• 천문학회보
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• 제43권1호
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• pp.59.4-60
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• 2018

To investigate the impact of the high-redshift quasars on cosmic reionization, the faint end slope of the quasars luminosity function has to be determined precisely. More quasars with low luminosity are needed to constrain the contribution to reionization in the early universe. However, finding these quasars has been regarded as tough process owing to the improper shallow depth of imaging data. In recent days, the release data of Subaru Hyper Suprime-Cam (HSC) Strategic Program survey which provide the deep images reaching ~ 25 mag facilitates searching the faint quasars candidates. To find faint quasar candidates in ELAIS-N1 field, along with the HSC data, two near-infrared (NIR) data sets also be used : The Infrared Medium-deep Survey (IMS) and The UKIRT Infrared Deep Sky Survey (UKIDSS) - Deep Extragalactic Survey (DXS). Quasar candidates selected from the multi-band color cut were observed by the SED camera for QUasars in EArly uNiverse (SQUEAN) instrument. To trace the redshifted Lyman break efficiently, appropriate medium bands comparable to targeted redshift range are chosen. The most reliable quasar candidates are finally determined through SED fitting. Using this less luminous quasars candidates, we can speculate the relation between the quasar growth and the host galaxy unbiasedly and estimate the contribution to the cosmic reionization.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5019-5024
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• 2015

Background: The purpose of this study was to assess the dosimetric and clinical feasibility of volumetric modulated arc based hypofractionated stereotactic radiotherapy (RapidArc) treatment for large acoustic schwannoma (AS >10cc). Materials and Methods: Ten AS patients were immobilized using BrainLab mask. They were subject to multimodality imaging (magnetic resonance and computed tomography) to contour target and organs at risk (brainstem and cochlea). Volumetric modulated arc therapy (VMAT) based stereotactic plans were optimized in Eclipse (V11) treatment planning system (TPS) using progressive resolution optimizer-III and final dose calculations were performed using analytical anisotropic algorithm with 1.5 mm grid resolution. All AS presented in this study were treated with VMAT based HSRT to a total dose of 25Gy in 5 fractions (5fractions/week). VMAT plan contains 2-4 non-coplanar arcs. Treatment planning was performed to achieve at least 99% of PTV volume (D99) receives 100% of prescription dose (25Gy), while dose to OAR's were kept below the tolerance limits. Dose-volume histograms (DVH) were analyzed to assess plan quality. Treatments were delivered using upgraded 6 MV un-flattened photon beam (FFF) from Clinac-iX machine. Extensive pretreatment quality assurance measurements were carried out to report on quality of delivery. Point dosimetry was performed using three different detectors, which includes CC13 ion-chamber, Exradin A14 ion-chamber and Exradin W1 plastic scintillator detector (PSD) which have measuring volume of $0.13cm^3$, $0.009cm^3$ and $0.002cm^3$ respectively. Results: Average PTV volume of AS was 11.3cc (${\pm}4.8$), and located in eloquent areas. VMAT plans provided complete PTV coverage with average conformity index of 1.06 (${\pm}0.05$). OAR's dose were kept below tolerance limit recommend by American Association of Physicist in Medicine task group-101(brainstem $V_{0.5cc}$ < 23Gy, cochlea maximum < 25Gy and Optic pathway <25Gy). PSD resulted in superior dosimetric accuracy compared with other two detectors (p=0.021 for PSD.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5107-5110
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• 2013

