• 상하수도학회지
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• 제23권6호
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• pp.711-717
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• 2009

In this study, SWMM model is used to reproduce the main storm sewer system located in the Nae-Hang drainage basin of the Mokpo city and keep track of flood discharge. Given the outlet of the reaches border the coastline, this paper has taken the dual-drainage approach to perform inundation simulation, considering both the overflows and inflows at the manholes of the sewer system, and at the same time, taking the impacts of tidal stage into consideration. The following conclusions are reached in this study: First, when planning lowland sewer system alongside the coastline or the riverside, the tidal stage or flood stage need to be considered in the planning and design processes. Second, an analysis that fails to consider overflow and inundation at the manholes may overestimate inundation depth of the flooded area. In other words, in order to estimate flood discharge and flood stage in a lowland storm sewer system, it is desirable to analyze the conveyance capacity of storm sewer system and simulate overflow and inundation at the manholes at the same time.

• Molecules and Cells
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• 제39권5호
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• pp.375-381
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• 2016

MicroRNAs (miRNAs) are small non-coding RNAs (~22 nucleotides) regulating gene expression at the post-transcriptional level. By directing the RNA-induced silencing complex (RISC) to bind specific target mRNAs, miRNA can repress target genes and affect various biological phenotypes. Functional miRNA target recognition is known to majorly attribute specificity to consecutive pairing with seed region (position 2-8) of miRNA. Recent advances in a transcriptome-wide method of mapping miRNA binding sites (Ago HITS-CLIP) elucidated that a large portion of miRNA-target interactions in vivo are mediated not only through the canonical "seed sites" but also via non-canonical sites (~15-80%), setting the stage to expand and determine their properties. Here we focus on recent findings from transcriptome-wide non-canonical miRNA-target interactions, specifically regarding "nucleation bulges" and "seed-like motifs". We also discuss insights from Ago HITS-CLIP data alongside structural and biochemical studies, which highlight putative mechanisms of miRNA target recognition, and the biological significance of these non-canonical sites mediating marginal repression.

• International Journal of Internet, Broadcasting and Communication
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• 제12권4호
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• pp.61-70
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• 2020

As mobile device usage time increases thanks to the development of information and communication alongside the increase in the spread of smartphones, mobile shopping has become a common trend. While mobile shopping has the advantage of saving both time and money, it may also result in dissatisfaction with product differences after purchase. For online clothing shopping malls, in particular, if the size does not match after purchase, it is difficult for customers to return or exchange the goods. To address this problem, some mobile apparel shipping malls offer a virtual fitting service and a size comparison function; however, the number of such malls remains low. In this paper, a usability evaluation was performed on a mobile apparel shopping mall that provides a size comparison function. The three apps selected for evaluation have different size input methods, and a slightly different method of providing results after comparing the user's dimensions with the dimensions of the clothes to be purchased. In this paper, the evaluators were asked to select clothes at the shopping mall and perform the task of deciding the size of the clothes to be purchased through their own measurements and comparison while also evaluating the effectiveness, meaning, and satisfaction of the apps. Based on the analysis of the results, this paper aims to produce an improvement plan and help design the size comparison UI (User Interface) in the future.

• 한국보육지원학회지
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• 제16권1호
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• pp.21-49
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• 2020

Objective: The purpose of this study was to understand the research trends of inclusive child-care for young children with disabilities and suggest some implications for future research on inclusive child-care. Methods: There were a total 330 previous research papers about child-care inclusion, which means the practice of educating and caring for children aged 0 to 5 years old with disabilities alongside their typically developing peers at child-care centers. The studies were analyzed in terms of main research topic, subject, and research methods. Results: The major results of this study were as follow. First, a quantitative increase of the research since 2003 and a sharp increase of total research in this area since 2006 were found. Second, as a result of the main topic analysis, recognition and attitude research was the most frequently conducted, followed by the research about child-care programs, teacher and family support, and the effect of inclusive child-care. Third, more than half of the researches were done by teachers. Lastly, quantitative research methods were mainly used. Conclusion/Implications: Based on these findings, this study suggested to extend the research on inclusive child-care effect, intervention programs, non-disabled children, infants, and qualitative research.

• 한국축산식품학회지
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• 제40권1호
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• pp.74-86
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• 2020

Horse meat is nutritionally adequate to the elderly, but it has a comparatively hard texture in contrast to most of the food. In practice, the meat intake in the elderly is generally bated because the relatively difficult texture of the meat can diminish mastication. Thus, strategies are being developed to produce meat products remanding detracted mastication exertion and possibly exalt ingestion and nutritional stand, in the elderly. Hence, the effects of enzymes on textural characteristics of horse meat were studied, because they have well-known favorable efficacy on the meat tenderness by causing important demotion of the myo-fibrillar protein and collagen. Four treatments namely, papain, bromelin, pepsin, and pancreatin, alongside one control were invoked to the horse meat. Their effects on the texture parameters were determined. All the above enzymatic treatments significantly reduced hardness and resilience (p<0.001). These results present opportunities to produce essential fatty acids fortified horse meat with soft texture and satisfied technological characteristics. The intake of the essential fatty acids intensified horse meat could aid the elderly to get their aimed essential fatty acid demands. Results also suggest that horse meat tenderized through enzymatic processing stand for auspicious options for the comprehension of texture-revised diets in the elderly population.

