• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 학술대회 논문집 정보 및 제어부문
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• pp.466-468
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• 2005

MMORPG enables thousands of players to play in an evolving virtual world at the same time over the internet. So, the load of this kind of games is heavier than that of any other precedents. One of load balancing methods is map-partition to divide the load of entire system which is vulnerable to delay message between clients and servers. In this paper, we propose a game architecture using MigAgent to help migration of player character between field servers and to reduce message traffic between clients and field servers.

• 동의생리병리학회지
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• 제23권6호
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• pp.1423-1430
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• 2009

Rosmarinic acid frequently found as a secondary metabolite in herbs and medicinal plants, has exhibited antimicrobial, antiviral, antioxidative, and anti-inflammatory activities. The proliferation and migration of human aortic smooth muscle cells (HASMC) in response to activation by various stimuli plays a critical role in the initiation and development of atherosclerosis. This study was conducted to examine the effects of Rosmarinic acid on the proliferation and migration of HASMC. Rosmarinic acid suppressed the proliferation of HASMC via induction of the expression of apoptotic proteins including cleaved poly ADP-ribose polymerase (PARP), and caspase-3. Rosmarinic acid decreased anti-apoptotic Bcl-2 and increased pro-apoptotic Bax. Moreover, treatment of rosmarinic acid decreased the G1/S cycle regulation proteins (cyclin D1, cyclin E, CDK2, CDK4 and CDK6) and increased p21, p27 and p53. Rosmarinic acid also blocked HASMC migration via suppression of MMP-9 and MMP-2. Taken together, these results indicate that rosmarinic acid has the potential for use as an anti-atherosclerosis agent.

• 정보처리학회논문지A
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• 제18A권4호
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• pp.159-164
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• 2011

본 논문에서는 다양한 센서 네트워크 응용을 위한 능동적 에이전트 미들웨어를 제안한다. 이를 위하여, 이동 에이전트가 네이밍 에이전트의 네임 스페이스의 메타 테이블로부터 제공되는 이주 대상 센서 노드들을 차례로 방문하여, 사용자 조건, 용도 및 필요에 따른 다양한 능동규칙을 통하여 센서 데이터를 수집 및 전송하며, 임의의 발생 사건들(센서 데이터 값 및 시간 등의 변화)에 상응하는 조치들을 직접 실행할 수 있는 능동규칙 탑재 이동 에이전트를 설계 구현한다. 또한, 기존의 센서 데이터 관련 규칙 및 상황 데이터베이스 시스템과의 연동을 통하여 다양한 능동적 센서 네트워크 응용에의 적용 가능성을 보인다.

• Journal of Microbiology and Biotechnology
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• 제15권3호
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• pp.510-518
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• 2005

In this study, we investigated whether PLGA microspheres in combination with hyaluronic acid (HA) gel have appropriate properties as a bulking agent for urologic injection therapies and whether the implantation of PLGA microspheres and HA gel induces angiogenesis in the newly formed tissues. In order to investigate whether this bulking agent is injectable, this material was injected through 24-gauge needles into the subcutaneous dorsum of the mouse. The bulking agent was easily injected without needle obstruction. Histological analyses of the hybrid tissues at 2 weeks showed that host cells at the surrounding tissues migrated into the spaces between the implanted PLGA microspheres and formed tissue-like structures. An inflammatory response to the implants was mild at 2 weeks and diminished at 8 weeks. Importantly, extensive ingrowth of blood vessels was observed in the hybrid tissues formed by the injection of PLGA microspheres and HA, whereas blood vessels rarely formed in the hybrid tissues formed by the injection of PLGA microspheres only. The implant volume was conserved for almost the entire implantation period. Histological analyses of the distant organs of the bulking agent-implanted animals, such as the lungs, liver, heart, brain, kidney, and spleen, showed no evidence of the injected microsphere migration. These results show that PLGA microspheres in combination with HA possess the appropriate characteristics for a bulking agent for urologic injection therapies and induce extensive blood vessel formation in the hybrid tissues.

