• Toxicological Research
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• v.22 no.4
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• pp.329-332
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• 2006

Ethanolic extract of Aloe vera (Aloe barbadensis Miller) was examined for the cellular toxicity on HepG2 human hepatocellular carcinoma cells. Treatment with Aloe vera extract resulted in DNA fragmentation but not LDH release, suggesting an apoptosis instead of necrosis. Aloe vera induced cytotoxicity was mediated by decrease in ATP levels, whereas GSH depletion, increase in intracellular $Ca^{2+}$, or activation of caspase-3/7 could not be observed with statistical significance. No activation of caspase-3/7 suggests the possibility of caspase-independent apoptosis. Taken together, our results show that Aloe vera extract induce HepG2 apoptosis by ATP depletion-related impairment of mitochondria, which is caspase-independent.

• Journal of the Korean Society of Food Culture
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• v.22 no.3
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• pp.330-335
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• 2007

This study was conducted to investigate the mechanical and sensory characteristics of aloe Suffitteok prepared with the different ratio of aloe sap for 4 days. Moisture content of Sulgitteok without aloe vera sap was 33.79%, and that of Sulgitteok prepared with 12% aloe vera sap decreased. As the storage time of Sulgitteok increased, moisture content reduced. The cohesiveness, springiness, adhesiveness, gumminess and chewiness of Sulgitteok decreased as aloe vera sap increased. The L values of aloe Sulgitteok significantly decreased with increasing aloe vera sap. The a value of Sulgitteok without aioe vera sap was -0.56, but showed negative value as aloe vela sap increased. The more aloe sap added, the higher b values rose. The overall acceptability of color, flavor, taste, softness and moistness in sensory evaluation showed that Sulgitteok prepared with 9% aloe vera sap had the highest score.