• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.930-938
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• 2003

The purpose of the present study was to investigate the effects of Hyunhosaiksan (HHS) on antithrombotic actions which include blood activation, thrombus removal, warming of circulating blood, and the control of pain on abdomen and lower and upper burning spaces. HHS significantly inhibited platelet aggregation induced by ADP and epinephrine in a HHS dose-dependent manner when analyzed by the Sigmoid Emax model in WinNonlin. EC50 values of HHS were 1.71 ㎍/ml and 0.004 ㎍/ml for ADP and epinephrine respectively. In the vivo study, HHS inhibited pulmonary embolism induced by collagen and epinephrine, which was however statistically insignificant. HHS increased number of platelets, APTT and volume of fibrinogen significantly as compared with the control group in dextran-induced thrombus model. Furthermore, HHS stimulated levels of blood flow in vivo though its effect was not observed in vitro. These results suggest that Hyunhosaiksan (HHS) can be used for treating numerous diseases related with blood aggregation and circulation problems. Further systematic investigations on the synergic effects among drugs used in the oriental medicine as well as in the western medicine in relation to thrombosis therapy would provide an important insight into the potential therapeutic applications.

• Korean journal of applied entomology
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• v.51 no.4
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• pp.411-419
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• 2012

The lure-distance of Riptortus pedestris aggregation pheromone was elucidated and the damage mitigation effect by mass trapping of R. pedestris was examined in commercial soybean fields. The recaptured ratio showed that 76.1% of total recaptured individuals were lured within 40 m and 89.0% of total recaptured adults were arrested in the lower 80 m. There is not much difference in the number of recaptured individuals according to the location of installed traps in the experiment. There was linear correlation between the total installed number of traps and the total number of trapped individuals in commercial soybean fields. and the highest yield (261.8 g/10 stems) was investigated in the field that had installed a pheromone trap per $770m^2$. No relationship wasf found between the covered areas of a pheromone trap for mass trapping and yield loss. The ratio of type A seed (healthy) was higher in the field that installed a trap per $385m^2$ and $770m^2$ (around 62%) and type B seed (showing distinct injury marks) was lower in the same fields (around 27%). From this result, we could reduce slightly the damage of soybean seeds by the mass trapping of Riptortus pedestris adults with an aggregation pheromone trap per $385{\sim}770m^2$ area range.

• Journal of Communications and Networks
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• v.6 no.1
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• pp.46-59
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• 2004

In this paper, we present two algorithms for efficiently aggregating link state information needed for quality-of-service (QoS) routing. In these algorithms, each edge node in a group is mapped onto a node of a shufflenet or a node of a de Bruijn graph. By this mapping, the number of links for which state information is maintained becomes aN (a is an integer, N is the number of edge nodes) which is significantly smaller than N2 in the full-mesh approach. Our algorithms also can support asymmetric link state parameters which are common in practice, while many previous algorithms such as the spanning tree approach can be applied only to networks with symmetric link state parameters. Experimental results show that the performance of our shufflenet algorithm is close to that of the full-mesh approach in terms of the accuracy of bandwidth and delay information, with only a much smaller amount of information. On the other hand, although it is not as good as the shufflenet approach, the de Bruijn algorithm also performs far better than the star approach which is one of the most widely accepted schemes. The de Bruijn algorithm needs smaller computational complexity than most previous algorithms for asymmetric networks, including the shufflenet algorithm.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.10 s.340
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• pp.9-16
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• 2005

The growth of the Internet over the last several years has placed a tremendous strain on the high bandwidth Hence, the amount of internet traffic has risen sharply and it has demanded to use the limited resource. MPLS (Multiprotocol Label Switching) is regarded as a core technology for migrating to the next generation Internet. It is important to reduce the number of labels and LSP(Label Switched Path)s for network resource management. In this thesis, we considered an MPLS multicast mechanism in the current Internet. The scalability problem due to lack of labels and multicast property is one of the serious problems in MPLS multicast mechanism, we proposed a Label Aggregation algorithm that the multicast packets on same link in MPLS allocates the same label for the scalability problem. In order to support the proposed algorithm we defined a new LDP(Label Distribution Protocol) multicast field and multicast packet is copied and transmitted for multicast group links of next node in LSR(label Switch Router).

