• Korean Journal of Biological Psychiatry
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• v.12 no.2
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• pp.196-206
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• 2005

Objectives:The purpose of this study is to evaluate the pathophysiology of alcoholics by investigating the differences in frequency of Aldehyde Dehydrogenase 2(ALDH2) genotypes and ALDH2 alleles between patients with alcohol dependence and controls, and the differences of drinking and personality traits in Korean male alcoholics with ALDH2 genotype variances. Methods:The authors selected 98 patients with alcohol dependence and 53 controls. Self-report questionnaires for acute reponses after alcohol ingestion, the AUI(Alcohol Use Inventory), and the NEO-PI-R(NEO Personality Inventory Revised) were given to all patients with alcohol dependence. ALDH2 genotypes were typed with MboII RFLP(Restriction Fragment Length Polymorphism) method in 53 controls and 98 patients with alcohol dependence. The authors divided alcoholic patients into two groups according to the presence of variant $ALDH2^2$ allele;normal ALDH2 alcoholics(N=87) and variant ALDH2 alcoholics(N=11). Results:1) The genotypic frequencies of subjects with $ALDH2^{1/1}$ were higher and those with $ALDH2^{1/2}$ and $ALDH2^{2/2}$ were lower in patients than in controls. 2) Alcohol dependence could be found in $ALDH2^{2/2}$ homozygote individuals. 3) Variant ALDH2 alcoholics had more family problems in the AUI than normal ALDH2 alcoholics. 4) Variant ALDH2 alcoholics experienced more flushing and cardiovascular responses after alcohol ingestion than normal ALDH2 alcoholics. 5) Variant ALDH2 alcoholics had less altruistic personality traits in the NEO-PI-R than normal ALDH2 alcoholics. 6) Variant ALDH2 alcoholics tended to have more tolerance to alcohol than normal ALDH2 alcoholics. Conclusion:Variant $ALDH2^2$ allele might play a protective role in the pathogenesis of alcohol dependence and there were several significant differences of drinking and personality traits in Korean male alcoholics with ALDH2 genotype variances.

• Nutrition Research and Practice
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• v.7 no.3
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• pp.216-223
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• 2013

The purpose of this study is to assess folate intake, and serum and red blood cell (RBC) folate concentrations, and investigate the association between folate status and health-related behaviors among Korean college students. A total of 169 students, aged between 18 and 27 years, participated in this study. Dietary intake data were collected by trained interviewers using a 24-hour recall method for three non-consecutive days in 2009. Information on health-related behaviors was obtained by a self-administered questionnaire. Serum and RBC folate concentrations were measured by microbiological assay. The average intakes of folate were $456{\mu}gDFE$ and $347{\mu}gDFE$ in male and female students, respectively. While the average serum folate concentration was significantly lower in male students (8.9 ng/mL) compared to female students (12.5 ng/mL), RBC concentrations were not significantly different between male (398.6 ng/mL) and female students (405.3 ng/mL). In male students, low serum folate concentrations were associated with total folate intake less than the Estimated Average Requirement, non-use of folic acid supplements, smoking, alcohol drinking at least once a week and low physical activity. In female students, low serum folate concentrations were associated with smoking and alcohol drinking at least two drinks at a time and BMI ${\geq}25$. Alcohol drinking and low physical activity were also associated with low RBC folate concentrations in both male and female students. In order to improve folate nutritional status of college students, the practice of desirable health-related behaviors, such as non-smoking, moderate alcohol drinking, regular physical activity, and maintenance of healthy BMI should be encouraged along with consumption of folate-rich foods and supplements.

• Korean Journal of Community Nutrition
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• v.11 no.6
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• pp.707-713
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• 2006

The purpose of this study was to test whether moderate alcohol consumption has any positive effect on lowering blood pressure among Koreans. Study subjects were Korean adults 20 years or older (n=5,234) who participated in the 2001 Korean National Health and Nutrition Examination Survey (KNHANES). Analysis of variance and analysis of covariance were used to construct univariate and multivariate models relating alcohol consumption to blood pressure for the analysis. After adjustment for possible covariates, drinkers (regardless of drinking level) had significantly higher systolic and diastolic blood pressure, compared with never-drinker for male subjects. Diastolic and systolic blood pressures were also significantly elevated with the drinking frequency and amount of alcohol intake among male subjects. For the female subjects, only diastolic blood pressure was significantly associated with the alcohol consumption at multivariate model. however, low level alcohol consumption did not show any sign of lowing effects on blood pressure. The result implies that moderate alcohol consumption did not have any positive effect on lowering blood pressure among Koreans for either sex.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.4
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• pp.473-479
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• 2013

