• Journal of Yeungnam Medical Science
• /
• 제38권2호
• /
• pp.83-94
• /
• 2021

The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

• 한국약용작물학회지
• /
• 제21권1호
• /
• pp.1-6
• /
• 2013

Buckwheat (Fagopyrum esculentum) has been known for having strong anti-oxidant, anti-mutagenic, and anti-carcinogenic activities. The free radical theory of aging, also known as the oxidative stress theory of aging, claims that cellular oxidative damage accumulated with time is a major causal factor of aging. In the present study, we investigated the effect of buckwheat extracts on resistance to oxidative stress and aging using Caenorhabditis elegans as a model system. Survival under an oxidative-stress condition induced by paraquat increased markedly following 500mg/L buckwheat extracts treatment, suggesting lower cellular oxidative damage by buckwheat extracts. A lifespan assay also revealed that treatment of buckwheat extracts significantly extended both the mean and maximum lifespan in C. elegans. Interestingly, this lifespan-extension by buckwheat extracts was not accompanied by reduced fertility. These findings suggest that buckwheat extracts can confer longevity phenotype to C. elegans through its strong anti-oxidant activity and support the aging theory which emphasizes a pivotal role of oxidative stress during aging.

• 한국기계가공학회지
• /
• 제21권1호
• /
• pp.56-65
• /
• 2022

The electrochemical corrosion properties of austenitic AISI 304 steel subjected to a long-term-aging heat treatment were investigated. AISI 304 steel was aged at 700 ℃ for up to 10,000 h. The variation in the microstructure of the aged specimens was observed by optical microscopy and scanning electron microscopy. Electrochemical polarization experiments were performed to obtain the corrosion current density (Icorr) and corrosion potential (Ecorr). Analyses indicated that the metastable intermetallic carbide M₂₃C₆ formed near the γ/γ grain boundary and coarsened with increasing aging time; meanwhile, the δ-ferrite decomposed into the σ phase and into M₂₃C₆ carbide. As the aging time increased, the current density increased, but the corrosion potential of the austenitic specimen remained high (at least 0.04 ㎛/cm²). Because intergranular carbide was absent, the austenitic annealed specimen exhibited the highest pitting resistance. Consequently, the corrosion resistance of austenitic AISI 304 steel decreased as the aging heat treatment time increased.

• 한국염색가공학회지
• /
• 제35권3호
• /
• pp.151-158
• /
• 2023

In this study, we investigated the durability properties of the recycled leather using shaving scrap with antioxidant. Recycled leather sheets were manufactured by mixing shaving scrap and NB latex as a binder. HALS(Hindered Amine Light Stabilizer) and UVA(UV absorbers) were used as antioxidant. Mechanical properties such as hardness, tensile strength, elongation, tear strength and abrasion resistance were measured. Light aging resistance was evaluated using UV lamp and the degree of discoloration of the recycled leather sheets using a gray scale. In addition, to evaluate heat aging and UV aging, the degree of discoloration of the recycled leather sheets over time was measured using colorimeter. Washing fastness was evaluated on the degree of dyeing of recycled leather sheets for six type of multi-fiber woven fabrics (Acetate, Cotton, Nylon-66, Polyester, Acryl, Wool). To determine whether hazardous substances were detected in recycled leather sheets, the contents of arylamine and Cr 6⁺ were evaluated. As a result, when used in combination with antioxidant, the heat aging and light aging of recycled leather were improved and hazardous substance were not detected.

• 한국재료학회지
• /
• 제9권4호
• /
• pp.409-413
• /
• 1999

Recently, the polymeric insulators have been accepted in several countries for the outdoor high voltage applications. In comparison with the conventional porcelain, polymeric insulators offer various advantages such as light weight, superior vandal resistance and better contamination performance. The outdoor polymeric insulating materials such as silicone rubber, ethylene propylene diene monomer(EPDM), ethylene vinyl acetate(EVA) and epoxy are aged such as silicone rubber, ethylene propylene diene monomer(EPDM), ethylene vinyl acetate(EVA) and epoxy are aged under the various natural environment with the long-term performance in outdoor. In this paper, the effects of UV-under the various natural environment with the long-term performance in outdoor. In this paper, the effects of UV-ray on the surface of silicone rubber were investigated by using the weather-Ometer. The accelerated aging stresses were simulated by UV radiation, high temperature and humidity as well as water spray. These aging characteristics were examined through contact angle measurements, tracking resistance test, FT-IR and SEM/EDS analysis. The experimental results showed that tracking resistance decreases with increase in the UV-ray irradiation period. But the surface of silicone rubber kept hydrophobicity. It is found that the inorganic filler such as)$ Al(OH_3$ improves tracking resistance and the $Tio_2$is very effective in preventing degradation of silicone rubber surface from UV-ray.

