• Title/Summary/Keyword: All-on-4

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Effects of Palmijihwangtang (PMT) and Exercise on Glucose Metabolism in Myocardium Cell Membrane and Pancreas $\beta$-Cell of Zucker Diabetic Fatty Rats

  • Lee Myeong-Jong
    • The Journal of Korean Medicine
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    • v.25 no.4
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    • pp.200-208
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    • 2004
  • Objective: Non-insulin Dependent Diabetes Mellitus (NIDDM) is characterized by insulin resistance, which affects the glucose transportation inside the cell. The purpose of this study was to find out how Palmijihwangtang (PMT) and exercise influence the glucose transport metabolism in the organ muscles of ZDF (zucker diabetic fatty) rat with insulin resistance. Methods: Using three male normal zucker rats and twelve male obese rats, they were divided into a normal lean group (N=3), obese control group (N=3), obese exercises group (N=3), obese medication group (N=3), obese exercise and medication group (N=3). Treadmill exercise were repeated with 27m/min speed for an hour a day, five days a week, for 8 weeks. And 20β/sub ¢/ of PMT was orally administered twice a day for 8 weeks, after that a period blood sample was exsanguinated by heart perforation and was analyzed. Results: The body weight of the OM and OEM group showed a significant decrease among all the obese groups. The blood insulin level increased significantly of all groups in comparison with the N group. All of the OE, OM and the OEM groups showed a significant decrease of insulin level compared with the OC group; especially the OEM group demonstrated the most among obese groups. Regarding GLUT-4 level, OEM was the unique group showed a significant increase among all the obese groups. The VAMP-2 level in myocardium cell membrane was increased significantly at OC group in comparison with the N group, whereas the OEM group only showed significant decrease of it. In addition, the VAMP-2 level in pancreas β-cell was significantly decreased at all the obese groups in comparison with the N group. Only the OEM group showed significant increase among all the obese groups. Conclusion: Palmijihwangtang (PMT) and exercise could effectively promote the insulin metabolism in pancreas β-cells and activate the glucose transport process in myocardium cell membrane by lowering the insulin resistance of ZDF rats.

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Clinical Significance of Co-expression of Aberrant Antigens in Acute Leukemia: A Retrospective Cohort Study in Makah Al Mukaramah, Saudi Arabia

  • Abdulateef, Nahla Ahmad Bahgat;Ismail, Manar Mohammad;Aljedani, Hanadi
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.1
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    • pp.221-227
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    • 2014
  • Background: Aberrant phenotypes in acute leukemia have variable frequency and their prognostic and predictive relevance is controversial, despite several reports of clinical significance. Aims: To determine the prevalence of aberrant antigen expression in acute leukemia, assess clinical relevance and demonstrate immunophenotype-karyotype correlations. Materials and Methods: A total of 73 (40 AML and 33 ALL) newly diagnosed acute leukemia cases presenting to KAMC, Kingdom of Saudi Arabia, were included. Diagnosis was based on WHO criteria and FAB classification. Immunophenotyping by flow cytometry, conventional karyotyping and fluorescence in situ hybridization for gene rearrangements were performed. Results: Aberrant antigens were detected in 27/40 (67.5%) of AML and in 14/33 (42.4%) in ALL cases. There were statistically significant higher TLC in Ly+ AML than in Ly-AML (p=0.05) and significant higher blast count in ALL with aberrant antigens at presentation and day 14 (p=0.005, 0.046). There was no significant relation to clinical response, relapse free survival (RFS) or overall survival (p>0.05), but AML cases expressing ${\geq}2$ Ly antigens showed a lower median RFS than those expressing a single Ly antigen. In AML, CD 56 was expressed in 11/40. CD7 was expressed in 7/40, having a significant relation with an unfavorable cytogenetic pattern (p=0.046). CD4 was expressed in 5/40. CD19 was detected in 4/40 AML associated with M2 and t (8; 21). In ALL cases, CD33 was expressed in 7/33 and CD13 in 5/33. Regarding T Ag in B-ALL CD2 was expressed in 2 cases and CD56 in 3 cases. Conclusions: Aberrant antigen expression may be associated with adverse clinical data at presentation. AML cases expressing ${\geq}2$ Ly antigens may have shorter median RFS. No specific cytogenetic pattern is associated with aberrant antigen expression but individual antigens may be related to particular cytogenetic patterns. Immunophenotype-karyotype correlations need larger studies for confirmation.

