• Tuberculosis and Respiratory Diseases
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• v.85 no.4
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• pp.289-301
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• 2022

Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammation characterized by fixed airflow limitation and chronic respiratory symptoms, such as cough, sputum, and dyspnea. COPD is a progressive disease characterized by a decline in lung function. During the natural course of the disease, acute deterioration of symptoms leading to hospital visits can occur and influence further disease progression and subsequent exacerbation. Moreover, COPD is not only restricted to pulmonary manifestations but can present with other systemic diseases as comorbidities or systemic manifestations, including lung cancer, cardiovascular disease, pulmonary hypertension, sarcopenia, and metabolic abnormalities. These pulmonary and extrapulmonary conditions lead to the aggravation of dyspnea, physical inactivity, decreased exercise capacity, functional decline, reduced quality of life, and increased mortality. In addition, pneumonia, which is attributed to both COPD itself and an adverse effect of treatment (especially the use of inhaled and/or systemic steroids), can occur and lead to further deterioration in the prognosis of COPD. This review summarizes the long-term outcomes of patients with COPD. In addition, recent studies on the prediction of adverse outcomes are summarized in the last part of the review.

• Journal of Korean Biological Nursing Science
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• v.25 no.4
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• pp.229-242
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• 2023

Purpose: The electronic frailty index (eFI), which is derived from electronic health records, has been recommended as screening tool for frailty due to its accessibility and ease of use. The objective of this systematic review was to identify the prevalence of frailty assessed by the eFI and its influence on health outcomes in older adults with chronic diseases. Methods: We searched PubMed, Embase, Web of Science, CINAHL, SCOPUS, Cochrane, Google search, and nursing journals in Korean from January 2016 to December 2022. Results: Twelve studies were analyzed. The eFI score, based on routine clinical data, was associated with adverse health outcomes. The most frequent outcome studied was mortality, and the eFI was associated with increased mortality in nine studies. Other outcomes studied included hospitalization, length of stay, readmission, and institutionalization in relation to hospital care usage, and cardiovascular events, stroke, GI bleeding, falls, and instrumental activities of daily life as health conditions. Conclusion: Early identification of frailty in older adults with chronic diseases can decrease the burden of disease and adverse health outcomes. The eFI has a good discriminative capacity to identify frail older adults with chronic diseases.

• Journal of the Korean Home Economics Association
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• v.47 no.6
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• pp.1-10
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• 2009

This study investigated the influence of children's emotional expression and sociability, and their mothers' communication pattern on their prosocial behavior. The participants were 65 preschool children aged between 5 and 6, and their mothers. Each child-mother dyad was observed for 30 minutes in a lab setting, which was designed to evaluate the child's socioemotional competence and the mother's socialization behavior. Videotaped data were analyzed by two coders for aspects of sharing behavior, the expression of happiness, sadness, anger, anxiety, and sociability for children, and mothers' communication strategies. Results showed that children's anger and anxiety expression were the most significant predictors for their prosocial behavior. Mothers' punitive communication pattern negatively affected children's prosocial behavior. However, when compared to the children's emotional expression, its' accountability were not significant. The influence of negative emotions, and its' adverse role in interpersonal interactions are discussed.

• Journal of environmental and Sanitary engineering
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• v.12 no.3
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• pp.87-94
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• 1997

Influences of clotrimazole on the blood cholesterol and HDL-cholesterol level were studied in rats. Rats were provided food and water ad libitum and clotrimazole and methylcellulose were gavaged for 6 days. Clotrimazole was suspended in 1% methylcellulose solution as and administered at concentration 20mg/Kg, 40mg/Kg, 60mg/Kg. Body weight gain and liver weight/body weight ratio, serum cholesterol level, serum HDL-cholesterol level, serum triglyceride level, the activity of cytochrome p450 and erythromycin demethylase were determined at 6th day. Clotrimazole decreased the body weight gain a little as compared with control group and did not show any influence on liver weight/body weight ratio. Clotrimazole increased the serum HDL-cholesterol and serum triglyceride level significantly. Clotrimazole increased the microsomal cytochrome P450 significantly and increased the erythromycin demethylase (cytochrome P450 IIIA) significantly too. It might be conclued that clotrimazole showed a little influence on body weight and increased the serum lipid, especially HDL-cholesterol level. It also increased microsomal cytochrome P450 IIIA significantly. It might be concluded that clotrimazole showed a corelative influence between HDL-cholesterol and cytochrome P450 IIIA. In these results clotrimazole can be used as an anti-atherosclerotic agent by increasing the HDL-cholesterol but it is necessary that cloreimazole will show any adverse or side action on body or not.