Purpose: This article tried to find the changes of the eye and a correlation depending on watching a smartphone and taking in alcohol. Methods: This paper conducted the refraction inspection, the radius of corneal curvature, tonometry and the corneal thickness measurement and analysis for 31 persons (18 males and 13 females) who have healthy drinking habit, not having the medical history of taking medicine related with disorders of the eye, a mental disease, systemic disease and alcohol metabolism. Results: Of respirations depending on watching a smartphone, the alcohol concentration was significantly decreased in 15 minutes, 30 minutes, 45 minutes, 60 minutes and the convalescent stage. (p<0.01, p<0.001) As the result of comparing the refraction inspection after and before watching a smartphone when drinking alcohol, there was a significant difference in the cylindrical power and the axis. (p=0.005, p=0.001) The change of intraocular pressure depending on watching a smartphone after drinking alcohol was decreased significantly from 30 minutes (p<0.001), and watching a smartphone didn't have any significant effect on the corneal thickness depending on the elapsed time from when drinking alcohol. Conclusions: Watching a smartphone and taking in alcohol had a significant effect on the cylindrical power and the axis. Watching a smartphone and taking in alcohol which may cause the visual function-strain are the factors that need to consider before the refraction inspection.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.4
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• pp.161-169
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• 2021

Objectives: Adolescent suicide is a serious social problem. Adolescent alcohol use is one of the most important risk factors for adolescent suicide. This study aimed to identify the relationship between drinking habits and suicide among Korean adolescents. Methods: Data from the 14th and 15th Korean Youth Risk Behavior Web-based Survey, conducted in 2018 and 2019, were used for analysis. Multiple logistic regression analysis was used to identify the relationship between drinking habits-including the age of drinking initiation, frequency of drinking, average drinking amount, frequency of drunkenness-and suicidal ideation, plans, and attempts. Results: Even after adjusting for age, sex, school grade, academic achievement, socioeconomic status, depression, stress, and drinking habits, the frequencies of drinking and drunkenness increased the risk of suicide attempts. Suicide attempts were associated with the frequency of drinking in girls and middle school students, and with the frequency of drunkenness in boys and high school students. Conclusion: This study identified associations between drinking habits (the age of drinking initiation, frequency of drinking, average amount of drinking, frequency of drunkenness) and suicidal behavior in adolescents. Our findings suggest that to prevent adolescent suicide, it might be necessary to investigate drinking habits, including the frequencies of drinking and drunkenness. Moreover, considering the differences in sex and school grade, it is important to include the individual group characteristics when evaluating drinking habits.

• The Journal of Korean Society for School & Community Health Education
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• v.16 no.1
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• pp.83-92
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• 2015

Objectives: This thesis intends to find out the extent of drinking problem which is caused by students' psychosocial stress, expected alcohol effects and problem drinker drinking as well as the influence of each factor. Methods: This study was conducted from September 1, 2014 to October 31, 2014 with the target of 466 students (66.6%), who are currently drinking, out of 700 students over the age of 16 and enrolled in 36 universities located in the whole country. This data were analyzed using the program SPSS21. Results: Age, gender, and the school district that showed significant differences in drinking problem compared to other general characteristics played the role of control variables. It was found that psychosocial stress does not affect the drinking problem. The self-reward and human-relation factors included in the expected drinking effect were revealed to influence significantly on the problem and the life and health related factors included in the reason of drinking refrain were also turned out to have significant effect on that problem. The degree of F is 15.665 and the degree of explanatory is 23.6%. Conclusions: Problem drinker in college and enhance the culture and health education policy is necessary to reduce college student drinking effects expected.

• Research in Community and Public Health Nursing
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• v.25 no.2
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• pp.75-84
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• 2014

Purpose: This study aimed to identify the level of knowledge on preventing cardiovascular disease (CVD) and nicotine dependency among smoking male college students, and to examine the predicting factors of nicotine dependency. Methods: This study was conducted as cross-sectional descriptive research using structured questionnaires. Data were collected from 411 smoking male college students ($22.5{\pm}2.59$ yr) at two universities located in two cities in Korea from September 2012 to April 2013. Logistic regression analysis was performed to estimate age-adjusted odds ratios of nicotine dependency. Results: The mean value of nicotine dependency was $4.2{\pm}1.96$ and the percentage of participants who had strong nicotine dependency (${\geq}7$) was 10.7%. Logistic regression analysis showed that, when adjustment was made for age, nicotine dependency was predicted by the frequency of alcohol drinking (${\geq}3$ times/week), knowledge on CVD prevention, the age starting drinking, and the total length of smoking. Conclusion: Nicotine dependency was strongly related to the frequency of drinking alcohol and lower knowledge on CVD prevention. Therefore, male college students who have a dependent smoking habit and drink alcohol frequently need to take more interest in health through educational counseling to modify their lifestyle behaviors and to have preventive knowledge related to CVD.