Background: Among women with haematuria, defining individuals under high risk for bladder cancer based on reproductive factors prior to cystoscopy would be of great benefit in the management of this condition. The aim of this study was to compare age and reproductive factors such as menopausal status, parity, age at first delivery and age at the last delivery between women who have haematuria with or without bladder cancer. Materials and Methods: A total of 463 patients underwent diagnostic cystoscopy in D$\ddot{u}$zce University Faculty of Medicine between 1 June 2008 and 1 June 2013. Female patients who presented with persistent microscopic or macroscopic haematuria and underwent standard evaluation for haematuria including urinalysis, urine culture, urine cytology, urinary tract imaging with excretory urography or computerized tomography with contrast enhancement and endoscopic evaluation of the urethra and bladder were included in this study. Exclusion criteria were tobacco use and high risk occupations for bladder cancer such as textile, dry cleaning, painting and etc. Forteen women had hematuria due to benign conditions, and 18 due to bladder cancer. Data were retrospectively retrieved from the medical records of Duzce University Hospital. Results: Patients with haematuria due to benign reasons did not significantly differ from patients who were found to have bladder cancer in terms of age (p=0.28), menopausal status (p=0.29), mean parity (p=0.38), being nulliparous (p=0.57), parity ${\geq}3$ (p=0.22), age ${\leq}18$ years at first delivery (p=1.00), age ${\geq}30$ years at last delivery (p=0.26), age ${\geq}35$ years at last delivery (p=0.23) and percentage of the patients with advanced age (${\geq}65$ years) (p=0.18). Conclusions: It is difficult to predict a high risk for developing bladder cancer in women with haematuria based solely on reproductive factors.

• Imaging Science in Dentistry
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• 제44권4호
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• pp.257-262
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• 2014

Purpose: This study was performed to evaluate the effect of changing the orientation of a reconstructed image on the accuracy of linear measurements using cone-beam computed tomography (CBCT). Materials and Methods: Forty-two titanium pins were inserted in seven dry sheep mandibles. The length of these pins was measured using a digital caliper with readability of 0.01 mm. Mandibles were radiographed using a CBCT device. When the CBCT images were reconstructed, the orientation of slices was adjusted to parallel (i.e., $0^{\circ}$), $+10^{\circ}$, $+12^{\circ}$, $-12^{\circ}$, and $-10^{\circ}$ with respect to the occlusal plane. The length of the pins was measured by three radiologists, and the accuracy of these measurements was reported using descriptive statistics and one-way analysis of variance (ANOVA); p<0.05 was considered statistically significant. Results: The differences in radiographic measurements ranged from -0.64 to +0.06 at the orientation of $-12^{\circ}$, -0.66 to -0.11 at $-10^{\circ}$, -0.51 to +0.19 at $0^{\circ}$, -0.64 to +0.08 at $+10^{\circ}$, and -0.64 to +0.1 at $+12^{\circ}$. The mean absolute values of the errors were greater at negative orientations than at the parallel position or at positive orientations. The observers underestimated most of the variables by 0.5-0.1 mm (83.6%). In the second set of observations, the reproducibility at all orientations was greater than 0.9. Conclusion: Changing the slice orientation in the range of $-12^{\circ}$ to $+12^{\circ}$ reduced the accuracy of linear measurements obtained using CBCT. However, the error value was smaller than 0.5 mm and was, therefore, clinically acceptable.

• 한국항공우주학회지
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• 제42권12호
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• pp.1013-1019
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• 2014

저궤도 관측위성에 탑재된 영상처리장치의 온도제어를 위하여 사용하는 열적완충질량을 대체할 수 있는 상변화물질의 성능에 대하여 수치해석적으로 분석하였다. 관측위성에 사용되는 고정밀 영상처리장치는 임무에 따라 주기적으로 작동하며 발열량이 매우 큰 반면, 온도에 민감하여 작동허용 온도범위가 매우 좁다. 이러한 장치의 온도를 제어하기 위하여 국산 저궤도 관측위성에서는 열적완충질량을 이용하여 부품의 온도변화 시상수를 증가시키는 효율적인 설계를 적용하였지만, 질량이 증가하는 단점이 있다. 본 연구에서는 질량을 최소화하며 부품 온도를 안정적으로 유지할 수 있도록 고상-액상 상변화물질을 이용한 열제어 장치를 제안하였으며, 수치해석을 통하여 열적 완충질량에 대한 유효성을 비교/검증하였다. 상변화물질을 이용한 열제어 장치는 열적완충질량을 대체하여 효과적인 온도제어가 가능할 뿐 아니라 질량도 열적완충질량의 약 12% 정도로 감소시킬 수 있었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제23권2호
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• pp.57-62
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• 2012

