• Journal of Ginseng Research
• /
• 제41권3호
• /
• pp.373-378
• /
• 2017

Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
• /
• pp.427-427
• /
• 2012

Ferroelectric-gate field effect transistor based memory using a nanowire as a conducting channel offers exceptional advantages over conventional memory devices, like small cell size, low-voltage operation, low power consumption, fast programming/erase speed and non-volatility. We successfully fabricated ferroelectric nonvolatile memory devices using both n-type and p-type Si nanowires coated with organic ferroelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] via a low temperature fabrication process. The devices performance was carefully characterized in terms of their electrical transport, retention time and endurance test. Our p-type Si NW ferroelectric memory devices exhibit excellent memory characteristics with a large modulation in channel conductance between ON and OFF states exceeding $10^5$; long retention time of over $5{\times}10^4$ sec and high endurance of over 105 programming cycles while maintaining ON/OFF ratio higher $10^3$. This result offers a viable way to fabricate a high performance high-density nonvolatile memory device using a low temperature fabrication processing technique, which makes it suitable for flexible electronics.

• Current Research on Agriculture and Life Sciences
• /
• 제16권
• /
• pp.37-44
• /
• 1998

낙동강 지류중 하나인 위천유역 및 동성유역권의 수공구조물 설계시 설계홍수량 결정을 위한 기본자료를 제공하고자 시간분포의 유형과 기저유량의 변화에 따른 가능최대홍수량의 양상을 분석하였다. 먼저 수문기상학적인 방법으로 PMP를 추정하고, Blocking방법의 central, advanced 그리고 delayed type를 각각 이용하여 시간 분포시킨 호우를 Clark방법을 이용하여 PMF를 산정한 결과 다음과 같은 결론을 얻었다. 1. PMP시간분포형에 따라서 첨두 PMF는 기저유량에 따라 advanced일 때 3145.3~3348.3cms, central일 때 3774.6~3977.7cms, delayed일 때 3814.6~4017.3cms로 나타났다. 여기서 강우의 시간분포가 advanced type이고 기저유량이 Minimum일 때 central과 delayed에 비하여 첨두PMF가 670cms정도 작게 나타남을 알수 있었다. 따라서 최대 첨두PMF와 최소 첨두PMF는 각각 delayed와 advanced일 때의 4017.3cms와 3145.3cms이며, 결과에 의한 평균 PMF는 3653.6cms로서 이 결과가 위천유역의 설계홍수량으로 타당하다고 사료된다. 2. 평균PMF와 가지야마에 의한 결과치와는 가지야마 값보다 1.7배 큰값으로 나타났고 이는 1,000년에서 10,000년 빈도사이의 홍수량으로 추정된다.

• Journal of Information Display
• /
• 제2권3호
• /
• pp.72-77
• /
• 2001

Amorphous silicon thin-film transistors (a-Si TFTs) were incorporated into Mo-tip-based triode-type field emitters and diode-type ones of carbon nanotubes for an active-matrix cathode (AMC) plate of field emission displays. Also, we developed a novel surface-treatment process for the Mo-tip fabrication, which gleatly enhanced in the stability of field emission. The field emission currents of AMC plates on glass substrate were well controlled by the gate bias of a-Si TFTs. Active-matrix field emission displays (AMFEDs) with these AMC plates were demonstrated in a vacuum chamber, showing low-voltage matrix addressing, good stability and reliability of field emission, and highly uniform light emissions from the anode plate with phosphors. The optimum design of AMFEDs including a-Si TFTs and a new light shield/focusing grid is discussed.

• Biomolecules & Therapeutics
• /
• 제26권5호
• /
• pp.439-445
• /
• 2018

T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder and neural tube defects. However, their function during embryonic development is largely unknown. Here, we investigated the function and expression of T-type calcium channels in embryonic neural progenitor cells (NPCs). First, we compared the expression of T-type calcium channel subtypes (CaV3.1, 3.2, and 3.3) in NPCs and differentiated neural cells (neurons and astrocytes). We detected all subtypes in neurons but not in astrocytes. In NPCs, CaV3.1 was the dominant subtype, whereas CaV3.2 was weakly expressed, and CaV3.3 was not detected. Next, we determined CaV3.1 expression levels in the cortex during early brain development. Expression levels of CaV3.1 in the embryonic period were transiently decreased during the perinatal period and increased at postnatal day 11. We then pharmacologically blocked T-type calcium channels to determine the effects in neuronal cells. The blockade of T-type calcium channels reduced cell viability, and induced apoptotic cell death in NPCs but not in differentiated astrocytes. Furthermore, blocking T-type calcium channels rapidly reduced AKT-phosphorylation (Ser473) and $GSK3{\beta}$-phosphorylation (Ser9). Our results suggest that T-type calcium channels play essential roles in maintaining NPC viability, and T-type calcium channel blockers are toxic to embryonic neural cells, and may potentially be responsible for neurodevelopmental disorders.

