• 제목/요약/키워드: Age regulation effect

검색결과 121건 처리시간 0.027초

폐식용유 혼입 및 양생방법에 따른 순환잔골재 사용 고로슬래그 벽돌의 품질특성 (Quality Properties of Blast Furnace Slag Brick Using the Recycled Fine Aggregates Depending on Waste Oil and Curing Method)

  • 박경택;손호정;김대건;김복규;한민철;한천구
    • 한국건축시공학회:학술대회논문집
    • /
    • 한국건축시공학회 2011년도 춘계 학술논문 발표대회 1부
    • /
    • pp.61-62
    • /
    • 2011
  • This study reviewed the effect of W/B, WO and curing method on the quality properties of RA using the BS brick under the zero cement condition. compressive strength was found to show an increasing trend as W/B increased, but to show a improvement in case steam curing was conducted, showing a higher increase at 1 day age in comparison with 7 day age. In addition, the compressive strength on the mixing of WO didn't show any specific trend. The absorption tended to decrease as W/B increased and met the less than 10% regulation value at 30~35% W/B in case WO was used, there appeared a decrease attributable to capillary pore filling effect due to saponification. On the other hand, compressive strength increases, th absorption showed a gradually decreasing tendency.

  • PDF

Sirtuin signaling in cellular senescence and aging

  • Lee, Shin-Hae;Lee, Ji-Hyeon;Lee, Hye-Yeon;Min, Kyung-Jin
    • BMB Reports
    • /
    • 제52권1호
    • /
    • pp.24-34
    • /
    • 2019
  • Sirtuin is an essential factor that delays cellular senescence and extends the organismal lifespan through the regulation of diverse cellular processes. Suppression of cellular senescence by Sirtuin is mainly mediated through delaying the age-related telomere attrition, sustaining genome integrity and promotion of DNA damage repair. In addition, Sirtuin modulates the organismal lifespan by interacting with several lifespan regulating signaling pathways including insulin/IGF-1 signaling pathway, AMP-activated protein kinase, and forkhead box O. Although still controversial, it is suggested that the prolongevity effect of Sirtuin is dependent with the level of and with the tissue expression of Sirtuin. Since Sirtuin is also believed to mediate the prolongevity effect of calorie restriction, activators of Sirtuin have attracted the attention of researchers to develop therapeutics for age-related diseases. Resveratrol, a phytochemical rich in the skin of red grapes and wine, has been actively investigated to activate Sirtuin activity with consequent beneficial effects on aging. This article reviews the evidences and controversies regarding the roles of Sirtuin on cellular senescence and lifespan extension, and summarizes the activators of Sirtuin including Sirtuin-activating compounds and compounds that increase the cellular level of nicotinamide dinucleotide.

가족복지조직의 조직문화가 건강가정사의 전문성에 미치는 영향 (The influence of organizational culture of family welfare organization on the professionalism of healthy families specialist)

  • 서종수;조희금
    • 가족자원경영과 정책
    • /
    • 제21권3호
    • /
    • pp.1-21
    • /
    • 2017
  • The purpose of this study was to investigate the effect of organizational culture on professionalism. A survey was conducted with 254 family health specialists from July 30th to September 30th in 2013. The results of this study can be summarized as follows; First, three professionalism factors of healthy family specialists were verified -business administration ability, and general administration ability- and five organizational culture factors of the Family Welfare Organization were verified-group culture, development culture, rational culture, sequence culture, and regulation culture. Second, the professionalism scores for healthy family specialists were 3.41 for business practice ability, 3.43 for business administration ability, and 3.18 for general administration. The organizational culture scores for the family welfare organization were 4.08 for group culture, 3.80 for development culture, 3.67 for rational culture, 3.50 for regulation culture,and 3.06 for sequence culture. Third, Rational culture, age, gender, and education level all affected to business practice ability. Position and education level both affected to business administration ability. Monthly income, gender, and education level all affected to general administration ability. This study showed the need for increased management of organizational culture to improve the professionalism of healthy family specialists.