The Effect of Abutment Inclined Angle on the Marginal Fit of Zirconia All-ceramic Crown (지대주 경사각이 지르코니아 전부도재관의 변연적합도에 미치는 영향)

  • Lee, Seo-Yeon;Chung, In-Sung;Jeon, Byung-Wook
    • Journal of Technologic Dentistry
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    • v.38 no.3
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    • pp.111-117
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    • 2016
  • Purpose: The present study was performed to investigate the effect of abutment inclined angle on the marginal fit of zirconia all-ceramic crown. Methods: The Ti abutments with 3 different inclined angle($2^{\circ}$, $4^{\circ}$ and $6^{\circ}$) were fabricated. The zirconia copings were fabricated for each abutment by using dental CAD/CAM system. The manufactured zirconia copings were duplicated through silicone replica technique, and a replicated specimen was sectioned in the center of bucco-lingual and mesio-distal axial to measure the marginal fit by using a stereo microscope. The results were analyzed using a one-way ANOVA with SPSS 22.0 for Windows(${\alpha}=0.05$). Results: On the bucco-lingual axial, marginal fit was the RL3($41.5{\pm}3.4{\mu}m$), RL2($44.3{\pm}4.3{\mu}m$) and RL1($47.5{\pm}5.7{\mu}m$), respectively. On the mesio-distal axial, marginal fit was the RL3($41.1{\pm}3.7{\mu}m$), RL2($45.7{\pm}5.3{\mu}m$) and RL1($46.2{\pm}4.5{\mu}m$), respectively. One-way ANOVA showed statistically significant difference between groups for marginal fit(p<0.05). Conclusion: For marginal fit of the abutments inclined angle, RL3 specimen was superior. The abutment inclined angle had influence on marginal fit of the zirconia copings. The marginal fit of each group were within clinically acceptable range.

28days Repeat Oral Dose Toxicity Test of 'Hyeonggaeyeongyotang' extract in SD Rats (형개련교탕(荊芥連翹湯) 추출물(抽出物)의 SD Rats에서 28일 경구(經口) 반복투여 독성시험)

  • An, Hyun-Jue;Hwang, Sun-Yi;Lee, Jong-Rok;Kim, Sang-Chan;Jee, Seon-Young
    • Herbal Formula Science
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    • v.16 no.1
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    • pp.147-168
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    • 2008
  • HYTE (Hyeonggaeyeongyotang Extract), a polyherbal formula has been used as folk medicine, 28days repeat oral dose toxicity was tested in SD rats according to KFDA Guideline[2005-60]. Methods : In this study, mortality, clinical signs, body weight and gains, food and water consumption, ophthalmologic observation, urinalysis, hematology, serum biochemistry, gross findings, organ weight and histopathological observations were conducted during 28days of dosing periods. Results: 1. No HYTE treatment-related mortalities and clinical signs were detected in all dosing levels tested in male and female rats during the whole experimental periods. 2. No HYTE treatment-related changes on body weight, gains and food consumption were detected in all dosing levels tested in male and female rats during the whole experimental periods except for 2000mg/kg-dosing female groups in which significantly increase of body weight, gains, food and water consumption were detected compared to that of vehicle control in some points. 3. No HYTE treatment-related changes on ophthalmologic examination were detected in all dosing levels tested in male and female rats. 4. No HYTE treatment-related changes on urinalysis were detected in all dosing levels tested in male and female rats except for 2000mg/kg-dosing female groups in which, significantly increase of urine volume and related decrease on the urine specific gravity were detected as secondary effects of increase on the water consumptions not HYTE treatment-related toxicological signs. 5. No HYTE treatment-related changes on hematology were detected in all dosing levels tested in male and female rats except for increases in the total WBC count and lymphocytes of 2000mg/kg-dosing male and female groups with decrease of large unstained cells as pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs. 6. No HYTE treatment-related changes on serum biochemistry were detected in all dosing levels tested in male and female rats. 7. No HYTE treatment-related changes on gross findings, organ weight and histopathology were detected in all dosing levels tested in male and female rats except for 2000mg/kg-dosing male and female groups in which, spleen and thymus organ weights, hypertrophy at gross observation and hyperpalsia of lymphoid cells and follicles at histopathological observation in spleen and thymus were detected as pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs. Conclusions : Based on these results, the NOAEL and MTD of HYTE in SD rats were considered as over 2000mg/kg, respectively at 28days repeat oral dose toxicity test because most of these findings were considered as results of pharmacological effects of immune enhancements not HYTE treatment-related toxicological signs or secondary effects.