• 한국통신학회논문지
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• 제27권7C호
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• pp.696-703
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• 2002

전통적인 지능망 부하제어에서 개별적인 SCP(Service Control Point) 보호가 주요 관점이었다면, 본 논문에서는 지능망 전체 네트워크 자원 활용의 최적화를 통한 부하제어를 주요 관점으로 하였다. 이는 이동 에이전트 기술의 이용으로 가능해 지는데 이동 에이전트는 실행환경이 구현된 모든 시스템으로의 이동이 가능하고 독자적으로 작업 수행이 가능한 소프트웨어이다. 본 논문에서는 이동 에이전트를 이용한 과부하 제어 메커니즘과 이동절차를 제안하였다. 제안한 이동 에이전트를 이용한 과부하 제어 메커니즘은 이동 에이전트를 이용해 서비스 특성에 따른 지능망 과부하를 제어할 수 있고 이동 절차는 지능망 부하 변화에 따른 이동 에이전트의 이동 방법이다. 시뮬레이션결과 제안한 메커니즘은 기존 Call Gapping메커니즘보다 SCP 부하율과 시도 호 실패 수에서 우수한 성능을 보였으며 SCP과부하 시 SS NO.7 네트워크 트래픽의 감소를 가져왔다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권1호
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• pp.123-144
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• 2014

Wireless sensor networks are generally deployed for specific applications to accomplish certain objectives over a period of time. To fulfill these objectives, it is crucial that the sensor network continues to function for a long time, even if some of its nodes become faulty. Energy efficiency and fault tolerance are undoubtedly the most crucial requirements for the design of an information extraction protocol for any sensor network application. However, most existing software agent based information extraction protocols are incapable of satisfying these requirements because of static agent itineraries and large agent sizes. This paper proposes an Information Extraction protocol based on Multiple software Agents with Dynamic Itineraries (IEMADI), where multiple software agents are dispatched in parallel to perform tasks based on the query assigned to them. IEMADI decides the itinerary for an agent dynamically at each hop using local information. Through mathematical analysis and simulation, we compare the performance of IEMADI with a well known static itinerary based protocol with respect to energy consumption and response time. The results show that IEMADI provides better performance than the static itinerary based protocols.

• Journal of Information Processing Systems
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• 제3권2호
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• pp.43-53
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• 2007

The use of agent paradigm in today's applications is hampered by the security concerns of agents and hosts alike. The agents require the presence of a secure and trusted execution environment; while hosts aim at preventing the execution of potentially malicious code. In general, hosts support the migration of agents through the provision of an agent server and managing the activities of arriving agents on the host. Numerous studies have been conducted to address the security concerns present in the mobile agent paradigm with a strong focus on the theoretical aspect of the problem. Various proposals in Intrusion Detection Systems aim at securing hosts in traditional client-server execution environments. The use of such proposals to address the security of agent hosts is not desirable since migrating agents typically execute on hosts as a separate thread of the agent server process. Agent servers are open to the execution of virtually any migrating agent; thus the intent or tasks of such agents cannot be known a priori. It is also conceivable that migrating agents may wish to hide their intentions from agent servers. In light of these observations, this work attempts to bridge the gap from theory to practice by analyzing the security mechanisms available in Aglet. We lay the foundation for implementation of application specific protocols dotted with access control, secured communication and ability to detect tampering of agent data. As agents exists in a distributed environment, our proposal also introduces a novel security framework to address the security concerns of hosts through collaboration and pattern matching even in the presence of differing views of the system. The introduced framework has been implemented on the Aglet platform and evaluated in terms of accuracy, false positive, and false negative rates along with its performance strain on the system.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제13권7호
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• pp.545-549
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• 2007

