• 한국임상약학회지
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• 제10권3호
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• pp.111-119
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• 2000

The objective of this study was to evaluate the efficacy and the pattern of regimens prescribed for the treatment of peptic ulcer disease in a regional community hospital. 226 patients were treated as an outpatient and followed for one year. 88 patients $(38.9\%)$ had gastric ulcer (GU) alone, 6 patients $(2.7\%)$ had duodenal ulcer (DV) alone, 5 patients $(2.2\%)$ had gastroesophageal reflux disease (GERD) alone, 25 patients $(11.1\%)$ had both GU and DU, 88 patients $(38.9\%)$ had both GU and GERD, and 14 patients $(6.2\%)$ had both DU and GERD. During this study period no one was treated for Zollinger-Ellison Syndrome. The disease showed higher occurrence in male population (139 patients, $61.5\%$) and among the ages of 30 and 40 $(62.4\%)$. The average age of these patients was 41.3 years and there was no difference between the genders. $81.4\%$ of these patients underwent CLO test to check for the existence of Helicobacter and $66.3\%$ of these Patients showed the positive response. $65.6\%$ of patients with GU and $80\%$ of patients with DU showed the positive response and there was no difference between the genders $(65.4\%\;vs.\;67.6\%)$. 184 patients $(81.4\%)$ were deemed to be cured based on the disappearance of their symptoms after completing the regimens. Compliance rate did not differ for gender or different diseases, while showing a difference in age. Patients between the ages of 20 to 30 years old showed the worst compliance rate. In addition, the compliance was lower among the patients who had previous occurrence of the disease, and this was more evident among female patients. Although 184 patients out of the total 226 patients were deemed to be cured, 36 patients $(20.65\%)$ of these returned to the hospital for relapsed diseases within one year. The factors that affected for patients to relapse were the diseases accompanied by ulcer and social environments, such as smoking, alcohol consumption, and previous history of the diseases (smoking P<0.001, alcohol consumption P<0.02, previous history of disease P<0.05). The regimen using $H_2$ receptor antagonists+tripotassium dicitrato bismuthate+clarithromycin showed the lower rate of relapse, and the regimens of omeprazole (OMP)+amoxicillin+tripotassium dicitrato bismuthate and OMP+amoxicillin+metronidazole showed better compliance rate. Patient education by pharmacists on the importance of compliance to regimens and the risk factors fer relapse can provide a better patient care. This would ultimately result in more cost-effective treatments by preventing additional cost for treating relapsed symptoms in approximately $20\%$ of patients.

• Korean Chemical Engineering Research
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• 제54권4호
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• pp.470-478
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• 2016

화석연료 사용으로 인한 환경오염과 기후변화는 전 지구적인 환경 문제로 대두되고 있다. 또한 화석연료 고갈 및 경제적 취약성을 극복하기 위하여 태양광, 풍력 등 신재생에너지 자원 기반 에너지공급 시스템 구축이 많은 관심을 받고 있다. 이러한 신재생에너지 시스템은 자원의 낮은 공급안정성을 극복하기 위하여 다양한 자원을 이용한 독립 통합 에너지공급 시스템 설계 및 운전 전략이 필요하다. 따라서 본 연구에서는 PV, Wind turbine, 화석연료 기반 발전 및 저장장치 등으로 구성된 독립 에너지공급 시스템을 설계하였다. 또한 최적화 모델을 이용하여 각 지역별 최적 전력생산 시스템의 구성요소를 규명하고 소요비용을 분석하였다. 제시된 모델 검증을 위하여 한국의 주거, 농업, 상업부문 등 주요 에너지수요 만족을 위한 설계문제를 해결하였다. 그 결과 주거부문의 경우 $0.37~$0.44/kWh, 농업부문의 경우 $0.15~$0.61/kWh, 상업부문의 경우 $0.12~$0.28/kWh의 단위전력 비용을 보였다.

• Journal of Animal Science and Technology
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• 제59권5호
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• pp.10.1-10.11
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• 2017

