• Title/Summary/Keyword: Al-P

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Development of a Quadrivalent Combined DTaP-HepB Vaccine with a Low Toxicity and a Stable HBsAg Immunogenicity

  • Bae, Cheon-Soon;Park, Kwung-Nam;Ahn, Sang-Jeom;Kim, Jong-Su;Hur, Byung-Ki
    • Journal of Microbiology and Biotechnology
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    • v.12 no.5
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    • pp.787-792
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    • 2002
  • When developing a combined DTaP-HepB vaccine, toxicity and HBsAg immunogenicity are both important considerations. Thus, for a combined DTaP-HepB vaccine with a low toxicity, the effect of the DTaP content and $Al(OH)_3$, gel concentration on the vaccine toxicity was investigated. Within the range studied, the higher the concentrations, the higher the vaccine toxicity. The importance of the tetanus toxoid content in the combined DTaP-HepB vaccine was also revealed. A higher concentration of the tetanus toxoid was found to have a negative effect on the stability of the HBsAg immunogenicity in the combined vaccine. Accordingly, considering the factors affecting toxicity and HBsAg immunogenicity, a novel DTaP-HepB vaccine (30 Lf/ml of diphtheria toxoid, 5 Lf/ml of tetanus toxoid, 10 $\mu\textrm{g}$ PN/ml of acellular pertussis, 24 $\mu\textrm{g}$/ml of HBsAg, and 500 $\mu\textrm{g}$ Al/ml of $Al(OH)_3$ gel) was developed. It has a low toxicity and a stable HBsAg immunogenicity and also satisfies the potency criteria of K-FDA for a combined DTaP vaccine.

Manufacturing and Damping Properties of Al-Si/Gr. Composite using extruded Al/Gr. Composite (Al/흑연 압출재를 이용한 Al-Si/흑연 복합재료 제조와 감쇠능)

  • Park, Hun-Berm;Kwon, Hyuk-Moo
    • Journal of Korea Foundry Society
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    • v.21 no.2
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    • pp.119-126
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    • 2001
  • Al/15%Gr. composite have been manufactured by mixing, compacting, and extruding aluminium powder and graphite powder. Then, Al-6%Si/x%Gr., Al-12%Si/x%Gr., and Al-18%Si/x%Gr.(x: 0, 2, 4, 6, 8) composites have been manufactured by remelting the extruded materials(Al/15%Gr.), Al-33.3%Si alloy, and Al ingot, etc. We conducted experiments to chracterize the microstructure, and damping properties and hardness. The result of microstructure experiment on Al-x%Si/y%Gr. composites reveals the good dispersion of graphite. As to Al-Si/y%Gr. composites, the more the graphite contents, the less the tensile strength. And the tensile strength varied according to contents of Si: with its highest value in Al-18%Si/y%Gr. composites and lowest in Al-6%Si/y%Gr. composites. As to Al-x%Si/y%Gr. composites, the more the contents of graphite, the more the vibration damping properties. And we can get the highest vibration damping rate in Al-12%Si/y%Gr. composites which matrix structure is an eutectic component.

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Mechanical properties of Al/Al2O3 and Al/B4C composites

  • Pandey, Vinod K.;Patel, Badri P.;Guruprasad, Siddalingappa
    • Advances in materials Research
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    • v.5 no.4
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    • pp.263-277
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    • 2016
  • Mechanical properties of $Al/Al_2O_3$ and $Al/B_4C$ composites prepared through powder metallurgy are estimated up to 50% $Al_2O_3$ and 35% $B_4C$ weight fractions using micromechanics models and experiments. The experimental Young's modulus up to 0.40 weight fraction of ceramic is found to lie closely between Ravichandran's/Hashin-Shtrikman lower/upper bounds, and close to self consistent method/Miller and Lannutti method/modified rule of mixture/fuzzy logic method single value predictions. Measured Poisson's ratio lies between rule of mixture/Ravichandran lower and upper bound/modified Ravichandran upper bounds. Experimental Charpy energy lies between Hopkin-chamis method/equivalent charpy energy/Ravichandran lower limit up to 20%, and close to the reciprocal rule of mixture for higher $Al_2O_3$ content. Rockwell hardness (RB) and Micro-hardness of $Al/Al_2O_3$ are closer to modified rule of mixture predictions.

