• 대한의용생체공학회:의공학회지
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• 제29권1호
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• pp.17-24
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• 2008

The aim of this paper is to report our preliminary results of investigating the spatial focalization of Zen-meditation EEG (electroencephalograph) in alpha band (8-13 Hz). For comparison, the study involved two groups of subjects, practitioners (experimental group) and non-practitioners (control group). To extract EEG alpha rhythm, wavelet analysis was applied to multi-channel EEG signals. Normalized alpha-power vectors were then constructed from spatial distribution of alpha powers, that were classified by Fuzzy C-means based algorithm to explore various brain spatial characteristics during meditation (or, at rest). Optimal number of clusters was determined by correlation coefficients of the membership-value vectors of each cluster center. Our results show that, in the experimental group, the incidence of frontal alpha activity varied in accordance with the meditation stage. The results demonstrated three different spatiotemporal modules consisting with three distinctive meditation stages normally recognized by meditation practitioners. The frontal alpha activity in two groups decreased in different ways. Particularly, monotonic decline was observed in the control group, and the experimental group showed increasing results. The phenomenon might imply various mechanisms employed by meditation and relaxation in modulating parietal alpha.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.309-321
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• 1995

In the present study, the relationship between the somatosympathetic reflexes and arterial blood pressure responses to electrical stimulation of the peripheral nerve was investigated in cats anesthetized with ${\alpha}-chloralose$. Single sympathetic postganglionic fiber activities were recorded from the hindlimb muscle and skin nerves and also from the cervical and abdominal sympathetic chains. Effects of the morphine on responses of the sympathetic nerve and arterial blood pressure to activation of the peripheral $A{\delta}-$ and C-afferent nerves were analyzed. The following results were obtained. 1) Arterial blood pressure was depressed by peripheral AS-afferent stimulation (A-response) and was elevated during C-afferent activation (C-response). 2) Intravenously administered morphine enhanced the C-response while the A-response decreased insignificantly, Only the C-response was decreased by intrathecal morphine. 3) All the ten recorded cutaneous sympathetic fibers showed periodic discharge pattern similar to respiratory rhythm and five of them also showed cardiac-related rhythm. However, most of the muscular sympathetic fibers had cardiac-related rhythm and only four fibers showed respiratory rhythm. 4) Morphine decreased the sympathetic C-reflex elicited by the peripheral C-afferent activation and the abdominal sympathetic A-reflex was also decreased by morphine. From the above results, it was concluded that supraspinal mechanisms were involved in the enhanced arterial pressor response to peripheral C-afferent activation by intravenous morphine.

• 대한한방소아과학회지
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• 제21권2호
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• pp.1-12
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• 2007

Objectives : Allergic children have known to have multiple behavior problems. Among them, attentional ability disorder is one of the most common problems. This study is to examine relationship between learning ability and allergic rhinitis by analyzing EEG status of children. Methods : We analyzed cognitive functions of two different children groups; 21 children with allergic rhinitis and 19 normal children with CANS 3000(Central & Autonomic Nervous System, LAXTHA Inc., Korea), cognitive functions assessment program by EEG. Results : 1. According to mean active EEG rhythm of Theta, Alpha, SMR, M-beta, there were no significant difference between allergic rhinitis and the normal group. 2. According to mean active EEG rhythm of right H-beta, Gamma wave allergic rhinitis group's value was significantly higher than that of the normal group. 3. According to mean cognitive strength, response, concentration, left / right brain activity and learning ability score, there were no significant difference between allergic rhinitis and the normal group. 4. According to mean workload score, allergic rhinitis group's value was significantly higher than that of the normal group. Conclusions : It is likely that allergic rhinitis group, which showed relatively high frequency EEG rhythm, is more fragile to stress and less active on mental processing. Along side with physical examination, psychological assessment should also be conjugated on treating children with allergic rhinitis.

• 동의신경정신과학회지
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• 제18권2호
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• pp.89-100
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• 2007

Objective : The purpose of this study is to examine relationship between cognitive function and sasang constitution by analyzing EEG status of company workers in Cheon-An. Method : 59 company workers were tested with cognitive assessment EEG program and questionaire for the Sasang Constitution Classification II. They were assorted by Sasang Constitutions, and we analyzed its correlation with cognitive assessment score and EEG data. Results : 1. According to mean active EEG rhythm of Alpha. H-Beta, Gamma wave, there were no significant difference among Sasang Constitution. 2. According to mean success, error, concentration, response, workload and left/right brain activity score, there were no significant difference among Sasang Constitution. 3. According to mean active EEG rhythm of Theta, SMR, M-Beta wave, Soyangin(少陽人)'s value was significantly higher than that of Taeumin(太陰人) 4. According to mean cognitive strenghth score, Soyangin(少陽人)'s value was significantly higher than that of Taeumin(太陰人). Conclusion : In conclusion, Sasang Constitutional difference has no relevance with cognitive abilities However, Soyangin(少陽人) showed higher mean active EEG rhythm of Theta, SMR, M-Beta wave than that of Taeumin(太陰人). In addition, Soyangin(少陽人) also showed higher mean cognitive strenghth score than that of Taeumin(太陰人).