Background: Transfer of pesticides from environment to animal products is inevitable, so the purpose of the present work was to evaluate phosalone consumption via feeding with or without sodium bentonite (SB) on performance, blood metabolites and its transition to milk of Iranian Baluchi sheep. Methods: Twenty Baluchi ewes were divided into four treatments (P1 as control, P2, P3, and P4) of five animals in which phosalone, an organophosphate pesticide, was given via diet (only for P2 and P3) at a dose of 280 mg/sheep/day for 63 consecutive days. The SB (32 g/sheep/day; for P3 and P4) was also evaluated for its ability to reduce deleterious effects of phosalone in the sheep diets. The control group (P1) did not receive any phosalone and SB during the experiment. Sampling was conducted in two periods of time including weeks 5 and 9. Results: Phosalone residues were observed in the milk samples of P2 and P3 groups during two sampling periods. During period 1, the transfer rate of phosalone from feed to milk was 0.23 and 0.02%, respectively for the contaminated diets (P2 and P3), which is relatively similar to period 2 (0.22 and 0.02%). Only 0.34 (period 1) and 0. 36% (period 2) of phosalone residue are excreted in the feces of P2 group following its daily consumption. Transfer of phosalone from feed to milk was affected (P < 0.05) by the dietary inclusion of a commercial SB, as it (SB) decreased excretion of phosalone via milk (P3). The phosalone and SB alone or together had no significant effect (P > 0.05) on the dry matter intake (DMI) and body weight (BW) gain, but feed efficiency, milk production, milk fat, dry matter (DM) and organic matter (OM) digestibility, acetylcholinesterase (AChE) inhibitory activity, hemoglobin (Hb), red blood cell (RBC), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), albumin and mean corpuscular hemoglobin concentration (MCHC) affected by the treatments in period 1 or 2 (P < 0.05). The Hb, RBC, and MCHC were significantly decreased (P < 0.05) by about 9.72, 20.77, and 9.71%, respectively in the group P2 as compared to those of the control group during period 1. The AChE inhibitory activity (period 1 and 2) significantly increased when phosalone administered via the diet (P < 0.05). Conclusions: Although there were no adverse effects on the performance of sheep following the intake of phosalone alone (P2 vs. P1), but other research on the long and short times to the phosalone in high and low doses with more animals is suggested. Overall, compared to the control group, addition of SB in the diet of sheep improved nutrient digestibility, animal performance, and milk health.

• 유통과학연구
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• 제18권7호
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• pp.37-48
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• 2020

Purpose: There has been an increasing focus on consumer ethics by researchers and practitioners alike with the former seeking to examine the general discrepancy between ethical attitude, intention and actual behaviour by proposing behavioural measures to understand ethical consumption. Research into the effects of generational cohorts and gender, two fundamental demographic factors that shape the consumer habituated repertoire, on consumer ethics has reported mixed findings. The present study investigates if there are differences in ethical consumer behavior by generational cohorts and by gender in the context of an emerging market - Vietnam. Research design, data and methodology: Data was collected using a quantitative survey (a link to the questionnaire was posted on relevant social media platforms). A total of 539 usable responses was used for ANOVAs and independent t-tests to test the hypotheses. Results: a) There are significant differences in terms of ethical consumer behavior between Gen Z and Gens Y/X, but no difference between Gen X and Gen Y; b) There is no gender difference in ethically minded consumer behavior. Conclusion: For consumer ethics, generational effects may be moderated by macroeconomic conditions, while gender alone as a biological variable may not be a reliable predictor.

• 한국수산과학회지
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• 제47권6호
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• pp.765-769
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• 2014

We examined the protective effects of Pyropia yezoensis glycoprotein (PYGP) against ethanol-induced gastric damage. The experimental animals were divided into four groups. They were treated with distilled water (control), ethanol alone (EtOH), ethanol + PYGP 150 mg/kg BW (EtOH+150), or ethanol + PYGP 300 mg/kg BW (EtOH+300). The groups were treated for 4 weeks. We measured mitogen-activated protein kinase (MAPK), the apoptotic signaling pathway, and PARP activity in gastric tissues obtained from the rats. Ethanol consumption increased apoptotic signal activity and ERK, JNK, and p38 phosphorylation. PYGP reduced the apoptotic signaling pathway activity and ERK, JNK, and p38 phosphorylation. Furthermore, PYGP regulated Bcl-2 family expression. In light of these findings, PYGP appears to prevent ethanol-induced gastric injury and oxidative stress.

• 자원ㆍ환경경제연구
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• 제10권2호
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• pp.135-159
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• 2001

This study analyses the energy consumption increase by using a physical production index (PPI) based decomposition method. The energy efficiency of the Korean industry deteriorated to a large extent in the 1992 to 1997 period. This outcome, however, does not contradict the result of a previous study that the physical energy intensities (measured by energy use per production unit) decreased in four Korean energy intensive industries such as steel, cement, petrochemical and pulp and paper in the same period. Although the physical energy intensities in four industries considered decreased significantly, the energy efficiency of the Korean industry deteriorated because the increase in the value-added production was smaller than that in the physical production except for the steel industry. This outcome suggests that the reduction in the physical energy intensity alone will not result in reducing the economic energy intensity, thereby reducing the increase in the energy consumption of the Korean industry. Therefore, it necessitates to restructure the Korean industry towards a higher value-added production and to strengthen energy efficiency improvement efforts in the Korean industry. As the overinvestment in the energy intensive industries caused a deep price fall of Korean products and a reduction of the value added of the Korean industry and with it an increase in the economic energy intensity, a decrease in this intensity will highly depend on reducing the overcapacity in the energy intensive industries which was partly responsible for the currency and economic crisis of 1997.

