these records, the present building has been considered to be built in 1657, the 8th year of King Hyojong, based upon Kim Bang - han's "Jangan - sa Daeoong - jeon - gi". Because the gongpo of Daeoong - jeon was finished with the type of the late period of Chosun Dynasty, we doubt of the correction on it's building date, just in the year of 1657. Now we are able to examine the building date and the alteration date, based upon the actual measurement and constructional records of Daeoong - jeon. So to speak, the building destroyed in 1592, had been restored in 1658, the 9th year of King Hyojong and was reconstructed in 1744, the 20th year of King Youngjo. Afterward it was repaired on small scales in 1947 and in 1951. Though this building is considered to be lack of the completeness owing to the later alterations, it is still worthy heritage for the research on the building type at the directly after the termination of Japanese Invasion of Korea in 1592.

• Journal of Animal Science and Technology
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• 제60권6호
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• pp.15.1-15.10
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• 2018

Methane emission from the enteric fermentation of ruminant livestock is a main source of greenhouse gas (GHG) emission and a major concern for global warming. Methane emission is also associated with dietary energy lose; hence, reduce feed efficiency. Due to the negative environmental impacts, methane mitigation has come forward in last few decades. To date numerous efforts were made in order to reduce methane emission from ruminants. No table mitigation approaches are rumen manipulation, alteration of rumen fermentation, modification of rumen microbial biodiversity by different means and rarely by animal manipulations. However, a comprehensive exploration for a sustainable methane mitigation approach is still lacking. Dietary modification is directly linked to changes in the rumen fermentation pattern and types of end products. Studies showed that changing fermentation pattern is one of the most effective ways of methane abatement. Desirable dietary changes provide two fold benefits i.e. improve production and reduce GHG emissions. Therefore, the aim of this review is to discuss biology of methane emission from ruminants and its mitigation through dietary manipulation.

• Clinical and Experimental Pediatrics
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• 제59권4호
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• pp.155-164
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• 2016

Cognitive impairment associated with childhood-onset epilepsy is an important consequence in the developing brain owing to its negative effects on neurodevelopmental and social outcomes. While the cause of cognitive impairment in epilepsy appears to be multifactorial, epilepsy-related factors such as type of epilepsy and underlying etiology, age at onset, frequency of seizures, duration of epilepsy, and its treatment are considered important. In recent studies, antecedent cognitive impairment before the first recognized seizure and microstructural and functional alteration of the brain at onset of epilepsy suggest the presence of a common neurobiological mechanism between epilepsy and cognitive comorbidity. However, the overall impact of cognitive comorbidity in children with epilepsy and the independent contribution of each of these factors to cognitive impairment have not been clearly delineated. This review article focuses on the significant contributors to cognitive impairment in children with epilepsy.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.134.1-134
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• 2003

Aecial host ranges of four Gymnosporangium species causing cedar-apple rust diseases, G. asiaticum, G. cornutum, 5. japonicum and G. yamadae, were investigated through artificial inoculation. Thirteen species of nine genera among Rosaceous plants, which have been reported as social hosts in Korea, were inoculated with fresh teliospores spores in early days of May of 2000 and of 2001, respectively. In the results, we re-confirmed that there was highly specific relationship between the rust species and aecial hosts and report new aecial hosts of four Gymnosporangium species. Teliospores of G. cornutum collected from Juniperus rigida successively produced spermogonia and aecia only on Sorbus alntifolia, the first report on host alteration of G. cornutum in Korea. Positive responses by teliospores of G. japonicum from J. chinenis of Suwon and from J. chinenis var. horizontalis of Jeju island were obtained only on P. villosa. Crataegus pinnatifida was confirmed as a new aecial host of G. viatium. Until this time, G. ymadae was believed to have Malus as the aecial host. However, teliospores of G. yamadae collected from J. chinensis var. kaizuka successively formed spermogonia and aecia on the leaves of Chaenomeles lagenaria, C. sinensis, Pyrus pyrtifolia var, culta, P. ussuriensis, Malus pumila and M. sileboldii. The date for maturation of spermogonia and aecia, and symptom development varied according to the rust fungi and aecial host plants, respectively.

