• Journal of Korea Foundry Society
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• v.30 no.3
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• pp.100-110
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• 2010

The solidification sequence and formation of intermetallic phase of Fe-rich Al-Si-Cu alloy were investigated by using real-time imaging of synchrotron X-ray radiation. Effects of cooling rate during uni-directional solidification on the resultant solidification behavior was also studied in a specially constructed vacuum chamber in the SPring-8 facility. The series of radiographic images were complementarily analyzed with conventional analysis of OM and SEM/EDX for phase identification. Detailed solidification sequence and formation mechanisms of various phases were discussed based on real-time image analysis. The growth rates of $\alpha$-AlFeMnSi and ${\beta}-Al_5FeSi$ were measured in order to understand the growth behavior of each phase. It is suggested that real-time imaging technique can be a powerful tool for the precise understanding of solidification behavior of various industrial materials.

• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.386-394
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• 2019

Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. In particular, we demonstrated accumulation of lipid droplets and impaired cardiac lipid metabolism in the hearts of cardiomyopathic mice and patients, and their association with impaired mitochondrial functions and endoplasmic reticulum (ER) stress in CD mice. In the present study, we examined whether treating infected mice with an ER stress inhibitor can modify the pathogenesis of cardiomyopathy during chronic stages of infection. T. cruzi infected mice were treated with an ER stress inhibitor 2-Aminopurine (2AP) during the indeterminate stage and evaluated for cardiac pathophysiology during the subsequent chronic stage. Our study demonstrates that inhibition of ER stress improves cardiac pathology caused by T. cruzi infection by reducing ER stress and downstream signaling of phosphorylated eukaryotic initiation factor ($P-elF2{\alpha}$) in the hearts of chronically infected mice. Importantly, cardiac ultrasound imaging showed amelioration of ventricular enlargement, suggesting that inhibition of ER stress may be a valuable strategy to combat the progression of cardiomyopathy in Chagas patients.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.83.4-84
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• 2015

We report that a strong downflow event caused three-minute oscillations in the solar atmosphere. Our observations were carried out by using the Fast Imaging Solar Spectrograph (FISS) of the 1.6 meter New Solar Telescope (NST) and the Interface Region Imaging Spectrograph (IRIS). Our main findings are as follows: (1) The strong downflow was seen at the $H{\alpha}$ absorption line at first, and then appeared at the Si IV and C II emission lines. It seems that the characteristics of the downflow are consistent with a coronal rain event. (2) After the event, oscillations of velocity were identified in the chromospheric lines and transition region lines. (3) The amplitudes of oscillations were 2km/s at Mg II line and 3km/s at C II and Si IV lines and decreased with time. (4) The period of the oscillation was 2.67 minutes at first, but gradually increased with time. Our findings are in agreement with Chae & Goode (2015)'s theory that of acoustic waves generated by a disturbance in a gravitationally-stratified medium.

• Journal of The Korean Astronomical Society
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• v.36 no.spc1
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• pp.145-149
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• 2003

LIST is the Lyman-$\alpha$ Imaging Solar Telescope, a project funded by the Korean government to fly on the second Korean Science and Technology research Satellite (STSat-2) due to launch in December 2005. The Principal Investigator is Dr. Minhwan Jang of Kyung-Hee University and of the Space Payload Research Center (SPARC), a consortium of Korean universities and institutions formed to develop scientific research projects in space. The purpose of the LIST project is to design, build, and operate an instrument on STSat-2 which will make images of the Sun from Earth orbit at the wavelength of the Hydrogen Lyman-a emission line at 121.6 nm. LIST has a simple design concept comprised of a small telescope to image the full disk of the Sun onto a CCD detector and a set of filters to isolate the 121.6 nm wavelength.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.11
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• pp.38-41
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• 1990

A new spline function for resampling discrete signal adaptively is proposed. In general, B-spline function is used for an image interpolation because of its smoothness and continuity, but accompanies a large amount of blurring effect. Hence, we developed a new spline function to remedy this effect, with two procedures ; deblurring of Gaussian blurring and diminishing of aliasing effect caused by deblurring procedure. The proposed function has a parametric expression with $\alpha$ which is related to the variance of Gaussian blurring model. Locally adaptive resampling scheme is obtained by changing a according to statistical characteristics of an image. The proposed, interpolation function shows edge-sharpening effect as well as noise smoothing, with comparison to the conventional schemes.

