• 정보보호학회논문지
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• 제33권6호
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• pp.989-1000
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• 2023

공급망 위협에 대응하기 위해 Secure Boot 등의 소프트웨어 위변조 방지 기술 및 SBOM(Software Bill of Materials) 등의 관리체계 개발 연구가 활발하게 이루어지고 있다. 특히 TCG(Trusted Computing Group)에서는 신뢰할 수 있고 안전한 컴퓨팅 부팅 환경을 제공할 수 있는 TPM(Trusted Platform Module) 표준을 제시하고 있다. 본 논문에서는 암호모듈이 공급망 위협에도 안전하고, 신뢰할 수 있는 기능을 제공할 수 있도록 암호모듈을 위한 안전한 부팅 기술 도입 필요성을 설명한다. 또한, ISO/IEC 19790 표준으로 검증된 암호모듈의 취약점을 분석하고, 취약점에 대응할 수 있도록 암호모듈의 안전한 부팅을 위한 보안 요구사항을 제안한다.

• 대한지리학회지
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• 제41권1호
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• pp.58-72
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• 2006

현대 경제는 첨단 산업의 발달로 연구개발 활동의 중요성이 더욱 부각되고 있다. 이에 본 연구는 우리나라의 기업 연구개발 활동의 공간적 분포 특징을 파악하고자 거시적으로 접근하였다. 분석 결과, 우리나라 기업부설연구소는 수도권 지역에서 높은 집중현상을 나타냈으나, 세부 분석에서 연구소들은 업종에 따라 상이한 입지 경향을 보였으며, 첨단산업의 성격이 낮을수록 연구소의 수도권 집중 현상은 낮아지는 것으로 나타났다. 또한 기업의 규모가 클수록, 고급 연구 인력 확보 수준이 높을수록 연구소의 입지는 분산되는 경향을 보였다. 이외에도 기업부설연구소들은 본사나 공장과 한 장소에 입지하거나 같은 업종의 연구소들과 한 장소에 입지하는 경향이 있으며, 이러한 입지 행태는 지역적으로 다르게 나타났다. 이러한 특징들을 종합하여 본 연구에서는 연구소의 입지 유형을 4가지로 분류하였다.

• Parasites, Hosts and Diseases
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• 제56권4호
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• pp.325-334
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• 2018

Toxoplasma gondii is an apicomplexan zoonotic protozoan parasite that infects most species of warm-blooded animals, including humans. The heavy incidence and severe or lethal damage caused by T. gondii infection clearly indicate a need for the development of an effective vaccine. T. gondii GRA8 is a member of the dense granules protein family and is used as a marker of acute infection. In the present study, we evaluated the protective immunity induced by DNA vaccination based on a recombinant eukaryotic plasmid, pDsRed2-GRA8, against acute toxoplasmosis in mice. BALB/c mice were intramuscularly immunized with the pDsRed2-GRA8 plasmid and then challenged by infection with the highly virulent GFP-RH strain of T. gondii. The specific immune responses and protective efficacy against T. gondii of this vaccine were analyzed by measuring cytokine and serum antibody titers, splenocyte proliferation assays, and the survival times of mice after challenge. Our results showed that mice immunized with pDsRed2-GRA8 demonstrated specific humoral and cellular responses, induced higher IgG antibody titers with predominant IgG2a production; increased levels of IL-10, IL-12 (p70), $IFN-{\gamma}$, $TNF-{\alpha}$, and splenocyte proliferation; and prolonged survival times compared to those of control mice. The present study showed that DNA immunization with pDsRed2-GRA8 induced humoral and cellular immune responses, and all immunized mice showed greater Th1-type immune responses and longer survival times than those of control mice. These results indicated that T. gondii GRA8 DNA immunization induces a partial protective effect against acute toxoplasmosis.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3395-3402
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• 2015

Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.

• The Journal of Asian Finance, Economics and Business
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• 제5권4호
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• pp.127-133
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• 2018

Corporate social responsibility (CSR) is one of the strategies for managing firms' business activities but may have heterogeneity depending on ownership structures. This study investigates the association between group-affiliation and CSR activities. Drawing on a theory from the prior research, this study predicts that group-affiliated firms are less likely to invest on CSR activities. For instance, prior research finds that controlling shareholders expropriate the values of minority shareholders. As one of the motivations of investing on CSR activities is the harmonization among the stakeholders, it leads to the prediction that firms controlled by large shareholders are less likely to engage in CSR activities. Second, group-affiliated firms under poor financial performance benefit from other group members through sharing their financial resources. Thus, there is less incentive for managers of group-affiliated firms to increase their financial performance by conducting CSR. By leveraging firms listed in Korean stock market and CSR score from Korea Economic Justice Institute, the result shows that the group-affiliation is negatively related to CSR activities. The result is consistent in case of applying propensity score-matched sample. Based on the findings of this study, this paper contributes to the related literature by showing the significant association between group-affiliation and CSR decisions.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3871-3875
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• 2013

