• 항공우주의학회지
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• 제24권2호
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• pp.21-27
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• 2014

We aimed to study about the effect of acute hyper-gravity (HG) on the allergic immune response in a murine model of allergic asthma. Thirty-two BALB/c mice were used. In Group A (control group, n=8), mice were sensitized and challenged with saline. Group B (HG control group, n=8) were exposed to HG (10 Gz, 1 hour) after intraperitoneal and intranasal saline challenge. Group C (asthma group, n=8) received intraperitoneal and intranasal ovalbumin (OVA) challenge. Group D (HG asthma group, n=8) were exposed to HG after intraperitoneal and intranasal OVA challenge. We evaluated serum total and OVA-specific IgE; serum titers of cytokines; and histopathologic examination of lung. As a result, titers of Serum total and OVA-specific IgE were not significantly different between groups. Compared to Group C, mice in Group D showed significant increase of Th2 cytokines (IL-4, IL-13), cytokines involved in eosinophilia (IL-3, IL-5, GM-CSF) and those involved in cell-medicated immunity (IFN-γ). In histopathologic examination, lungs of Group D showed significantly more infiltration of inflammatory cells compared to Group C. However, these differences were not so significant between Groups A and B. In conclusion, acute HG could exacerbate allergic asthma in experimental animals.

• 항공우주의학회지
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• 제30권2호
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• pp.75-79
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• 2020

This study focuses on the comparative and quantitative analysis of the epidemiologic trends and aspects of severe fever with thrombocytopenia syndrome (SFTS) outbreaks between Korea and Japan from 2013 to 2017. The following factors were analyzed; cumulative incidence rate (CIR), cases-fatality rate (CFR), and the epidemic aspects, including cases related to gender, male-to-female morbidity ratio (MFMR), age, seasonal, and geographical distributions. We observed 607 SFTS cases with CIR in Korea during the period 2013 to 2017 were as 0.24 per 100,000 populations and with a 127 fatal-cases (F.C.s), corresponding to a CFR of 20.9%, respectively. During the same period in Japan, 319 SFTS cases with a CIR of 0.05 and with 60 F.C.s to a CFR of 18.8% observed. When compared, the CIR of SFTS in Korea was significantly higher than in Japan (P<0.01), but there were no significant differences levels of the CFR and MFMR between Korea and Japan. Also, a higher incidence of SFTS was observed in people aged over 50-years or elders in Korea and those of 60-years or elders in Japan (P<0.01). The seasonal distribution of SFTS outbreak cases showed that the incidence in summer through autumn in Korea (92.4% of total cases) was higher than in Japan (65.2%), while the outbreaks of SFTS in spring was much higher in Japan (31.0%) than in Korea (7.4%), (P<0.01). The regional distribution revealed no significant difference between the eastern area (44.8%) and the western area (46.8%) of the Korean peninsula except Jeju-island (8.4%). However, in Japan, the incidence only occurred in Chubu-Kinki-Chugoku (30.3%), Shikoku (25.7%), Kyushu (42.6%) and Okinawa (0.3%), which are the western and southern areas of Japan. These differences in SFTS occurrence may reflect the influences of vector/hosts, climate, and geographical and cultural characteristics between the two countries.

• Archives of Plastic Surgery
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• 제46권4호
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• pp.386-389
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• 2019

The development of breast implant technology continues to evolve over time, but changes in breast shape after implantation have not been fully elucidated. Thus, we performed computerized finite element analysis in order to better understand the trajectory of changes and stress variation after breast implantation. The finite element analysis of changes in breast shape involved two components: a static analysis of the position where the implant is inserted, and a dynamic analysis of the downward pressure applied in the direction of gravity during physical activity. Through this finite element analysis, in terms of extrinsic changes, it was found that the dimensions of the breast implant and the position of the top-point did not directly correspond to the trajectory of changes in the breast after implantation. In addition, in terms of internal changes, static and dynamic analysis showed that implants with a lower top-point led to an increased amount of stress applied to the lower thorax. The maximum stress values were 1.6 to 2 times larger in the dynamic analysis than in the static analysis. This finding has important implications for plastic surgeons who are concerned with long-term changes or side effects, such as bottoming-out, after anatomic implant placement.

• Journal of Ginseng Research
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• 제46권3호
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• pp.489-495
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• 2022

Background: Although ginsenosides and saponins in Korea red ginseng (KRG) shows various pharmacological roles, their roles in the inflammatory response are little known. This study investigated the anti-inflammatory role of ginsenosides identified from KRG saponin fraction (RGSF) and the potential mechanism in macrophages. Methods: The ginsenoside composition of RGSF was identified by high-performance liquid chromatography (HPLC) analysis. An anti-inflammatory effect of RGSF and its mechanisms were studied using nitric oxide (NO) and prostaglandin E₂ (PGE₂) production assays, mRNA expression analyses of inflammatory genes and cytokines, luciferase reporter gene assays of transcription factors, and Western blot analyses of inflammatory signaling pathways using the lipopolysaccharide (LPS)-treated RAW264.7 cells. Results: HPLC analysis identified the types and amounts of various panaxadiol ginsenosides in RGSF. RGSF reduced the generation of inflammatory molecules and mRNA levels of inflammatory enzymes and cytokines in LPS-treated RAW264.7 cells. Additionally, RGSF inhibited the signaling pathways of NF-κB and AP-1 by suppressing both transcriptional factors and signaling molecules in LPS-treated RAW264.7 cells. Conclusion: RGSF contains ginsenosides that have anti-inflammatory action via restraining the NF-κB and AP-1 signaling pathways in macrophages during inflammatory responses.

