• Title/Summary/Keyword: Aging Resistance

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Improvement of Learning Behavior of Mice by an Antiacetylcholinesterase and Neuroprotective Agent NX42, a Laminariales-Alga Extract (Acetylcholinesterase 억제 및 신경세포 보호 활성을 갖는 다시마목 해조 추출물 NX42의 마우스 학습능력 향상 효과)

  • Lee, Bong-Ho;Stein, Steven M.
    • Korean Journal of Food Science and Technology
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    • v.36 no.6
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    • pp.974-978
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    • 2004
  • Brown-alga-derived natural agent NX42, mainly composed of algal polysaccharides and phlorotannins, showed mild but dose-dependent inhibition of acetylcholinesterase with $IC_{50}=600-700\;{\mu}g/mL$. Phlorotannin-rich fraction of NX42 showed substantial increase of the activity by more than one order of magnitude ($IC_{50}=54\;{\mu}g/mL$) and significant protection of SK-N-SH cells from oxidative stress by $H_2O_2$. Learning trials of mice for 5 consecutive days revealed electric-shock treatment during learning period significantly retarded learning process, whereas NX42-treated mice showed significant resistance against leaning deficiency possibly mainly due to anticholinesterase and neuroprotective activities of phlorotannin.

Establishment of Sesame Cultivation Practices as Succeeding Cropping System of Watermelon in the Greenhouse Condition

  • Shim, Kang-Bo;Hwang, Jung-Dong;Pae, Suk-Bok;Lee, Myoung-Hee;Ha, Tae-Joung;Park, Chang-Hwan;Park, Keum-Yong;Son, Jeong-Hee
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.55 no.3
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    • pp.195-199
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    • 2010
  • This experiment was conducted to develop optimum sesame cultivation practices as succeeding cropping system of watermelon in the greenhouse condition. We also compared major components in sesame seed cultivated in the greenhouse and open field condition. The adaptable varieties under the greenhouse condition were white sesame 'Pyoungan' and black sesame 'Jinki' which showed higher yield and disease resistance. We also conducted several experiments to determine optimum sowing date, planting density and pinching time. Grain yields were statistically different according to the several sowing dates. In general, sesame sowing on June 30th showed higher grain yields than July 10th, July 20th and July 30th in the greenhouse. We also found out sesame cultivation practice with the row spacing of 40 cm and interplant spacing of 30 cm (a few branch type) or 40 cm (many branch type) showed higher yield than other treatments. Optimum pinching time was 25 days after first flowering in main stem when thousand seed weight and grain yield were highest. In the comparison of major components of sesame at the different cultivation conditions, sesame seeds cultivated in the greenhouse contained 4% much more oil content than open field condition. The lignan compounds, sesamin and sesamolin were also higher by 6% in the greenhouse than open field condition. It was concluded that sesame cultivation practices as succeeding cropping system of watermelon in the greenhouse condition guaranteed higher grain yield with less labor input which is now emerging alternative farming practice system in present aging rural society and will also give sesame cultivation farmers to increase net income in Korea.

Effects of Aquarobics on Metabolic Syndrome and Health Fitness in Abdominally Obese Elderly Women (아쿠아로빅 운동이 복부비만 노인여성의 대사증후군 및 건강체력에 미치는 영향)

  • Park, Young-Ah;Kim, Dong-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.8
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    • pp.5180-5188
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    • 2015
  • The purpose of this study was to investigate the effects of a 12-weeks aquarobics on metabolic syndrome risk factors and health fitness in 25 abdominally obese elderly women. As the results, while waist circumference(87.40/82.76cm, p<.01) decreased, HDL-C(41.13/45.42mg/dl, p<.05) increased after the exercise program. Blood pressure and TG, however, decreased with no significance. And while muscle strength increased(17.06/19.08kg, p<.05), the increase in flexibility, muscle endurance, and cardiopulmonary endurance and the decrease in body fat showed some positive effects of the exercise program. In conclusion, we found that the aquarobics improves the aging-induced deterioration in the muscular skeletal function by lowering abdominal obesity and improving metabolic syndrome and physical fitness for health. In addition, the aquarobics can be an effective alternative to an aerobics or a resistance exercise on the ground.

Evaluation of Cerebrovascular Reactivity According to Age Using Transcranial Doppler (Transcranial Doppler를 이용한 연령에 따른 뇌혈관 반응성 평가)