Purpose: MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression. Materials and Methods: Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated. Results: Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P<0.05). Enforced expression of miR-181a -5p promoted cell proliferation ability. Conclusions: This study suggested that increased miR-181a-5p is related to GC progression. MiR-181a-5p may represent a potential therapeutic target for GC.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1703-1706
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• 2013

Lung cancer remains a deadly disease with unsatisfactory overall survival. Resveratrol (Res) has the potential to inhibit growth of several types of cancer such as prostate and colorectal examples. In the current study, we evaluated in vitro and in vivo anticancer efficiency of Res in a xenograft model with A549 cells. Cell inhibition effects of Res were measured by MTT assay. Apoptotis of A549 cells was assessed with reference to caspase-3 activity and growth curves of tumor volume and bodyweight of the mice were measured every two days. In vitro cytotoxicity evaluation indicated Res to exert dose-dependent cell inhibition effects against A549 cells with activation of caspase-3. In vivo evaluation showed Res to effectively inhibit the growth of lung cancer in a dose-dependent manner in nude mice. Therefore, we believe that Res might be a promising phytomedicine for cancer therapy and further efforts are needed to explore this potential therapeutic strategy.

• Journal of East Asia Management
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• 제3권2호
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• pp.1-19
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• 2022

This study suggests an integrated theoretical framework for the relationship between political risk and multinational corporation (MNC) subsidiary's performance in the emerging market. The political risk would have a negative impact on MNC subsidiary's performance in the emerging countries that are developing in Asia, the Commonwealth of Independent States, Africa, and South America. The major reason is that political risks could generate a loss of benefit or a loss of control for MNC's subsidiary. In this study, I suggest that corporate social responsibility (CSR) strategy would be a solution to overcome various political risks. Specifically, the affiliated firms with diversified industries or greater financial resources could mitigate the negative impact of political risk than unaffiliated firms. Because they can use their tangible or nontangible asset such as information, technology, and construction in order to gain legitimacy and trust from local government, local community, and local firms in the emerging market. Finally, I claimed the costs of the affiliated firms would exceed the benefits at the initial stages, while the benefits of affiliated firms would exceed the costs over time when political risks become higher. The reason is that the trust gained from local stakeholders accumulates over time and the impact of CSR strategy would become an important solution to overcome the risks in and unstable context.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6009-6014
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• 2014

Aims: To investigate changes in cellular immune function of patients with lung cancer before and after cytokine-induced killer (CIK) cell therapy and to identify variation effects on overall survival (OS) and progression-free survival (PFS). Materials and Methods:A total of 943 lung cancer patients with immune dysfunction were recruited from January 2002 to January 2010, 532 being allocated to conventional therapy and 411 to CIK therapy after a standard treatment according to the NCCN Clinical Practice Guidelines. All the patients were investigated for cellular immune function before and after therapy every three months. and clinical prognostic outcomes were analyzed. Results: After six courses of treatment, immune function was much improved in patients receiving CIK cells therapy as compared to controls. The percentages of recurrence and/or metastases for patients undergoing CIK cell therapy was 56.2% and 49.1% respectively but 78.6% and 70.3% among controls (p<0.001). The median OS times for CIK cell therapy and control groups were 48 and 36 months respectively. The OS rates at 12, 36, 60, 84 months in CIK treated patients were 97.8%, 66.9%, 27.7%, and 4.1% while they were 92.3%, 44.5%, 9.2%, and 1.5% in controls. OS and PFS were significantly different by log rank test between the two groups and across the three immune improvement classes. Conclusions: The immune function of lung cancer patients was improved by CIK cell therapy, associated with an increase in the OS rate and extension of the time to recurrence and/or metastasis.

• 한국가스학회지
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• 제14권4호
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• pp.1-5
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• 2010

국내 대학 또는 기업 부설 연구소 실험실에서 유해화학 물질 사용 증가에 따라 가스누출 등으로 인한 폭발 화재 등 각종 대형 사고가 발생하여 사회적 이슈로 관심이 집중되었고, 실험실에서 안전관리에 대한 중요성이 강조되어 국내 대학 또는 기업 부설 연구소에서 연구 실험하는 연구 활동종사자의 생명과 신체를 보호하고, 쾌적한 실험 환경 조성을 위하여 연구실 안전환경조성에 관한 법률이 제정되었다. 국내 대학 또는 기업 부설 연구소에서는 이러한 사고 방지를 위하여 실험실 안전관리체계를 구축하고 안전점검과 정밀안전진단 등을 실시하고 있다. 이러한 조치에도 불구하고 국내 실험실에서는 사고가 지속적으로 발생하여 사고에 대한 근본원인분석이 필요한 실정이다. 이 논문에서는 국내 대학 또는 기업 부설 연구소 실험실에서 발생한 사건 사고에 대해 근본원인분석(Root Cause Analysis) 기법을 활용하여 사고 원인에 대해 분석한 결과를 보여주고, 국내 실험실의 안전관리방향을 제시 하고자 한다.