• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4791-4795
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• 2015

Purpose: This study was conducted to observe the efficacy and safety of pemetrexed based chemotherapy in treating patients with locally advanced or metastatic cancers as first-line, second-line or third-line therapy. Materials and Methods: From May 2011 to January 2015, we recruited 29 patients with advanced breast cancer, 19 patients with advanced ovary cancer, 17 patients with advanced esophageal cancer,5 patients with advanced gallbladder cancer,5 patients with advanced cervical cancer and 1 patient with advanced tongue cancer in Jiangsu Cancer Hospital and Research Institute.All of them were pathologically confirmed and treated with pemetrexed based chemotherapy. After two cycles of treatment,efficacy and safety can be evaluated. Results: For pemetrexed based regimens,including 76 patients with 6 kinds of advanced cancer were considered eligible for inclusion. Complete remission represents CR, partial remission represents PR, stable disease represents SD, progressive disease represents PD. Among 29 patients with advanced breast cancer, 4 patients chose pemetrexed based regimens as second-line treatment,1 of them was PR,the other 3 got SD. The last 25 patients made use of this chemotherapy as third-line treatment, except one patient could not be assessed, 2 of them got PR,6 of them got SD,the remaining 16 of them finally were PD.19 patients with advanced ovary cancer,5 patients used this regimens as second-line treatment, 3 of them got PD,the remaining patients got SD, respectively. The last 14 patients made use of pemetrexed based regimens as third-line treatment,. RR (CR+PR) was 28.5%. Among 17 patients with advanced esophageal cancer, 2 patients made use of pemetrexed based regimens as first-line treatment,both of them got PR.4 of them used this chemotherapy as second-line regimen, except 2 patients could not be assessed,the remaining 2 was PD at last. The last 11 patients was third-line users, RR (CR+PR) was 18.2%. Among 5 patients with advanced gallbladder cancer, pemetrexed based regimens was used in 1 patient as first-line treatment and 1 patient as second-line treatment. The curative effect was SD and PD, respectively. 3 patients accepted pemetrexed based regimens as third-line treatment, 2 of them got PD as results and another was SD. Among 5 patients with advanced cervical cancer, just 1 patient adopted pemetrexed based regimens as first-line treatment, whose curative effect was PR.2 patients chose this chemotherapy regimens as second-line treatment. Both of them got PD as their consequence. The last 2 patients made use of the regimens as third-line treatment, the effect of them was PD and SD, respectively. The one who with advanced tongue cancer, pemetrexed based regimens was used as second-line treatment, and the consequence was PD. About 71.1% patients experienced bone marrow suppression. Among them, 5 patients reached 4 grade. Other toxicity of pemetrexed were neurotoxicity, fatigue, diarrhea, dysphagia and vomiting. No treatment related death occurred with pemetrexed-based treatment. Conclusions: Pemetrexed based chemotherapy has considerable effect in patients with advanced cancers such as breast cancer,esophageal cancer and ovary cancer. More randomly clinical trials are needed to verify the results.

• 상하수도학회지
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• 제19권3호
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• pp.323-329
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• 2005

Advanced processes such as ozonation or activated carbon filtration (ACF) in water treatment plants have been used in Korea since 1994. At present, seventeen drinking water treatment plants are currently operating. This survey compares the treatment performance of advanced processes in eight plants which have comparable water quality data. The three parameters (DOC, $UV_{254}$, and $KMnO_4$ consumption) of water quality were selected as an indicator of treatment efficiency. The treatment efficiency of ozonation and ACF processes was found to vary with large deviations in each plant. Treatment efficiency of DOC, $UV_{254}$, and $KMnO_4$ consumption by post ozonation ranged from 3 to 11%, 6 to 33%, and 12 to 28% respectively. On the other hand, for ACF, treatment efficiency of DOC, $UV_{254}$, and $KMnO_4$ consumption ranged from 7 to 38%, 8 to 48%, and 16 to 66% respectively. These large deviations indicate the advanced processes of water treatment plants to be further optimized.

• 열처리공학회지
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• 제32권5호
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• pp.195-200
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• 2019

For expanding the applications and workability of TiAl alloy, elongation is very important property. Fine microstructure is needed for elongation and physical properties of TiAl alloys. In this study, The effects of cyclic heat treatment process for fine microstructure of Ti-46Al-Nb-W-Cr-Si-C alloy, which was made by VAR (vacuum arc remelting) and VIM(vacuum induction melting) centrifugal casting process, was investigated. Cycle heat treatment process was very effective for recrystallization of this TiAl system, which has microstructure size of $50{\sim}100{\mu}m$ through pre-heat treatment, cyclic heat treatment in ${\alpha}+{\gamma}$ phase region and solution heat treatment respectively. Refined grain size was finally confirmed by photos of optical microscope and scanning electron microscope.

