• Elastomers and Composites
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• v.33 no.3
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• pp.159-167
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• 1998

Rubber products are aged like human complexion by the attack of oxygen, ultra violet, ozone, etc.. Aging is very important and also very complicated phenomenon to understand. This may explain the rarity of papers on this subject. In this study, we tried to understand the aging behavior of EPDM compared to that of natural rubber. We also compared the sulfur vulcanized system to the peroxide vulcanized one. In our experiment, the peroxide vulcanizates were more advantageous in aging than the sulfur vulcanizates. The authors belived that this study about the high performance EPDM would be applicable to rubber industry.

• The Journal of Bigdata
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• v.6 no.2
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• pp.151-159
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• 2021

Construction of a blockchain network needs a cumbersome and time consuming activity. To overcome these limitations, global IT companies such as Microsoft are providing cloud-based blockchain services. In this paper, we propose a blockchain-based construction and management tool that enables blockchain developers, blockchain operators, and enterprises to deploy blockchain more comfortably in their infrastructure. This tool is implemented using Hyperledger Fabric, one of the famous private blockchain platforms, and Ansible, an open-source IT automation engine that supports network-wide deployment. Instead of complex and repetitive text commands, the tool provides a user-friendly web dashboard interface that allows users to seamlessly set up, deploy and interact with a blockchain network. With this proposed solution, blockchain developers, operators, and blockchain researchers can more easily build blockchain infrastructure, saving time and cost. To verify the usefulness and convenience of the proposed tool, a blockchain network that conducts electronic voting was built and tested. The construction of a blockchain network, which consists of writing more than 10 setting files and executing commands over hundreds of lines, can be replaced with simple input and click operations in the graphical user interface, saving user convenience and time. The proposed blockchain tool will be used to build trust data infrastructure in various fields such as food safety supply chain construction in the future.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.3 s.47
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• pp.393-397
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• 2004

L-Carnitine $({\beta}-hydroxy-{\gamma}-trimethyl-ammoniumbutyric{\;}acid)$ is a small water-soluble molecule important in mammalian fat metabolism. It is essential for the normal oxidation of fatty acids by the mitochondria, and is involved in the trans-esterification and excretion of acyl-CoA esters. In this paper, to investigate the relationship between aging and L-carnitine, we investigated the effects of in vitro matrix-metalloproteinase (MMP) inhibition and activity and expression of UYA-induced MMPs in human skin fibroblasts. Also, we studied to develop as anti-aging cosmetics with L-carnitine. Fluorometric assays of the proteolytic activities of MMP-1 (collagenase) were performed using fluorescent collagen substrates. ELISA (enzyme linked immune sorbent assay), gelatin-substrate zymography, RT-PCR ELISA techniques were used for the effects of L-carnitine on MMP expression, activity, and MMP mRNA expression in UVA irradiated fibroblast $(5\;J/cm^2)$, respectively. In addition, we performed clinical study with L-carnitine cream. L-carnitine inhibited the activities of MMP-1 in a dose-dependent manner and the $IC_{50}$ values calculated from semi-log plots were 2.45 mM, and L-carnitine showed strong inhibition on MMP-2 (gelatinase) activity in UVA irradiated fibroblast by zymography. Also, UVA induced MMP-1, 2 expression was reduced $43\%,\;53\%$ by treated with L-carnitine at 1.25 mM, and MMP-1 mRNA expression was reduced dose-dependent manner. Therefore L-carnitine was able to significantly inhibit the MMP activity, and regulate MMP expression in protein and mRNA level. The results of clinical study showed that $1.0\%$ L-carnitine treated group reduced wrinkle significantly compared with placebo treated group (P<0.05). All these results suggest that L-carnitine may be useful as new anti-aging cosmetics for protection against UVA induced Mm expression and activity.