  • Lee, Gyu Taek;Kim, Jong Gyu
    • Korean Journal of Clinical Laboratory Science
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    • v.36 no.1
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    • pp.43-48
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    • 2004
  • Cerebral vasoreactivity is an index of autoregulation of cerebral perfusion, and can be measured using functional images such as Xe CT, SPECT and PET in reponse to hypercapneic stimulus. In order to measure cerebral $CO_2$ vasoreactivity in routine TCD study conveniently and reliably, we devised a method of rebreathing into closed volume of reservoir bag as a hypercapneic stimulus, and applied it to 44 healthy volunteers. As a hypercapneic stimulus, we applied fitting mask connected with closed reservoir bag for about 90 seconds, and mean blood flow velocity(MBFV) and pulsatility index(PI) were evaluated at proximal middle cerebral arteries(MCA) of 50-55 mm depth, before and after the hypercapneic stimulus. Age affected the MFV and PI value showed significant and the MFV was 56.45(SD=9.75)cm/sec, while PI was 0.406(SD=0.089). As age increases the flow velocity decreased significantly whereas PI value increased(P<0.05). The vasoreactvity significantly decreased with age(P<0.05). The decrease of cerebral blood flow quantity and cerebral blood flow velocity is not only because of increase of diameter of cerebrovascular resulting from aging, but the resistance increase of small blood vessel resulting from the increase of PI & RI value is regarded. We suppose that the rebreathing method is a reliable and convenient technique as a hypercapneic stimulus in determining cerebral $CO_2$ vasoreactivity. The rebreathing method could be non-invasive and useful methods in estimation of the cerebrovascular reactivity and could be applied to the basal and follow-up evaluation of the cerebrovascular reserve of the ischemic stroke patients.

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Microstructure and Mechanical Properties of Sn-3.5wt.%Ag Solder with Bi Addition (Bi를 첨가한 Su-3.5wt.%Ag 땜납의 미세조직 및 기계적 성질)

  • Lee, Kyung-Ku;Baek, Dae-Hwa;Seo, Youn-Jong;Lee, Doh-Jae
    • Journal of Korea Foundry Society
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    • v.21 no.4
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    • pp.239-245
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    • 2001
  • Microstructure and mechanical properties of Sn-3.1 wt.%Ag-6.9 wt.%Bi system solders on Cu-substrate were studied. The Sn3.1 wt.%Ag-6.9 wt.%Bi alloy was designed by phase diagram and chemical properties and was prepared by melting in argon atmosphere. The mechanical properties of solder/Cu joints were examined by shear strength test, and also creep test. The microstructure of Sn-3.1 wt.%Ag-6.9 wt.%Bi alloy consists of Bi-rich phase and $Ag_3Sn$ precipitate in {\beta}-Sn$ matrix phase. The shear strength of the joint was decreased with aging treatment. Crack path under shear test was through the solder. Similar crack path change mode was observed at the creep test of solder/Cu joint. The creep behavior of Sn-3.1 wt.%Ag-6.9 wt.%Bi alloy represented the inverse primary creep behavior at all test condition. It is suggested that the inverse primary creep behavior is induced from Bi solute atoms in Sn-matrix. The creep resistance of Sn-3.1Ag-6.9Bi alloy is better than that of Sn-3.5 wt.%Ag alloy at all test conditions.

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A Study on the Subjectivity of Skin Care (일반여성의 피부미용관리에 대한 주관성 연구)

  • Yang, Eun-Soon
    • Journal of the Korean Society of Fashion and Beauty
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    • v.2 no.3 s.3
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    • pp.1-10
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    • 2004
  • The purpose of this study is to find out the operant factors, or types of skin care, and, more importantly, to propose the intervention for more effective skin care and marketing strategies in this business. That is the main reason that the study employes Q methodology which measures human subjectivity objectively and scientifically. This study finally revealed three distinctive factors : Type I, The Passive Follower, Type II, The Active Needs, and Type III, The Independent Judgment. The first type includes people who show passive recognition. They want to be put in charge of experts in the skin care center and to buy cosmetics recommended by experts, and are deep interest in the reaction of other people. The second type contains people who desire things actively. To live delightfully and fashionably, they think of the necessity of skin and body care as an important thing, and feel that it is necessary to take care of the skin beauty actively and regularly for the aging resistance. The third type includes people who judge independently. In general, they recognize and desire the necessity of the skin care, but they think of the skin care as a part of the health care more widely rather than a special thing. These three types are not fixed, but continuously changed in the accordance with the condition and interaction with the circumstance, the results will be utilized as basic materials for the skin and health care through the application according to the characteristic of each type they belong.

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Thermal and Electrical Properties of Poly(vinylidenefluoride-hexafluoropropylene)-based Gel-Electrolytes (Poly(vinylidenefluoride-hexafluoropropylene)계 겔-전해질의 열적, 전기적 특성)

  • 김영완;최병구;안순호
    • Polymer(Korea)
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    • v.24 no.3
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    • pp.382-388
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    • 2000
  • Polymer electrolyte films consisting of poly(vinylidenefluoride-hexafluoropropylene) (PVdF-HFP), LiClO$_3$ and a mixture of ethylene carbonate (EC) and ${\gamma}$-butyrolactone (GBL) were examined in order to obtain the best compromise between high ionic conductivity, homogeniety, dimensional and electrochemical stability. Measurements of ionic conductivity, differential scanning calorimetry and linear sweep voltammetry have been carried out for various compositions. The highest conductivity of 3.8$\times$10$^{-3}$ S$cm^{-1}$ / at 3$0^{\circ}C$ were obtained for a film of 30(PVdF-HFP)+7.8LiClO$_4$+62.2EC/GBL. From the DSC study, it has been found that the PVdF-HFP gels are stable up to 10$0^{\circ}C$, and the salt lowers the melting temperature of crystalline part of PVdF by interacting sensitively with polymer segments. When Lithium metal is in contact with the gel films, it tends to undergo corrosion and the reaction products accumulate resulting in the formation of a passive film on Li electrode. As the aging time progresses, the interfacial resistance increases continuously. Anodic stability is measured to extend up to about 4.5 V vs. Li.

