• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.2
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• pp.125-151
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• 2008

Purpose: In this study, we investigated the anti-thrombotic efficacy of "Eungapbang-gagam(EGB)" currently used in clinical treatment of PID Methods: We studied inhibitory effect of platelet cohesion, suppressive effect of GPIIb/IIIa activity, inhibitory effect of $TXB_2$ and $PGE_2$ biosynthesis, and oxidative damage suppression effects of "EGB" in vitro. Also, suppression of pulmonary embolism and changes of related factors in dextran coagulation condition model were studied in vivo. Results: In this study, EGB extract showed dose-dependent inhibitory effect on platelet coagulation induced by ADP, epinephrine, collagen, arachidonic acid. Also it showed dose-dependent inhibition effect on GPIIb/IIIa activities compared to the control group. EGB extract significantly suppressed the decrease of speed of bloodstream caused by blood coagulation in dextran coagulation condition model and increased the number of platelets and amount of fibrinogen, and decreased the APTT in dextran coagulation condition model compared to the control group. EGB extract showed dose-dependent decrease of oxidative damages caused by DPPH and superoxide anion radicals, whereas dose-dependent increase of superoxide dismutase like activity was observed compared to the control group. Conclusion: We confirmed the anti-thrombosis and anti-oxidative efficacy of "Eungapbang-gagam". Various clinical applications of "Eungapbang-gagam" as well as use of data for the construction of EBM is anticipated.

• Journal of Korea Water Resources Association
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• v.48 no.3
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• pp.233-243
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• 2015

The bimodal flocculation of cohesive sediments in water environments describes the aggregation and breakage process developing a bimodal floc size distribution with dense flocculi and floppy flocs. A two class population balance equation (TCPBE) was tested for simulating the bimodal flocculation by a model-data fitting analysis with two sets of experimental data (low and high turbulent flows) from 1-D flocculation-settling column tests. In contrast to the Single-Class PBE (SCPBE), the TCPBE could simulate interactions between flocculi and flocs and the flocculation mechanism by differential settling in a low turbulent flow. Also, the TCPBE could perform the same quality of simulation as the elaborate Multi-Class PBE (MCPBE), with a small number of floc size classes and differential equations. Thus, the TCPBE was proven to be the simplest model that is capable of simulating the bimodal flocculation of cohesive sediments in water environments and water, wastewater treatment systems.

• The KIPS Transactions:PartC
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• v.17C no.1
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• pp.69-80
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• 2010

Wireless sensor networks (WSN) consisting of a large number of sensors aim to gather data in a variety of environments and are being used and applied to many different fields. The sensor nodes composing a sensor network operate on battery of limited power and as a result, high energy efficiency and long network lifetime are major goals of research in the WSN. In this paper we propose a novel tree-based clustering approach for energy efficient wireless sensor networks. The proposed scheme forms the cluster and the nodes in a cluster construct a tree with the root of the cluster-head., The height of the tree is the distance of the member nodes to the cluster-head. Computer simulation shows that the proposed scheme enhances energy efficiency and balances the energy consumption among the nodes, and thus significantly extends the network lifetime compared to the existing schemes such as LEACH, PEGASIS, and TREEPSI.

• Journal of KIISE
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• v.43 no.10
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• pp.1144-1153
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• 2016

Group recommendation analyzes the characteristics and tendency of a group rather than an individual and provides relevant information for the members of the group. Existing group recommendation methods merely consider the average and frequency of a preference. However, if the users' preferences have large deviations, it is difficult to provide satisfactory results for all users in the group, although the average and frequency values are high. To solve these problems, we propose a method that considers not only the average of a preference but also the deviation. The proposed method provides recommendations with high average values and low deviations for the preference, so it reflects the tendency of all group members better than existing group recommendation methods. Through a comparative experiment, we prove that the proposed method has better performance than existing methods, and verify that it has high performance in groups with a large number of members as well as in small groups.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2005.06a
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• pp.230-232
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• 2005

The formation of insoluble aggregation of the recombinant kringle fragment of human apolipoprotein(a), rhLK8, in endoplasmic reticulum was identified as the rate-limiting step in the rhLK8 secretion in Saccharomyces cerevisiae. To analyze the protein secretion pathway, some of yeast genes closely related to protein secretion was rationally selected and their oligomer DNA were arrayed on the chip. The expression profiling of these genes during the induction of rhLK8 in fermentor fed-batch cultures revealed that several foldases including pdi1 gene were up-regulated in the early induction phase, whereas protein transport-related genes were up-regulated in the late induction phase. The coexpression of pdi1 gene increased rhLK8-folding capacity. Hence, the secretion efficiency of rhLK8 in the strain overexpressing pdi1 gene increased by 2-fold comparing in its parental strain. The oligomer DNA chip arrayed with minimum number of the genes selected in this study could be generally applicable to the monitoring system for the heterologous protein secretion and expression in Saccharomyces cerevisiae. With the optimization of fed-batch culture conditions and the alteration of genetic background of host, we obtained extracellular rhLK8 at higher yields than with Pichia pastoris systems, which was a 25-fold increased secretion level of rhLK8 compared to the secretion level at the initiation of this study.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.2 no.1
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• pp.23-35
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• 2008

