• Title/Summary/Keyword: Alcohol

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Effect of Puffer Fish Extract on the Hepatic Alcohol Metabolizing Enzyme System in Alcohol-Treated Rat (Alcohol 섭취 쥐에서 Alchol 대사효소계에 미치는 복어추출물의 효과)

  • 김동훈;김동수;최종원
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.23 no.2
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    • pp.181-186
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    • 1994
  • The present study was undertaken to clarify the effect of Puffer fish skin extract (PF) on the hepatic alcohol metabolism in rats. It was observed that alcohol concentration in blood had been markedly decreased by the pretreatment of PF for two weeks. Activities of alcohol dehydrogenase (ADH) and microsomal ethanol-oxidizing system (MEOS) were significantly incrased (more than 20% of control) by pretreatment of PF for two weeks and acute alcohol intoxication (5 g/kg) on final day. When rats were fed with subacute toxic state by alcohol (25v/v % , once a day for six weeks), activities of ADH and MEOS were significantly increased by additional treatments of PF for final two weeks. But the catalase activity was not affected by any of both case. And also activities of ADH and MEOS in vitro were not changed . These results suggest that PF treatemnt prompted the recovery from alcohol intoxication.

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Ethanol이 allyl alcohol 독성에 미치는 영향

  • 이주영;정진호
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.323-323
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    • 1994
  • Allyl alcohol은 간에서 두 단계의 효소 반응을 거쳐 대사되는데, 먼저, alcohol dehydrogenase (ADH)에 의해 독성 활성체인 acrolein으로 바뀌고, 이후 계속하여 aldehyde dehydrogenase (ALDH)에 의해 acrylic acid로 무독화되어 배설된다. Ethanol 역시 간에서 대사되는데 있어 같은 효소들을 공유하므로 allyl alcohol과 경쟁적으로 반응할 것이다. 따라서, 본 실험에서는 ethanol에 의한 대사 효소 경쟁반응에 의해 allyl alcohol 의 간독성이 어떻게 변화하는지를 연구하였다. 우선 ethanol과 allyl alcohol을 동시 투여할 경우 5시간째에 allyl alcohol에 의해 증가된 ALT level을 낮춘다는 보고를 확인하고자 ethanol 2 g/kg과 allyl alcohol 40 mg/kg을 동시투여했으나 오히려 치사율이 증가했고, ethanol을 2시간 전처리한 군에서도 역시 치사율이 증가되고, 간의 glutathione 양은 allyl alcohol 단독 처리군에 비해 현저히 감소되는 양상을 보였다.

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Estimation of High-Risk Drinkers and Drinking Behavior in Korea - Focusing on Korean National Health and Nutrition Examination Survey (KNHANES) and Korean Statistical Information Service Data -

  • Hwang, Seonghee
    • Journal of Environmental Health Sciences
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    • v.46 no.1
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    • pp.65-77
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    • 2020
  • Objectives: This study investigated the average number of drinkers in Korea, the number of high-risk drinkers, the average amount of alcohol consumed by high-risk drinkers, and the types of alcohol consumed according to the characteristics of the group of dependent drinkers. Methods: The results were obtained by analyzing the following data: The Global Status Report on Alcohol and Health; Country Profile 2014; WHO Country Profile 2014; Korea National Health and Nutrition Examination Survey 2014, Korean Statistical Information Service; National Tax Statistics-Liquor Tax; Gallup Drinking Frequency Survey 2015 Results: This study found that a large proportion of drinkers in Korea are already high-risk drinkers, and even among drinkers, alcohol consumption was highly biased. It was reported that 49.8% of men in the problem, abuse, and dependence groups accounted for 92.4% of total alcohol consumption among the male population. Notably, the 9.6% of men making up the dependent group consumed more than 30% of the alcohol ingested among males. Women had significant variations within groups that were considered high-risk and exhibited a large share of alcohol consumption in the problem (10.0% of the female population), abuse (1.8% of the female population), and dependence (1.5% of the female population) groups, constituting 72.8% of total alcohol consumption. The average amount of alcohol consumed by drinkers in Korea seems to have exceeded the level of intake by high-risk groups. Alcohol-dependent groups consumed 900.7 mL of soju, 405.2 mL of table wine, and 2,043.8 mL of beer, which is very similar to the consumption average of 2,031 mL of beer and 895.2 mL of soju in the drinking group. Conclusion: It has been shown that men's dependence on alcohol is serious, and it is possible to infer that alcohol consumption in some vulnerable groups is very high. As the average alcohol intake among alcohol-dependent groups and ordinary drinkers is very similar, it is highly likely that the drinker is an alcohol-dependent consumer in Korea.