• Preventive Nutrition and Food Science
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• 제19권4호
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• pp.367-372
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• 2014

Caffeine is widely consumed and well known for stimulating the central nervous system. When developing new foods and beverages that contain caffeine, it is important to explore the potential synergistic effects of consuming amino acids and other food ingredients with caffeine on humans. Given the physiological pathways affected by the amino acid ornithine, consumption of ornithine with caffeine may have synergistic effects. The purpose of the present study was to examine the effect of consuming caffeine with ornithine in humans. The study used a randomized, placebo-controlled, double-blinded crossover design. The subjects were all healthy office workers who ingested the placebo, 100 mg caffeine, or 100 mg caffeine plus 200 mg ornithine in the morning and completed questionnaires about their mood. Office workers who consumed the combination of caffeine and ornithine had higher mood ratings 8 h after consumption than office workers who consumed caffeine alone. The results of the present study suggest that there is a unique synergistic effect between caffeine and ornithine on the mood of healthy office workers and that ornithine may potentiate the effects of caffeine.

• Food Science and Biotechnology
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• 제17권6호
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• pp.1151-1155
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• 2008

This study aimed to investigate the alterations in plasma antioxidant activity after the consumption of a single oral dose of curcumin, vitamin C, and E administered individually or in combination to (i) assess possible synergies or antagonism between the antioxidants and (ii) determine the optimal composition of the antioxidant mixture such that the duration of action is prolonged to beyond that of individual antioxidants. Each antioxidant was administered to male Sprague-Dawley rats, and blood samples were drawn at different time points up to 180 min to measure the plasma total antioxidant capacity (TAC). Five antioxidant compositions (M1-M5) were evaluated to assess the possible synergies or antagonisms among them and to determine the optimal composition of the antioxidant mixture. Blood samples were collected up to 360 min post-consumption. A single oral dose of individual antioxidants significantly increased the TAC values; however, the time to reach the peak TAC value varied. Among the 5 antioxidant compositions, M2 exhibited the highest and most prolonged antioxidant effect in plasma; this was greater than the proportional sum of the effects of the individual antioxidants in the composition. This result indicates a synergistic interaction among antioxidants in the optimal composition M2.

• 한국축산식품학회지
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• 제41권1호
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• pp.8-15
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• 2021

Vegetarians have claimed and actively promoted the advantages of plant-based alternative milks as the best option for human nutrition and health, compared to the natural dairy milk. However, numerous scientific evidences and reports have demonstrated that the natural milk possesses more beneficial nutrients and bioactive components than artificially manufactured plant-derived milks. The biochemical and nutritional advantages and functionalities of natural dairy milk cannot be replaced by man-made or crafted plant-based beverage products. On the other hand, the tremendous increase in production and consumption of the plant-based alternative milks in recent years has led a serious business downturn in traditional roles and stability of the dairy industry, especially in the major dairy producing Western countries. Although plant-based milk alternatives may have some benefits on nutrition and health of certain consumers, the plant-derived alternative milks may not overshadow the true values of natural milk. Milk is not a high fat and high cholesterol food as animal meat products. Unlike plant-based alternative milks, natural milk contains many bioactive as well as antiappetizing peptides, which can reduce body weight. It has proven that taking low-fat, cultured and lactase treated milk and dairy products with other diversified nutritionally balanced diets have been shown to be healthier dietary option than plant-based milk/foods alone.

• Journal of Nutrition and Health
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• 제56권4호
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• pp.404-418
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• 2023

본 연구는 국민건강영양조사 자료를 활용하여 한국의 김치 섭취 추세를 분석하고 김치 섭취와 관련 있는 특성을 파악하고자 하였다. 추세 분석에서, 총 81,680 명 (남자 33,988명, 여자 47,692)을 대상으로 연도별 연령표준화 김치, 채소, 과일 평균섭취량을 구하였고, 섭취 추세에 대한 경향성을 확인하였다. 관련 요인 분석에서, 총 22,122명 (남자 15,134명, 여자 6,988명)를 대상으로 김치, 과일, 채소를 기준치 또는 중위수 이상으로 섭취할 오즈비를 특성 변수에 따라 로지스틱 회귀분석을 실시하였다. 본 연구에서 남녀 모두 김치 섭취량이 감소하고 있으며, 관련 요인으로 김치의 주된 섭취 장소인 가정에서의 식사 비율 감소, 서구화된 식습관, 식생활에 영향을 주는 배우자의 유무, 1인 가구 증가에 따른 혼자 식사하는 빈도의 증가를 고려해볼 수 있다. 따라서 이러한 요인을 고려한 식생활 지침 마련이 필요하다.