• 한국학교ㆍ지역보건교육학회지
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• 제17권3호
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• pp.11-25
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• 2016

Background & Objectives: There were increasing evidence about the relationship between allergy related disease such as asthma, atopic dermatitis and allergic rhinitis and suicide ideation. However little was known about the concrete relatedness between severity and comorbidity of allergy related disease with suicide ideation. The objective of this study was to investigate the cases of the prevalence of suicide ideation among adolescents with allergy related disease such as asthma, atopic dermatitis and allergic rhinitis, and examine the association between allergy related disease and suicidal ideation among adolescents in South Korea. Methods: Data was based on Korean Youth Risk Behavior Web-based Survey(2014) which was a cross-sectional study containing 34,874 Korean middle and high school students who diagnosed with allergy related disease. We used the weights, strata and primary sampling unit information provided by the public use dataset to compute descriptive statistics and logistic regressions. Computations were done with SPSS version 20.0. Results: 19.9%, 15.6%, 13.8% of adolescents who suffered from one, two and three of allergy related diseases respectively reported having been thought of suicide ideation. Socio-demographic factors were adjusted as control variables. Students with greater severity of disease were more likely to have suicide ideation. Odds ratio for students who were absent one to three days from school because of allergies was 1.96(95% CI 1.51-2.46), and odds ratio for those who were absent more than four days from school was 3.60(95% CI 2.46-5.28). Conclusions: Given that adolescents' severity and comorbidity of allergy related disease were clearly associated with suicide ideation, suicide prevention programs for adolescents with allergy related disease should be improved by strategic approaches towards the severity and comorbidity of disease.

• 생명과학회지
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• 제19권7호
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• pp.899-904
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• 2009

옻 allergy 유발물질을 분리하고 그 특성을 연구하기 위하여 국내산, 중국산 및 일본산 생 옻을 사용하였다. 옻의 crude extracts로부터 crude urushiol을 정제하고, 다시 allergy 유발물질로 알려져 있는 3종의 urushiol congeners를 분리하였다. 분리한 urushiol congeners는 RV-1 였으며, 전체의 80%에 해당하였다. RV-1의 함량은 중국산에서 70.07%로 가장 많았으며, 일본산에서 62.38%로 가장 적었다. 반면에 RV-2는 일본산은 9.25%로서 국내산과 중국산의 4.28 및 3.09%에 비하여 약 2$\sim$3 배정도 많았다. Allergy 유발특성을 보면, RV-1은 초기유발강도가 강하고 지속적이어서 회복속도도 늦었다. RV-2는 초기유발강도는 약하지만 회복속도는 늦었다. 반면에 RV-3는 초기유발강도는 비교적 약했지만, 감작 후 48시간 째에 가장 강하게 유발되었고, 회복속도가 빨라서 72시간이 경과하였을 때에는 거의 대조군 수준으로 회복되었다. 따라서 allergy유발에 가장 큰 영향을 미치는 urushiol은 RV-1이었으며, RV-1의 함량이 가장 많은 중국산이allergy의 유발강도가 가장 강하였고 회복속도도 늦음을 알 수 있었다.

• 대한소아치과학회지
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• 제49권2호
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• pp.180-187
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• 2022

이 연구의 목적은 소아 수면 설문지(PSQ)를 활용하여, 구강 내 소견, 체질량 지수(BMI) 및 병력과 비교함으로써 수면 호흡 장애(SDB)와 관련된 잠재적 위험 요인을 조사하는 것이다. 만 7세에서 11세 사이의 787명의 어린이가 포함되었으며, 어린이의 보호자는 설문지를 작성하였다. Angle의 분류, 수평피개 및 Brodsky 편도 등급을 포함한 구강 증상을 조사하였다. 이중 PSQ 점수가 0.33점 이상인 대상은 SDB 고위험군으로 분류되었다. 787명 중 34명(4.3%)이 SDB 고위험군으로 분류되었다. 알레르기성 비염, 아토피성 피부염, 과도한 수평피개, 편도 비대를 가진 어린이는 그렇지 않은 어린이보다 SDB 위험이 훨씬 더 높았다. 또한 BMI 상태에 따라 SDB 위험도에 유의한 차이가 있었다. 성별, 재태 연령, 모유 수유 및 Angle의 분류는 SDB와 관련이 없었다. 이 연구에서 SDB 고위험군의 어린이는 4.3%로 나타났으며, 예측인자로는 편도 비대, 알레르기성 비염, 비만 및 아토피성 피부염이 있었다. 이러한 예측인자를 가진 어린이는 SDB가 발생할 위험이 높고 조기개입이 필요한 대상이 될 수 있다.