Intravenous Toxicity Study of Water-soluble Ginseng Pharmacopuncture in SD Rats

  • Yu, Jun-Sang;Sun, Seung-Ho;Lee, Kwang-Ho;Kwon, Ki-Rok
    • 대한약침학회지
    • /
    • 제18권4호
    • /
    • pp.38-44
    • /
    • 2015
  • Objectives: Radix Ginseng has been used for thousands of years to treat a wide variety of diseases. Radix ginseng has also been used as a traditional medicine for boosting Qi energy and tonifying the spleen and lungs. Traditionally, its effect could be obtained orally. Nowadays, a new method, the injection of herbal medicine, is being used. This study was performed to investigate the single-dose intravenous toxicity of water-soluble ginseng pharmacopuncture (WSGP) in Sprague-Dawley (SD) rats. Methods: All experiments were carried out at Biotoxtech, an institute authorized to perform non-clinical studies under the regulation of Good Laboratory Practice (GLP). At the age of six weeks, 40 SD rats, 20 male rats and 20 female rats, were allocated into one of 4 groups according to the dosages they would receive. The WSGP was prepared in the Korean Pharmacopuncture Institute under the regulation of Korea-Good Manufacturing Practice (K-GMP). Dosages of WSGP were 0.1, 0.5 and 1.0 mL/animal for the experimental groups, and normal saline was administered to the control group. The rat's general conditions and body weights, the results of their hematological and biochemistry tests, and their necropsy and histopathological findings were investigated to identify the toxicological effect of WSGP injected intravenously. The effect was examined for 14 days after the WSGP injection. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech. Results: No deaths were found in this single-dose toxicity test on the intravenous injection of WSGP, and no significant changes in the rat's general conditions and body weights, the results on their hematological and biochemistry test, and their necropsy findings were observed during the test. The local area of the injection site showed minial change. The lethal dose was assumed to be over 1.0 mL/animal in both sexes. Conclusion: These results indicate that WSGP is safe at dosages up to 1 mL/animal.

Effect of Majoon Idraare Haiz in Polycystic Ovarian Syndrome - A pilot study

  • Firdose, Kouser fathima;Begum, Wajeeha
    • 셀메드
    • /
    • 제12권1호
    • /
    • pp.3.1-3.7
    • /
    • 2022
  • Background & Objectives: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine abnormality in women of reproductive age affecting from 4% - 21% of the reproductive women and is characterized by chronic anovulation and hyperandrogenism. The aim of the study was to evaluate the effect of majoon idraare haiz in menstrual regulation and morphological changes in ovaries in poly cystic ovarian syndrome. Methods: A Pilot study was carried out in the department of Ilmul qabalat wa amraze niswan, National institute of unani medicine, hospital, Bengaluru. Fifteen Patients of PCOS aged 18-35 diagnosed using Rotterdam criteria were included in the study. Patients with insulin sensitizing treatment within 3 months, hormonal treatment and those with h/o diabetes mellitus, hypertension, pregnant and lactating women were excluded.Majoon idraare haiz was administered orally at a dose of 10 g with 20 ml arqbed mushk once daily from fifth day of cycle for 21 days for three consecutive cycles. Primary outcome measure was menstrual regularity while changes in USG pelvis(normal ovarian morphology) was considered as secondary outcome measure. In addition, duration of flow and changes in basal metabolic index (BMI), modified Ferriman Gallwey (mFG) score, acanthosis nigricanswere observed. Data were analyzed using, ANOVA, paired student 't' test, fisher exact test. Results: Changes in duration of cycle, duration and amount of flow was achieved in 93.3% patients with p<0.0001 and 46.6% patients showed normal findings on pelvic ultrasonography with p=0.006. In addition, significant changes were also observed in BMI, hirsutism and acanthosis nigricans with p value of 0.0001, p=0.003 and p=0.009 respectively Conclusion: Majoonidraare haiz can be used as an effective alternative in management of PCOS patients. It has significant effect on menstrual regulation and changes in polycystic ovarian morphology to normal.

