• Journal of Oriental Neuropsychiatry
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• v.29 no.2
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• pp.79-97
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• 2018

Objectives: The purpose of this systematic review was to investigate the clinical effects of neurofeedback training on reducing anxiety. Methods: Eight databases were used to extract clinical reports on neurofeedback intervention for anxiety reduction published until 2016. We analyzed the characteristics of selected studies and evaluated biases using the Risk of Bias (RoB) assessment. Results: A total of 22 clinical trials were extracted for the analysis. The risk of bias in most studies was high or unclear. The Chinese Classification of Mental Disorders-3 (CCMD-3) was the most frequently used diagnostic criteria, the Hamilton Rating Scale for Anxiety (HAMA) was the most frequently used assessment tool, and the alpha wave activity increase, sensorimotor rhythm (SMR), and theta wave training were the most frequently used intervention methods. All papers showed a statistically significant decrease of anxiety symptoms; however, significant adverse events were not reported. Conclusions: Neurofeedback intervention might be beneficial for reducing anxiety. However, the quality of the studies used in the analysis was low, and the heterogeneity of the population and interventions was revealed. Therefore, more scientifically designed clinical studies regarding neurofeedback training are required.

• Journal of Pharmacopuncture
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• v.26 no.3
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• pp.276-284
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• 2023

Objectives: Previous studies have shown that anger can lead to frontal lobe α (8-13 Hz) band asymmetry (FAA) in electroencephalogram (EEG), in accordance with motivational direction. This pilot study aimed to investigate the impact of acupuncture on FAA elicited by anger. Methods: Thirty-four right-handed participants scoring above 75 points on the Novaco Anger Scale were included. Baseline EEG signals were recorded for eight minutes using a 32-channel cap under comfortable conditions. Anger was induced through a nine-minute sequence of Articulated Thoughts in Simulated Situations (ATSS) task. Following that, participants received acupuncture at GB20 and GB21 for 10 minutes. Fast Fourier transform was employed for frequency analysis, and repeated measure ANOVA was conducted for statistical analysis. Results: The results revealed that participants exhibited significantly higher FAA (p = 0.026), particularly in the left hemisphere, after the ATSS task sequence compared to the baseline. During acupuncture treatment, the greater left-sided FAA was significantly reduced (p = 0.027) and reversed. Upon the cessation of acupuncture, FAA returned to a value between the baseline and the anger-evoked stage (p = 0.046). Conclusion: The EEG results of this study revealed that anger stimulation induced an increase in left-sided FAA, which was effectively alleviated by acupuncture. This led to an immediate restoration of FAA asymmetry induced by anger. These findings suggest the potential of acupuncture as a treatment option for reducing FAA associated with anger.

• BMB Reports
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• v.56 no.5
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• pp.296-301
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• 2023

Retinoic acid receptor-related orphan receptor α (RORα) plays a vital role in various physiological processes, including metabolism, cancer, circadian rhythm, cerebellar development, and inflammation. Although RORα is expressed in the skin, its role in skin physiology remains poorly elucidated. Herein, Rorα was expressed in the basal and suprabasal layers of the epidermis; however, keratinocyte-specific Rorα deletion did not impact normal epidermal formation. Under pathophysiological conditions, Rorα-deficient mice exhibited alleviated psoriasis-like symptoms, including relatively intact epidermal stratification, reduced keratinocyte hyperproliferation, and low-level expression of inflammatory cytokines in keratinocytes. Unexpectedly, the splenic population of Th17 cells was significantly lower in keratinocyte-specific RORα deficient mice than in the control. Additionally, Rorα-deficiency reduced imiquimod-induced activation of nuclear factor-κB and STAT3 in keratinocytes. Therefore, we expect that RORα inhibitors act on immune cells and keratinocytes to suppress the onset and progression of psoriasis.

