• Clinical and Experimental Reproductive Medicine
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• v.38 no.4
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• pp.210-215
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• 2011

Objective: This study was performed to identify whether growth and differentiation factor-9 (GDF-9) and transforming growth factor-${\beta}1$ (TGF-${\beta}1$) expressions would be lower in the follicular fluid (FF) of those over age 35 who underwent IVF than under age 35. Methods: A total of 24 IVF cycles (20 patients) were included in this study. All of patients were stimulated for IVF by the GnRH short protocol and divided into two groups for analysis, according to their age: <35 group (14 cycles, 11 patients) vs. ${\geq}35$ group (10 cycles, 9 patients). The expression levels of GDF-9 and TGF-${\beta}1$ were determined by western blotting and quantitative enzyme-linked immunosorbent assay. Results: The numbers of retrieved oocytes and metaphase II oocytes were significantly lower in the ${\geq}35$ group. Lower expression of GDF-9 and TGF-${\beta}1$ by western blotting in the ${\geq}35$ group were observed as well. The mean GDF-9 and TGF-${\beta}1$ levels by enzyme-linked immunosorbent assay were lower in the ${\geq}35$ group. The values were $6,850.5{\pm}928.4$ ng/L vs. $3,333.3{\pm}1,089.2$ ng/L of GDF-9 ($p$ <0.05) and $3,844.1{\pm}571.1$ ng/L vs. $2,187.7{\pm}754.0$ ng/L of TGF-${\beta}1$ ($p$ <0.05). A negative correlation between GDF-9 and age was observed (r=-0.546, $p$=0.006). Conclusion: GDF-9 and TGF-${\beta}1$ production from stimulated ovaries during IVF appears to decrease with age.

• The Journal of Korean Physical Therapy
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• v.6 no.1
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• pp.75-84
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• 1994

This study was carried out to know correlation between age and balance performance. factors to effect on balance and prepare the basic data in balance performance evaluation clinically. 180 adults without neurosurgical and orthopedic disability from 20 to 79 years of age participated in this study voluntarily. The subjects performed One Legged Stance Test in five conditions 1) eye open 2) eye close 3) eye open & ear close 4) eye & ear close 5) on sponge. The results of this study were as follows : 1. The mean balance performance time by one legged stance test was 25.97 seconds in eye open, 10.45 seconds in eye close, 23.14 seconds in eye open & ear close, 10.18 seconds in eye & ear close and 23.15 seconds in on sponge. 2. The balance performance declined according to age increasing. 3. The visual factor effected on balance performance greatly. 4. The auditory factor effected less than visual factor on balance performance 5. The compliant surface effected on balance performance in over-fifty age group greatly.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.193-201
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• 2018

Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner. AGE-induced CTGF expression was mediated via ERK1/2, JNK, and Egr-1 pathways, but not p38; consequently, cell proliferation and migration and ECM accumulation were regulated by CTGF signaling pathway. AGE-stimulated VSMC proliferation, migration, and ECM accumulation were blocked by fluvastatin. However, the inhibitory effect of fluvastatin was restored by administration of CTGF recombinant protein. AGE-induced VSMC proliferation was dependent on cell cycle arrest, thereby increasing G1/G0 phase. Fluvastatin repressed cell cycle regulatory genes cyclin D1 and Cdk4 and augmented cyclin-dependent kinase inhibitors p27 and p21 in AGE-induced VSMCs. Taken together, fluvastatin suppressed AGE-induced VSMC proliferation, migration, and ECM accumulation by targeting CTGF signaling mechanism. These findings might be evidence for CTGF as a potential therapeutic target in diabetic vasculature complication.

• Journal of the Korean Society of Costume
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• v.52 no.2
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• pp.115-124
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• 2002

The purposes of this study were to classify somatotype was obtained from the factor scores of the upper half of bodies and analyze the Somatometric characteristics. The sample group (hereinafter referred to as "1st age group") was drawn from bays at the ages 7 to 8 living in Pusan and Kyungsangnam-do. Data from each boy comprised 36 anthropometric measurements and 7 photographic measurements. The study reached following conclusions. 1. According to the analysis to draw Somatometric factors by the 1st age group, seven indicative factors were obtained from measurements of the upper half of bodies. The most significant factor "sectional size" and the second most significant factor "longitudinal size" characterized most aspects of body shape of boys at the ages 7 to 8. 2. According to the analysis of Somatometric characteristics by the upper half of bodies, the 1st age group was categorized into three types : Boys in type 1 had highest stature, biggest frame, broadest shoulders, most protruded chest and shoulder blades and flattest belly : boys in type 2 had shortest stature, smallest frame, sloping shoulders and most protruded belly boys in type 3 had quite high stature and his other measurements were close to the averages of this age group.he averages of this age group.

• Journal of the Korean Society of Clothing and Textiles
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• v.28 no.11
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• pp.1361-1371
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• 2004

This was a follow-up study to the 'Study on the Body Types of Chinese Adult Women I,' which looked into the body types and classified them into representative body type groups, with the subjects of the women residing in Beijing and Shanghai, and it intends to compare the features of the body types by the residential area of each age range. The results were as follows: 1. The measurements physical items of the women residing in Beijing and Shanghai were compared by the age range, and differences were found in all age ranges. In particular, as the age ranges got higher, the differences in the physical measurements were significant. 2. The comparison of the factor score for the women residing in Beijing and Shanghai by the age range indicated the differences in all the age ranges, and the differences were larger as the age got higher. 3. The comparison of the type distribution for the women residing in Beijing and Shanghai by the age range indicated the differences in their 30's and 40's, while any differences in the type distribution were not found in their 20's.

