• 한국식품영양과학회지
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• 제39권7호
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• pp.1024-1029
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• 2010

폴리에틸렌글리콜(PEG) 4,000을 20, 30, 40% 농도로 처리하여 백년초와 알로에 절편을 건조한 후, 열풍건조와 동결건조 처리된 시료와 복원율, 색도, 관능평가 등을 비교, 분석하였다. 건조시간에 따른 탈수 양은 두 시료 모두 PEG의 농도가 높을수록 탈수효율이 좋았다. 복원율에서는 열풍건조와 동결건조 처리 시료보다 PEG 처리 시료가 더 높은 복원율을 가졌다. 색도에서는 동결건조와 유사하였고 열풍건조보다는 우수하였다. 관능평가에서는 열풍건조나 동결건조보다 PEG 처리한 시료가 더 우수하였다. 따라서 본 연구 결과, PEG를 이용한 백년초와 알로에 절편의 건조는 시료의 세포파괴를 최소화하고 신선한 시료 본래의 상태로 복원될 수 있는 매우 효율적인 건조방법이라고 판단되며, 건조된 제품을 향후 기능성화장품 원료 등으로의 활용이 가능하다고 판단된다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.62-62
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• 2003

It is now convincing that free radical generation is involved in the pathophy siological mechanisms of ischemic stroke, particularly in ischemia-reperfusion injury. The present study, therefore, examined neuroprotective effect of aloesin isolated from Aloe vera, which was known to have antioxidative activity, in a rat model of transient focal cerebral ischemia. Transient focal cerebral ischemia was induced by occlusion of middle cerebral artery for 2 hr with a silicone-coated 4-0 nylon monofilament in male Sprague-Dawley rats under isoflurane anesthesia Aloesin (1, 3, 10, 30 and 50 mg/kg/injection) was administered intravenously 3 times at 0.5, 2 and 4 hr after onset of ischemia. Neurological score was measured 24 hr after onset of ischemia immediately before sacrifice. Seven serial coronal slices of the brain were stained with 2,3,5-triphenyltetrazolium chloride and infarct size was measured using a computerized image analyzer. Treatment with the close of 1 or 50 mg/kg did not significantly reduce infarct volume compared with the saline vehicle-treated control group. However, treatments with the closes of 3 and 10 mg/kg significantly reduced both infarct volume and edema by approximately 47% compared with the control group, producing remarkable behavioral recovery effect. Treatment with the close of 30 mg/kg also significantly reduced infarct volume to a lesser extent by approximately 33% compared with the control group, but produced similar degree of behavioral recovery effect. In addition, general pharmacological studies showed that aloesin was a quite safe compound. The results suggest that aloesin can serve as a lead chemical for the development of neuroprotective agents by providing neuroprotection against focal ischemic neuronal injury.