• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2285-2289
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• 2016

Background: Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is an entity introduced in the latest WHO classification of lymphoid tumors and defined in patients older than 50 years without prior lymphoma or immunodeficiency. However, recently it has also been seen in patients under 50. There is thus debate as to whether these are separate entities. Materials and Methods: In this retrospective study, we analyzed de novo DLBCL admitted to our institute over a period of two years. Clinical data included age, sex, nodal and extranodal presentation. The results of an immunohistochemistry (IHC) panel were also reviewed. IHC findings were mainly used to sub-classify DLBCL as germinal center vs. non germinal center types. IHC for identification of LMP-1 (latent membrane protein) and in situ hybridization for detection of EBV-encoded RNA (EBER) was performed. EBV prevalence, clinical data and IHC findings were compared between patients under and over 50 years of age. Results: Out of 95 DLBCL, 11.6% were EBV positive (7.5% and 14.5% in the young and old groups). We did not find any significant differences in IHC subclasses and clinical data between EBV positive DLBCL (EBV+DLBCL) of young and old groups. Conclusions: EBV+DLBCL are not exclusive to patients older than 50 years. With regard to clinical data as well as IHC subclasses, no differences were evident between EBV+DLBCL of young and old groups. Our suggestion is to eliminate any cut off age for EBV+DLBCL.

• 대한지역사회영양학회지
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• 제6권3호
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• pp.290-296
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• 2001

This study investigated the intake of alcoholic and non-alcoholic beverages in college students. Five hundred and eighty seven students age 19-30 (432 male and 155 female) responded to the beverage consumption survey. Of the students 19.9% were freshman, 42.2% sophomore, 23% junior, and 15% seniors. Results are summarized as follows : 1) Beer and soju were the most commonly consumed alcoholic beverages by the college students. The amount of beverage normally consumed was 3 cans of beer or 1 bottle of soju. 2) There was no age related change in amount of alcoholic beverage consumed, but preference for liquor rather than beer increased with age. 3) Foods most commonly consumed prior to drinking were cooked rice and milk. 4) Following the drinking of alcoholic beverages the most commonly consumed food or beverage was cold water for both males and females. The next most commonly foods were cooked rice, instant noodles, and cola for males ; and cooked rice, milk, and fruit for females. 5) Cola and pear juice were the preferred non-alcoholic beverages for college students. Also popular among students were date juice for males and orange juice for females. Milk and non-cola carbonated beverages were not commonly consumed. This study provides information for the identification of possible alcoholic beverage related public health risks among college students.

• 대한의용생체공학회:의공학회지
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• 제39권2호
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• pp.63-68
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• 2018

In modern society, speech recognition technology is emerging as an important technology for identification in electronic commerce, forensics, law enforcement, and other systems. In this study, we aim to develop an age classification algorithm for extracting only MFCC(Mel Frequency Cepstral Coefficient) expressing the characteristics of speech in Korean and applying it to deep learning technology. The algorithm for extracting the 13th order MFCC from Korean data and constructing a data set, and using the artificial intelligence algorithm, deep artificial neural network, to classify males in their 20s, 30s, and 50s, and females in their 20s, 40s, and 50s. finally, our model confirmed the classification accuracy of 78.6% and 71.9% for males and females, respectively.

• Natural Product Sciences
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• 제23권4호
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• pp.274-280
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• 2017

In a search for novel treatments for diabetic complications from natural resources, we found that the ethyl acetate-soluble fraction from the 80% ethanol extract of the leaves of Homonoia riparia has a considerable inhibitory effect on advanced glycation end product (AGE) formation. Bioassay-guided isolation of this fraction resulted in identification of 15 phenolic compounds (1 - 15). These compounds were evaluated in vitro for inhibitory activity against the formation of AGE. The majority of tested compounds, excluding ethyl gallate (15), markedly inhibited AGE formation, with $IC_{50}$ values of $2.2-89.9{\mu}M$, compared with that of the positive control, aminoguanidine ($IC_{50}=962.3{\mu}M$). In addition, the effects of active isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish was investigated; (-)-epigallocatechin-3-O-gallate (6), corilagin (7), and desmanthine-2 (11) significantly decreased HG-induced dilation of hyaloid-retinal vessels compared with the HG-treated control group.

