• Proceedings of the Korea Contents Association Conference
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• 2014.06a
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• pp.209-210
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• 2014

• Journal of Acupuncture Research
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• v.31 no.2
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• pp.165-171
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• 2014

Objectives : The purpose of this study was to examine and report improvements of facial wrinkles with the use of subcision. Methods : Subcision acupuncture was performed on outpatients with facial wrinkles for one to two times. Evaluation of improvement was conducted with patient-report questionnaires and comparison of before and after pictures. Items for satisfaction and adverse events were included in the questionnaire, and it was filled out after treatment. The photographs were taken three times; before the first and the second subcision acupuncture, and two to four weeks after the second subcision acupuncture. Results : The results from questionnaire and photo comparison were reported positive and satisfactory. There were minor adverse events such as bruise or conspicuousness of other wrinkles that were not treated. Conclusions : Our study results suggests that the use of subcision acupuncture is effective for facial wrinkles.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.11
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• pp.1082-1089
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• 2011

Most engineered systems are designed with high levels of system redundancies to satisfy required reliability requirements under adverse events, resulting in high systems' LCCs (Life-Cycle Costs). Recent years have seen a surge of interest and tremendous advance in PHM (Prognostics and Health Management) methods that detect, diagnose, and predict the effects of adverse events. The PHM methods enable proactive maintenance decisions, giving rise to adaptive reliability. In this paper, we present a RAP (Resilience Allocation Problem) whose goal is to allocate reliability and PHM efficiency to components in an engineering context. The optimally allocated reliability and PHM efficiency levels serve as the design specifications for the system RBDO (Reliability-Based Design Optimization) and the system PHM design, which can be used to derive the detailed design of components and PHM units. The RAP is demonstrated using a simplified aircraft control actuator design problem resulting in a highly resilient actuator with optimally allocated reliability, PHM efficiency and redundancy for the given parameter settings.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9587-9592
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• 2014

Nausea and vomiting are common adverse events in chemotherapy. In spite of the serious effects on the quality of life and further treatment, they remain overlooked by physicians, and no standard treatment has been developed. Neurokinin-1 (NK-1) receptor antagonists and palonosetron are the major agents in the standard regimen for treating moderately and highly emetogenic chemotherapy-induced nausea and vomiting (CINV). However, NK-1 receptor antagonists first became commercially available at the end of 2013 and palonosetron has not been extensively applied in China. Olanzapine was recommended as a therapy for moderate and severe CINV in antiemesis-clinical practice guidelines in oncology in 2014 for the first time. It is an atypical antipsychotic agent, which can block multiple receptors on neurotransmitters. During more than 10 years, olanzapine has demonstrated significant effects in preventing CINV and treating breakthrough and refractor CINV, which was observed in case reports, precise retrospective studies, and phase I, II and III clinical trials, with no grade 3 to 4 adverse events. In particular, it is superior to aprepitant and dexamethasone in delayed nausea and vomiting. Therefore, this compound is worthy of further investigation.

• Journal of Digital Contents Society
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• v.19 no.3
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• pp.587-593
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• 2018

The syndromic surveillance system is designed to identify illness clusters before diagnoses are confirmed and reported to public health agencies, to provide rapid public health response, and thereby to reduce morbidity and mortality. Korea Centers for Disease Control and Prevention (KCDC) has implemented the emergency department-based syndromic surveillance system. To design upgraded and enhanced functions of the current syndromic surveillance system in KCDC for the early warning of adverse disease events, we surveyed many papers. This paper describes the operation status of syndromic surveillance system in other countries and the improvement of the syndromic surveillance system in KCDC.

• Journal of Korean Medicine Rehabilitation
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• v.26 no.4
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• pp.23-35
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• 2016

Objectives This systematic review is to support the effectiveness of herbal medicine for the treatment of simple obesity in adults. Methods A total of 8 electronic databases were searched in English, Chinese and Korean. Standard methodologies for the systematic review were used to search, analyze and synthesize data based on NECA's guideline for undertaking systematic review and meta-analyses for intervention. Results After screening 1781 potential articles, we identified 13 randomized controlled trials (RCTs). We conducted a meta-analysis for the study using Bangpungtongsung-san and Taeeumjowi-tang to evaluate the effectiveness of herbal medicines on weight loss compared to placebo control. Both herbs showed positive effect in weight, body mass index and waist circumference. In an analysis comparing herbal effects considering constitutions showed that proper treatment can lower adverse events. Conclusions Our results provide evidence that herbal medicine can be an effective treatment for the obesity compare to placebo or to conventional medicine without serious adverse events. Further study is needed to evaluate effectiveness of herbal medicines considering personalized treatment and its safety.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4391-4394
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• 2016

