• 대한임상검사과학회지
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• 제44권3호
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• pp.97-102
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• 2012

This study was performed to investigate the average fasting blood sugar levels from various Homeless and the old at nursing homes. Subjects (297 Homeless and 190 aged people) were examined in April, 2011 to June, 2010 in Daegu city area and only fasting blood sugar was measured. Subjects consist of 274 (56.30%) men and 213 (43.70%) women but primarily comprise over 60s. Blood was collected by vein-puncture, centrifuged and analyzed by TBA-C8000. The number of each subject for blood sugar levels of men groups were shown 197 (40.50%) with under 110, 24 (4.90%) with 110~125, and 53 (10.90%) with over 126. On the other hand, 127 (26.10%) with under 110, 33 (6.80%) with 110~125 and 53 (10.90%) with over 126 from women groups. This means that the average prevalence rate of diabetes is approximately 10% at each sex. Depending on age, the fasting blood sugar level over 126 increased with advancing age but the significance of results was not shown. Two groups, Homeless and aged people at nursing homes, the fasting blood sugar level was alittle high (2.9%) from Homeless but not significant. Regular blood sugar test and HbA1c test for people could be play an important role to prevent diabetic disorders under the government's interest.

• Journal of Medicine and Life Science
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• 제19권3호
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• pp.79-89
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• 2022

Whereas systolic blood pressure (SBP) continuously rises with age, diastolic blood pressure (DBP) gradually decreases after the age of 55 years. Therefore, hypertension in the elderly shows the pattern of isolated systolic hypertension. There is evidence on the benefits of controlling blood pressure (BP) in elderly patients with hypertension. The BP lowering effect has also been demonstrated in patients over 80 years of age with hypertension. The BP threshold for the initiation of antihypertensive drug treatment for older adults with hypertension is gradually decreasing. The antihypertensive treatment is recommended if, despite therapeutic lifestyle modifications, SBP ≥140 mmHg or DBP ≥90 mmHg in those aged 65-79 years old, and SBP ≥140-160 mmHg or DBP ≥90 mmHg in those aged ≥80 years old. Although there is no consensus on the target BP for older adults with hypertension, a target SBP of <130-140 mmHg and DBP of <80-90 mmHg are recommended. In older adults over 80 years of age with hypertension, the target SBP is <140-150 mmHg. When the dose of antihypertensive drugs is increased to reach the target SBP, DBP may decrease to less than 70 mmHg, but it should not be <60 mmHg. Thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers can be selected as the first-line drug for older adults with hypertension. Beta-blockers may be selected in case of compelling indications.

• Journal of Korean Neurosurgical Society
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• 제65권1호
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• pp.123-129
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• 2022

Objective : Chronic subdural hematoma (CSDH) is one of the most common pathology in daily neurosurgical practice and incidence increases with age. The aim of this study was to evaluate the prognostic factors and surgical outcome of CSDH in patients aging over 90 years compared with a control group of patients aging under 90 years. Methods : This study reviewed 25 patients with CSDH aged over 90 years of age treated in our department. This group was compared with a younger group of 25 patients aged below their eighties. At admission past medical history was recorded concerning comorbidities (hypertension, dementia, ictus cerebri, diabetes, and heart failure or attack). History of alcohol abuse, anticoagulant and antiplatelet therapy, head trauma and seizures were analyzed. Standard neurological examination and Markwalder score at admission, 48 hours after surgery and 1-6 months follow-up, radiologic data including location and CSDH maximum thickness were also evaluated. Results : Their mean age was 92.8 years and the median was 92.4 years (range, 90-100 years). In older group, the Markwalder evaluation at one month documented the complete recovery of 24 patients out of 25 without statistical difference with the younger group. This data was confirmed at 6-month follow-up. One patient died from cardiovascular failure 20 days after surgery. The presence of comorbidities, risk factors (antiplatelet therapy, anticoagulant therapy, history of alcohol abuse, and head trauma), preoperative symptoms, mono or bilateral CSDH, maximum thickness of hematoma, surgical time and recurrence were similar and statistically not significant in both groups. Conclusion : In this study, we demonstrate that surgery for very old patients above 90 years of age affected by CSDH is safe and allows complete recovery. Comparing two groups of patients above and under 90 years old we found that complication rate and recovery were similar in both groups.