$Al_2O_3/SiO_2$, $HfO_2/SiO_2$ 적층 감지막의 두께 최적화를 통한 Electrolyte Insulator Semiconductor 소자의 pH 감지감도특성 비교

  • Gu, Ja-Gyeong;Jang, Hyeon-Jun;Jo, Won-Ju
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.02a
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    • pp.448-448
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    • 2012
  • 최근에 pH 감지막의 감지감도특성을 평가하기 위해 electrolyte insulator semiconductor (EIS) 구조가 유용하게 이용되고 있다. EIS는 간단한 구조와 pH 용액에 빠른 응답속도, 낮은 단가 및 집적이 용이하다는 장점이 있다. EIS 구조에서 화학적 용액에 대한 감지감도 평가 중 가장 중요하게 작용하는 부분이 감지막이다. 이 감지막은 감지 대상 물질과 물리적으로 직접 접촉되는 부분으로서 일반적으로 기계적/화학적 강도가 우수한 실리콘 산화막($SiO_2$)이 많이 사용되어져 왔다. 최근에는 기존의 $SiO_2$ 보다 성능이 향상된 감지막을 개발하기 위하여 $Al_2O_3$, $HfO_2$, $ZrO_2$, 그리고 $Ta_2O_5$와 같은 고유전 상수(high-k)를 가지는 물질들을 EIS 센서의 감지막으로 이용하는 연구가 활발하게 진행되고 있다. High-k 물질 중 $Al_2O_3$는 산성에서 알칼리성 영역까지의 넓은 화학안정성을 가지며 화학용액에 대해 내구성이 우수한 특성을 가진다. $HfO_2$은 내식성이 뛰어나며 출력특성이 높은 장점을 가진 물질이다. 본 실험에서는 특성이 다른 두 물질을 EIS의 감지막으로 각각 사용하여 두께에 따른 의존성을 평가하였다. 제작한 EIS 구조의 pH 센서를 바이오 센서에 적용하였을 때 신호대 잡음비(SNR: signal to noise)가 여전히 취약하다는 문제점이 있었다. 이런 문제점을 보완하기 위하여 감지막의 물리적 두께는 점점 얇아지게 되었고 그 결과 높은 출력 특성을 얻게 되었지만, 감지막이 얇아짐에 따라서 화학 용액 중의 이온 침투로 인한 감지막 자체의 손상 또한 심각한 문제로 대두되었다. 이로 인해 최적화 된 감지막의 두께를 얻을 필요가 있다. 결론적으로 $Al_2O_3$, $HfO_2$ 두 감지막 모두 두께가 23 nm일 때 가장 우수한 특성을 보였으며, $Al_2O_3$를 감지막으로 사용하였을 경우 화학적 용액에 대해 내구성이 뛰어났고, $HfO_2$을 사용하였을 때에는 화학적 용액에 대한 안정성 보다는 pH 용액변화에 따른 향상된 감지감도특성을 보였다.

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Direct printing process based on nanoimprint lithography to enhance the light extraction efficiency of AlGaInP based red LEDs