• Journal of Microbiology and Biotechnology
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• 제27권8호
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• pp.1367-1378
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• 2017

Epigenetic alterations such as DNA methylation, histone acetylation, and chromatin remodeling can control gene expression by regulating gene transcription. DNA methylation is one of the frequent epigenetic events that play important roles in cancer development. Cancer cells can gain significant resistance to anticancer drugs and escape programmed cell death through major epigenetic changes, including DNA methylation. To date, several research groups have identified instances of both (i) hypermethylation of tumor suppressor genes, and (ii) global hypomethylation of oncogenes. These changes in DNA methylation status could be used as biomarkers for the diagnosis and prognosis of cancer patients undergoing chemotherapies or other clinical therapies. Herein, we describe genes for which methylation is dependent upon anticancer drug resistance in patients with gastric cancer; we then suggest a significant epigenetic target to focus on for overcoming anticancer drug resistance.

• 자원환경지질
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• 제20권1호
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• pp.61-75
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• 1987

The Daejang mine is one of the representatives of Cu-Pb-Zn-(Ag) vein deposit related genetically to late Cretaceous granitoid in Korea. Sericite from an alteration halo of the mine yielded a K-Ar date of $95{\pm}3.5Ma$. Based on macrostructures of vein filling, three major mineralization stages (I, II and III) are distinguished by tectonic breaks. Major ore constituents are arsenopyrite, pyrite, pyrrhotite, sphalerite, chalcopyrite, galena, boulangerite, with small amounts of Ag-bearing tetrahedrite, pyrargyrite, native bismuth, marcasite, siderite, ankerite, gudmundite and calcite. Characteristic feature of each mineralization stage and compositional variation of sphalerite and arsenopyrite are discussed in relation to the genetic environments. The FeS contents of sphalerites are 20.5~14.9 mole % in stage I, 17.9~11.9 mole % in stage IIA, 17.0~9.2 mole % in stage IIB, and 6.9~4.7 mole % in stage III. Their results are indicative of decreasing FeS contents during mineralization process in sphalerite coexisting with sulfur-rich sulfide assemblages, such as monoclinic pyrrhotite and pyrite, and is agreement with the conclusions shown by Scott and Kissin(1973). The composition of arsenopyrite decrease also in As content from stage I to stage III, and the compositional variation correlate with position of the associated minerals in the paragenesis. Temperature and pressure of the mineralization are determined as $250{\sim}430^{\circ}C$ and 4.0~0.3kb respectively, based on the chemistry of the minerals.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제31권3호
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• pp.131-145
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• 2020

The microbiota-gut-brain axis, which refers to the bidirectional communication pathway between gut bacteria and the central nervous system, has a profound effect on important brain processes, from the synthesis of neurotransmitters to the modulation of complex behaviors such as sociability and anxiety. Previous studies have revealed that the gut microbiota is potentially related to not only gastrointestinal disturbances, but also social impairment and repetitive behavior-core symptoms of autism spectrum disorder (ASD). Although studies have been conducted to characterize the microbial composition in patients with ASD, the results are heterogeneous. Nevertheless, it is clear that there is a difference in the composition of the gut microbiota between ASD and typically developed individuals, and animal studies have repeatedly suggested that the gut microbiota plays an important role in ASD pathophysiology. This possibility is supported by abnormalities in metabolites produced by the gut microbiota and the association between altered immune responses and the gut microbiota observed in ASD patients. Based on these findings, various attempts have been made to use the microbiota in ASD treatment. The results reported to date suggest that microbiota-based therapies may be effective for ASD, but largescale, well-designed studies are needed to confirm this.

