• 제목/요약/키워드: Allergic Dermatitis

검색결과 450건 처리시간 0.022초

공동주택 강제 환기 시스템의 건물에너지 측면에서의 장기적 운영 방안에 관한 연구 (A Study on the Long-term Operating plan of Ventilation System of Apartment House in terms of Energy Performance)

  • 김승철;윤종호;백남춘;신우철
    • 한국태양에너지학회:학술대회논문집
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    • 한국태양에너지학회 2011년도 추계학술발표대회 논문집
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    • pp.115-123
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    • 2011
  • Because buildings recently built have been highly insulated and highly airtight, it is impossible to emit toxic substances from interior finishing materials only by natural ventilation. Therefore, they cause indoor air pollution and it may threaten the user"s health such as atopic dermatitis, bronchial asthma and (allergic) rhinitis. Domestically, users spend indoors 80 percent of their time of a day. With the increased interest in indoor air quality, the introduction of forced ventilation system for new-built apartment buildings has been legislated. However, toxic substances from indoor are mostly below there commended standard approximately 23 months later. Thus, this study has assumed the status of the apartment buildings 23 months later through a simulation, regarded $CO_2$ as an exclusive indoor air pollution source. In the process of effectively eliminating the $CO_2$, this study has also been conducted on an operating plan that can provide superior performance from the energy side.

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LC-MS/MS Assay Validation for a New Immune Modulator, JHL45, and its Major Metabolite in Plasma: Application to Pharmacokinetic Studies in Rats

  • Baek, In-Hwan;Chae, Jung-Woo;Song, Gyu-Yong;Kwon, Kwang-Il
    • Bulletin of the Korean Chemical Society
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    • 제30권11호
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    • pp.2631-2636
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    • 2009
  • JHL45, a novel immune modulator for anti-atopic dermatitis and allergic airway disease, was synthesized from decursin isolated from Angelica gigas. In order to conduct a pharmacokinetic study of JHL45, an analytical method, ideally one that uses a minimal amount of biological sample must first be validated. In this study, a HPLC-MS/MS method was developed and validated for the quantification of JHL45 and its major metabolite, (+)-decursinol, from 10 ${\mu}L$ of rat plasma. JHL45 was stable under the analysis conditions, and intra- and inter-day accuracies exceeded 90.06%, with a precision variability ${\leq}$ 13.16% for each analyte. The mean values for Cmax, AUC8h, half-life of JHL45 in rats after intravenous administration of 5 mg/kg JHL45 were 24.59 μg/mL, 10.02 ${\mu}g{\cdot}h/mL$, and 1.88 h, respectively. The validated method herein will be useful for further pharmacokinetic studies of JHL45, as well as in preclinical and clinical phases.

A Potent Medicinal Plant: Polygala Tenuifolia

  • Anvi, RANA
    • 식품보건융합연구
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    • 제9권1호
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    • pp.1-9
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    • 2023
  • Polygala Tenuifolia, also described as Yuan Zhi, is a conventional botanic plant found in Korea and China. It's most well- known promise is to improve cognition and guard against mental disorders, cure sputum, anxiety, and sleeplessness, and keep the central nervous system health. The pharmacological aspects of Polygala Tenuifolia's genesis and component compounds reveal the neuroprotective potential in connection to Alzheimer's disease. It contains three herbs: Bokshin, Sukchangpo, and Wongi. P. Tenuifolia's primary ingredients are Xanthone glycosides, Triterpenoid saponins, and Oligosaccharides. Polygalasaponins and Etrahydrocolumbamine are the major components, and they've been widely used for more than a century to relieve mood and psychological illnesses, particularly in North Asian countries such as Korea, China, Japan, and Taiwan. P. Tenuifolia extract eliminates allergic illnesses such as eczema and contact dermatitis by modulating Protein kinase-A and Mitogen-protein kinase-38. In vitro and in vivo studies linking P. tenuifolia root ingredients to a variety of pharmacological effects pertinent to AD show that this species' isolates may function through polyvalency. In great health, people can take up to 250-300 mg per day. It was given in peer-reviewed studies at dosages of 100-150 mg many times each day. There is minimal evidence that it improves verbal memory in experimental animals.