• 말소리와 음성과학
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• 제9권2호
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• pp.9-22
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• 2017

The purpose of this paper is to report the whole process of developing Korean Standard Speech Database (KSS DB). This project is supported by SPO (Supreme Prosecutors' Office) research grant for three years from 2014 to 2016. KSS DB is designed to provide speech data for acoustic-phonetic and phonological studies and speaker recognition system. For the samples to represent the spoken Korean, sociolinguistic factors, such as region (9 regional dialects), age (5 age groups over 20) and gender (male and female) were considered. The goal of the project is to collect over 3,000 male and female speakers of nine regional dialects and five age groups employing direct and indirect methods. Speech samples of 3,191 speakers (2,829 speakers and 362 speakers using direct and indirect methods, respectively) are collected and databased. KSS DB designs to collect read and spontaneous speech samples from each speaker carrying out 5 speech tasks: three (pseudo-)spontaneous speech tasks (producing prolonged simple vowels, 28 blanked sentences and spontaneous talk) and two read speech tasks (reading 55 phonetically and phonologically rich sentences and reading three short passages). KSS DB includes a 16-bit, 44.1kHz speech waveform file and a orthographic file for each speech task.

• 한국제4기학회지
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• 제18권2호통권23호
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• pp.3-3
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• 2004

One short core with length of 146cm(HB-107, at coordinates of $N51^{\circ}$11'37.5";$E100^{\circ}$24'45.6", from 229m water depth was subject of the present study. The sub-samples of the core were analyzed for the water contents (WC%), biogenic silica, identification of the main phases, grain size distribution, geochemistry and some physical properties of sediment(Wet density and Magnetic susceptibility) with aims of recording palaeo-environmental changes in Northem Mongolia. The evaluation of the geochemical and mineralogical proxies on palaeo-climated and palaeo-environmental changes are based on comparison to the behvior of biogenic silica through core, as later one had been showed itself, as good indicator of the climate and environmental fluctuation. Age model of the investigating core based on previously C 14 dated core HB105 taken from the central part of the Hobsgol Lake and the result had been published elsewhere. The core consists of two litological varieties : upper diatomaceous silt, lower clay. According to the age model the upper diatomaceous silt formed during the Holocene, lower caly-during the late Pleistocene glacial period. The geochemistry and phase identification analysis on the core samples are resulted in determining main minerals that form the bottom sediments and their geochemistry. The main include quartz, felspar, muscovite, clinochlore, amphibole and carbonate phase(dolomite and calcite). Through the core not only occur the relative quantitative changes of the main phases, but also happen that the carbonate phase completely disappear in diatomaceous silt. This is believed to be related to the lake water salinity changes, which occurred during the trassition period from Pleistocene glacial-to the Holocene interglacial. These abrupt changes of the mineralogy have been clearly traced in geochemistry of sediments, specially in calcium concentration, which is high in lower clay and low in upper diatomaceous silt. That means, geochemistry and mineralogy of the bottom sediments can be used as proxy data on palaeo-climate and palaeo-environmental changes.

• Clinical and Experimental Pediatrics
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• 제61권6호
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• pp.180-186
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• 2018

Purpose: Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children. Methods: Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013 and December 2015. Viral epidemiology and clinical profiles of single virus infections were evaluated. Results: Of 3,505 patients, viruses were identified in 2,424 (69.1%), with the assay revealing a single virus in 1,747 cases (49.8%). While major pathogens in single virus-positive cases differed according to age, human rhinovirus (hRV) was common in patients of all ages. Respiratory syncytial virus (RSV), influenza virus (IF), and human metapneumovirus (hMPV) were found to be seasonal pathogens, appearing from fall through winter and spring, whereas hRV and adenovirus (AdV) were detected in every season. Patients with ARIs caused by RSV and hRV were frequently afebrile and more commonly had wheezing compared with patients with other viral ARIs. Neutrophil-dominant inflammation was observed in ARIs caused by IF, AdV, and hRV, whereas lymphocyte-dominant inflammation was observed with RSV A, parainfluenza virus, and hMPV. Monocytosis was common with RSV and AdV, whereas eosinophilia was observed with hRV. Conclusion: In combination with viral identification, recognition of virus-specific clinical and laboratory patterns will expand our understanding of the epidemiology of viral ARIs and help us to establish more efficient therapeutic and preventive strategies.

