• Asian-Australasian Journal of Animal Sciences
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• v.17 no.9
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• pp.1183-1187
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• 2004

The natural resistance-associated macrophage protein 1 (NRAMP1) gene was identified as a candidate gene controlling the resistance and susceptibility to a number of intracellular parasites in pigs. The genetic variations in a 1.6 kb region spanning exon 1 and exon 3 of the porcine NRAMP1 gene were investigated by PCR-HinfI-RFLP in samples of 1347 individuals from 21 Chinese indigenous pig populations and 3 western pig breeds. Three alleles (A, B, C) and four genotypes (AA, BB, AB, BC) were detected. Significant differences in genotype and allele frequencies were observed between Chinese indigenous pig populations and exotic pig breeds, while in general the differences in genotype and allele frequencies among Chinese indigenous pig populations were not significant. The allele C was detected only in Duroc, Leping Spotted and Dongxiang Spotted pig, and the two Chinese pig populations showed similar genotype and allele frequencies. Four Chinese Tibetan pig populations displayed genetic differentiation at the NRAMP1 gene locus. In addition, intron 5 of the NRAMP1 gene was isolated and characterized by directly sequencing the PCR products encompassing intron 5. The alignment of intron 5 of the porcine, human, equine and ovine NRAMP1 gene showed a similarity of 45.38% between pig and human, 52.55% between pig and horse, 63.47% between pig and sheep, respectively.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.8
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• pp.1089-1095
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• 2012

Neonatal Fc receptor (FcRn) gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G (IgG) and is responsible for IgG transport and stabilization. In this report, the 8,900 bp porcine FcRn genomic DNA structure was identified and putative FcRn protein included 356 amino acids. Alignment and phylogenetic analysis of the porcine FcRn amino acid sequences with their homologies of other species showed high identity. Tissues expression of FcRn mRNA was detected by real time quantitative polymerase chain reaction (Q-PCR), the results revealed FcRn expressed widely in ten analyzed tissues. One single nucleotide polymorphism (SNP) (HQ026019:g.8526 C>T) in exon6 region of porcine FcRn gene was demonstrated by DNA sequencing analysis. A further analysis of SNP genotypes associated with serum Classical Swine Fever Virus antibody (anti-CSFV) concentration was performed in three pig populations including Large White, Landrace and Songliao Black pig (a Chinese indigenous breed). Our results of statistical analysis showed that the SNP had a highly significant association with the level of anti-CSFV antibody (At d 20; At d 35) in serum (p = 0.008; p = 0.0001). Investigation of expression and polymorphisms of the porcine FcRn gene will help us in further understanding the molecular basis of the antibody regulation pathway in the porcine immune response. All these results indicate that FcRn gene might be regarded as a molecular marker for genetic selection of anti-CSFV antibody level in pig disease resistance breeding programmes.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.2
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• pp.163-169
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• 2012

Interferon regulatory factor 6 (IRF6) gene is a member of the IRF-family, and plays functionally diverse roles in the regulation of the immune system. In this report, the 13,720 bp porcine IRF6 genomic DNA structure was firstly identified with a putative IRF6 protein of 467 amino acids. Alignment and phylogenetic analysis of the porcine IRF6 amino acid sequences with their homologies to other species showed high identity (over 96%). Tissues expression of IRF6 mRNA was observed by RT-PCR, the results revealed IRF6 expressed widely in eight tissues. One SNP (HQ026023:1383 G>C) in exon7 and two SNPs (HQ026023:130 G>A; 232 C>T) in the 5′ promoter region of porcine IRF6 gene were demonstrated by DNA sequencing analysis. A further analysis of SNP genotypes associated with immune traits including IFN-${\gamma}$ and IL10 concentrations in serum was carried out in three pig populations including Large White, Landraces and Songliao Black pig (a Chinese indigenous breed). The results showed that the SNP (HQ026023:1383 G>C) was significantly associated with the level of IFN-${\gamma}$ (d 20) in serum (p = 0.038) and the ratio of IFN-${\gamma}$ to IL10 (d 20) in serum (p = 0.041); The other two SNPs (HQ026023:130 G>A; 232 C>T) were highly significantly associated with IL10 level in serum both at the day 20 (p = 0.005; p = 0.001) and the day 35 (p = 0.004; p = 0.006). Identification of the porcine IRF6 gene will help our further understanding of the molecular basis of the IFN regulation pathway in the porcine immune response. All these results should indicate that the IRF6 gene can be regarded as a molecular marker associated with the IL10 level in serum and used for genetic selection in the pig breeding.

• Journal of Information Display
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• v.13 no.2
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• pp.55-59
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• 2012

In this paper, a concept of an integrated elastomer substrate for a three-dimensional (3D) liquid crystal display based on the integral-imaging method is presented. The elemental lens array and columnar spacers were integrated into one of the two substrates, an elastomer substrate, through an imprinting process. The integrated elastomer substrate was capable of maintaining the uniform liquid crystal (LC) cell gap and promoting homeotropic LC alignment without any surface treatment. The monolithic approach reported herein will provide a key component for 3D displays with enhanced portability through a more than 40% weight reduction compared with the conventional integral-imaging method.