  • Cho, Joong-Yeon;Kim, Jin-Seung;Kim, Gyu-Tae;Lee, Heon
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2012.11a
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    • pp.171-171
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    • 2012
  • In this study, we fabricated the high-brightness AlGaInP-based red light emitting diodes (LED)s using by direct printing technique and inductive coupled plasma (ICP) reactive ion etching (RIE). In general, surface roughening was fabricated by wet etching process to improve the light extraction efficiency of AlGaInP-based red LED. However, a structure of the surface roughening, which was fabricated by wet etching, was tiled cone-shape after wet etching process due to crystal structure of AlGaInP materials, which was used as top-layer of red LED. This tilted cone-shape of surface roughening can improve the light extraction of LED, but it caused a loss of the light extraction efficiency of LED. So, in this study, we fabricated perfectly cone shaped pattern using direct printing and dry etching process to maximize the light extraction efficiency of LED. Both submicron pattern and micron pattern was formed on the surface of red LED to compare the enhancement effect of light extraction efficiency of LEDs according to the diameter of sapphire patterns.After patterning process using direct printing and ICP-RIE proceeded on the red LED, light output was enhanced up to 10 % than that of red LED with wet etched structure. This enhancement of light extraction of red LED was maintained after packaging process. And as a result of analyze of current-voltage characteristic, there is no electrical degradation of LED.

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Ellipsometric Study in Vacuum

  • Kim, Yeong-Dong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.63-63
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    • 2012
  • 편광분석법(ellipsometry)은 대상 물질의 유전율 함수의 실수부와 허수부를 Kramers-Kronig 관계식의 도움 없이 그 물질상수를 정확히 측정할 수 있는 매우 우수한 기술이다. 이 기술의 큰 장점 중 하나는 빛의 편광상태의 변화를 이용한 비파괴적인 방법으로써 실시간 측정이 가능하며, 박막의 두께측정의 오차범위는 0.1 nm 이하로써 매우 정확하다는 것이다. 본 연구자는 이러한 우수한 측정 기술인 편광분석법을 고진공의 분자살박막증착장치(MBE) 와 결합하여 AlSb, AlP의 유전율 함수를 측정하였다. Al 계열을 포함하는 반도체 화합물은 Al의 산소친화력이 강해 대기 중에서 순수한 유전율 함수를 얻기가 불가능하다. 하지만 본 연구실에서 초고진공 상태의 MBE 챔버에서 시료를 성장시키는 동시에 실시간으로 편광분석기를 이용하여 측정하였고, 지금까지 발표된 결과들 중 가장 순수한 상태의 AlSb 유전율 함수를 얻어낼 수 있었다. 또한 순수한 AlP의 유전함수를 측정할 수 있었고, 이는 편광분석기를 이용한 최초의 실험결과로써 이차미분을 이용한 전이점 분석결과 이론적인 전자밴드구조에서 E1, E1+${\Delta}1$, E2에 해당하는 밴드갭들을 확인할 수 있었다. 또한 표면의 원자배열 구조와 실시간으로 일어나는 그들의 역학적인 현상들에 관한 정보를 얻을 수 있는 surface photoabsorption (SPA)를 metalorganic chemical vapor deposition (MOCVD)에 장착하여 실시간 모니터링이 가능하도록 하였다. SPA를 이용하여 GaAs/AlGaAs 양자우물구조의 성장을 원자층 수준으로 실시간 모니터링을 할 수 있었다. 그리고 SPA를 이용하여 MOCVD 안에서 InP에 As가 흡착 및 탈착되는 현상을 분석하여, As의 흡착이 두 단계에 의해 이루어짐을 분석하였다. 그리고 편광분석법의 빠르고 정확한 측정 기술을 규칙적인 구조체에서 전자기파의 회절을 구할 수 있는 Rigorous Coupled-Wave Analysis (RCWA) 계산방법과 결합하여 나노구조의 기하학적인 모양을 정확하고 빠르게 구할 수 있었다. 본 연구를 위해 규칙적인 3차원 Si 구조체 제작하여 편광분석기로 측정하고 $SiO_2$와 표면 거칠기를 고려하여 RCWA로 분석한 결과, 규칙적인 Si 구조와 산화막 층까지 정확하게 분석할 수 있음을 확인하였다. 또한 규칙적인 나노구조분석 연구를 넘어 불규칙적인 나노구조에 대한 분석 가능성을 보이기 위해 InAs 양자점을 증착하여 분석하였고, 이를 통해 편광분석법과 RCWA를 이용하여 불규칙적인 나노구조의 모양과 크기, 분포의 분석이 가능함을 보였다.