Drinking Pattern and Nonfatal Injuries of Adults in Korea (우리나라 성인의 음주행태와 비치명적 손상의 연관성)

  • Lee, Won Kyung;Kim, Yoon
    • Journal of Trauma and Injury
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    • v.22 no.2
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    • pp.233-241
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    • 2009
  • Purpose: Alcohol is a major risk factor for injuries, but little is known about the relationship between chronic drinking pattern and injuries. The purpose of this study was to evaluate the incidence of alcohol-related injuries and the differences in the characteristics of the injuries between Alcohol Use Disorder Identification Test (AUDIT) categories. Methods: Among a representative sample of the third Korea National Health and Nutrition Examination Survey. 7,697 adults answered questions about injuries, drinking patterns, and socioeconomic status. Incidences of alcohol-related injuries and of non-alcohol-related injuries were calculated, and the relative ratio of injuries between AUDIT categories was analyzed. Results: The incidences of all injuries and alcohol-related injuries were 69.2 and 6.8 per 1000 person-year. After adjustment, the incidences of non-alcohol-related injuries showed no differences between AUDIT categories. But the adjusted relative ratios (RRs) of alcohol-related injuries were 3.73 (95% CI: 1.54~8.99) and 7.70 (95% CI: 3.61~16.44) for risk drinkers and for alcohol-dependent drinkers respectively. No specific body part could be identified as being frequently injured in cases of risk drinkers and alcohol-dependent drinkers. In contrast, the adjusted RRs of fractures, bruises, and open wounds were 1.76 (95% CI: 1.03~3.02), 1.73 (95% CI: 1.15~2.61), and 1.85 (95% CI: 1.17~2.93) for alcohol-dependent drinkers. Assaults occurred 4.66 times more frequently in alcohol-dependent drinkers. Conclusion: Alcohol-related injuries occur more frequently as the person becomes more dependent on alcohol. Fractures, Bruises, open wounds, and assaults occur more frequently in alcohol-dependent drinker. This study suggests that efforts should be carried out in the ED to screen and treat alcohol-use disorders associated with patients injured after drinking.

The Effect of Dietry Se Levels and Alcohol Administration on the Lipid Hyperoxidation and the Lipid Metabolism in the Rats (식이내 Se수준과 알콜 섭취가 흰쥐의 지질과산화와 지방대사에 미치는 영향)

  • 김갑순;김민식
    • The Korean Journal of Food And Nutrition
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    • v.4 no.1
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    • pp.21-34
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    • 1991
  • The purposes of this studies were to investigate the effect of dietry Se levels and alcohol administration on the lipid hyperoxidation and the lipid metabolism in the rat. Seventy two male rats of Sprague-Dawley Strain weighting about 58~629 were divided into 12groups. The dietary Se levels were 10, 0.4 and Omg, and the dietary a-tocopherol levels were 150 and 0mg per kg diet, respectively. Alcohol-administrated groups received drinking water solution containing 10% of ethanol from the 3-weeks of experimental periods. The obtained experimental results are summarized as follows. 1. Food intake, body weight gain and food efficiency ratio were significantly lower in H-, L-and alcohol administrated groups(-A) by administrated Se and alcohol in diet. The weight of liver and spleen tended to be greater in H- and alcohol administrated groups. 2. The glutathione values in liver tend to be lower in alcohol or Vit. E administrated groups than nonadministrated groups. Also there were higher in H- and L- than C-groups, but the increasing range decreased due to administrated alcohol. The lipid peroxide values In liver were significantly higher in alcohol groups, and L- and tocopherol groups were higher values. Specially the increasing of lipid peroxide values were significantly effected by alcohol in low Se and Vit. E groups. 3. The contents of total glyceride in plasma were higher in alcohol groups, there were significantly higher values in alcohol administrated groups under low Se and Vit. E groups. The contents of total cholesterol and HDL-cholesterol In plasma were significantly higher in alcohol groups. 4. The contents of total lipid in liver were higher alcohol groups, and slightly higher values in low Se groups(L-groups) than other groups, also higher values in low Vit. E groups. Those of total glyceride in liver were significantly higher in alcohol groups, appeared highest values when alcohol was administrated in low Se and Vit. E groups. The increasing of total glyceride content was significantly effected by alcohol in low Se groups than that in C-groups.