Ursolic acid downregulates thymic stromal lymphopoietin through the blockade of intracellular calcium/caspase-1/NF-κB signaling cascade in HMC-1 cells

  • Phil-Dong Moon;Na-Ra Han;Jin Soo Lee;Hyung-Min Kim;Hyun-Ja Jeong
    • International Journal of Molecular Medicine
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    • 제43권5호
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    • pp.2252-2258
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    • 2019
  • Thymic stromal lymphopoietin (TSLP) plays an important role in allergic disorders, including atopic dermatitis and asthma. Ursolic acid (UA) has various pharmacological properties, such as antioxidant, anti-inflammatory and anticancer. However, the effect of UA on TSLP regulation has not been fully elucidated. The aim of the present study was to analyze how UA regulates the production of TSLP in the human mast cell line HMC-1. Enzyme-linked immunosorbent assay, quantitative polymerase chain reaction analysis, western blotting, caspase-1 assay and fluorescent measurements of intracellular calcium levels were conducted to analyze the regulatory effects of UA. The results revealed that UA inhibited TSLP production and mRNA expression. In addition, UA reduced the activation of nuclear factor-κB and degradation of IκBα. Caspase-1 activity was increased by exposure to phorbol myristate acetate plus calcium ionophore, whereas it was reduced by UA. Finally, UA treatment prevented an increase in intracellular calcium levels. These results indicated that UA may be a useful agent for the treatment and/or prevention of atopic and inflammatory diseases, and its effects are likely mediated by TSLP downregulation.

알레르기 鼻炎의 臨床的 硏究 (A Clinical Study on Allergic rhinitis)

  • 조수현;지선영
    • 한방안이비인후피부과학회지
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    • 제14권2호
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    • pp.173-182
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    • 2001
  • This Study is attempted in order to observe a clinical analysis from Constitution medical view point about allergic rhinitis. We studied 71 patients who had visited Dept. surgery, opthalmology & otolaryngology, col1ege of Oriental Medicine, Kyungsan University, Pohang, Korea and were treated by medications of Sasang Constitution and Constitution-Acupunture with allergic rhinitis from March 1, 2000 to February 28, 2001. The results were as follows: 1. The sex distribution was 71 males($69\%$), 22 femail($31\%$), In age distribution, the average was 29.6. The peak age was thirties($36.7\%$), teen-ager was $23.9\%,\;fortieth\;was\;15.5\%,\;under\;10\;years\;old\;was\;9.9\%,\;twenties\;was\;7\%,\;fifties\;was\;5.6\%,\;sixtisth\;was\;1.41\%$. 2. In the age of onset, thirties was $29.6\%$, teen-ager was $19.7\%$, twenties was $18.3\%$, under 10 years old and fortieth was $14.1\%$, fifties was $3.8\%$, sixtisth was $1.41\%$. 3 In monthly distribution. september was $25.8\%$, january was $14.1\%$, october was $11.3\%$. november and august was $8.5\%$, april was $7\%$, febuary and may were $5.6\%$, june, july. December were each $4.2\%$, In the distribution of season. the peak season was fall from september to November. 4. In the duration of the disease, 1-3 years was $26.8\%$, 3-5 years was $19.7\%$, 6 months - 1 year $16.9\%$, 5-10 years was $14.1\%$, under 6 months was $11.3\%$, over 10years and over 15 years were each $5.6\%$. 5. In the three main symptom, hydrorrhoea was $71.8\%$, nasal obstruction was $67.6\%$, sneezing was $64.8\%$. In others, fatique was $25.6\%$, headache was $14.1\%$, itching and cough was $11.3\%$, laryngopharyngeal discomfort and red eye were $4.2\%,\;infirmity\;was\;2.8\%$. 6. Patients whose families have allergic disease account for 26 cases($36.6\%$). 7. There was no past history in 37 cases($52.l\%$). In past history distribution, digestive tract disease was $12.7\%$, paranasal sinusitis was $8.5\%$, allergic dermatitis was $7\%$, common cold was $4.2\%$. otitis media, bronchitis, asthma, tonsillitis were $2.8\%$. 8. Sasang Constitution classification was Soyanggin in 52 cases($73.2\%$), Taeumgin in 12 cases($16.9\%$). Soumgin in 7 cases($9.9\%$). 9. In the duration of treatment, it was 1-2 weeks in 26 cases($36.6\%$), 2-4 weeks was $21.1\%$, under 1weeks was $14.1\%$, 4-6 weeks was $11.3\%$, 6-8 weeks was $8.5\%$, 8-10 weeks was $5.6\%$, over 10 weeks was $2.8\%$. 10. We had a follow-up survey the effect of treatment in the 60 cases. there was fair in 25 cases($41.7\%$), good in 21cases($35\%$), excellent in 3cases($5\%$)로 total rate of treatment was $81.7\%$. The case of no change was $16.7\%$, the case of poor was $1.6\%$.