• 보건교육건강증진학회지
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• 제18권2호
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• pp.141-156
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• 2001

This study was performed to identify the occupational diseases in the dental technicians working in Korea, and to elucidate the main related affecting factors for the occurrence of the occupational diseases. The research was carried out using a mail questionnaire and data collection was done for two months from April 15, 2000. The questionnaires were delivered to 1000 dental technicians working at 250 dental laboratories which were chosen among the total 1330 dental laboratories in south Korea. And 763 questionnaires were collected, then 739 questionnaires were used for a logistic and a multiple regression analyses. The results obtained in this study are summarized as follows: 1. The occupational diseases in the dental technicians included pneumoconiosis, chronic bronchitis, asthma, pneumonia, hyposmia, allergic dermatitis, eczema, contagious dermatitis, central nervous disorder, dysfunction of finger, vertebral disorder, dysfunction of interphalangeal joint, ophthalmitis, auditory dysfunction, otitismedia, optic trauma, and bum. 2. The main related affecting factors for the occurrence of the occupational diseases in the dental technicians were elucidated as follows: On the ccurrence of chronic bronchitis, vibration of equipment and job career were affected positively. On the ccurrence of asthma, job career and career on current working part were affected positively, but exhaust ventilation, work hour were affected negatively. On the occurrence of eczema, career on current working part and vibration of equipment were affected positively, but personal protective equipment, local exhaust ventilation, isolation of gas source were affected negatively. And eczema was occurred more in methyl methacrylate work than in any other work part. On the occurrence of finger dysfunction, vibration of equipment and noise of work place were affected positively. But personal protective equipment, local exhaust ventilation, isolation of dust and gas source were affected negatively. But finger dysfunction was occurred more in metal polishing than in any other work part. On the occurrence of auditory dysfunction, noise of work place were affected negatively. The results obtained in this study can give a valuable information for a prevention of the occupational diseases in the dental technicians working in Korea, and for keeping them in healthy. This study also can be helpful for a researcher who is aiming at a identification of occupational diseases and a elucidation of related affecting factors in a similar occupation.

• 대한수의학회지
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• 제48권4호
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• pp.413-421
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• 2008

It was previously found that PG102, a water-soluble extract derived from Actinidia arguta, was able to modulate Th1/Th2 pathways and suppress IgE production resulting in dramatic amelioration of atopic dermatitis in NC/Nga mouse and hairless rat models. In order to evaluate the subacute toxicity of PG102, female and male SD rats were daily fed with various doses of PG102 for 4 weeks. Six week old SD rats were randomly divided into 4 groups and orally administrated with 100-, 300-, and 1,000- mg/kg of PG102 as well as the vehicle only. At the end of the study, no significant differences in the body and organ weights were observed between control and treated rats of both genders. Hematological and blood chemical analysis showed little differences between the animal groups. Neither gross abnormalities nor histopathological changes were found. PG102 produced little or no subacute toxicity and could be used as a safe nutraceutical for the treatment of individuals with allergic diseases including atopic dermatitis.

• 한국한의학연구원논문집
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• 제16권3호
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• pp.107-113
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• 2010

Objective : Active treatment for a skin condition has produced a substantial change in the history of allergic contact or wound induced dermatitis. The frequency of opportunistic contacts and allergen-related dermatitis has increased, though new skin treatments have developed. Especially, there has been a interest in the korean herbal bathing. This study was performed to investigate the effects of the korean herbal bathing candidates on skin lesions in mice model. These candidates are Korea's representative herbs on skin lesions. Method : ICR mice were divided into five groups : naive, control, experimental group A and B and C. Control and experimental groups induced skin lesions by DNFB and TMA. Each experimental group was pasted with corresponding korean herbal bathing candidates on skin lesions. Result : Significant improvements in skin wound index, epidermal thickness associated with skin lesions were seen with the korean herbal bathing candidates. Conclusion : These results suggest that the korean herbal bathing candidates could be at least as effective as steroid, anti-histamine for the treatment of skin lesions.

• 대한한방소아과학회지
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• 제12권1호
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• pp.183-210
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• 1998

