• Title/Summary/Keyword: Ahn Jae-Hong

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Synthesis and hypoglycemic Activity of the Substituted Pyrrolidine Thiazolidinedione Derivatives

  • Kim, Bok-Young;Ahn, Joong-Bok;Lee, Hong-Woo;Shin, Jae-Soo;Moon, Kyoung-Sik;Kim, Joon-Kyum;Lee, Do-Young;Ahn, Soon-Kil;Hong, Chung-Il
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.342.3-343
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    • 2002
  • Non-insulin dependent diabetes mellitus (NIDDM) is characterized by hyperglycemia, hyperinsulinemia. and impaired insulin action. Insulin resistance is considered to be the underlying mechanism in the pathogenesis of type 2 diabetes. which also leads to dyslipidemia, hypertension. and obesity. Thazolidinediones are a class of oral insulin-sensitizing agents that improve glucose utilization without increasing insulin release. They significantly reduce glucose, lipid and insulin levels in rodent models of NIDDM and obesity, and recent clinical data support theri efficacy in obese diabetic patients. (omitted)

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HANTZSCH DIHYDROPYRIDINE: AN EFFECTIVE AND CONVENIENT REGIOSELECTIVE REDUCING AGENT FOR 5-BENZYLIDENE-2,4- THIAZOLIDINEDIONE DERIVATIVES

  • Lee, Hong-Woo;Kim, Bok-Young;Ahn, Joong-Bok;Son, Hoe-Joo;Lee, Jae-Wook;Ahn, Soon-Kil;Hong, Chung-Il
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.252.3-252.3
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    • 2003
  • An effective and convenient regioselective reduction of 5-benzylidene 2,4-thiazolidinedione derivatives to the corresponding 5-benzyl 2,4-thiazolidinedione derivatives has been accomplished using 3,5-dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine (Hantzsch dihydropyridine ester: HEH) with silica gel as an acid catalyst in a good yield.

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