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2006년도 하계종합학술대회
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• pp.1017-1018
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• 2006

We measured EEG, extracted the feature vectors using alpha and beta rhythm from the measured EEG and pattern recognition was simulated by using the feature vector and the algorithms which are conventional LVQ and Forward only Counter Propagation Networks. And then the successful rate of pattern class of EEG data had about 76 %.

• Journal of Photoscience
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• 제9권2호
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• pp.246-248
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• 2002

Light is a major environmental signal for entrainment of the circadian clock, but little is known about the phototransduction pathway triggered by light-activation of photoreceptive molecule(s) responsible for the phase shift of the clock in vertebrates. The chicken pineal gland and retina contain the autonomous circadian oscillators together with the photic entrainment pathway, and hence they provide useful experimental model for the clock system. We previously demonstrated the expression and light-dependent activation of rod-type transducin $\alpha$-subunit (Gtl$\alpha$) in the chicken pineal gland. It is unlikely, however, that the pineal Gt$_1$$\alpha$ plays a major role in the photic entrainment, because the light-induced phase shift is unaffected by bloking the signaling function of Gt$_1$$\alpha$. Here, we show the expression of G 11 $\alpha$, an $\alpha$-subunit of another heterotrimeric G-protein, in the chicken pineal gland and retina by cDNA cloning, Northern blot and Western blot analyses. GIl$\alpha$-immunoreactivity was colocalized with pinopsin in the chicken pineal cells and it was found predominantly at the outer segments of photoreceptor cells in the retinal sections, suggesting functional coupling of G11 $\alpha$ with opsins in the both the tissues. By coimmunoprecipitation experiments using the retina, we showed the light- and GTP-dependent interaction between rhodopsin and G11 $\alpha$. Upon ectopic expression of a Gq/ 11-coupled receptor in cultured pineal cells, pharmacological (non-photic) activation of endogenous G11 induced phase-dependent phase shifts of the melatonin rhythm in a manner very similar to the effect of light. These results suggested opsin-G11 pathway contributing to the photic entrainment of the circadian clock.

• 생물정신의학
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• 제23권4호
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• pp.193-198
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• 2016

Objectives Obsessive-compulsive disorder (OCD) and schizophrenia have many common clinical and neurocognitive features. However, not all of them share the same underlying mechanism. The aim of this study was to discover evidences that indicate a pathophysiological mechanism specific to OCD by comparing correlations of quantitative electroencephalography (QEEG) patterns and neurocognitive function in patients with OCD and schizophrenia. Methods Resting-state QEEG data of total 265 patients were acquired retrospectively and parameters such as absolute power, relative power and peak frequency were analyzed from the data. Stroop test and Trail Making Test results as well as demographic features were reviewed for this study. The correlation of neurocognitive functions and brain electrical activities in each group were assessed and compared by correlation analysis. Results Compared with the OCD group, the schizophrenia group performed poorly in neurocognitive tests. Mean values of QEEG parameters in patients with OCD and schizophrenia did not show significant differences. Both absolute and relative power of alpha rhythm in central and frontal regions showed significant positive correlation with Stroop test results in OCD patients. Conclusions Findings in this study shows distinctive correlations between frontal executive dysfunction and frontal alpha rhythm in the OCD patients, both of which might be a candidate for endophenotype underlying obsessive rumination.

• 한국산학기술학회논문지
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• 제18권8호
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• pp.285-293
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• 2017

본 연구의 목적은 다면적 인성검사(MMPI-2)의 임상척도와 뇌기능지수 중 자기조절지수와의 관련성을 알아보고자 하는데 있다. 연구는 상담센터에 내원한 20세 이상의 성인 남녀 중 자원한 41명을 대상으로 진행하였다. 자기보고식 검사지인 다면적 인성검사(MMPI-2)를 이용해 검사를 진행했으며, 2채널 뇌파측정기를 이용해 Fp1,과 Fp2에서 뇌파를 측정하였다. 연구결과는 다면적 인성검사(MMPI-2)의 임상척도인 척도2(D)와 자기조절지수 중 휴식 즉, 알파파와 음의 상관을 보였으며, 다면적 인성검사(MMPI-2) 척도3(Hy)은 집중력 즉, 저베타파와 양의 상관성을 보였고, 척도 7(Pt)은 휴식과 음의 상관성을 보였다. 상담현장에서 다면적 인성검사(MMPI-2)와 SQR을 상호 보완하여 사용할 수 있다는데 본 연구의 의의가 있다. 이러한 결과는 세 가지 시사점을 갖는 것으로 해석 가능하다. 첫째, 우울한 정서를 가진 사람들은 타인의 시선과 평가에 민감하여 대인관계를 맺을 시 많은 에너지를 사용하게 되어 휴식이 유지되지 못하기 때문에 피로도가 상승할 수 있다. 둘째, 지나치게 타인의 관심을 얻으려고 하고 쾌활한 모습을 지닌 사람들은 활동력이 높을 것으로 여겨진다. 셋째, 불안과 긴장 상태로 스트레스가 높아진 사람들은 쉽게 지치고 짜증과 불쾌감이 상승할 수 있다는 것을 시사한다.