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Stability of Henna Natural Hair Dye Cream Formulation According to Cetyl Alcohol Contents (Cetyl alcohol 함량에 따른 크림 제형 Henna 천연 염모제의 안정성)

  • Kang, Eyoung;Lee, Seunghee;Kim, Woonjung;Jung, Jongjin
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.4
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    • pp.1176-1182
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    • 2021
  • In this study, the emulsion stability of henna, a natural hair dye, according to the content of cetyl alcohol, one of the emulsification stabilizers, was analyzed, and the content of cetyl alcohol showing the most stable emulsification was confirmed. To analyze the emulsion stability, differences in particle size, particle shape, viscosity, and color after dyeing were compared according to the content of cetyl alcohol. As a result of dynamic light scattering (DLS) zeta analysis, cetyl alcohol 3% showed the highest zeta potential value of 115.9 mV, and the particle size distribution was henna in which a cream-type hair dye containing 3% cetyl alcohol was dispersed in distilled water. The width of the particle size distribution was narrow compared to. As a result of viscometer analysis, the viscosity increased as the content of cetyl alcohol increased. As a result of measuring the henna pH of the cream formulation, it was measured in a pH range suitable for the scalp. As a result, emulsion stability increases as the content of cetyl alcohol increases in henna cream formulations for hair dye.

Effect of Fermented Blackberry Drinks Formed from Radiation-induced Mutant on Alcohol Metabolism and Hangover in Rats (방사선 유도 돌연변이체 블랙베리 발효음료의 알코올 대사 및 숙취 억제 효과)

  • Cho, Byoung Ok;So, Yangkang;Lee, Chang Wook;Cho, Jung Keun;Woo, Hyun Sim;Jin, Chang Hyun;Jeong, Il Yun
    • Journal of Radiation Industry
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    • v.7 no.1
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    • pp.75-80
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    • 2013
  • This study was designed to elucidate the effect of fermented blackberry drinks (BD) on alcohol metabolism and hangover in alcohol-treated rats. We showed that the administration of BD increased the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in alcohol-treated rats. Moreover, the administration of BD reduced the serum alcohol and acetaldehyde concentrations in alcohol-treated rats. Furthermore, the administration of BD attenuated the levels of serum aspartate aminotransferase and alanine aminotransferase in alcohol-treated rats. Taken together, these results suggest that BD plays an important role in alcohol metabolism and liver function by reducing blood alcohol and acetaldehyde through the activation of ADH and ALDH in alcohol-treated rats and could be used as a functional anti-hangover drinks.

Effects of Environmental Correlates on Alcohol-related Problems among Colleges (대학교의 환경적 특성이 음주폐해에 미친 영향)

  • Kim, Kwang-Kee;Jang, Seung-Ock;JeKarl, Jung
    • Korean Journal of Health Education and Promotion
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    • v.23 no.3
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    • pp.65-83
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    • 2006
  • Objectives: This is one of the first efforts to describe incidence of alcohol-related problems and to identify environmental correlates associated with them among colleges. Methods: Date were collected by a sample of 105 college administrators who are in charge of student affairs in colleges nationwide through self-administrated questionnaire. Both logistic and linear multiple regression analyses were employed to identify the correlates associated with alcohol-related problems. Results: Most of colleges(76.6%) under study reported to have at least one alcohol-related problem in previous years. Interpersonal violence was alcohol-related problem taken placed most frequently, followed by making noise episode, having property damaged and motor vehicle accidents. Logistic regression analysis identified factors associated with incidents of alcohol related problems. They included being private colleges, numbers of prevention activities, product promotion and marketing by alcohol industry and alcohol accessibility to drinking context. Multiple regression analyses showed that correlates associated with numbers of alcohol-related problems included being a private college, being located in rural area, having drinking density, product promotion and availability of alternative activities to drinking. Conclusions: Environmental correlates were associated with incidence of alcohol related problems in colleges nationwide. Policy implications were discussed.