Background: Platinum-based regimens are effective treatments for advanced non-small cell lung cancer (NSCLC), but the five-year survival rate is still less than 20%. One possible factor appears to be resistance involving polymorphisms in the CTR1 gene which plays an importance role in accumulation of platinum in the cytoplasm. Purpose: To establish both prevalence of CTR1 polymorphism and its impact on treatment related toxicity in Thai advanced NSCLC patients. Materials and Methods: Thirty-two advanced NSCLC participants received carboplatin and gemcitabine during January to June 2016 at King Chulalongkorn Memorial Hospital (KCMH) were recruited for analysis of the CTR1 rs12686377 genotype. These participants were planning to be treated with platinum-based chemotherapy for at least two cycles. Results: Allele frequency of CTR1 polymorphism $G{\rightarrow}T$ was found to be 25%. The results showed that genetic polymorphism at CTR1 rs12686377 was associated with emesis side effects (P = 0.020) and neuropathic symptoms (P = 0.010). In addition, hematologic side effects in terms of anemia also tended to be related to this polymorphism. Conclusions: This is the first study suggesting that polymorphism at CTR1 rs12686377 may be associated with toxicity from platinum-based regimens. Therefore, it could be a factor to aid in treatment decision-making.

• Archives of Plastic Surgery
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• v.36 no.5
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• pp.548-554
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• 2009

Purpose: To evaluate clinical efficacy and safety of hyaluronic acid based autologous dermal fibroblasts (Hyalograft 3D) in the treatment of diabetic foot ulcers. Methods: A total of 28 patients with diabetic ulcers were randomized to either the control group with nonadherent foam dressings(n=14) or the treatment group with autologous tissue - engineered grafts(n=14). Weekly assessment contained vital sign checks, ulcer size measurements, and wound photos. At 12th week, percentages of complete wound healing and mean healing times were compared. Safety was also monitored by adverse events. Results: Complete wound healing was achieved in 84.6% of the treatment group and 23.1% of the control group (p<0.005). The mean times of closures for the treatment versus control groups were 6.1 weeks and 10.9 weeks, respectively. No adverse events related to the study treatment occurred. Conclusion: The use of hyaluronic acid based autologous fibroblast grafts was found to be a safe and effective treatment for diabetic foot ulcers.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.10.1-10.11
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• 2018

Cancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. Monoclonal antibodies that target immune checkpoints provided an immense breakthrough in cancer therapeutics. Among the immune checkpoint inhibitors, PD-1/PD-L1 and CTLA-4 inhibitors showed promising therapeutic outcomes, and some have been approved for certain cancer treatments, while others are under clinical trials. Recent reports have shown that patients with various malignancies benefit from immune checkpoint inhibitor treatment. However, mainstream initiation of immune checkpoint therapy to treat cancers is obstructed by the low response rate and immune-related adverse events in some cancer patients. This has given rise to the need for developing sets of biomarkers that predict the response to immune checkpoint blockade and immune-related adverse events. In this review, we discuss different predictive biomarkers for anti-PD-1/PD-L1 and anti-CTLA-4 inhibitors, including immune cells, PD-L1 overexpression, neoantigens, and genetic and epigenetic signatures. Potential approaches for further developing highly reliable predictive biomarkers should facilitate patient selection for and decision-making related to immune checkpoint inhibitor-based therapies.

• The Journal of Internal Korean Medicine
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• v.42 no.5
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• pp.1062-1073
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• 2021

Objectives: This study examined the case of a patient with recurrent salivary duct carcinoma and hepatic metastasis. Methods: The patient was treated with Casodex/Nolvadex from January 25^th 2021 onward with doses of bicalutamide (150 mg/day) and tamoxifen (10 mg/day) every four weeks. Simultaneously, the patient was treated with Korean medicine. The tumor size was measured using computed tomography (CT). Adverse events were evaluated according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0. Results: Following the four-month treatment, the extent of the proximal portion of hepatic metastasis decreased, and discomfort and physical activity gradually improved. Conclusions: The results suggest that combined chemotherapy and Korean medicine may help to reduce tumor size and improve quality of life.