• 한국통신학회논문지
• /
• 제36권6A호
• /
• pp.558-567
• /
• 2011

본 논문에서는 Type 1 relay를 이용하는 3GPP (3rd Generation Pattnership Project) LTE Long Term Evolution)-Advanced 시스템을 위한 부분 전이중 (partial full duplex) relay 기법을 제안한다. Type 1 relay는 백홀 링크 (backhaul link)와 액세스 링크 (access link)가 같은 대역을 이용하는 inband relay로 동시에 백홀 링크와 액세스 링크에서 송수신 하는 경우에 self-interference가 발생하여 수신 성능이 크게 열화되기 때문에 동시에 송수신할 수 없다. 이와 같은 특징 때문에 Type 1 relay는 eNB (evolved NodeB)가 동기 신호를 송신할 때, 자신에게 접속하고 있는 R-UE (Relay-User Equipment)에게 동기 신호를 송신해야 하는 특정에 의해서 eNB가 송신하는 동기 신호를 수신할 수 없어 셀 ID (Identity)를 검출할 수 없는 문제점을 갖는다. 따라서, 이러한 문제점을 해결하기 위하여 본 논문에서는 eNB와 Type 1 relay가 동기 신호를 송신하는 subframe에서만 Type 1 relay가 동시에 송수신하는 부분 전이중 relay 기법을 제안한다. 또한, 동시에 Type 1 relay가 백홀 링크와 액세스 링크에서 송수신하여 발생하는 self-interference를 제거하기 위하여 Type 1 relay의 송수신 안테나 사이의 공간적 분리 (geometric isolation)와 SIC (Self-Interference Cancellation) 방식을 적용하고, SIC의 성능을 높이기 위한 정확한 채널 추정 방안으로 부분 채널 추정 (partial channel estimation) 기법을 제안하며, 다양한 환경에서의 성능 평가를 통해 제안된 방식이 Type 1 relay를 이용하는 3GPP LTE-Advanced 시스템에서 매우 유용한 것을 입증하였다.

• Journal of Electrical Engineering and Technology
• /
• 제8권6호
• /
• pp.1424-1430
• /
• 2013

This paper presents design procedure of the magnetic bearings used for high-speed electric machines and flywheel energy storage systems. Magnetic bearing can be categorized by inner-rotor type and outer-rotor type according to the position of the rotary disc. These two types are applicable based on application environments such as application space, required attraction force, and controllability. Magnetic bearing is generally designed based on the ratio (geometrical coefficient or geometrical efficiency) of pole width to rotor journal radius but proper ratio is only decided by the analysis. This is the difficulty of the magnetic bearing design. In this paper, proper design technology of the inner-rotor type and outer-rotor-type eight pole magnetic bearings is introduced and compared with the FEM analysis results, which verifies the proposed design procedure is suitable to be applied to the design of the magnetic bearings for the industrial applications and flywheel energy storage system.

• 대한수학회지
• /
• 제50권3호
• /
• pp.493-507
• /
• 2013

We construct a new family of simply connected minimal complex surfaces of general type with $p_g$ = 1, $q$ = 0, and $K^2$ = 3, 4, 5, 6, 8 using a $\mathbb{Q}$-Gorenstein smoothing theory.

• 세라미스트
• /
• 제21권3호
• /
• pp.283-292
• /
• 2018

Here, we introduce various type of inorganic nanostructure synthesized with functional nanoparticles and silica. From two decades ago, functional inorganic nanoparticles have been synthesized and highlighted, now we moved to next level of wet-chemical synthesis. By integrating functional nanoparticles with silica, we were able to synthesize multi-functional nanostructure, which expand the applications of nanoparticles to catalyst, drug carrier, sensors. In this context, silica has been spotlighted due to its versatility. Silica has highly biocompatible, relatively transparent and stable under harsh conditions. Thus it can be used as good supporter to synthesize complex multi-functional nanostructure when mixed with other functional nanoparticles. A various shape of complex nanostructures have been synthesized including core-shell type, yolk-shell type and janus type etc. In this paper, we have described the purposes of synthesizing silica noncomplex and various case studies for biomedical applications and self-assembly.

• Applied Microscopy
• /
• 제46권2호
• /
• pp.110-115
• /
• 2016

Transmission electron microscopy (TEM) is a powerful tool for analyzing a broad range of materials and provides localized information about the microstructure. However, the analysis results are strongly influenced by the quality of the thin foil specimen. Sample preparation for TEM analysis requires considerable skill, especially when the area of interest is small or the material of interest is difficult to thin because of its high hardness and its mechanical instability when thinned. This article selectively reviews recent advances in TEM sample preparation techniques using a tripod polisher. In particular, it introduces two typical types (fl at type and wedge type) of TEM sample preparation and the benefits and drawbacks of each method; finally, a method of making better samples for TEM analysis is suggested.