Cheonggisan(CGS) is well known for its effect on such allergic disease as urticaria and atopic dermatitis. Gagamcheonggisan(GCGS) was formulated by subtracting several herbs from CGS and adding several herbs to CGS. Even though it is being used frequently in the clinicai medicine for the treatment of above hypersensitivity diseases, basic study to make sure the mechanism of its action is rare. In this study the author tried to know the effect of CGS and GCGS on the vascular permeability, contact dermatitis, granular secretion from mast cells and function of macrophages. The results obtained in this study are as follows : 1. Administration of CGS and GCGS decreased the vascular permeability induced by serotonin and histamine. The decrease by serotonin is more typical and dose-dependent. 2. Administration of CGS and GCGS inhibited foot-pad and ear swelling responses induced by sheep red blood cells and picryl chloride respectively, the inhibition of foot-pad swelling responses is bigger than that of ear swelling responses and both of them are not dependent on the dose3. Treatment of peritoneal mast cells with CGS and GCGS water extract decreased the histamine release triggered by compound 48／80 in a dose dependent fashion 4. Administration of CGS and GCGS increased the phagocvtic activity of peritoneal macrophages and treatment of peritoneal macrophages with CGS activated phagocytic function in a dose dependent fashion. 5. Administration of CGS and GCGS enhanced such reactive oxygen intermediates(ROIs) as superoxide and hydrogen peroxide production from peritoneal macrophages. 6. Treatment of CGS and GCGS activated peritoneal macrophages for the production of ROIs. The above results show that CGS and GCGS decreased the hypersensitivity reactions by inhibiting non-specific inflammatory mediator release and vascular permeability without affecting general immune responsiveness.

• 대한한의학방제학회지
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• 제25권2호
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• pp.123-134
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• 2017

Wounds are commonly created during almost every kind of surgery, trauma and skin diseases. Delayed wound healing affects a plenty of patients and requires prolonged treatments that seriously reduce the quality of life for patients. Skin damage involving large areas or great severity can lead to disability or even death. Wound healing involves a complicated series of actions, of various tissues and cell lineages, concerning inflammation, migration, proliferation, reepithelialization, and remodeling. Sopung-san is reported to have anti-inflammatory effect and has been used for various skin diseases such as allergic dermatitis and atopic dermatitis. In this study, the hypothesis that oral treatment with Sopung-san could enhances healing potential on rat full thickness skin wounds was tested. Twenty young male Sprague-Dawley rats were used for the studies. A full-thickness skin wound was made on the dorsal skin of the rats. Either Sopung-san water extract (SPS) or saline (Control) was orally administrated every day. The wound area was measured and the percentages of wound contraction, wound healed and wound epithelization were calculated. Wound tissue samples were excised following injection for histopathological and immunohistological examination. Wound area in rats of SPS group significantly was decreased compared to Control. SPS group showed significant promotion of wound healing compared to Cotrol group in the percentages of wound contraction, wound healed and wound epithelization. Histopathological examination revealed that SPS induces neo-vascularization potential in wound healing process. SPS treatment in rats significantly accelerated cutaneous wound healing in the neo-vascularization process by increasing VEGF and $TGF-{\beta}1$ synthesis. The results suggest that Sopung-san affects key cellular processes responsible for wound repair and point to a unique potential for this molecule in the therapy of skin wounds, particularly as an angiogenic agent.

• 동의생리병리학회지
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• 제19권6호
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• pp.1659-1665
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• 2005

Gamipaidok-san(GPDS) is the Hyungbangpaidok-san prescription fortified with the additional ingredients known to be effective for dermatitis. So it has been used for atopic dermatitis in the clinic work actually. In this study, we investigated the effects of GPDS on in vitro and in vivo anti-allergic effect on RBL-2H3 rat basophilic leukemia Cells and on IgE-induced passive cutaneous anaphylaxis (PCA) in mice. The in vitro anti-inflammatory activity of GPDS in RAW 264.7 cells was investigated. GPDS potently inhibited $\beta$-hexosaminidase release from RBL-2H3 and the IgE-mediated PCA reaction in mice. GPDS inhibited LPS-induced NO and PGE2 production in a dose-dependent manner Furthermore, It also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in RAW 264.7 cells, and the activation of the transcription factor, NF-kB, in nuclear fraction. The antiallergic action of GPDS may originate from anti-inflammatory activities, and can improve the inflammation caused by allergies.

• 한국융합학회논문지
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• 제10권6호
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• pp.347-353
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• 2019

본 연구는 제6기 국민건강영양조사(2015년)의 원시자료를 이용하여 한국청소년의 알레르기질환에 영향을 미치는 비만, 흡연, 음주를 파악하기 위한 서술적조사연구이다. 연구대상은 만 12세에서 18세 청소년 535명이었고, Rao-Scott $x^2$. 복합표본 로지스틱 회귀분석을 실시하였다. 연구결과는 청소년의 천식 진단율 5.4%, 아토피피부염 진단율 15.5%, 알레르기비염 진단율 22.8%순으로, 비만, 흡연, 음주 여부에 따른 천식, 아토피피부염, 알레르기비염 진단율의 차이는 나타나지 않았다. 반면에. 알레르기 진단의 위험을 높이는 변수로 천식은 비만, 아토피피부염은 음주가 유의하게 나타났다. 본 연구결과를 바탕으로, 알레르기 질환을 진단받은 청소년에게 질 높은 삶을 중재하기 위한 차별화된 간호를 제공하기 위하여 비만, 흡연, 음주와 관련된 건강증진 프로그램 개발의 기초자료를 제공하고자 한다.