• Journal of Fisheries and Marine Sciences Education
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• v.24 no.6
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• pp.845-853
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• 2012

To investigate the role of temperatures and photoperiods as environmental cues regulating reproductive rhythm in Pseudobagrus fulvidraco, rearing experiments were conducted using sveral rearing regimes conbined with photoperiods and water temperatures during gonadal degeneration periods. Gonadosomatic index (GSI) in control was $8.16{\pm}1.50%$, while in other experiment GSI levels in female were lower than that in the control. In case of experimental precinct of 9 light (L) and 15 L, GSI levels were decreased. But GSI level with $20^{\circ}C$ was no diffrence after 40 and 60 days. GSI level in male of control was $0.35{\pm}0.05%$. GSI under 9 L and $25^{\circ}C$ was similar to that in control, whereas its level in other experiments was lower than that in control. Testosterone (T) of female was $3.68{\pm}0.22$ ng/mL at experimental precinct. In case of 9 L and 15 L, concentration of T were lower than experimental precinct in all of water temperature. Estradiol-$17{\beta}$ ($E_2$) and $7{\alpha}$, $20{\beta}$-dihydroxy-4-pregnen-3-one ($17{\alpha}20{\beta}OHP$) levels of female were $0.42{\pm}0.02$ and $0.83{\pm}0.01$ ng/mL at experimental precinct. $E_2$ levels of 9 and 15 L were higher than experimental precinct and $17{\alpha}20{\beta}OHP$ levels of 9 and 15 L were higher than experimental precinct. In case of T and 11-ketotestosterone levels were $0.69{\pm}0.11$ and $.62{\pm}0.03$ ng/mL in male. During the period of gonadal degeneration, gonadal maturation did not occur in any of the experimental regimes. However, comparatively high levels of $E_2$ observed at low temperature regimes ($20^{\circ}C$) regardless of photoperiods.

• Progress in Superconductivity
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• v.4 no.2
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• pp.114-120
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• 2003

We employed a method eliminating a temporally partial principal component (PC) of multichannel-recorded neuromagnetic fields for excluding spatially correlated noises from event-evoked signals. The noises in magnetoencephalography (MEG) are considered to be mainly spontaneous neuromagnetic fields which are spatially correlated. In conventional MEG experiments, the amplitude of the spontaneous neuromagnetic field is much lager than that of the evoked signal and the synchronized characteristics of the correlated rhythmic noise makes it possible for us to extract the correlation noises from the evoked signal by means of the general PC analysis. However, the whole-time PC of the fields still contains a little projection component of the evoked signal and the elimination of the PC results in the distortion of the evoked signal. Especially, the distortion will not be negligible when the amplitude of the evoked signal is relatively large or when the evoked signals have a spatially-asymmetrical distribution which does not cancel out the corresponding elements of the covariance matrix. In the period of prestimulus, there are only the spontaneous fields and we can find the pure noise PC that is not including the evoked signal. Besides that, we propose a method, called the extended temporal decorrelation method (ETDM), to suppress the distortion of the noise PC from remanent evoked signal components. In this study, we applied the Partial Principal component elimination method (PPCE) and ETDM to simulated signals and the auditory evoked signals that had been obtained with our homemade 37-channel magnetometer-based SQUID system. We demonstrate here that PPCE and ETDM reduce the number of epochs required in averaging to about half of that required in conventional averaging.

• Journal of Power System Engineering
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• v.14 no.4
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• pp.29-36
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• 2010

This study was performed with 5 subjects and used three kinds of music and vibroacoustic stimuli wave based upon each kinds of music. Executing music stimulation, vibro tactile and acoustic wave stimulation to human body were performed. Then measured brain waves were analyzed under each condition including before stimulation, stimulation 1, and stimulation 2. Effects by stimulation results could be studied with experiments and summarized results are followings. 1. It may be concluded that effects on brain waves by music and vibroacoustic stimulation might differ under different situations such as stimulation types with vibroacoustic equipment, human body and mental conditions when measuring, etc.. 2. During stimuli by using music A, B, and C, the effect of $\alpha$ wave, $\beta$ wave, and SMR wave power values show same tendency to the subject c but music C had very different tendency during vibroacoustic stimuli. 3. During vibroacoustic stimuli by applying the signals of music C, because SMR wave power value was continually increased with consistency comparing to Bst, this can be estimated that an application of inducing mind concentration condition would be possible under relaxed body and mind conditions. 4. To secure data significance, all measured data need to be tested statistically whether data would be interrelated or not.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.688-695
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• 2010

The aim of this study is to examine the change of Electroencephalogram (EEG) and concentration by practicing acupressure at the GB20 on normal humans. We selected 36 children and divided them into GB20 group and SP6 group. Electrode was measured in Fp1 and Fp2, and EEG was measured before and after practicing acupressure at the GB20 and SP6. Sensorimotor rhythm (SMR) increased significantly at the GB20 group (p=0.043). M-$\beta$ wave increased significantly at the GB20 group (p=0.022). H-$\beta$ wave increased significantly at the GB20 group (p=0.040). $\gamma$ wave increased significantly at the GB20 group (p=0.021). $(SMR+M-\beta)/\Theta$ ratio increased significantly at the GB20 group (p=0.023). $\beta/\Theta$ ratio increased significantly at the GB20 group (p=0.020). On the other hand, $\alpha$ and $\Theta$ wave did not have significant changes. Through this experiment, we conclude that acupressure at the GB20 on normal humans could increase the ability of concentration.