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알레르기성 鼻炎 患者에 對한 臨床的 考察 (Clinical Observation of The Allergic Rhinitis)

  • 김남권;임규상;황충연
    • 한방안이비인후피부과학회지
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    • 제10권1호
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    • pp.367-382
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    • 1997
  • The author analyzed 46 cases of allergic rhinitis patients, who were treated in the Kwang-ju Oriental Medical Hospital of Wonkwang University from January 1997 to April 1996. I've examined the 46 cases in the view of age and sex distribution, seasonal distribution, distribution of the job, duration of the disease, past history, family history, distribution of complicated signs, the degree of recovery about the total patient, the relationship of the ages and the remedial value, the relationship of the duration of disease and the remedial value. The following results are obtained. 1. The ratio of under teenagers was $32.61\%$(15 cases), teenagers was $30.43\%$(11 cases), 2th decade was $17.39\%$(8 cases), 3th decade was $17.39\%$(8 cases), 4th decade was $4.35\%$(2 cases), 5th decade was $2.17\%$(1 case), over sixty was $2.17\%$(1 case). 2. The ratio of the male was $58.70\%$(27 cases) and femal was $41.30\%$(19 cases). 3. The ratio of spring was $21.74\%$(10 cases), summer was $8.70\%$(4 cases), fall was $43.48\%$(20 cases), winter was $43.48\%$(20 cases) and unknown was $10.87\%$(5 cases). 4. The ratio of the students was $45.65\%$(21 cases), house-wives was $15.22\%$(7 cases), office men was $10.87\%$(5 cases), farmers was $4.35\%$(2 cases), driver was $2.17\%$(1 case) and unemployed was $21.74\%$(10 cases). 5. The ratio of the under six months was $8.70\%$(4 cases), under 1 year was $17.39\%$(8 cases), under 3 years was $32.60\%$(15 cases), over 3 years was $41.31\%$(19 cases). 6. The ratio of atopic dermatitis was $32.61\%$(15 cases), allergic dermatitis was $21,74\%$(10 cases), the asthma was $17.39\%$(8 cases), digestion disorder was $6.52\%$(3 cases) and etc. 7. The ratio of paternal line was $21.74\%$(10 cases), maternal line was $13.04\%$(6 cases), paternal and maternal lines was $4.35\%$(2 cases), brother or sisters was $13.04\%$(6 cases) and non-significant was $47.83\%$(22 cases). 8. The ratio of sneezing was $100\%$(46 cases) , nasal discharge was $100\%$(46 cases), nasal obstruction was $86.96\%$(40 cases), pruritus was $45.65\%$(21 cases), headache was $13.04\%$(6 cases), asthma was $10.87\%$(5 cases), digestion disorder was $6.52\%$(3 cases), light phovia was $6.52\%$(3 cases), tears was $4.35\%$(2 cases), nosebreeding was $2.17\%$(1 case). 9. The total remedial value of the 46 patients was revealed $52.17\%$. 10. The remedial value of under teenagers, teenagers were higher than the total remedial value($52.17\%$). 11. The remedial value of under 6 months, under 1 year were higher than the total remedial value($52.17\%$). These results demonstrated that in the point of remedial view, the patients who were younger and shorter of the duration of disease, would be well recovered.