오늘날 널리 개발되고 있는 생태계 모방형 시스템[1]은 대규모 네트워크 응용 서비스를 위한 효과적인 시스템 모델로 각광 받아왔지만, 이런 모형의 특징인 확장성과 적응성, 생존성 등을 응용에 맞추어서 구현하기 어렵다는 문제점을 가지고 있다. 본 논문에서는 이런 문제점을 해결하기 위하여 에코전트(Ecogent)라는 멀티 지능형 모바일 에이전트와 이런 에코전트가 세가지 생태계 특징을 위한 서비스를 제공하는 플랫폼을 설계하였다. 이 생태계 모델 플랫폼은 두 부분으로 나누어 설계 하였는데, Registration, Life Cycle, Migration, Communication, Location, Fault Tolerance와 같은 모바일 에이전트의 기본 기능들을 제공하는 ERS(Ecogent Runtime Services) 플랫폼과 Evolution & Stigmergy Control의 기능을 통해 진화력과 적응성을 제공하는 BIO 플랫폼으로 나누어 설계 및 구현하였다. 생존력과 자율성을 갖춘 에코전트와 융통성 및 확장성을 위해서 단순하게 모듈화된 플랫폼 구조는 생태계를 모방하는 다양한 시스템 모델 응용들의 개발을 쉽게 구현할 수 있도록 도와준다.

• Biomolecules & Therapeutics
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• 제23권5호
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• pp.434-441
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• 2015

Histone deacetylase (HDAC) inhibitors are considered novel agents for cancer chemotherapy. We previously investigated MHY219, a new HDAC inhibitor, and its potent anticancer activity in human prostate cancer cells. In the present study, we evaluated MHY219 molecular mechanisms involved in the regulation of prostate cancer cell migration. Similar to suberanilohydroxamic acid (SAHA), MHY219 inhibited HDAC1 enzyme activity in a dose-dependent manner. MHY219 cytotoxicity was higher in LNCaP ($IC_{50}=0.67{\mu}M$) than in DU145 cells ($IC_{50}=1.10{\mu}M$) and PC3 cells ($IC_{50}=5.60{\mu}M$) after 48 h of treatment. MHY219 significantly inhibited the HDAC1 protein levels in LNCaP and DU145 cells at high concentrations. However, inhibitory effects of MHY219 on HDAC proteins levels varied based on the cell type. MHY219 significantly inhibited LNCaP and DU145 cells migration by down-regulation of matrix metalloprotease-1 (MMP-1) and MMP-2 and induction of tissue inhibitor of metalloproteinases-1 (TIMP-1). These results suggest that MHY219 may potentially be used as an anticancer agent to block cancer cell migration through the repression of MMP-1 and MMP-2, which is related to the reduction of HDAC1.

• 대한본초학회지
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• 제24권4호
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• pp.77-86
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• 2009

Objectives : The proliferation and migration of human aortic smooth muscle cells (HASMC) in response to activation by various stimuli plays a critical role in the initiation and development of atherosclerosis. This study was conducted to examine the effects of Nelumbo nucifera leaves (NNL) on the proliferation and migration of HASMC. Additionally, the mechanisms involved in any observed effects were also evaluated. Methods : Apoptotic cells were measured by staining with FITC-labeled annexin V, followed by flow cytometric analysis. The expression level of apoptosis related proteins was confirmed by western blot. And MMP-9 activity was measured by gelatin zymography and MMP-9 expression was measured by ELISA Results : NNL completely inhibited the proliferation of HASMC via induction of the expression of apoptotic proteins including annexin V, cleaved poly ADP-ribose polymerase (PARP), and caspase-3 and -8. NNL treatment resulted in the release of cytochrome c into cytosol, a loss of mitochondrial membrane potential, a decrease in Bcl-2 and Bcl-xL and an increase in Bax expression. NNL also blocked HASMC migration via suppression of MMP-9. Conclusions : Taken together, these results indicate that NNL has the potential for use as an anti-artherosclerosis agent.