• Journal of Advanced Marine Engineering and Technology
• /
• 제27권3호
• /
• pp.453-459
• /
• 2003

In this study, the effect of heat treatment to the electrochemical polarization resistance for the Ti-6Al-4V alloy was measured. The solution heat treatments were carried out at $1066^{circ}E, 966^{\circ}$E$, followed by aging heat treated $550^{circ}E, 600^{circ}E, and 650^{circ}E$. The electrochemical polarization resistance behavior was measured by potentio-dynamic polarization in the 1N $HNO_3$ + 15ppm HF solution. The obtained results were as follows. 1. As solution heat temperature increased. the corrosion potential was increased, whereas passive current density and critical current density were decreased. 2. As aging heat temperature increased, the corrosion potential was almost constant, but passive current density was decreased 3. The results of composition test measured by EDS at grain boundary and near $\gamma'$ precipitates indicated that S, Cl. and Si which originated from base metal were segregated at the grain boundaries Al and Ti which were the main alloying element in $\gamma'$ were depleted at the $\gamma'$ precipitated. The depletion of Al and Ti in $\gamma'$ was caused to early breakdown of passive film.

• Molecules and Cells
• /
• 제45권11호
• /
• pp.763-770
• /
• 2022

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.

• 한국도로학회논문집
• /
• 제9권3호
• /
• pp.123-134
• /
• 2007

본 연구는 $154^{\circ}C$로 2시간의 단기노화를 거친 혼합물로 제작한 공시체를 $110^{\circ}C$에서 24, 48, 72, 96시간 동안 장기노화를 시켜 아스팔트 혼합물의 노화와 소성변형 저항성을 평가하였다. 혼합물의 노화 시간이 증가함에 따라 강성의 증가로 인한 소성변형 저항성이 증가할 것을 고려하여 변형강도를 이용해 단기노화와 장기노화를 거친 공시체에 대해 소성변형특성을 측정하였다. 또한 노화 시간의 증가에 따른 바인더의 노화 정도를 측정하기 위하여 GPC (Gel-permeation chromatograph) 분석을 통하여 대형분자비율(LMS(%))을 측정하였다. 노화 시간이 길어짐에 따라 LMS(%)가 증가하고 혼합물의 변형강도 값이 커지는 것을 확인하였다. 또한 상관성 분석으로부터 LMS(%)와 변형강도가 상관성이 높은 것으로 나타나 이를 통해 혼합물이 노화되면 소성변형 저항성이 증가됨을 확인하였다. 따라서 LMS(%)의 측정으로 아스팔트 혼합물의 바인더 추출 없이도 소성변형특성을 추정 가능함을 확인하였다.

• 한국환경과학회지
• /
• 제13권4호
• /
• pp.421-427
• /
• 2004

With the help of mechanical mixing method such as Banbury mixer and open 2 roll mill, ethylene propylene diene terpolymer (EPDM) was blended with the chloroprene rubber (CR) then mechanical properties and ozone resistance test of blends were subsequently investigated. It was noted that the hardness increased with an increasing of CR contents. Generally the hardness was increased with heat aging time most likely due to the post cure. In ozone resistance test of blend, after 8 hours a portion of fine crack is obtained for pure CR. It is confirmed that ozone resistance is greatly improved by addition of 25wt% EPDM to CR.

• 동의생리병리학회지
• /
• 제27권3호
• /
• pp.331-335
• /
• 2013

This study investigated the relationship between drinking and health factors including vaso-aging degree, stress index, stress resistance, fatigue and activity of autonomic nerve system etc. The subjects were 20,925 persons who had received health examination by Korean Medicine and submitted questionnaires about drinking history, for 8 months from March to November. The vaso-aging degree were measured by APG (Accelerated Photoplethysmograph). The stress index and resistance, fatigue and activity of autonomic nerve system were measured by HRV (Heart Rate Variability). We analyzed the relationship between drinking and various variables by chi-square test with SPSS ver. 19.0. Regarding the relationship between drinking and vaso-aging degree, there was significant differences(p<0.05). But regarding the relationship between drinking and the other factors, there were no statistically differences. This study suggests that the vaso-aging degree is affected by drinking alcohol.