Alcohol and Sleep (수면과 알코올)

  • Park, Doo-Heum;Yu, Jae-Hak;Ryu, Seung-Ho
    • Sleep Medicine and Psychophysiology
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    • v.13 no.1
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    • pp.5-10
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    • 2006
  • Alcohol has extensive effects on sleep and daytime sleepiness. Alcohol has a sleep inducing effect and the effect of increased non-REM sleep and suppressed REM sleep during the first half portion of night sleep, but alcohol induces the effect of decreased non-REM sleep and increased light sleep and frequent awakenings and REM rebound during the second half portion of night sleep. Alcohol provokes chronobiological change such as the changes of amplitude or the phase shifts of hormones or core body temperature. The sleep disruption resulting from alcohol drinking may lead to daytime fatigue and sleepiness. The elderly are at particular in the increased risk of alcohol-related sleep disorders because they achieve higher levels of alcohol in the blood and brain than do younger adults after consuming an equivalent dose. Bedtime alcohol consumption among older adults may lead to unsteadiness if walking is attempted during the night, with increased risk of falls and injuries. Continued alcohol use for sleep induction often induces aggravation of insomnia, alcoholism or sleep related breathing disorders such as obstructive sleep apnea. Alcohol should not be used as substitution of sleep pill because of the dependence and tolerance for sleep inducing effect, and the sleep disruption produced by alcohol withdrawal.

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Effects of Benzyl Alcohol on Structures and Calcium Transport Function of Biological Cell Membranes (Benzyl Alcohol이 세포막의 형태 및 Calcium 이온 이동에 미치는 영향)

  • Lee, Hwang-Hyun;Hah, Jong-Sik;Kim, Ku-Ja
    • The Korean Journal of Physiology
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    • v.21 no.2
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    • pp.157-167
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    • 1987
  • Benzyl alcohol is known to have dual effect on the red blood cell shape change. At low concentration up to 50 mM benzyl alcohol transformed the shape from discocyte to stomatocyte by preferent binding to the inner hemileaflet, however, at higher concentratransformed the shape from discocyte to stomatocyte by preferential binding to the inner monolayer, however, at higher concentration above 50 mM benzyl alcohol transformed to echinocyte by affecting both monolayers. These results suggest that the effect of benzyl alcohol on the red blood cell shape and $Ca^{++}$ transport across cardiac cell membranes to assess the effects of the drug on the structures and functions of the biological cell membranes. The results are as follows: 1) Benzyl alcohol up to 40 mM caused progressive stomatocytic shap change of the red blood cell but above 50 mM benzyl alcohol caused echinocytic shape change. 2) Benzyl alcohol up to 40 mM inhibited both osmotic hemolysis and osmotic volume change of the red blood cell in hypotonic and hypertonic NaCl solutions, respectively. 3) Benzyl alcohol inhibited both Bowditch Staircase and Wood-worth Staircase phenomena at rat left auricle. 4) Benzyl alcohol at concentration of 5 mM increased $Ca^{++}-ATPase$ activity of red blood cell ghosts slightly but above S mM benzyl alcohol inhibited the $Ca^{++}-ATPase$ activity. 5) Benzyl alcohol at concentrations of 5 mM and 10 mM increased $Ca^{++}-ATPase$ activity slightly at rat gastrocnemius muscle S.R. but above 10 mM benzyl alcohol inhibited the $Ca^{++}-ATPase$ activity. Above results indicate that benzyl alcohol inhibit water permeability and $Ca^{++}$ transport across cell membranes in part via effects on the fluidity and transition temperatures of the bulk lipid by preferential intercalation into cytoplasmic monolayer and in part via other effect on the conformational change of active sites of the $Ca^{++}-ATPase$ molecule extended in cytoplasmic face.

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