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Analysis of the Fasting Insulin Level Associating factors in Elderly Females with Normal Glycemic Control (정상 혈당을 가진 여자노인에서의 인슐린 수준 관련 요인분석)

    • Journal of Nutrition and Health
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    • v.35 no.10
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    • pp.1060-1069
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    • 2002
  • High insulin level is known to be a risk factor of coronary heart disease. High insulin level with normal glycemic control is known to be an indicator for insulin resistance. This study was aimed to find out the influencing factors for the fasting serum insulin levels in elderly females with normal glycemic control. One hundred thirty-eight older females aged over 60 years without diabetes medication and high blood HBA1c level were examined on the serum fasting insulin concentration, anthropometry and asked about nutrient intake and exercise habits. The elderly were categorized into 3 group according to the fasting insulin level. The high insulin group was in a state of hyperinsulinemia. Except vitamin C, the nutrient intakes showed no difference according to fasting serum insulin level. But the intakes of calorie and protein per kg body weight were significantly lower in the high insulin group. The intakes of most nutrients except vitamin B$_1$, C and niacin were lower than the korean RDA in all the insulin group. Especially, the intakes of vitamin B$_1$ and Ca were below 75% of the korean RDA. Weight, BMI, body fat percent, body fat mass and fat-free mass, circumferences of waist and hip, WHR of elderly females were significantly higher in the group with the highest insulin level. The body fat percent in the highest insulin group was 35.8%. showing a state of obesity. The high insulin group showed higher proportion of low exercise frequencies per week and short exercise duration. Therefore, the mean energy expenditure for exercise were lower in this group, showing a state of very low exercise activity. Age and waist circumference in elderly females could explain to the 14.5% variances of the fasting insulin level according to multiple stepwise regression. It can be concluded that aging and central body fat deposition influence independently the serum fasting insulin level in elderly females with normal glucose level.

Electrical fire prediction model study using machine learning (기계학습을 통한 전기화재 예측모델 연구)

  • Ko, Kyeong-Seok;Hwang, Dong-Hyun;Park, Sang-June;Moon, Ga-Gyeong
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.11 no.6
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    • pp.703-710
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    • 2018
  • Although various efforts have been made every year to reduce electric fire accidents such as accident analysis and inspection for electric fire accidents, there is no effective countermeasure due to lack of effective decision support system and existing cumulative data utilization method. The purpose of this study is to develop an algorithm for predicting electric fire based on data such as electric safety inspection data, electric fire accident information, building information, and weather information. Through the pre-processing of collected data for each institution such as Korea Electrical Safety Corporation, Meteorological Administration, Ministry of Land, Infrastructure, and Transport, Fire Defense Headquarters, convergence, analysis, modeling, and verification process, we derive the factors influencing electric fire and develop prediction models. The results showed insulation resistance value, humidity, wind speed, building deterioration(aging), floor space ratio, building coverage ratio and building use. The accuracy of prediction model using random forest algorithm was 74.7%.

A Study on the Lifetime Estimation and Leakage Test of Rubber O-ring in Contacted with Fuel at Accelerated Thermal Aging Conditions (가속노화조건 하 연료접촉 고무오링의 수명예측 및 누유시험 연구)

  • Chung, Kunwoo;Hong, Jinsook;Kim, Young-wun;Han, Jeongsik;Jeong, Byunghun;Kwon, Youngil
    • Tribology and Lubricants
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    • v.35 no.4
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    • pp.222-228
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    • 2019
  • As rubber products such as O-rings, which are also known as packings or toric joints, come in regular, long term contact with liquid fuel, they can eventually swell, become mechanically weakened, and occasionally crack; this diminishes both their usefulness and intrinsic lifetime and could cause leaks during the steady-state flow condition of the fuel. In this study, we evaluate the lifetime of such products through compression set tests of FKM, a family of fluorocarbon elastomer materials defined by the ASTM international standard D141; these materials have great compression, sunlight, and ozone resistance as well as a low gas absorption rate. In this process, O-rings are immersed in the liquid fuel of airtight containers that can be expressed as a compression set, and the liquid fuel leakage in a flow rig tester at variable temperatures over 12 months is investigated. Using the Power Law model, our study determined a theoretical O-ring lifetime of 2,647 years, i.e. a semi-permanent lifespan, by confirming the absence of liquid fuel leakage around the O-ring assembled fittings. These results indicate that the FKM O-rings are significantly compatible for fuel tests to evaluate long-term sealing conditions.