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Equivalence of ℤ4-actions on Handlebodies of Genus g

  • Prince-Lubawy, Jesse
    • Kyungpook Mathematical Journal
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    • v.56 no.2
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    • pp.577-582
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    • 2016
  • In this paper we consider all orientation-preserving ${\mathbb{Z}}_4$-actions on 3-dimensional handlebodies $V_g$ of genus g > 0. We study the graph of groups (${\Gamma}(v)$, G(v)), which determines a handlebody orbifold $V({\Gamma}(v),G(v)){\simeq}V_g/{\mathbb{Z}}_4$. This algebraic characterization is used to enumerate the total number of ${\mathbb{Z}}_4$ group actions on such handlebodies, up to equivalence.

The effect of Laundry Detergents, Fabric Softeners, and Bleaches on Bactericidal Activities (의류용 세제와 섬유유연제 및 표백제가 미생물 제거에 미치는 영향)

  • 차옥선;최해운
    • Journal of the Korean Home Economics Association
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    • v.37 no.4
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    • pp.29-40
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    • 1999
  • Effects of the commercial laundry detergents, fabric softeners, and bleaches on bactericidal activities were studied. Bactericidal activities under various conditions during washing, rinsing, and bleaching were evaluated in terms of minimum inhibitory concentration(MIC) by a broth dilution method. The experiments were carried out using Staphylococcus aureus and Escherichia coli which were usually employed in antibacterial activity tests. The results are summarized as follows : 1. All samples of Powder detergents(10 samples), soaps(7 samples) and fabric softeners(4 samples) were inactive against the Staphylococcus aureus and Escherichia coli. 2. One sample in the liquid detergents(6 samples) showed a very low MIC for Staphylococcus aureus and Escherichia coli., and three samples showed a selective effect for two bacterial strains. 3. Bleaching agent(containing peroxide) did not have bactericidal effect for Staphylococcus aureus and Escherichia coli. but the other(containing chlorine) had the effect for every bacterial strain in standard concentration. 4. All samples showed bactericidal effect above 60$^{\circ}C$.

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Online Searching Behavior of Social Science Researchers' in IR Interfaces of E-journal Database Systems: A Study on JMI, JNU, and DU

  • Kumar, Shailendra;Rai, Namrata
    • Journal of Information Science Theory and Practice
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    • v.1 no.4
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    • pp.48-66
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    • 2013
  • The aim of this study is to examine the user's online searching behavior in IR interfaces of e-journal database systems. The study is purely based on survey methods and tries to analyse the online searching behavior of respondents of social science disciplines who were doing research in three target central universities of Delhi (i.e. DU, JMI, and JNU). For measuring the responses of the respondents in IR interfaces of e-journal database systems, a total of 396 questionnaires were distributed among the students and out of all, 305 responses were used for the study. The findings of the study reveal that most of the students were not using all the facilities offered in IR interfaces of e-journal database systems for their retrieval process and also encourages menu based searches rather than command based searching.

A Cost-competitive Optical Receiver Engine Based on Embedded Optics Technology for 400G PAM4 Optical Transceivers in Data Center Applications

  • Lee, Eun-Gu;Lee, Jyung Chan;Kang, Chang Hyun;Jeon, Kyeongwan;Choi, Jun-Seok;Lee, Hyun Soo;Park, Jong Woon;Moon, Jong Ha
    • Current Optics and Photonics
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    • v.5 no.2
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    • pp.121-128
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    • 2021
  • We propose a novel, tiny optical receiver engine utilizing an all-in-one package based on embedded optics technology. The package's best transmission S21 and reflection S22 opto-electric (OE) bandwidths are 49.8 GHz and 34.9 GHz, respectively, and the reflectance of the optical engine is below -31.7 dB for all channels. The engine satisfies the MIL-STD-883G standard for reliability tests, such as mechanical and thermal shock, and vibration resistance. The sensitivity after 10 km single-mode fiber (SMF) transmission is below -8 dBm. The optical receiver engine is cost-competitive and applicable for 400G coarse wavelength division multiplexing 4 (CWDM4) 10 km optical transceivers.