• Journal of Information Technology Applications and Management
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• 제31권2호
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• pp.1-13
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• 2024

The purpose of this study is to identify the quality of life (QOL) and factors influencing the QOL in middle-aged and elderly cancer patients. Among the 2019 data of the Korea Health Panel, data from 498 adults over the age of 40 who were diagnosed with cancer by doctors were analyzed. As a result of the study, the mean QOL of middle-aged cancer patients was 0.90 (±0.09) and that of elderly cancer patients was 0.86 (±0.12). The QOL of middle-aged cancer patients was significantly higher than that of elderly cancer patients. Factors influencing the QOL of middle-aged cancer patients were subjective health status, anxiety, suicidal ideation, and bedridden status. Factors influencing the QOL of elderly cancer patients were subjective health status, bedridden status, economic activity, education level, regular physical activity, stress, and age. In order to improve the QOL of middle-aged and elderly cancer patients, along with interest in the QOL of middle-aged and elderly cancer patients, it is necessary to develop an age-specific intervention program, such as reducing anxiety and suicidal ideation for middle-aged cancer patients, and improving regular physical activity and reducing stress for elderly cancer patients.

• Journal of Animal Science and Technology
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• 제63권5호
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• pp.984-997
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• 2021

This study sought to evaluate DNA damage and repair in porcine postovulatory aged oocytes. The DNA damage response, which was assessed by H2A.X expression, increased in porcine aged oocytes over time. However, the aged oocytes exhibited a significant decrease in the expression of RAD51, which reflects the DNA damage repair capacity. Further experiments suggested that the DNA repair ability was suppressed by the downregulation of genes involved in the homologous recombination (HR) and nonhomologous end-joining (NHEJ) pathways. The expression levels of the cell cycle checkpoint genes, CHEK1 and CHEK2, were upregulated in porcine aged oocytes in response to induced DNA damage. Immunofluorescence results revealed that the expression level of H3K79me2 was significantly lower in porcine aged oocytes than in control oocytes. In addition, embryo quality was significantly reduced in aged oocytes, as assessed by measuring the cell proliferation capacity. Our results provide evidence that DNA damage is increased and the DNA repair ability is suppressed in porcine aged oocytes. These findings increase our understanding of the events that occur during postovulatory oocyte aging.

• Nutrition Research and Practice
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• 제17권4호
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• pp.747-761
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• 2023

BACKGROUND/OBJECTIVES: In Korea, studies of diet in elementary school children are hindered by the need for a comprehensive dietary assessment tool. Thus, the aim of this study was to develop a semi-quantitative food frequency questionnaire (FFQ) for Korean elementary school children. SUBJECTS/METHODS: The 24-h recall data for 1,624 subjects aged 6-11 yrs from the seventh Korea National Health and Nutrition Examination Survey were used to extract the items included in the questionnaire. The FFQ items were developed by selecting major dishes based on the results of nutritional contribution and between-person variability for energy and 14 nutrients (carbohydrate, protein, fat, crude fiber, calcium, phosphorous, iron, sodium, potassium, vitamin A, thiamin, riboflavin, niacin, and vitamin C). We selected the major dishes with over 90% of the total contribution to each nutrient and with over 90% of the accumulated R² for each nutrient. Among the 452 dishes, we selected 248 dishes contributing more than 1% of the total consumption. RESULTS: Finally, the FFQ included 107 items combined from 248 dishes based on nutrient profile and recipe. The FFQ items accounted for an average of 88.6% of the energy, 14 nutrient intakes, and 91.4% of the between-person variability. Quantities of dietary intake were assessed by 9 categories of frequency and 3 categories of portion size. Percentages of coverage for energy, protein, fat, carbohydrate, and calcium were 90.2%, 87.8%, 89.9%, 90.8%, and 88.7%, respectively. CONCLUSIONS: We developed a dish-based, semi-quantitative FFQ comprising 107 items for Korean elementary school children aged 6 to 11. Further studies are needed to evaluate the reproducibility and validity of this FFQ for elementary school children.

• 한국임상약학회지
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• 제34권2호
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• pp.118-125
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• 2024

Background: Numerous studies have consistently demonstrated that depression can be associated with cognitive function decline, primarily focusing on older adults due to the neurodegenerative characteristics of dementia. With persistent depression frequently reported in patients with early-onset or young-onset dementia, this study aimed to assess the impact of depression, specifically the changes in depressive symptoms over time, on the risk of cognitive function decline in middle-aged adults in Korea. Methods: This retrospective study utilized data from the first four waves (2006-2012) of the Korean Longitudinal Study of Aging (KLoSA), focusing on middle-aged adults with normal cognitive function at baseline. Changes in depressive symptoms were categorized into four groups based on the CES-D score, and their association with cognitive function decline was evaluated using a multivariate logistic regression model. Results: Of the initial 10,254 participants, 3,400 were included in the analysis. Depressive status, particularly newly onset (adjusted odds ratio [aOR] 1.96; 95% confidence interval [CI] 1.32-2.93) and persistent depression groups (aOR 5.59; 95% CI 2.90-10.78), were significantly associated with cognitive function decline. In contrast, recovery from depressive symptoms was not significantly associated with cognitive function decline (p=0.809). Conclusions: Our study showed a significant association between changes in depressive symptoms and cognitive function decline in middle-aged Korean adults. This suggests that management of depressive symptoms could be crucial for the prevention of cognitive function decline in this population.