• Korean Journal of Clinical Pharmacy
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• v.29 no.2
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• pp.125-132
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• 2019

Objective: To examine the perceptions and attitudes toward spontaneous adverse drug reaction (ADR) reporting system among community pharmacists and identify factors that influence reporting, by implementing a survey. Methods: A structured questionnaire was developed and distributed online. Request for the survey was posted on the website of pharmacy's billing program, and the survey was conducted for 8 days. We collected the participants' response on their work environment, experience of ADR reporting, and their perception and attitude on the reporting system. Multivariate logistic regression was used to evaluate factors influencing ADR reporting. Results: A total of 382 pharmacists participated in the survey. Significant contributing factors for reporting level were age (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.84-0.96), knowledge of reporting method (OR, 53.56; 95% CI, 9.10-315.41), installation of reporting program (OR, 31.92; 95% CI, 4.16-244.75), and encouragement from the Korean pharmaceutical association (OR, 4.13; 95% CI, 1.11-15.35). Regarding the attitude toward spontaneous ADR reporting system, 'lack of time for reporting' (OR, 0.29; 95% CI, 0.15-0.53) and 'complexity of reporting procedure' (OR, 0.51; 95% CI, 0.31-0.84), were associated with a low likelihood of reporting. Conclusion: Our results indicated that the knowledge of ADR reporting method, installation of the reporting program, and encouragement from the Korean Pharmaceutical Association contribute to active reporting. It is necessary to simplify the reporting method, make the ADR reporting program user-friendly, and provide educational interventions to increase participation in spontaneous reporting by the community pharmacists.

• Journal of Korean Dental Hygiene Science
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• v.3 no.2
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• pp.9-18
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• 2020

This study analyzed 183 for dental hygienists working at dental hospitals and clinics in Daegu to survey organizational socialization of them. The adversity index of the study subjects averaged 58.60±9.16 points out of a total score of 100, with the highest individual initiative of 16.58±3.09 points, and a low of 13.86±3.66 points for continuity of the situation. Organizational socialization averaged 123.40±12.82 points out of 190, with the highest personal characteristics of 30.37±3.71 points, and the lowest occupational identity of 10.34±1.94. The adversity index of the participants was significantly higher in graduate school or higher (F=3.112, p=0.047), the lower the intensity of their work (F=2.860, p=0.060), and the more often the degree of turnover (F=5.196, p<0.006). In organizational socialization, age (F=9.290, p<0.001), educational background (F=8.655, p<0.001), and higher position (F=5.425, p=0.005) were significantly higher when working in hospitals (F=4.534, p=0.012). The higher the position (F=5.425, p=0.005), the higher the work experience (F=5.320, p=0.002), the lower the turnover (F=22.935, p<0.001), and the highrer the intensity of the work(F=7.02, p<0.001). The study subjects' organizational socialization showed a significant correlation with the adverse event index (r=0.395, p<0.000). The regression analysis using organizational socialization as a dependent variable showed that the degree of turnover (β=0.300, p<0.001) had a significant effect on organizational socialization. The total explanatory power of this variable was 41.6%, with significant effects on individual initiative (β=0.255, p<0.000) and personal control (β=0.180, p<0.009) among the adverse events index. The above findings confirmed that a high adverse event index of dental hygienists has the effect of increasing organizational socialization. Dental hygienists' adversity index is average, meaning they live a smooth life in smooth conditions, however, when major adversity arises, organizational socialization is highly necessary. In addition, to strengthen the organizational socialization of new dental hygienists, as well as experienced dental hygienists, a customized program should be administered to raise the adverse index of dental hygienists, and provide a human management tool through regular confirmation of the program.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6237-6241
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• 2015