• Journal of Applied Biological Chemistry
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• v.62 no.1
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• pp.93-100
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• 2019

The root of Panax ginseng is used in ethnomedicine throughout eastern Asia and various recent studies have proved that Panax ginseng has inhibitory effects on cardiovascular disease. Each factor causing cardiovascular disease is known to have a very complex process which is achieved by a diverse number of mechanisms. Among these factors, platelets are the most important because they directly participate in thrombogenesis. Therefore, inhibiting the activity of platelets is an essential element for prevention of cardiovascular diseases. Our previous study showed the antiplatelet effects of Korean red ginseng extract and two of its components, ginsenoside Rg3 and ginsenoside Ro. However, the inhibitory mechanism of other ginsenosides remains unclear. Therefore, we investigated the inhibitory mechanism of ginsenoside F4 (G-F4) from Korean red ginseng on the regulation of signaling molecules involved in human platelet aggregation. With the use of G-F4, collagen-induced human platelet aggregation was inhibited in a dose-dependent manner, and it suppressed collagen-induced elevation of $[Ca^{2+}]_i$ mobilization through elevated phosphorylation of inositol 1, 4, 5-triphosphate receptor I ($Ser^{1756}$). In addition, G-F4 inhibited fibrinogen binding to ${\alpha}IIb/{\beta}_3$ during collagen-induced human platelet aggregation. Thus, in the present study, G-F4 showed an inhibitory effect on human platelet activation, suggesting its potential use as a new natural medicine for preventing platelet-mediated cardiovascular diseases.

• Asian Journal of Atmospheric Environment
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• v.9 no.2
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• pp.101-113
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• 2015

Air quality index (AQI) or air pollution index (API) is commonly used to report the level of severity of air pollution to public. A number of methods were developed in the past by various researchers/environmental agencies for determination of AQI or API but there is no universally accepted method exists, which is appropriate for all situations. Different method uses different aggregation function in calculating AQI or API and also considers different types and numbers of pollutants. The intended uses of AQI or API are to identify the poor air quality zones and public reporting for severity of exposure of poor air quality. Most of the AQI or API indices can be broadly classify as single pollutant index or multi-pollutant index with different aggregation method. Every indexing method has its own characteristic strengths and weaknesses that affect its suitability for particular applications. This paper attempt to present a review of all the major air quality indices developed worldwide.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.64-64
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• 2003

In growing number of diseases it has been shown that the aggregation of specific proteins has an important role in the pathogenesis of the disorder. This has been demonstrated in structural detail with the liver cirrhosis of ${\alpha}$$_1$-antitrypsin deficiency, and it is now believed that similar protein aggregation underlies many neurodegenerative disorders such as autosomal dominant Parkinson disease, prion diseases, Alzheimer disease, Huntington disease.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.57-57
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• 2003

In growing number of diseases it has been shown that aggregation of specific proteins has an important role in pathogenesis of the disorder. This has been demonstrated in structural details with the liver cirrhosis of ${\alpha}$$_1$-antitrypsin deficiency, and it is now believed that similar protein aggregation underlies many neurodegenerative disorders such as autosomal dominant Parkinson disease, prion diseases, Alzheimer disease, and Huntington disease. ${\alpha}$$_1$-Antieypsin, a member of serine pretense inhibitor (serpin) family, functions as an inhibitor of neutrophil elastase.

• International Journal of Internet, Broadcasting and Communication
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• v.10 no.2
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• pp.68-73
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• 2018

In recent years, the utilization of the WSN have been rapid. Energy consumption of these networks must be as low as possible. LEACH algorithm is one of the clustering technique. We modify the traditional LEACH algorithm in such way that it will be capable to self-organize large number of nodes and for saving communication resources such as processing time and initiation time. The efficiency of the network highly depends on how the algorithm divides cluster area and selects cluster head. The proposed algorithm can be evaluated through the extensive simulation the result we obtained shows that the life time of a network is increased when energy load is distributed equally among the sensor.

• Korean journal of applied entomology
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• v.44 no.4 s.141
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• pp.265-270
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• 2005

Seasonal occurrence of the stink bug Piezodorus hybneri (Gmelin) (Heteroptera: Penta-tomidae) was monitored at a soybean field and the campus of Gyeongsang National University, Gyeongnam. Korea, in which host plants are less available for the bug with aggregation pheromone traps of Riptortus clavatus Thunberg (Heteroptera: Alydidae) in 2004. At soybean field, P. hybneri began to be attracted to traps from June 28, earlier than flowering stage of soybean plants. Number of P. hybneri attracted increased sharply after October 11. At the campus the bugs were not attracted to traps from March 21 to October 5, but began to be attracted since October 11. Difference in the occurrences in the two sites may suggest that the stink bug immigrates actively into soybean field to find host plant. P. hybneri that had been attracted to traps since October 11 was assumed to be diapausing adults emigrating to hibernation sites. There was no difference between sexes in trap catches. The fact that P. hybneri was attracted from June to late November may suggest that the aggregation pheromone of R. clavatus was attractive to both non-diapausing and diapausing adults of P. hybneri. The aggregation pheromone traps, when baited with 16.7+16.7+16.7 mg or 7+36+7 mg of (E)-2-hexenyl (Z)-3-hexenoate, (E)-2-hexenyl (E)-2-hexenoate, and myristyl isobutyrate, attracted significantly higher number of both sexes of P. hybneri adults than the live male traps baited with ten R. clavatus males and hexane control.