Effects of enzymolysis and fermentation of Chinese herbal medicines on serum component, egg production, and hormone receptor expression in laying hens

  • Mei Hong Jiang;Tao Zhang;Qing Ming Wang;Jin Shan Ge;Lu Lu Sun;Meng Qi Li;Qi Yuan Miao;Yuan Zhao Zhu
    • Animal Bioscience
    • /
    • 제37권1호
    • /
    • pp.95-104
    • /
    • 2024
  • Objective: In the present study, we aimed to investigate the effects of enzymolysis fermentation of Chinese herbal medicines (CHMs) on egg production performance, egg quality, lipid metabolism, serum reproductive hormone levels, and the mRNA expression of the ovarian hormone receptor of laying hens in the late-laying stage. Methods: A total of 360 Hy-Line Brown laying hens (age, 390 days) were randomly categorized into four groups. Hens in the control (C) group were fed a basic diet devoid of CHMs, the crushed CHM (CT), fermented CHM (FC), and enzymatically fermented CHM (EFT) groups received diets containing 2% crushed CHM, 2% fermented CHM, and 2% enzymatically fermented CHM, respectively. Results: Compared with crushed CHM, the acid detergent fiber, total flavonoids, and total saponins contents of fermented CHM showed improvement (p<0.05); furthermore, the neutral and acid detergent fiber, total flavonoids, and total saponins contents of enzymatically fermented CHM improved (p<0.05). At 5 to 8 weeks, hens in the FC and EFT groups showed increased laying rates, haugh unit, albumin height, yolk color, shell thickness, and shell strength compared with those in the C group (p<0.05). Compared with the FC group, the laying rate, albumin height, and Shell thickness in the EFT group was increased (p<0.05). Compared with the C, CT, and FC groups, the EFT group showed reduced serum total cholesterol and increased serum luteinizing hormone levels and mRNA expressions of follicle stimulating hormone receptor and luteinizing hormone receptor (p<0.05). Conclusion: These results indicated that the ETF group improved the laying rate and egg quality and regulated the lipid metabolism in aged hens. The mechanism underlying this effect was likely related to cell wall degradation of CHM and increased serum levels of luteinizing hormone and mRNA expression of the ovarian hormone receptor.

Study on the Effect of Film Therapy on the Frustration Affordability of College Students in Northeast China : based on film industry aesthetics in the age of IT

  • Du, Nan;Yu, Chuandong;Kim, Chee-Yong
    • Journal of Multimedia Information System
    • /
    • 제7권2호
    • /
    • pp.157-164
    • /
    • 2020
  • Considering the frustration affordability level of college entrants and investigating the frustration tolerance of undergraduates in Shenyang City University, this paper provides the basis for the research of improving frustration tolerance of undergraduates through quantitative research results and applies film therapy to the frustration regulation of college students by discussing the role of film therapy in improving frustration affordability ability of college entrants. This paper has concluded that the necessary of improving the frustration tolerance of college students in Northeast China and the feasibility of the film therapy programs on improving the frustration tolerance of college students in Northeast China. Meanwhile, this paper shows that the principle of film selection in film therapy should be based on the requirements of the aesthetics of the film industry in the IT environment. This paper provides a reference for refining the target of film therapy for film therapists to better apply film and television psychotherapy technology, and a basis for the film therapy activity program; Furthermore, it also has a certain reference significance for film and television media workers.

Factors Affecting Consumer Intention on QR Payment of Mobile Banking: A Case Study in Indonesia

  • KOSIM, Krisananda Putera;LEGOWO, Nilo
    • The Journal of Asian Finance, Economics and Business
    • /
    • 제8권5호
    • /
    • pp.391-401
    • /
    • 2021
  • Technological developments facilitate payment transactions. In 2020, Bank Indonesia issued a regulation that supports QR payments using the Indonesian Standard Quick Response Code (QRIS). PT ABC is one of the banks that launched a QR payment feature on mobile banking with QRIS standards to make it easier for customers to make payment transactions at various merchants. In its implementation, the interest of QR payment users still tends to be small, so an analysis of the interests of QR payment users is carried out. The purpose of this study is to analyze the factors that influence user interest by using a modified UTAUT model. The UTAUT model was modified by adding variables to perceived trust, perceived risk, perceived regulatory support, and promotional benefits. The population taken is the company's customers in the DKI Jakarta area and it takes 403 samples for this case study. The results of empirical analysis show that 8 out of 12 hypotheses are considered proven where business expectations, social influence, perceived trust, perceived risk, perceptions of regulatory support, promotion benefits, age-moderated performance expectations, and age-moderate effort expectations have a significant effect on behavioral intentions, while performance expectations, facilitation conditions, business expectations are moderated by experience and social influence.