Usage of traditional, complementary and alternative medicine (TCAM) has gained popularity over the past few years. However, very little is known about TCAM use among Malaysian cancer patients. This study aimed to identify the determinants of TCAM usage among cancer patients with determination of relationships between demographic factors, patient satisfaction with conventional treatment, knowledge on TCAM and healthcare professional influence. Patient's perceptions towards TCAM were also determined. A simple random convenient sampling method was used to recruit 354 patients from Hospital Kuala Lumpur between February to April 2013. All were directly interviewed with a structured questionnaire. In this study, 172 respondents were TCAM users. There was no significant differences between demographic background of respondents in the usage of TCAM. Minimal correlation was found between patient satisfaction with the conventional treatment and usage of TCAM (r=0.091). A poor correlation was found between healthcare professional's influence and TCAM usage (r=-0.213) but the results suggested that increase in influence would decrease TCAM usage. Patient TCAM knowledge correlated negatively with the TCAM usage (r=-0.555) indicated that cancer patients are less likely to use TCAM when they have more TCAM knowledge. Healthcare professionals should be fully equipped with the necessary TCAM knowledge while maintaining patient satisfaction with the conventional treatment. They should also intervene on patient TCAM usage where a potential drug interaction or a harmful adverse event can occur.

• Journal of Nutrition and Health
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• v.26 no.2
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• pp.154-154
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• 1993

A factorial experiment was conducted to determine the influence of phytate(0 or 10g/kg diet) and calcium (Ca)(3 or 10g/kg diet) intakes on Ca, P and Zn metabolism by growing female rats. Food intake and weight were similar for the all groups, however, phytate ingestion for six weeks depressed femur growth. The low Ca plus phytate group showed the lowest Ca content of total femur and this was related to a significant decrease of Ca retention. Phytate intake depressed zinc(Zn) absorption in the first metabolic collection. This inhibitory effect of phytate on Zn absorption was improved in the low Ca plus phytate group after several weeks. Impared Zn absorption however remained in the high Ca plus phytate group which was reflected in the lowest Zn content of femur, phytate intake with high Ca also depressed phosphorous(P) absorption and serum and urinary P. These adverse effects of phytate on Zn and P absorption when the dietary Ca was high could explain reduced femur weight despite the highest concentration of femur Ca(mg/g ash) in this group. Results suggest that phytate can adversely affect not only Ca metabolism but Zn and P utilization. Thus, for the normal bone growth when phytate intake is high, the ingesion of Ca, P, Zn and other minerals should be enhanced.

• Journal of Mechanical Science and Technology
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• v.17 no.1
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• pp.57-63
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• 2003

An eigenvalue design sensitivity formulation of a general nonsymmetric-matrix rotor-bearing system is devised. using the DDM (direct differential method). Then, investigations on the design sensitivities of critical speeds are carried out for an APU turbogenerator with a spline shaft connection. Results show that the dependence of the rate of change of the critical speed on the stiffness changes of bearing models of spline shaft connection points is negligible, and thereby their modeling uncertainty does not present any problem. And the passing critical speeds up to the 4th critical speed are not sensitive to the design stiffness coefficients of four main bearings. Further, the dependence of the rate of change of the critical speed on the shaft-element length changes shows quantitatively that the spline shaft has some limited influence on the 4th critical speed but no influence on the 1st to 3rd critical speeds. With no adverse effect from the spline shaft, the APU system achieves a critical speed separation margin of more than 40% at a rated speed of 60,000 rpm.

• Journal of Power Electronics
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• v.16 no.5
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• pp.1928-1938
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• 2016

The three-phase four-wire shunt active power filter (APF) is an effective method to solve the harmonic problem in three-phase four-wire power systems. In addition, it has two possible topologies, a four-leg inverter and a three-leg inverter with a split-capacitor. There are some studies investigating DC-link voltage control in three-phase four-wire APFs. However, when compared to the four-leg inverter topology, maintaining the balance between the DC-link upper and lower capacitor voltages becomes a unique problem in the three-leg inverter with a split-capacitor topology, and previous studies seldom pay attention to this fact. In this paper, the influence of the balance between the two DC-link voltages on the compensation performance, and the influence of the voltage balance controller on the compensation performance, are analyzed. To achieve the balance between the two DC-link capacitor voltages, and to avoid the adverse effect the voltage balance controller has on the APF compensation performance, a new DC-link voltage balance control strategy for the three-phase four-wire split-capacitor APF is proposed. Representative simulation and experimental results are presented to verify the analysis and the proposed DC-link voltage balance control strategy.