• 항공우주의학회지
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• 제31권1호
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• pp.21-23
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• 2021

Purpose: Human papillomavirus (HPV) vaccination schedule is recommended by Strategic Advisory Group of Experts on Immunization of World Health Organization to achieve high efficacy and immunogenicity. However, the patients often cannot keep up their schedule for several reasons. Methods: Monthly numbers of visitors for HPV vaccination between 2019 and 2021 were analyzed to measure the impact of coronavirus disease-19 (COVID-19) outbreak which was the main cause of this delay. Results: In February 2020, the number of foreign patients vaccinated with HPV was dropped suddenly due to COVID-19. Prior to this impact, the average patients per month for HPV vaccination was 160 (95% confidence interval [CI]: 143-176). It was then 30 (95% CI: 20-40). However recent trends show a gradual recovery. Conclusion: If a woman is pregnant after starting the HPV vaccine series, the reminder doses should be delayed until she is no longer pregnant. If this series is interrupted for any length of time, it can be resumed without restarting the series. HPV vaccine series need to be administered with a minimum interval of 14 days before or after administration of COVID-19 vaccines.

• 항공우주의학회지
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• 제30권3호
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• pp.113-129
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• 2020

With the operation of the KC-330 MRTT (Multi Role Tanker Transport), which had been fielded in 2019, the ROKAF (Republic of Korea Air Force) has given fighter pilots a new mission of air refueling. As a result, fighter pilots are more likely to be exposed to risks they have never faced before, and it is necessary to look at the risk factors associated with human factors in air refueling missions. Therefore, in this study, an analysis using the HFACS (Human Factors Analysis and Classification System) model was performed for fighter pilots with air refueling qualifications. This study tried to prevent hazard in advance by discriminating the risk factors according to the human factors related to the fighter pilot during the air refueling mission.

• 항공우주의학회지
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• 제30권3호
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• pp.100-107
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• 2020

Internet of Things (IoT) is a technology that communicates data between devices, which are things, using an embedded sensor connected through network backbone such as the internet. Here, data communication technology, sensor technology, and actuator (interface) technology are fused into IoT and it turns devices into smart things. As a result, vast sized data are being generated and that data is being processed into useful actions that can control the things that are devices to make our lives much fruitful. Nowadays, the IoT, early defined as Machine-to-Machine (M2M) connection, becomes a key technology powered by growing innovation of wireless communication trends in the internet connectivity through mobile networking. This paper gives an overview of Internet of Things and brief information about major technologies and its applications in various fields focusing aviation.

• 항공우주의학회지
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• 제30권2호
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• pp.54-60
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• 2020

Pilot fatigue is a great hazard to aviation safety. In recent years, long-distance fights have been increasing and flight hours have been increasing, which has made fatigue issues important. International organizations in the aviation sectors (ICAO, FAA, IATA etc.) recommend management of fatigue within the SMS (Safety Management System) framework. A scientific and systematic approach to measuring fatigue is required as a prerequisite to preparing safety management measures for pilot's fatigue. Therefore, in this study, I would like to consider recent trends and implications for fatigue measurement. First, I aimed to consider recent the accident cases related to fatigue. Second, I also considered how to measure the pilot's fatigue. Finally, the direction of the countermeasures against fatigue through fatigue measurement was developed and suggested.

• 항공우주의학회지
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• 제30권2호
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• pp.61-65
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• 2020

In the case of aviation maintenance work, several kinds of shift works are performed during day and night, and a lot of works are performed on the ramp due to the characteristics of the aircraft flight schedule. Maintenance workers are often exposed to the sun or in cold temperatures for aircraft maintenance works. The fatigue risk of the maintenance workers will be weighted. In particular, the work at night shift under normal biological rhythms can make maintenance workers feel sleepy during daytime work. It can also affect the safety of aircraft and individual workers. Accordingly, this study will consider fatigue-related previous researches in the field of aviation maintenance, review the effects of shift work, and how fatigue affects aviation mechanics during the day/night shifts. Considering these factors, we tried to present a plan that can minimize the fatigue of aviation workers through this study.

• 항공우주의학회지
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• 제30권3호
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• pp.91-94
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• 2020

The coronavirus infectious disease-19 (COVID-19) pandemic has had a profound impact on the aviation industry. In order to overcome this crisis, airlines have made their efforts in various fields. Therefore, we tried to summarize these efforts of airlines. It is also essential to keep aircraft that have been in landing for a long time in optimal condition. In this paper, we tried to find out about efforts to maintain landing aircraft and maintenance of personnel. Through such constant care, airlines will be able to quickly respond to increasing aviation demand when the infectious disease situation is stabilized in the future. Finally, airlines and passengers must make several efforts to ensure that passengers are free from COVID-19 while traveling by air. These include general precautions to prevent infection, separation of airline personnel and passengers, changes in seat assignments and in-flight services, periodic aircraft disinfection, and prevention of in-flight infections.