• 한국식품위생안전성학회지
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• 제33권3호
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• pp.162-167
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• 2018

본 연구는 과일류의 국내 명칭에 상응하는 코덱스 명칭과 코드번호, 그리고 변경 또는 검토가 요구되는 국내 명칭과 분류를 파악하기 위해 수행되었다. 국내 명칭과 분류에 대해서는 식품공전과 식품의 농약 잔류허용기준 발간물을 그리고 코덱스에 대해서는 'Codex Classification of Foods and Animal Feeds'를 검토하였다. 연구 결과는 다음과 같았다. 첫째 구기자, 무화과, 석류, 오미자에 대한 분류가 국내와 코덱스가 다르므로 이에 대한 검토가 필요한 것으로 나타났다. 둘째 감, 감귤, 구기자, 금귤, 나무딸기, 대추, 대추야자, 리치, 매실, 머루, 모과, 복분자, 산딸기, 산수유, 앵두, 오미자, 유자, 으름, 자두, 코코넛, 키위, 탱자의 경우 국문 또는 영명을 국내에서 조차 달리 사용하고 있거나 코덱스와 차이가 있으므로 이들 식품 명칭에 대한 개정이나 검토가 필요한 것으로 나타났다. 셋째 복숭아의 경우 천도복숭아를 포함하는 지가 명확하지 않고 라즈베리와 나무딸기 둘 모두가 국내 영명이 Raspberry 이므로 이들 식품 명칭에 대한 면밀한 검토가 필요한 것으로 판단된다.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2000년도 국제심포지움
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• pp.7-8
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• 2000

Transgenic animals are very useful for scientific, pharmaceutical, and agricultural purposes. In livestock, transgenic technology has been used forthe genetic alteration of farm animals, the production of human proteins inlarge quantities in the milk of transgenic farm animals, and the generation of animals with organs suitable for xenotransplantation. To date, the transfer of foreign genes into farm animals has been performed mainly by microinjection of DNA into the pronuclei of fertilized eggs. However, the overall success rate of transgenic animals in livestock so far has been disappointingly low, eg., the efficiency is 0∼5% in swine, and less than 1% in sheep and cattle, compared with the rate in mice where 5% microinjected develop into transgenic animals. Recently, McGreath et al. (2000) have succeeded in producing the gene targeted sheep by the use of nuclear transfer from cultured somatic cells transfected with a foreign gene in vitro. However, we may need plenty of time until currently employ this method for gene transfer to farm animals. We have been studying to exploit the method for improving production efficiencies of transgenic animals with emphasis of its application to farm animals. The present paper describes three approaches that we have made in our laboratory to improve production efficiencies of transgenic animals, based on the DNA microinjection method. 1. Co-injection of restriction enzyme with foreign DNA into the pronucleus for elevating production efficiencies of transgenic animals. 2. Efficient selection of transgenic mouse embryos using EGFP as a marker gene. 3. Phenotypes of tansgenic mice expressing WAP/hGH-CAG/EGFP fusion gene produced by selecting transgenic embryos. 4. Efficient site-specific integration of the transgene targeting an endogenous lox like site in early mouse embryos.

• 대한한방내과학회지
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• 제26권2호
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• pp.489-497
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• 2005

Conversion disorder lacks temperamental grounds and is a type of somatoform disorder that includes alteration or loss of physical functions implicated in physical deficit suggestive psychological conflict. There is high incidence of return of conversion disorder and difficulty in producing exact approaches of cure and apparent effects of remedy with symptomatic treatment alone because of its complex clinical symptoms. The approach of Oriental Medicine in treatment of conversion disorder is to apprehend relative symptoms from the syndrome combined with several annexational symptoms centering around sequential symptoms. Thereupon, author made a Ganyanghwapung comprehensive diagnosis was conducted using Oriental Medicine measures by differential diagnostic methods in psychosomatic patients whose cases are diagnosed as conversion disorder. Then, Cheonmagudeungeum Gagambang was prescribed for them and it brought on satisfactory effects from the first or second treatment. There have been many cases reporting the application of Oriental Medicine treatment to conversion disorder to date and outcomes have also been favorable. Results of this study likewise suggest that this Oriental Medicine treatment for conversion disorder is effective.