• Advances in concrete construction
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• 제9권3호
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• pp.327-335
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• 2020

Concrete pipes are considered important structures playing integral role in spread of cities besides transportation of gas as well as oil for far distances. Further, concrete structures under seismic load, show behaviors which require to be investigated and improved. Therefore, present research concerns dynamic stress and strain alongside deflection assessment of a concrete pipe carrying water-based nanofluid subjected to seismic loads. This pipe placed in soil is modeled through spring as well as damper. Navier-Stokes equation is utilized in order to gain force created via fluid and, moreover, mixture rule is applied to regard the influences related to nanoparticles. So as to model the structure mathematically, higher order refined shear deformation theory is exercised and with respect to energy method, the motion equations are obtained eventually. The obtained motion equations will be solved with Galerkin and Newmark procedures and consequently, the concrete pipe's dynamic stress, strain as well as deflection can be evaluated. Further, various parameters containing volume percent of nanoparticles, internal fluid, soil foundation, damping and length to diameter proportion of the pipe and their influences upon dynamic stress and strain besides displacement will be analyzed. According to conclusions, increase in volume percent of nanoparticles leads to decrease in dynamic stress, strain as well as displacement of structure.

• Advances in nano research
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• 제8권3호
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• pp.191-202
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• 2020

The article brings the study of nonlocal, surface and the couple stress together to apparent the frequency retaliation of FG nanobeams (Functionally graded). For the examination of frequency retaliation, the article considers the accurate spot of neutral axis. This article aims to enhance the coherence of proposed model to accurately encapsulate the significant effects of the nonlocal stress field, size effects together with material length scale parameters. These considered parameters are assimilated through what are referred to as modified couple stress as well as nonlocal elasticity theories, which encompasses the stiffness-hardening and softening influence on the nanobeams frequency characteristics. Power-law distribution is followed by the functional gradation of the material across the beam width in the considered structure of the article. Following the well-known Hamilton's principle, fundamental basic equations alongside their correlated boundary conditions are solved analytically. Validation of the study is also done with published result. Distinct parameters (such as surface energy, slenderness ratio, as nonlocal material length scale and power-law exponent) influence is depicted graphically following the boundary conditions on non-dimensional FG nanobeams frequency.

• 셀메드
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• 제2권3호
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• pp.22.1-22.9
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• 2012

The aim of this study is to collate all available data on experiments reporting the antiproliferative, cytotoxic effects of plants and natural products in Morocco in the last two decades. A bibliographic investigation was carried out by analyzing recognized books and peer-reviewed papers, consulting worldwide accepted scientific databases (Scirus, Embase, HighWire, MEDLINE/PubMed, LILACS, Ovid, ScienceDirect, SciELO, Google Scholar). We used medical subject heading terms and the words 'anticancer', 'antiproliferative', 'antineoplastic', 'antitumoral', 'cytotoxic', 'Morocco', to identify relevant articles. Moroccan plants with attributed anti-cancer properties studied as plant extracts that have been evaluated for cytotoxic effects, antitumoral effects, plants with active compounds tested on cancer cell lines, and plants with active compounds that have been assayed on animal models were chosen for this research. In the present study, interest is focused on experimental research conducted on medicinal plants, particularly those which show antiproliferative or cytotoxic activities alongside bioactive components. A total of 20 plant species belonging to 12 families have been identified as active or promising sources of phytochemicals with antiproliferative properties. The plant families, which cover all the species studied in this field, are Lamiaceae (7 species) and Asteraceae (4 species); the most studied species being Argania spinosa (Sapotaceae) and Arisarum vulgare (Araceae), Thymus Genus (Labiateae) and Peganum harmala (Zygophyllaceae). Based on the search results, it is recommended to increase the number of experimental studies and to begin conducting clinical trials with Moroccan plants and their active compounds selected by in vitro and in vivo activities.

• BMB Reports
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• 제40권2호
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• pp.226-231
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• 2007

Housekeeping genes are widely used as internal controls in a variety of study types, including real time RT-PCR, microarrays, Northern analysis and RNase protection assays. However, even commonly used housekeeping genes may vary in stability depending on the cell type or disease being studied. Thus, it is necessary to identify additional housekeeping-type genes that show sample-independent stability. Here, we used statistical analysis to examine a large human microarray database, seeking genes that were stably expressed in various tissues, disease states and cell lines. We further selected genes that were expressed at different levels, because reference and target genes should be present in similar copy numbers to achieve reliable quantitative results. Real time RT-PCR amplification of three newly identified reference genes, CGI-119, CTBP1 and GOLGAl, alongside three well-known housekeeping genes, B2M, GAPD, and TUBB, confirmed that the newly identified genes were more stably expressed in individual samples with similar ranges. These results collectively suggest that statistical analysis of microarray data can be used to identify new candidate housekeeping genes showing consistent expression across tissues and diseases. Our analysis identified three novel candidate housekeeping genes (CGI-119, GOLGA1, and CTBP1) that could prove useful for normalization across a variety of RNA-based techniques.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1626-1629
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• 2005

Recently many countries have concentrated their effort on the port automation, in order to be the Hub-port, that the Ultra Large Container Ship could come alongside the Quay, in their region. As the magnitude of the container ship increase, that of the Quay crane increases from 50ton-class to 61ton-class more and more. The wind speed criteria to design the structures used in the port was upgraded from 20m/s to 40m/s due to change of the weather condition. Our laboratory could have the ability to design the wedge type rail clamp for 50ton-class Quay crane in 30m/s wind speed. Accordingly we analyzed the load condition of the Quay crane about 40m/s wind speed upgraded from 20m/s and designed the wedge type rail clamp for 50ton and 61ton-class Quay crane.