• Annual Conference on Human and Language Technology
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• 1997.10a
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• pp.430-435
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• 1997

통계적인 방법으로 병렬 코퍼스(parallel corpus)로부터 사전정보를 추출해 내는 정렬 시스템에 대한 연구가 세계 여러곳에서 진행되고 있다(신중호 1996; Dagan 1996; Fung 1995; Kupiec 1993). 그 결과로 만들어진 사전정보는 유용한 대역어와 대역 확률을 포함하고 있지만, 불필요하거나 잘못된 요소들도 많이 포함되어 있어 재조정 작업이 필요하다. 이는 사전정보를 직관적으로 확인함으로써 조정을 할 수도 있지만, 좀 더 정확한 조정을 위해 각각의 사전정보(정렬의 결과)가 코퍼스의 어떤 문장에서 나온 것인가 등을 확인할 필요가 있다. 정렬 워크벤치는 이와 같은 작업을 효율적으로 처리할 수 있도록 만들어졌으며, 현재 구현되어 작동되고 있다. 본 논문에서는 정렬 워크벤치를 위해 필요한 정렬시스템의 변형과 사전작업의 편의를 위해 제공되어져야 하는 기능 등에 관하여 설명하고, 간단한 평가 결과를 설명한다.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.10a
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• pp.189-189
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• 2000

본 연구에서는 기업의 성과측정시스템을 평가하고 성과측정관행의 성숙도를 진단하는 방법을 제시하고 이를 토대로 우리나라 서비스 기업 두 곳을 선정하여 적용 연구를 수행하였다. 구체적으로 K병원과 A항공사의 경영층과의 면담을 통하여 각 기업에 적합한 성과측정시스템의 틀(framework)을 균형성과표(balanced scorecard)를 기초로 구현하고 다양한 성과차원의 주요성과지표들(KPIs: key performance indicators)을 기업이 추구하는 전략과 부합할 수 있도록 인과관계로 연계하였다. 그리고 구성원들을 대상으로 실시한 구조화된 설문조사를 통하여 각 사례기업의 성과측정시스템의 적합도를 alignment analysis, congruence analysis, consensus analysis, confusion analysis 등 네 가지 차원의 차이분석(gap analyses)을 이용하여 평가하고, 그들의 현행 성과측정관행의 성숙도를 진단하였다.

• Journal of Navigation and Port Research
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• v.34 no.7
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• pp.595-601
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• 2010

This paper aims to diagnose the strategy execution ability and to provide corresponding measures for Korean oceanic shipping companies. The analysis method is the t-test between importance awareness and Corresponding ability for strategy execution diagnosis index(XPP). According to the diagnosed results, the strategy development is unsatisfactory because the strategy implemented does not adhere to concurrent environmental change. Moreover, the execution of the strategy is also unsatisfactory. Therefore, an evaluation shows that there is a need for a SWOT analysis using BSC, an organization structure to strengthen the strategy execution ability and the support from the market condition analysis prediction center.

• Asian Journal of Business Environment
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• v.4 no.4
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• pp.19-26
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• 2014

Purpose - The study is primarily aimed at framing "Position Descriptions" for some key positions in the executive cadre of the testing department of CESC Limited. Research design, data, and methodology - The questionnaire, interview, and observation methods have been used for the purpose of data collection. The position descriptions are validated by superiors belonging to the respective departments. Results - It has been found that there is overlapping of job duties and job responsibilities in the department. This overlapping is quite alarming for the organization and may even become a hurdle in the path of its progress. It can be seen as a classic case of de-layering. Conclusions - The study concludes that good communication along with interpersonal and negotiation skills are absolutely essential to facilitate the performance of the day-to-day duties of a job, including handling the union, solving IR related issues, development of the subordinates, job setting, distribution and allocation, etc. Position descriptions will help in the alignment of the employee direction, and can be a useful tool to aid the communication between management and employees.

• Knowledge Management Research
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• v.1 no.1
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• pp.127-137
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• 2000

Effective knowledge sharing and creating requires human networking as well as system. Corporation 'S' organized 'community of practice(CoP),' which is a virtual group based on work process, skill, and interest. The purpose of this study is to suggest effective CoP establishment and implementation methods, based upon 'S' experience. The effective methods this study suggests are : setting up clear CoP objectives by each CoP; dual CoP system with career centered and subject centered; alignment with business strategy; guide by knowledge integrator, and professional competence development as CoP purpose. Key success factors to CoP activities also include effective communication, facilitators' competency, and managers' support.

• Journal of Industrial Technology
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• v.24 no.B
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• pp.139-142
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• 2004

To identify conserved structural or functional subunit(s) in the CP1 (editing) domains of class Ia tRNA synthetases, five available structures were compared and analyzed. Through sequence alignments of the CP1 domains, three conserved regions were found near the amino acid binding site in the editing domain. Structural overlapping of the three subunits clearly showed that there exist three common structural subunits in all of the five editing RS structures. The new alignment suggests a translocation movement of the CP1 domain caused by the binding with tRNA. Based on the experimental and modeling results, it is proposed that subunits 1 and 3 accommodate the incoming amino acid binding, while subunit 2 contributes to the interactions with the adenosine ring of the A76 to stabilize the overall tRNA binding.. Since these subunits are critical for the editing reaction, we expect that these key structures should be conserved through all class Ia editing RSs.