Objectives : Characteristic symptoms, including hyperactivity and easy distractibility, in children with attention-deficit hyperactivity disorder (ADHD) suggest that their brain status, even at rest, might differ from that of healthy children. This study was conducted in order to determine whether resting state brain activity is compromised in medication-naive children with ADHD. Methods : Twenty medication-naive children with ADHD (mean age $10.3{\pm}2.5$) and 28 age- and gender-matched healthy volunteers (mean age $10.3{\pm}2.0$) underwent measurements for resting state brain activity using functional magnetic resonance imaging (fMRI). Among resting state related-independent components (RSICs) extracted from fMRI data using independent component analysis, a significant difference in RSICs was observed between groups, using a mixed Gaussian/gamma model. Results : Except for IQ, which was higher in the healthy control group, no demographic difference was observed between the two groups (p<.001). Significantly less activation of one RSIC, which includes the bilateral precuneus/posterior cingulate cortex, occipito-temporal junction, and anterior cingulate cortex, was observed in the ADHD group, compared with the control group (p<.05). Conclusion : An abnormal RSIC, posterior default mode network (DMN), was observed in the medication-naive ADHD group. Results of our study suggest that abnormality of posterior DMN is one of the main pathophysiologies of ADHD.

• 천문학회지
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• 제36권3호
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• pp.81-87
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• 2003

It is suggested that a flying-by star in a hot accretion disk may cool the hot accretion disk by the Comptonization of the stellar emission. Such a stellar cooling can be observed in the radio frequency regime since synchrotron luminosity depends strongly on the electron temperature of the accretion flow. If a bright star orbiting around the supermassive black hole cools the hot disk, one should expect a quasi-periodic modulation in radio, or even possible an anti-correlation of luminosities in radio and X-rays. Recently, the unprecedentedly accurate infrared imaging of the Sagittarius A$\ast$ for about ten years enables us to resolve stars around it and thus determine orbital parameters of the currently closest star S2. We explore the possibility of using such kind of observation to distinguish two quite different physical models for the central engine of the Sagittarius A$\ast$, that is, a hot accretion disk model and a jet model. We have attempted to estimate the observables using the observed parameters of the star S2. The relative difference in the electron temperature is a few parts of a thousand at the epoch when the star S2 is near at the pericenter. The relative radio luminosity difference with and without the stellar cooling is also small of order $10^{-4}$, particularly even when the star S2 is near at the pericenter. On the basis of our findings we tentatively conclude that even the currently closest pass of the star S2 is insufficiently close enough to meaningfully constrain the nature of the Sagittarius A$\ast$ and distinguish two competing models. This implies that even though Bower et al. (2002)have found no periodic radio flux variations in their data set from 1981 to 1998, which is naturally expected from the presence of a hot disk, a hot disk model cannot be conclusively ruled out. This is simply because the energy bands they have studied are too high to observe the effect of the star S2 even if it indeed interacts with the hot disk. In other words, even if there is a hot accretion disk the star like S2 has imprints in the frequency range at v $\le$ 100 MHz.

• Journal of Radiation Protection and Research
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• 제30권1호
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• pp.17-25
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• 2005