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유산균 발효에 의한 율피(Castanea crenata inner shell) 열수추출물의 아토피 피부 질환에 관한 효과 연구 (Anti-allergic activities of Castanea crenata inner shell extracts fermented by Lactobacillus bifermentans)

  • 최미옥;김배진;조성경;정희경;이진태;김학윤;권대준
    • 한국식품저장유통학회지
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    • 제20권4호
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    • pp.583-591
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    • 2013
  • 본 연구에서는 밤나무 과실의 속껍질인 율피를 이용하여 알레르기성 피부질환 기능성 원료로 사용 가능성을 조사하였다. 율피 열수추출물과 율피 발효추출물의 총 폴리페놀 함량은 1 mg/mL에서 각각 $73.85{\pm}1.78$, $81.32{\pm}1.73{\mu}g/mL$였으며, 동일한 농도에서 총 플라보노이드 함량은 $18.72{\pm}0.20$, $14.70{\pm}0.21{\mu}g/mL$로 나타났다. 항산화 활성으로 율피 열수 추출물과 율피 발효추출물의 전자공여능은 1 mg/mL에서 각각 $73.74{\pm}1.18$, $67.17{\pm}1.87%$로 나타났으며, superoxide anion radical 소거능은 동일한 농도에서 각각 $91.58{\pm}2.51$, $100.15{\pm}4.30%$로 두 그룹 간 항산화 활성은 큰 차이를 보이지 않았다. HS68 세포를 대상으로 율피 열수추출물과 율피 발효추출물에 대한 세포 독성을 조사 한 결과, 율피 발효추출물에서 율피 추출물과 비교 시 세포 생존율이 1.33배 증가하였다. 또한 LPS로 유도된 RAW264.7 대식세포에서 0.05 mg/mL 율피 열수추출물과 율피 발효추출물 처리에 의한 NO생산량은 각각 $36.27{\pm}4.52$, $29.56{\pm}4.91{\mu}M$로 율피 발효 추출물 처리군에서 항염증 활성이 유의적으로 높았다. 아토피 유발 NC/Nga 마우스 모델에서 율피 열수추출물 및 율피 발효추출물을 도포하여 육안 상 관찰한 피부 병변은 율피 열수추출물 처리군에서 대조군과 비교해 피부 형태학적으로 일부 호전되는 경향을 보였으나, 율피 발효추출물 처리군은 멜라닌 함량과 피부 홍반의 감소 등 뚜렷한 개선효과를 보였으며 정상군과 유사한 피부 형태를 나타내었다. 또한 피부에 존재하는 염증성 사이토카인인 IL-$1{\beta}$와 TNF-${\alpha}$의 발현이 율피 열수추출물과 비교 시 율피 발효추출물에서는 각각 13.68, 3.63% 억제되었다. 이는 in vitro 실험과 유사하게 염증과 관련된 유전자의 발현을 저해함으로써 율피 발효추출물이 염증억제 효과는 물론 항아토피 효능을 나타내는 것으로 여겨진다. 따라서 율피 열수추출물 뿐만 아니라 율피 발효추출물 역시 아토피 피부질환을 개선하는데 유용한 물질로 활용될 수 있는 효과적인 조성물이라 사료된다.

기미생료사물탕의 항염증효과와 지양고의 아토피피부염 손상 및 지양 효과에 미치는 영향 (Anti-inflammatory action by Gamisangryosamul-tang and The effect of Ziyang-Go on atopic dermatitis-like lesion and pruritus in NC/Nga mice)

  • 김정진;양성완;손낙원;안규석
    • 동의생리병리학회지
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    • 제17권2호
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    • pp.428-435
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    • 2003
  • This research was performed to examine an anti-inflammatory effects of Gamisangryosamul-Tang(GSS) and anti-pruritus effects of Ziyang-Go(Salve). This study was processed by three experiments; Experiment 1: Inhibitory activity of GSS extract on the degranulation of mast cell and histamine release in plasma induced by compound 48/80 i.p, injection after the pretreatment of GSS extract i.p, injection in Sprague-Dawley rats, Experiment 2: Anti-inflammatory effect of GSS extract on macropharge raw 264,7 cells treated by LPS 250 ppm (before 2 hours). Experiment 3: Measurement of passive cutaneous anaphylaxis and atopic dermatitis using NC/Nga mice, GSS extract inhibited histamine release by 70% compared to compound 48/80 treated control group and histologically significantly reduced (P<0,01) the degranulation of mast cell in SD rats. In GSS extract treated group, the expression of TNF-α in macropharge cell showed the remarkable inhibitory effect about 62% (P<0,01) compared to LPS treated control group. The expression of IL-6 appeared more effective by 46% than the LPS treated control group and by 6% compared to hydrocortison treated group, Comparing with steroid (0.05% prednisolon) ointment, Ziyan-Go treated group showed the significant(30%) recovery on skin response index in atopic dermatis like anaphylaxis mice(NC/Nga), Finally, in scratching behavioral tests of NC/Nga mice for three weeks, Ziyang-Go treated group significantly (P<0.05) suppressed the pruritus on the face, neck, ears and dorsal skin than inbred NC/Nga mice. However, the change of IgE and IFN-γ from the spleen cell of NC/Nga mice was not significantly different between the oral intake of GSS extract group and of saline intaked control group. Summary and Conclusion: This study demons trates that Ziyang-go have the equal anti-pruritus effect to steroid ointment and GSS extract have the notable immunologic activity on inflammatory in vivo and in vitro model. Advanced experiment of this study will be required for more reliable information about the correlation between the lymphokine (i.e. IgE) and the anti-allergic effects of GSS.