• The Korean Journal of Physiology
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• v.2 no.1
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• pp.73-78
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• 1968

The changes of urinary excretion after alcohol drinking on 6 normal subjects sweated in a hot chamber were studied. The results are summarized as follows: 1. The urinary minute flow is increased rapidly to maximum about 60 minutes after intake of alcohol, and this is supposed to be originated from the antidiuretic suppressive action on osmoreceptor by ethyl alcohol. 2. Free water clearance and osmolarity of the urine showed the maximal and minimal values respectively at the sane time when the urinary flow is maximal. 3. The concentrations of Na, K and Cl were roughly proportionate to the urinary osmolarity and the minimal values after drinking were diluted to more than 10-fold than those before drinking, but the minute amounts of these ions is decreased only slightly during tile diuresis. 4. The concentrations of urea were decreased less than 10-fold but the minute amounts were rather increased slightly. 5. The diuresis could not excrete whole quantity of fluid intake in the period of 2 hours, and considerable amount of water was still retained in the body.

• Korean Journal of Health Education and Promotion
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• v.22 no.4
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• pp.17-40
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• 2005

Objective: The purpose of the this study was to test the effect of the alcohol preventive educational program for elementary school students through developing the web-based learning instruments. It will prevent the serious alcohol problem for adolescents and be the opening-learning according to learner's needs beyond the traditional classroom learning which has limitation of space and time. Method: This research designed based on web-based instructional system design by In-sung Jong(1997). This study was performed on the elementary school students who are the six grade in M city. The number of experimental group was 72 and control group's number was 72, totaled 144. Data were collected from September, 30th, 2004 to November, 5th, 2004, totaled 37days. The pretest and the posttest for web-based alcohol preventive education program were tested about knowledge and attitudes toward drinking. After the performance, the posttest was also tested the effect of this program under items by the interest of web-based learning, satisfaction, adequateness of material and so on. The data analysis was done using SPSS/Win 11.0 program. Result: The results of this study are as follows: 1) Compared with control group, experimental group which was educated the web-based alcohol preventive educational program for elementary school students was improved the knowledge on drinking, thin there was no significant difference. However, it showed significant difference between two groups after education. It was, therefore, partially supported. 2) Compared with control group, the experimental group which was educated the web-based alcohol preventive educational program for elementary school students showed significant difference in attitudes toward drinking. After education, it showed no significant difference attitudes. toward drinking between experimental group and control group. It was, therefore, partially supported. 3) The degree of learning motivation was an average.595 of 1 after learning applied to by the web-based alcohol preventive educational program for elementary school students. Then, it is relatively more higher than the result of existing studies. So, it showed that the motivation was done well. 4) Correlation among study variables It showed that there was the significantly positive correlation between knowledge and attitudes toward drinking of pretest experimental group. Also, there was the significantly positive correlation between attitudes toward drinking and learning motivation of pretest and posttest experimental group. Conclusion: I found that the web-based educational program helps the elarning process for the health education in the school field which the instructional materials lack. As a result, the web-based education motivates the learner's pleasure and promotes the learners interest. Also, it is possible for students to learn according to their own learning pace, repeated learning and active learning participation in the necessary parts. Therefore, I think the web-based educational program is worth as a intervention to get positive influence for the health education.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.23 no.4
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• pp.440-447
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• 2016

Purpose: The purpose of this study was to identify factors affecting problem drinking in male nursing students. Methods: This study was conducted using a cross-sectional survey. A total 126male nursing students completed a self-report questionnaire to assess alcohol consumption, motives for drinking, and self-efficacy in drinking refusal self-efficacy. The participants were divided into 2 groups, moderate and problem drinkers. Multivariate analysis was used to identify factors affecting problem drinking in these nursing students. Results: Problem drinkers was found to be related to young age (adjusted OR=0.83, 95% CI [0.71, 0.96], coping motives (adjusted OR=1.19, 95%CI [1.00, 1.42], and drinking refusal self-efficacy (OR=0.96, 95% CI [0.93, 0.99]). Conclusion: The findings highlight the important role that coping motives and drinking refusal self-efficacy play in the problems in the drinking behavior of male nursing students.