• 한국산학기술학회논문지
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• 제19권6호
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• pp.715-721
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• 2018

청각 및 후각의 다감각 자극을 통하여 에너지를 절감하기 위하여 불쾌해진 촉각을 보상함으로써 에너지는 절감하면서 근무자의 뉴로에너지(쾌적성, 집중력, 신체적 및 심리적 안정 등)는 증강시키는 연구를 하였다. 온도 $25[^{\circ}C]$, 상대습도 50[RH%], 조도 1,000[lux] 및 기류 속도 0.02[m/sec]의 항온 항습실에서 1/f의 변동리듬으로 청각을 자극하고 아로마 향기로 후각을 자극하여 실험을 진행하였으며, 접촉식으로 인체의 심리상태를 측정하는 뇌파, 학습능력 및 심박동변이도와 비접촉식으로 심리상태를 측정하는 진동이미지 방법을 사용하였다. 피험자는 신체적으로 활동하는데 지장이 없고, 심신의 안정과 집중력의 최대 상태를 가져오는 상대 ${\alpha}$파(8~13[Hz])의 활성도가 후두엽에서 높은 유형인 20대 대학생 8명(남성 4명, 여성 4명)으로 선정하였다. 측정자세는 쾌적한 열적 환경에서 의자에 착석해 안정을 취하고 있을 때의 활동량으로써 1met로 하였으며, 착의량 상태는 약 0.7clo로 통일하였다. 측정결과 쟈스민 향기와 변동리듬 a=1.106 음원의 다감각자극에서 감성 및 심신안정과 집중력이 가장 높아졌으며, 상대$M{\alpha}$파와 상대$M{\beta}$파가 각각 70.49[%], 89.72[%] 증가하였고, HRT는 38.09[%] 감소하였으며, 피로도와 긴장 불안은 각각 36.85[%], 15.54[%] 감소하였다.

• 전자공학회논문지SC
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• 제42권5호
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• pp.27-34
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• 2005

심실세동은 심장의 무질서한 전기적 활동으로 인해 심근 수축이 동시에 이뤄지지 않게 되어 급성심장사에 이르게 하는 부정맥이다. 본 연구에서는 이러한 심실세동 검출을 위해 적은 양의 학습 데이터만으로 좋은 분류 성능을 보이는 SVM(Support Vector Machine) 분류기 기반의 심실세동 검출 알고리즘을 제안하였다. 심전도 신호로부터 SVM 분류기에 입력할 입력 특징을 추출하기 위하여 웨이브렛 변환기반의 대역통과 필터링, R점 검출, 입력 특징 추출구간 설정의 전처리 과정을 수행하였으며 입력 특징으로는 리듬 기반의 정보 및 웨이브렛 변환 계수를 선택하였다. SVM 다원분류기는 정상리듬(NSR) 분류기, 심실 세동과 유사한 심실빈맥(VT) 분류기, 심실세동(VF) 분류기 그리고 그 외 부정맥 분류기로 구성하였다. SVM 분류기의 파라미터 C값과 ${\alpha}$값은 실험을 통하여 최고 성능을 나타내는 C=10, ${\alpha}=1$을 선택하였다. SVM 다원 분류기를 통한 정상리듬, 심실빈맥 심실세동의 검출 평균값은 98.39%, 96.92%, 99.88%의 우수한 검출 성능을 나타냈다. 본 연구에서 제안된 동일 입력특징을 사용하여 SVM 분류기의 심실세동 검출 결과와 다층퍼셉트론 신경망 및 퍼지추론 방법에 의한 결과를 비교하였으며 SVM 분류기가 비슷하거나 우수한 결과를 보였다. 또한 기존 다른 알고리즘에 비하여도 우수한 결과를 보임으로써 제안된 입력 특징을 통한 SVM 분류기 기반의 심실세동 검출이 유용함을 확인할 수 있었다.