원자력 발전의 안정성이 사회적 문제로 제기된 이후 작업종사자에 대한 작업 중 방사선 피폭량에 대한 관심이 높아지고 있다. 현재의 방법에 의하면 방사선 작업 계획의 수립 시 작업 공간 내 선량률이 일정하다는 가정 하에 피폭선량을 예측하므로 작업 경로에 따른 피폭선량의 변화에 대한 고려가 이루어지지 않고 있다. 본 연구에서는 작업자와 선원과의 거리가 고려되 수정된 방사선 피폭량 계산식을 이용하여 방사성 폐기물 저장시설에서의 작업 중 작업경로 변화에 따른 방사선 피폭량을 계산하였다. 이 계산식을 이용하여 주어진 작업 공간과 선원 조건하에서 작업 중 방사선 피폭량을 최소로 하는 최적 작업경로를 탐색할 수 있는 수치해석 알고리즘을 제안하였다. 이를 위하여 2차원 작업공간에서 무한개의 작업경로를 유한개의 경로로 근사화하고 근사화된 모든 작업경로 중 피폭선량이 최소가 되는 작업경로를 탐색하였다. 또한, 3차원 그래픽 기술과 Java 프로그래밍을 이용한 가상작업 시뮬레이션 프로그램을 개발하고 작업 공간의 선량률 가시화 및 가상 작업 시뮬레이션을 수행하여 방사선 작업 계획의 수립을 위한 도구로서의 가능성을 검토하였다. 수치해석 계산과 시뮬레이션 과정을 통하여 최적 작업경로는 작업자와 선원과의 거리를 증가시키고 작업 시간을 단축시킬 수 있는 경로로 제시되었고, 이를 바탕으로 방사선 피폭량은 작업시간뿐만 아니라 작업자와 선원간의 거리에 영향을 받음과 최적화된 방사선 방호를 위해 작업경로가 고려되어야 함을 확인하였다.

• Journal of Gastric Cancer
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• 제12권2호
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• pp.99-107
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• 2012

Purpose: Gastric mucosal neoplastic lesions should have characteristic endoscopic features for successful endoscopic submucosal dissection. Materials and Methods: Out of the 1,010 endoscopic submucosal dissection, we enrolled 62 patients that had the procedure cancelled. Retrospectively, whether the reasons for cancelling the endoscopic submucosal dissection were consistent with the indications for an endoscopic submucosal dissection were assessed by analyzing the clinical outcomes of the patients that had the surgery. Results: The cases were divided into two groups; the under-diagnosed group (30 cases; unable to perform an endoscopic submucosal dissection) and the over-diagnosed group (32 cases; unnecessary to perform an endoscopic submucosal dissection), according to the second endoscopic findings, compared with the index conventional white light image. There were six cases in the under-diagnosed group with advanced gastric cancer on the second conventional white light image endoscopy, 17 cases with submucosal invasion on endoscopic ultrasonography findings, 5 cases with a size greater than 3 cm and ulcer, 1 case with diffuse infiltrative endoscopic features, and 1 case with lymph node involvement on computed tomography. A total of 25 patients underwent a gastrectomy to remove a gastric adenocarcinoma. The overall accuracy of the decision to cancel the endoscopic submucosal dissection was 40% (10/25) in the subgroup that had the surgery. Conclusions: The accuracy of the decision to cancel the endoscopic submucosal dissection, after conventional white light image and endoscopic ultrasonography, was low in this study. Other diagnostic options are needed to arrive at an accurate decision on whether to perform a gastric endoscopic submucosal dissection.

• 방사선산업학회지
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• 제10권4호
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• pp.189-192
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• 2016

$^{68}Ga$ has emerged as a promising candidate for non-invasive diagnostic imaging within Positron Emission Tomography (PET) because of its advantageous radiochemical characteristics ($t_{1/2}=68min$, ${\beta}^+$ yield ~89%). $^{68}Ga$ forms a stable chelation with various ligands and it is possible to be quickly and easily study using a $^{68}Ge/^{68}Ga$ generator. Commercial $^{68}Ge/^{68}Ga$ generators are chromatographic system using the inorganic materials such as alumina and tin dioxide which are employed as column matrixes for $^{68}Ge$. In this study, we tried out to make $^{68}Ge/^{68}Ga$ generator system with the $^{68}GeO_2$ microstructures for column matrix. $^{68}Ge$ tends to have stable bond with oxide as $^{68}GeO_2$ microstructures. The $^{68}GeO_2$ has been synthesized by hydrolysis of $GeCl_4$ (sol-gel method) and characterized by X-ray diffraction and scanning electron microscope for geometrical analysis. The stability of $GeO_2$ was tested using eluents with diverse solvents(water, ethanol and 0.1 N HCl). The radioactivity of $^{68}Ga^{3+}$ in eluate through $GeO_2$ was measured to prove a function as column material for a generator.