• 대한한방소아과학회지
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• 제32권4호
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• pp.51-62
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• 2018

Objectives The purpose of this study is to analyze the characteristic of pediatric patients who visited oriental medical hospital for growth treatment. Methods The study was conducted with 130 pediatric patients who visited ${\bigcirc}{\bigcirc}$ Korean medicine hospital from January 2016 to August 2017. The patient's data was classified by sex, age, pattern identification and diseases. The classified data was analyzed to find the correlations and characteristics among variables. Results There were 50.8% of boys and 49.2% of girls. 6.2% of the total patients were in 'early childhood', 50.8% were in 'late childhood' and 43.1% were in 'puberty' stage. In terms of pattern identification, 44.6% of the total patients were 'Spleen-lung Qi Deficiency', 53.8% were 'Lung-kidney Yin Deficiency' and 1.5% were 'Weakness of Heart and gallbladder'. 44.3% of the patients had various diseases including rhinitis (77.6% of 120.7%). Height percentile of the children with using the Growth chart of 2017 was lower than using the Growth chart of 2007. Predicted height based on the child's bone-age were higher than the predicted height based on the parental height, although both of the precited factors were correlated to the current child's height. Conclusions This study showed the characteristic of the pediatric patients who visited oriental medical hospital for growth treatment. It helps to determine prognosis and treatment, and to explain treatment measures.

• 대한한방소아과학회지
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• 제33권3호
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• pp.69-81
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• 2019

Objectives The purpose of this study is to examine 33 cases of chronic sinusitis in children who were treated with Korean medicine. Methods Herbal medicine, acupuncture, and nebulizer and laser therapy were used to treat chronic sinusitis, and a plain radiography (paranasal sinus water's view) was used to confirm improvement of the children's sinusitis. Then, the data was classified by sex, age, frequency and duration of common cold, severity of sinusitis, duration of treatment, pattern identification and so on. Results There were 72.7% boys and 27.3% girls. The average age of children is $4.48{\pm}2.18years$. 70% of the children had common cold more than once a month, and 85.1% of the children from the study group had common cold lasting more than a week. The sinusitis severity score ranged from 10 to 200. 81.8% were more than 100. Duration of the treatment was $157.21{\pm}83.4day$, duration of herbal medicine treatment was $79.3{\pm}31.23day$, rate of herbal medicine was $62.12{\pm}29.21%$. The frequency of acupuncture, nebulizer and laser therapy ranged from 1 time to 11 times but was much lower than expected. Conclusions 33 cases of chronic sinusitis in children were treated with Korean medicine, and cure of the illness was confirmed by PNS water's view, and clinical characteristic of the patients with chronic sinusitis was analyzed.

• 대한물리의학회지
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• 제14권4호
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• pp.173-181
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• 2019

PURPOSE: This study examined the necessity of a musculoskeletal injury-prevention program for automobile parts manufacturing workers by assessing the body composition, muscle strength, and posture according to sex and age. METHODS: Two hundred eighty-two workers (men, 218; women, 64; mean age, 38.97 years; and mean work tenure, 10.29 years) participated in this study. They completed a questionnaire on their general characteristics, excluding personal identification codes. The participants were evaluated for body composition, muscle strength, and posture using InBody, a hand dynamometer, and the Image J program through photography, respectively. An independent t-test and one-way analysis of the variance were used for the comparisons according to sex and age, respectively. RESULTS: Significant sex-related differences in muscle strength and grip force were observed (p<.05). In addition, the left-side pelvic inclination was significantly higher in the female participants than in the male participants (p<.05). Significant age-related differences in the skeletal muscle mass and muscle strength were observed around 40 years (p<.05). Significant correlations were observed among the body composition (skeletal muscle and body fat masses), muscle strength, and posture (pelvic inclination; p<.01). CONCLUSION: Significant differences in pelvic inclination by sex and muscle strength by age were found, even in healthy workers. Additional posture and muscle strength measurements will be needed for workers who participate in the musculoskeletal injury prevention program because they are exposed to an incorrect posture for many hours or in many repetitive tasks.