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Surface Treatment of Al(OH)3 using Dilute Hydrofluoric Acid Aqueous Solution (저농도 HF 수용액을 이용한 Al(OH)3의 표면처리)

  • Kim, Do-Su;Lee, Churl-Kyoung;Yang, Dong-Hyo
    • Journal of the Korean Ceramic Society
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    • v.39 no.3
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    • pp.315-320
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    • 2002
  • Treatment effects of dilute hydrofluoric acid (6 wt% HF) on the surface properties of $Al(OH)_3$ were investigated at the molar ratio of F/Al(fluoride/aluminum)=0.15. Temperature and pH variations in the reaction system were recorded to analyze reaction mechanism between $Al(OH)_3$ and aqueous Hf. The reaction of HF to the surface of $Al(OH)_3$ accompanied with a quantity of heat evolution, resulting in increasing temperature of a reactionsystem. And also the reaction was proceeded as transitional state which metastable ${\alpha}-form\;AlF_3{\cdot}3H_2O$ was transferred to insoluble ${\beta}$-form. The resulting ${\beta}-form\;AlF_3{\cdot}3H_2O$ formed by a surface treatment was identified by FT-IR and X-ray diffractormetry. The formation of ${\beta}$-form aluminum fluoride hydrates with diameter less than $1{\mu}m$ on the surface of $Al(OH)_3$ could be visulaized by SEM imgae, making up a coating layer as precipitate-like. The surface whiteness of $Al(OH)_3$ treated with aqueous HF was furthermore increased approximately 6.6% due to the formation of surface hydrates.

Legal View on Recent Cases of the U.S. and Korea on P2P Service (법적 관점에서 본 P2P서비스:미국연방대법원 평결 및 한국의 소리바다 판결)

  • Kim, Eun-Yeong
    • International Commerce and Information Review
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    • v.8 no.1
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    • pp.205-223
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    • 2006
  • File sharing through P2P was decided as illegal according to Supreme Court of the U.S. and the Highest Court of Korea in 2005. Metro-Goldwyn-Mayer Studios Inc. et al. v. Grokster, LTD., et al. and Soribada v. Korea Association for Music Providers have the same ground for decision. P2P service company has vicarious liability for illegal file sharing of its customers. Balance between copyright protection and development of technology was considered in that decision. Programmer who will develop new program for free download and copyright holders who will exploit every measures to protect their right may compromise for their mutual benefits.

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ZnO Piezoelectric Thin Film Fabrication and Its Application as a Flow-rate Control Microvalve (ZnO 압전박막의 제조와 유량조절밸브로서의 응용)

  • 박세광
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1989.06a
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    • pp.66-69
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    • 1989
  • After reviewing previous work done on two piezoelectric thin films(PZT, ZnO), ZnO thin piezofim of 1-3UM is fabricated by sputtering on the different substrates(i. e., P+Si/N-Si, SiO2/P+Si/ N-Si, Al/SiO2/ P+Si/ N+Si). The result shows that ZnO piezofilm on the Al has the best c-axis orientation. One of applications for the ZnO piezofilm as an microvalve to control liquid flow is introduced, and which can be controlled electrically and remotely.

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THE QUASI-HADAMARD PRODUCTS OF CERTAIN p-VALENT FUNCTIONS WITH NEGATIVE COEFFICIENTS

  • Aouf, Mohamed Kamal
    • Bulletin of the Korean Mathematical Society
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    • v.44 no.4
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    • pp.597-606
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    • 2007
  • The object of the present paper is to show quasi-Hadamard products of certain p-valent functions with negative coefficients in the open unit disc. Our results are the generalizations of the corresponding results due to Yaguchi et al. [10], Aouf and Darwish [3], Lee et al. [5] and Sekine and Owa [9].