• 복식문화연구
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• 제24권2호
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• pp.233-247
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• 2016

The purpose of this study is to propose a specialized clothes-sizing system for elderly (aged 60~79) obese women satisfying the following conditions based on the data from the fifth Korean Agency for Technology and Standards (2004): a Rohrer's index of over 1.6, a BMI of over 25, and a WHR of over 0.85. The lower bodies of elderly obese women tends to be shorter and wider than average. Particularly, their torsos from the chest to the waist tend to be more obese than other areas. According to the KS standards, the clothes-sizing system sets up its size intervals as follows: 5cm in stature, 5cm and 3cm in bust, 3cm in waist, and 3cm in hip. Based on the dualistic distribution of each section, the names of the sections indicating high distribution are suggested. For suit tops, 11 sizes are selected as distributed in the 145-155cm stature section and 91-103cm bust section. For casual tops, nine sizes are selected as distributed in the 145-155cm stature section and 90-105cm bust section. For bottoms, 11 sizes are selected as distributed in the 82-97cm waist section and 91-97cm hip section. According to the KS standards, detailed sizes are suggested in the division of basic and reference areas.

• 대한환경공학회지
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• 제27권8호
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• pp.859-869
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• 2005

소각장 off gas에 장기간 노출이 되어 활성이 저하된 상용 $V_2O_5-WO_3/TiO_2$ aged 촉매를 물리화학적 방법으로 재생 처리를 수행한 후, 재생 처리에 따른 촉매의 물성 변화를 확인하고 이에 따른 촉매 활성변화를 고찰하였다. 촉매의 특성분석은 XRD(x-ray diffractometer), BET, POROSIMETER, EDX(energy dispersive x-ray spectrometer), ICP(inductively coupled plasma), TGA(thermogravimetric Analyze,), SEM(scanning electron microscopy)등을 이용하여 수행하였고 NOx 전환반응실험은 소각장 off gas를 모사하여 $NH_3$에 의한 SCR 반응을 통해 수행하였다. 본 연구에서 수행된 재생처리 방법 중, 열처리 방법으로 재생처리를 수행 할 경우 fresh 촉매환성의 95% 이상을 회복하였으며, 화학적 재생 처리 방법으로는 산성용액의 경우는 pH가 5인 용액으로 재생 처리된 촉매가, 염기성 용액의 경우는 pH가 12인 용액으로 재생 처리된 촉매가 fresh 촉매활성의 90% 이상의 촉매 활성을 회복 하였다. 촉매 특성 분석 결과, 상기와 같은 방법으로 재생 처리된 촉매의 경우 비표면적은 fresh 촉매의 $85{\sim}95%$ 수준으로 회복 되었으며, aged 촉매 표면에 축적되어 있던 촉매 비활성 물질로 잘 알려진 황(S)이나 칼슘(Ca)등은 최대 99%이상 제거 되었다. Aged 촉매 표면상의 인(P), 크롬(Cr), 아연(Zn) 등과 같은 중금속의 경우는 최대 95% 이상 제거 되었으나 납(Pb)의 경우는 제거율이 $10{\sim}30%$ 수준으로 매우 미흡한 것으로 나타났다.

• 복식문화연구
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• 제19권5호
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• pp.1009-1018
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• 2011

The purpose of this study was to develop slacks patterns for middle-aged abdomen-obese adult males by using the 3D virtual-twin and virtual-garment simulation system. The criteria for subjects in this study were males who had over $25kg/m^2$ of BMI, over 90cm of waist, and over 0.90 of WHR. A total of 211 adult males who met these criteria were enrolled. The results were as follows: first, a new slacks pattern considerate of abdomen-obese men was development. The basic numerical formula were as follows: front and back hip girth H/4+3.5, front waist girth W/4+1+0.5, back waist girth W/4+1-0.5, front crotch extension H/16, back crotch extension H/8-0.5, front pleats amount 2.7, and back dart amount 1.5. Second, according to the results of the new slacks patterns appearance evaluation, the new slacks pattern scored more highly than the existing pattern in silhouette and ease amount, confirming that the new slacks pattern is appropriate for the abdomen-obese men. Also, the new slacks pattern was evaluated allowing proper space length of waist, abdomen and hip. Virtual models of production through data from a 3D body scan, pattern draft and virtual garment digital program were applied to a prototypic design method in order to enhance the fitness of ready-made garments. The use of the virtual twin made it impossible to comprehend the appearances and ease correspondent to motions. In order to evaluate wearing fitness, therefore, the system should be improved so as to change arm positions and perform various motions.