• Science of Emotion and Sensibility
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• v.26 no.4
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• pp.125-132
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• 2023

This study investigated the effects of continuous Singing Bowl healing on brainwaves and autonomic nervous system responses. The variations in brainwaves were measured during 45-minute sessions in eight participants, before and after Singing Bowl healing sessions to assess the changes in brainwaves before and after five weeks of Singing Bowl healing treatment. BioBrain BIOS-S8 was used to obtain brainwave measurements. Electrodes were placed on six channels: F3, F4, T3, T4, P3, and P4. A standard limb lead I with electrodes was used for electrocardiogram (ECG) measurements. Using the collected brainwave data, changes in brain waves were observed before and after five weeks of Singing Bowl healing. Beta waves, alpha waves, and sensorimotor rhythm were found to have reduced, while theta waves, delta waves, and the standard deviation of normal-to-normal intervals in heart rate variability had increased. These results indicate that continuous Singing Bowl healing over five weeks can stabilize brainwaves, activate the autonomic nervous system, and increase the relaxation-inducing effects of the parasympathetic nervous system.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.10
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• pp.2551-2561
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• 2014

Several algorithms have been developed to detect AFIB(Atrial Fibrillation) which either rely on the linear and frequency analysis. But they are more complex than time time domain algorithm and difficult to get the consistent rule of irregular RR interval rhythm. In this study, we propose algorithm for optimal value detection of irregular RR interval for AFIB classification based on linear analysis. For this purpose, we detected R wave, RR interval, from noise-free ECG signal through the preprocessing process and subtractive operation method. Also, we set scope for segment length and detected optimal value and then classified AFIB in realtime through liniar analysis such as absolute deviation and absolute difference. The performance of proposed algorithm for AFIB classification is evaluated by using MIT-BIH arrhythmia and AFIB database. The optimal value indicate ${\alpha}=0.75$, ${\beta}=1.4$, ${\gamma}=300ms$ in AFIB classification.

• Journal of The Korean Association For Science Education
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• v.21 no.3
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• pp.516-528
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• 2001

In the educational study, the measure of EEG(brain waves) can be useful method to study the functioning state of brain during learning behaviour. This study investigated the changes of neuronal response according to four times repetition of audio-visual learning. EEG data at the prefrontal$(Fp_{1},Fp_{2})$ were obtained from twenty subjects at the 8th grade, and analysed quantitatively using FFT(fast Fourier transform) program. The results were as follows: 1) In the first audio-visual learning, the activities of $\beta_{2}(20-30Hz)$ and $\beta_{1}(14-19Hz)$ waves increased highly, but the activities of $\theta(4-7Hz)$ and $\alpha$ (8-13Hz) waves decreased compared with the base lines. 2). According to the repetitive audio-visual learning, the activities of $\beta_{2}$ and $\beta_{1}$ waves decreased gradually after the 1st repetitive learning. And, the activity of $\beta_{2}$ wave had the higher change than that of $\beta_{1}$ wave. 3). The activity of $\alpha$ wave decreased smoothly according to the repetitive audio-visual learning, and the activity of $\theta$ wave decreased radically after twice repetitive learning. 4). $\beta$ and $\theta$ waves together showed high activities in the 2nd audio-visual learning(once repetition), and the learning achievement increased highly after the 2nd learning. 5). The right prefrontal$(Fp_{2})$ showed higher activation than the left$(Fp_{1})$ in the first audio-visual learning. However, there were not significant differences between the right and the left prefrontal EEG activities in the repetitive audio-visual learning. Based on these findings, we can conclude that the habituation of neuronal response shows up in the repetitive audio-visual learning and brain hemisphericity can be changed by learning experiences. In addition, it is suggested once repetition of audio-visual learning be effective on the improvement of the learning achievement and on the activation of the brain function.