한국의 도덕 가치관이 게이머 호감에 미치는 영향에 대한 분석: 세대의 매개효과를 중심으로 (An Analysis on the Effect of the Korean Moral Values on Fondness for Game Users: Focusing on the Mediating Effect of Generation)

  • 박현아;유승호
    • 한국콘텐츠학회논문지
    • /
    • 제18권6호
    • /
    • pp.294-302
    • /
    • 2018
  • 한국 정부의 게임 산업 규제는 부모 세대가 자녀의 게임 행위를 규제하는 것과 밀접한 관련이 있다. 이것은 부모와 자녀 간에 디지털 문화 경험의 차이가 존재하기 때문이다. 이 연구는 도덕적 가치가 게임 사용자의 자각 또는 인식에 어떻게 영향을 미치는지에 대한 차이점을 살펴보았다. 연구 결과에서 규범 순응은 게이머에 대한 인식에 부정적인 영향을 미치는 것으로 나타났다. 연령 또한 게이머들에 대한 인식에 부정적인 영향을 미쳤다. 이러한 결과를 바탕으로 우리는 또한 연령의 중재 효과가 게임 이용자에 대한 규범 순응과 게이머에 대한 인식의 관계와 관련하여 발견된다는 것을 확인했다. 결론적으로 이 연구는 한국의 게임 산업 진흥 정책은 목표를 모든 사람에게 초점을 맞추는 것에서부터 고 연령층에게 맞추는 것으로 전환해야한다고 제안한다.

교토의정서체제에서의 환경세정책이 무역경쟁력에 미치는 영향에 대한 연구 (A Study on the Effect of Environmental Tax Policy on Trade Competitiveness in Kyoto Protocol Age)

  • 권오성
    • 환경정책연구
    • /
    • 제8권2호
    • /
    • pp.145-164
    • /
    • 2009
  • 환경세를 비롯한 경제적 유인수단이 직접규제 방식의 환경정책수단보다 비용 효율적이고 오염저감기술개발의 유인을 제공하는 장점이 있기 때문에 우리나라에서도 1990년대 들어서부터 환경세 도입 및 환경친화적 세제개편에 대한 논의가 활발하게 진행되고 있다. 그러나 환경세가 무역경쟁력에 미치는 부정적 영향에 대한 우려가 현실적으로 환경친화적 세제개편을 단행하기 어려운 장애요인으로 작용하고 있다. 따라서 환경세의 부정적인 파급효과를 최소화하기 위하여 환경세의 도입은 철저하고 신중한 사전 준비를 통하여 이루어져야 하는데, 본고에서는 이에 대한 기초연구로서 환경과 무역을 연계한 국제적 논의의 추세와 국내외 선행연구를 개관하고, 환경세가 무역에 미치는 영향에 대한 이론분석결과를 제시하였다. 환경세가 무역에 미치는 영향에 있어서는 다른 나라보다 높은 환경세를 부과하는 경우, 오염유발산업보다 친환경적인 산업이 무역에 있어서 가격경쟁력이 있다는 결과를 도출하였다. 이는 환경세를 도입하는 경우 친환경적인 산업에 경쟁력 인센티브를 제공하여 중장기적으로 오염저감기술을 개발하는 긍정적인 효과를 기대할 수 있으며, 정부의 입장에서는 환경친화적인 산업 등을 육성, 지원하는 것이 환경개선과 동시에 무역부문에서의 국제경쟁력을 제고시키는 정책방향임을 시사한다.

  • PDF