• IMMUNE NETWORK
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• v.12 no.3
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• pp.113-117
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• 2012

FasL, perforin, $TNF{\alpha}$, IL-1 and NO have been considered as effector molecule(s) leading to ${\beta}$-cell death in autoimmune diabetes. However, the real culprit(s) of ${\beta}$-cell destruction have long been elusive despite intense investigation. Previously we have suggested $IFN{\gamma}/TNF{\alpha}$ synergism as the final effector molecules in autoimmune diabetes of NOD mice. A combination of $IFN{\gamma}$ and $TNF{\alpha}$ but neither cytokine alone, induced classical caspase-dependent apoptosis in murine insulinoma and pancreatic islet cells. $IFN{\gamma}$ treatment conferred susceptibility to $TNF{\alpha}$-induced apoptosis on otherwise resistant murine insulinoma cells by STAT1 activation followed by IRF-1 induction. Here we report that $IFN{\gamma}/TNF{\alpha}$ synergism induces apoptosis of human pancreatic islet cells. We also observed STAT1 activation followed by IRF-1 induction by $IFN{\gamma}$ treatment in human islet cells. Taken together, we suggest that $IFN{\gamma}/TNF{\alpha}$ synergism could be involved in human islet cell death in type 1 diabetes, similar to murine type 1 diabetes.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.2
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• pp.118-122
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• 2016

Integrin ${\alpha}_v{\beta}_3$ plays an important role in the tumor metastases and angiogenesis. Arginine-glycine-aspartate (RGD) peptide motif binds to the integrin ${\alpha}_v{\beta}_3$. General $^{68}Ga$-labeled cyclic RGD peptides was rapidly eliminated from the circulatory system by renal excretion because of its hydrophilic property. The purpose of this study was to develop a novel $^{68}Ga$-labeled cyclic RGD peptides, which could acquire enhanced PET tumor images with improved pharmacokinetics by adopting biphenyl group between chelator and RGD peptides. $^{68}Ga$-DOTA-2P-c(RGDyK) was demonstrated a 12% higher lipophilicity level than $^{68}Ga$-DOTA-c(RGDyK) as a reference compound. In the animal PET, $^{68}Ga$-DOTA-2P-c(RGDyK) represented relatively lower blood-clearance, and an increased signal to noise ratio compared to $^{68}Ga$-DOTA-c(RGDyK). From these perspective, $^{68}Ga$-DOTA-2P-c(RGDyK) could be a good candidate for in integrin ${\alpha}_v{\beta}_3$-expressed tumor imaging.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.83.2-83.2
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• 2017

We report observations of light bridge (LB) jets taken with the New Solar Telescope. Jets as dark, fine threads occurred lined along both edges of a LB of a sunspot, which is a bright and elongated structure that divides a sunspot's umbra into two or more parts. This LB jets are observed for about three hours with $H{\alpha}$ filtergraph at ${\pm}0.4{\AA}$, ${\pm}0.8{\AA}$ from the line center, TiO filtergraph, and near infra-red imaging spectropolarimeter (NIRIS). High resolution $H{\alpha}$ data revealed that subsequent ejection of LB jets were associated with subsequent brightening along the edge of the LB. Also, this subsequent brightening was spatially correlated with both photospheric flow and magnetic field change detected from the TiO and NIRIS data, respectively. Preliminary results of LB jet observation and discussions on its formation mechanism will be presented.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.465-467
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• 2015

We presents a study of interactions between galaxies in the low-redshift group known as the NGC 4065 group. Imaging data were taken using the 2.4 meter telescope at the Thai National Observatory (TNO) for B, V and $R_c$ broadband filters and [$S\small{II}$] and Red-continuum narrowband filters. There are 21 galaxies in our sample. The results show that most early type galaxies (ETGs) with equivalent width EW($H{\alpha}$) < $10{\AA}$ are gas-deficient galaxies, while late type galaxies (LTGs) show more EW($H{\alpha}$) and are bluer than the ETGs. This means that star formation activity in the LTGs could be triggered by tidal interactions between galaxy members due to dense environmental effects in the compact group.

• The Bulletin of The Korean Astronomical Society
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• v.32 no.2
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• pp.32.1-32.1
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• 2007