Mobile IP (MIP) is the solution supporting the mobility of Mobile Nodes (MNs), however, it is known to lack the support for NEtwork MObility (NEMO). NEMO manages situations when an entire network, composed of one or more subnets, dynamically changes its point of attachment to the Internet. NEMO Basic Support (NBS) protocol ensures session continuity for all the nodes in a mobile network, however, there exists a serious pinball routing problem. To overcome this weakness, there are many Route Optimization (RO) solutions such as Bi-directional Tunneling (BT) mechanism, Aggregation and Surrogate (A&S) mechanism, Recursive Approach, etc. The A&S RO mechanism is known to outperform the other RO mechanisms, except for the Binding Update (BU) cost. Although Improved Prefix Delegation (IPD) reduces the cost problem of Prefix Delegation (PD), a well-known A&S protocol, the BU cost problem still presents, especially when a large number of Mobile Routers (MRs) and MNs exist in the environment such as train, bus, ship, or aircraft. In this paper, a solution to reduce the cost of delivering the BU messages is proposed using a multicast mechanism instead of unicasting such as the traditional BU of the RO. The performance of the proposed multicast-based BU scheme is examined with an analytical model which shows that the BU cost enhancement is up to 32.9% over IPDbased, hence, it is feasible to predict that the proposed scheme could benefit in other NEMO RO protocols.

• Korean Journal of Food Science and Technology
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• v.19 no.2
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• pp.89-96
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• 1987

The denaturation mechanism of the protein during heating of myosin and paramyosin extracted from the ordinary muscle of yellowtail (Seriola qrinqueradits) and the adductor muscle of whelk (Neptunea arthritica cuming) were investigated by analyzing the hydrophobicity, solubility, SH group and protein-protein interaction. The free hydrophobic residue of the two proteins were increased by increase of heating temperature up to $65^{\circ}C$ and then decreased for further temperature raise. The protein-protein interaction was proportional to the increment of the free hydrophobic residue. The aggregation of protein was begun from $65^{\circ}C$ with the decrease of the free hydrophobic residues. The results of Arrhenius equation for the data on proteinprotein interaction showed that the denaturation course was made up with multi-steps in the myosin and two-steps in the paramyosin. The number of free hydrophobic residue and SH group, solubility and protein-protein interaction were significantly differed with the denaturation temperature (p<0.01).

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.6 no.3
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• pp.164-179
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• 2001

Spatio-temporal variation in species composition, abundance and distribution of fisheries resources caught by large purse seine off Korea from 1991 to 1994 was analysed. Out of 19 species, Scomber japonicus (54.7%), Sardinops melanostictus (20.4%), Trachurus japonicus (9.1%), and Scomberomorus niphonius (6.2%) were predominated in catch. These 4 pelagic fishes occupied 90% of total catch. Major pelagic fishes caught by large purse seine were dispersed to northward from spring to summer, and migrated to the southern wintering ground during winter. Fishing effort (number of haul) was high in summer, but catch per unit effort showed a peak in winter. The high CPUE in winter seemed to be related to aggregation of the pelagic fish to the wintering ground in the southern sea. After spawning, they were widely dispersed for feeding in warm months.

• The Journal of Korean Medicine
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• v.16 no.2 s.30
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• pp.365-385
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• 1995

In order to prove the antitumor effect of Wekyungtang(WKT) that was originated in Bigeubchunkeumyobang(備急千金要方), Wekyungtang with Houttuyniae Herba(WKT-I) and Wekyungtang with Oldenlandiae diffusae Herba(WKT-II) experimentally, the studies were done, We evaluated the cytotoxic activity against B16- Fo as well as the synergistic effects with anticancer drugs such as cyclophophamide (CPM), cisplatin(CPT) and 5-fluorouracil (5-FU) in vitro and measured body weight, survival time, hematological changes, changes of tissues in G57BL／6 implanted with B16-Fo. The results were obtained as follows: 1. In vitro cytotoxic effect against B16-Fo was shown in all groups as compared with control group, but the concentrations showing inhibitory growth rate below 55% of control was recognized in all concentrations of Wekyungtang(WKT) against B16-Fo and also concentration of $10^4$g／ml above in all group with cyclophophamide (CPM), concentration of $10^3$g／ml in Wekyungtang(WKT-l) with cisplatin(CPT) in synergistic effect, 2. In vivo body and tumor weight were significantly suppressed in all groups as compared with control group 3. The number of platelet, WBC, RBC were significantly increased in all groups, platelet aggregation was significantly increased in WKT-I and WKT-II as compared with control group. 4. In changes of tissues heavy infiltration oh cancer was shown in portal vein, pulmonary tissue, vein, peribronchiole, aveoli, while WKT-I was effective in antihepatic metastasis and WKT-II in pulmonary matastasis. From above results it was concluded that wekyungtang(WKT), wekyungtang with Houttuyniae Herba(WKT-I) and wekyungtang with Oldenlandiae diffusae Herba(WKT -II) had antitumor effect, and also wekyungtang combined with Houttuyniae Herba or Oldenlandiae diffusae Herba were more effective than wekyungtang only and also cyclophophamide (CPM), cisplatin(CPT) showed the more synergistic effect which suggests the necessity of continuous study on the mechanism of antitumor action of Houttuyniae Herba or Oldenlandiae diffusae Herba.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.571-573
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• 2018

Wireless sensor networks have unbalanced energy consumption due to the convergence structure in which data is concentrated to sink nodes. To solve this problem, in the previous research, the relay node was placed between the source node and the sink node to merge the data before being concentrated to the sink node. However, selecting a relay node that does not consider the link quality causes packet loss according to the link quality of the reconfigured routing path. Therefore, in this paper, we propose a link cost calculation method for data reliability in routing path reconfiguration for relay node selection. We propose a link cost estimation formula considering the number of hops and RSSI as the routing metric value and select the RSSI threshold value through the packet transmission experiment between the sensor modules.