우엉뿌리추출물이 ICAM-1과 NO조절에 미치는 항염증효과 (Anti-inflammatory Effects by Arctium lappa L. Root Extracts through the Regulation of ICAM-1 and Nitric Oxide)

  • 김예진;강세찬;남궁승;정명근;손은화
    • 한국자원식물학회지
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    • 제25권1호
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    • pp.1-6
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    • 2012
  • 본 연구는 우엉추출물의 항염증효과를 측정하였다. 인간 유래 폐상피세포 A549를 이용하여 염증반응을 유발하고 유지시키는데 중요한 역할을 나타낸다고 알려진 ICAM-1의 억제적 조절 효과를 평가하였으며, 염증매개인자로 알려진 NO와 이의 생성에 영향을 미치는 iNOS의 발현조절에서도 억제효과가 있음을 확인하였다. 또한, 우엉추출물이 인간각질형성세포주의 세포증식에 효과가 있음을 나타내었다. 본 연구에서 사용되는 폐상피세포는 호흡기질환의 천식 등의 알러지 및 만성염증연구에 주로 활용되고 있으며, 각질형성세포는 아토피 피부염의 만성 염증반응에서 주요하게 확인하는 요소이다. 따라서 본 연구결과에서 나타난 우엉추출물의 항염증 효과는 다양한 염증반응에서도 특히, 알러지 및 아토피 피부염 질환을 더욱 악화시키는 만성 염증에 있어서 우엉추출물이 유용한 소재로 사용될 수 있음을 시사한다고 할 수 있다.

잔가시 모자반 에탄올 추출물의 항아토피 효과 (Anti-atopic Activity of Sargassum micracanthum Ethanol Extracts)

  • 정다현;김꽃봉우리;김민지;강보경;박시우;박원민;김보람;박홍민;임무혁;안동현
    • 한국미생물·생명공학회지
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    • 제42권1호
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    • pp.82-88
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    • 2014
  • 본 연구는 DNCB 도포를 통해 아토피 피부염을 유발시킨 BALB/c mice에 SMEE를 2주 동안 지속적으로 처리하여 SMEE의 아토피 피부염 완화 효과에 대해 연구하였다. 따라서 IFN-${\gamma}$ 및 IL-4 cytokine의 분비량, 비장세포 증식능, 혈청 중 총 IgE 함량, 육안 평가 및 skin clinical severity score를 실시하였다. 그 결과 SMEE를 지속적으로 도포함으로써 IL-4 cytokine과 총 IgE 함량이 현저히 감소하는 것을 확인할 수 있었으며 IFN-${\gamma}$ cytokine은 유의적으로 증가하는 것을 확인하였다. 세포증식능 측정결과, SMEE 처리구의 경우 negative control군과 유사한 수준까지 억제됨을 나타냈으며, 비장세포의 비이상적인 증식에 SMEE 도포처리가 큰 영향을 미치지 않는 것으로 나타났다. 육안평가 및 skin clinical severity score 결과, SMEE를 2주간 지속적으로 도포 처리하였을 때, 그 증상이 눈에 띄게 완화되는 것을 확인할 수 있었으며 score 또한 positive control과 비교 시 유의적으로 감소하였다. 결과적으로 SMEE는 Th1 cytokine 생성은 증가시키고 Th2 cytokine 생성은 억제하여 IgE의 과다발현을 억제함으로써 아토피 피부염의 개선에 뛰어난 효능을 가지고 있는 것으로 사료된다.