• Biomedical Science Letters
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• v.13 no.3
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• pp.183-187
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• 2007

Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) playa key role in development of atherosclerosis. To take into account the atherogenic properties of MCP-1 and IL-8 and its influence on insulin resistance, we examined circulating levels of MCP-1 and IL-8 in adults. We recruited 292 subjects (84 males and 208 females) aged between 29 and 79 years. MCP-1 and IL-8 levels were measured by enzyme-linked immunosorbent assay. Age, total cholesterol, HDL-cholesterol, and LDL-cholesterol levels were significantly higher in female subjects (P<0.01, respectively), but diastolic blood pressure (BP) was significantly lower in female subjects compared to male subjects. MCP-1 and IL-8 levels were tended to increase with age, the highest in their seventies. MCP-1 (P=0.05) and IL-8 (P<0.01) levels were higher in males than in females. MCP-1 was positively correlated with age (r=0.17, P<0.05), IL-8 (r=0.26, P<0.01), fasting insulin (r=0.30, P<0.01), and HOMA-IR (r=0.29, P<0.01). In linear regression analysis, age was found to be independent factor associated with MCP-1 adjusted by age, BMI, fasting glucose, triglyceride, and systolic BP. In conclusion, age was found to be independent factor associated with MCP-1. It is possible that an increase of MCP-1 in adults with age may be risk to atherosclerosis and diabetic properties.

• Journal of the Korean housing association
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• v.14 no.4
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• pp.49-56
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• 2003

The object of this study is to analyze the influential factors of characteristics of residential locations by age, and to offer a groundwork that can be utilized to direct setting of residential development and housing policies. The main findings are drawn as follows: First, it determines the age groupings which can describe the distribution pattern of residential location, which is broken down into two social subgroups - the older group aged 50 and over, and the younger group, being our educational target. Second, actuality of our education is to influence residential location. Third, four groups that can describe residential location are abstracted. Fourth, the prime of manhood and old age prime of life have been superior within inner zone, while middle age and those who are obliged to support the older group have been superior around the outer zone.

• Journal of the Korean Home Economics Association
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• v.31 no.4
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• pp.141-155
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• 1993

The purpose of this study is to investigate Korean youth's motivations for parenthood and concepts of parental role and to examine closely the relationship with the sociodemographic variables(age, sex, religious orientation, growth region, father's occupational level, parental education degree). the subjects are 465 students of the three universities in National Capital region. The data are collected by questionnair methods and analyzed by t-test, F-test, factor analysis. The major findings are as follows: 1) The motivations for parenthood are classified into five factors. These are acquisition of social status factor, continuation of self factor, achevement and creativity factor, tradition factor, primary group ties factor. The korean youth think the most of achievement and creativity factor among five motivation factors. 2) The korean students have somewhat stereo-typed concepts of parental role and place the stress on training the behaviors of the child and encouraging the development of the child. 3) The sociodemographic variables to have relationship with the motivations for parenthood are age, sex, growth region and father and mother's educational degrees. And the variables related with the concepts of parental role are sex, father's occupational level. 4) There are relationships between traditional role concepts of a father and motivation of acquisition of social status factor and tradition factor. And traditional role concepts of a mother are related with motivations of acquisition of social status factor and primary group ties factor among the motivations for parenthood.

• Journal of Fashion Business
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• v.26 no.1
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• pp.30-40
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• 2022

This study aims to provide basic information on the changes in lower body measurements and shapes of women in their 20s for developing better fitting slacks patterns and a more applicable sizing system that can be widely utilized for women of all ages. Factor and cluster analysis were performed on 1,360 women's direct measurement data within the age group from the 5^th (2004) and 7^th (2015) Korean Human Body Measurement Investigation. The factor analysis identified four factors and explained 82.54% of the total variance; Factor 1, horizontal measurements of lower body; Factor 2, vertical lengths of lower body; Factor 3, measurements of leg and hip areas; Factor 4, lengths of hip and crotch areas. The cluster analysis categorized the lower body shapes of each age group into four shapes; Shape 1, a petite lower body with short legs; Shape 2, a long lower body with medium built; Shape 3, an obese abdomen and legs; Shape 4, a short and slim lower body. Shape 4 (36.5%), Shape 2 (31.2%), Shape 1 (27.8%), and Shape 3 (4.5%) were placed in the order of frequency from the highest to lowest among all the age groups. The findings of this study showed gradual changes in the lower body measurements and shapes of women in their 20s and relevant physical features of each age group. They can be utilized for developing women's slacks patterns with better fitting and more comfort.

• The Korean Journal of Food And Nutrition
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• v.30 no.2
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• pp.345-355
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• 2017

The purpose of this study is to provide basic data for the development direction and strategy for medicines through analysis of differences in choice attributes according to customers awareness of medicines and experience. In order to achieve the purpose of this study, a questionnaire survey was conducted on dietary education among national network trainees and lecturers by the Ministry of Food, Agriculture, Forestry and Livestock in Daegu, Gyeongsan, and Ulsan, Seoul from December 5, 2016, respectively. First, factor analysis results showed that six factors were extracted with respect to the choice of the restaurant. Second, the difference in each factor according to the recognition and experience of medicinal herbs was the health related factor as sex, females, age 50~59 years, companion others, and publicity and advertising' factors were more important for publicity and advertisement when the gender was female, the customer's age was 40~49 years, the companion was other, and the time of use was during the weekend. Among the factors related to 'getting dressed', the more important gender was female, age 40~49 years, and the other partner, The factors related to 'time' were as follows: sex, age, age 20~29 years, no accompanying companions, no time of use, and time importance. The 'menu' factors were more important for men, gender, women, age 40~49 years, companion for guitar, and usage time for weekend dinner. The 'service' factors were more important in 'service' as sex, male age, age 20~29, companion family, usage time, and weekend dinner.