• Korean Chemical Engineering Research
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• 제48권5호
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• pp.589-597
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• 2010

하수처리 시스템에서의 생물학적 영양염류 기준이 강화됨에 따라, 표준활성슬러지공법으로 운전 중인 하수처리장의 고도처리 공법으로의 개보수 필요성이 증가하고 있다. 그러나 실제 하수처리 시스템에서의 다양한 유입조건 및 운전조건의 복잡한 반응 구성으로 인해 실험을 통하여 개보수된 고도처리공법의 최적조건을 찾는 것은 쉽지 않은 일이며, 이는 많은 시간과 비용을 소모하여 비효율적이다. 따라서 본 연구에서는 활성슬러지공정모델(ASMs)을 기반으로 한 하수처리장의 모델링 및 시뮬레이션 기법을 통하여 하수처리장의 고도처리공법으로의 upgrading 설계를 수행하며, 이를 통계적이며 체계적으로 접근하기 위해 반응표면분석법(Response surface method)을 통한 고도처리공법의 설계 최적화를 수행하였다. 또한 실규모 하수처리장에서의 운전 최적화를 위해서는 하수처리의 동력학적 매개변수에 대한 정확한 분석이 수행되어야 한다. 본 연구에서는 다변량 통계분석 기법인 부분최소승자법(PLS)을 통하여 하수처리 시스템의 동력학적 매개변수 간의 상관관계를 파악하며, 고도처리공법 하수처리장의 운전 결과에 가장 큰 영향을 미치는 매개변수를 도출하였다. 본 연구를 통해 하수처리장의 고도처리공법 upgrading 설계 및 운전 최적화를 위한 방법론을 제시하였으며, 이를 통하여 설계시간 및 경비 절감 등 고도처리공법으로의 고효율적인 개보수가 가능할 것으로 예상된다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제16권2호
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• pp.147-150
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• 2016

The prevalence of thyroid disease, particularly hyperthyroidism, has rapidly increased in Korea in the past 10 years. Therefore, it is important to consider the complete medical history including thyroid disease in patients under dental treatment. Both the drugs used for dental treatment and psychological symptoms associated with treatment can induce emergencies in hyperthyroid patients. This case report considers emergency situations during dental treatment for hyperthyroid patients, and discusses risk factors and related concerns.

• Membrane and Water Treatment
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• 제3권3호
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• pp.181-200
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• 2012

At present water crisis is not an issue of scarcity, but of access. There is a growing recognition of the need for increased access to clean water (drinkable, agricultural, industrial use). An encouraging number of innovative technologies, systems, components, processes are emerging for water-treatment, including new filtration and disinfectant technologies, and removal of organics from water. In the past decade many methods have been developed. The most important membrane-based water technologies include reverse osmosis (RO), ultrafiltration (UF), microfiltration (MF), and nanofiltration. Beside membrane based water-treatment processes, other techniques such as advanced oxidation process (AOP) have also been developed. Some unconventional water treatment technology such as magnetic treatment is also being developed.

• 대한금속재료학회지
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• 제47권3호
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• pp.169-174
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• 2009

The effect of sub zero treatment on the damping capacity in austempered ductile cast iron investigated. Austenite transformed in to martensite by subzero treatment, and with the decrease of subzero treatment temperature, volume fraction of martensite increased. Damping capacity of austempered ductile cast iron was highly increased by subzero treatment, with the decrease of subzero treatment temperature, damping capacity was slowly increased. With the decrease of subzero treatment time, damping capacity was rapidly increased to 30 min. and then slowly increased. With the increase of volume fraction of martensite, damping capacity rapidly increasing to 5% and then slowly increased.

• 한국분말재료학회지
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• 제21권2호
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• pp.142-146
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• 2014

Fundamental experiences have been studied for development of pre-treatment process of Sn by-products such as solders. Dry and wet separation/recovery processes were considered by the differences of physical properties. The by-products, which are analyzed by solder metal and oxides. The metal and oxide were simply separated by dry ball-milling process for 12 hours, after that recovery metal powder might be reusable as lead or lead-free solders. In terms of wet separation process, samples were dissolved in $HNO_3+H_2O_2$ and the precipitation were analyzed by $SnO_2$. Overall efficiency of recovery might be increasing via developing simple pre-treatment process.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2007년도 추계학술대회 논문집
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• pp.138-139
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• 2007

The microstructure and micro-hardness of high velocity oxygen fuel-sprayed (HVOF) WC-CoCr coatings are comparatively studied for both before and after laser heat-treatment (LT) of the coatings. The results indicate that compared to HVOF WC-CoCro coating, the laser treatment has eliminated the pores almost entirely providing a more homogeneous and densified microstructure. And the compact interface of the coating with substrate is achieved by laser treatment. The thickness of the coating has decreased from 300 ${\mu}m$ to 225 ${\mu}m$ As a result, the average porosity is five times higher in HVOF coating than in the coating by laser treatment. The laser treatment has produced a considerable increment in the hardness of the coating near surface whose average value increases from Hv0.2=1262.4 in the HVOF-sprayed coating to Hv0.2=1818.7 in the coatings treated with laser.

• 대한암한의학회지
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• 제19권1호
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• pp.25-32
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• 2014

Objectives : The purpose of this study is to report the effect of Korean Medicine Treatment (KMT) on the advanced gastric carcinoma (AGC) patient. Method : One advanced gastric carcinoma patient was treated by Korean Medicine Treatment composed of pharmacopuncture, acupuncture and herbal medicine. At the same time, he received chemotherapy (S-1 and Cisplatin) and radiotherapy. The effect of KMT was measured by scanning with Computed tomography (CT) and Esophagogastroduodenoscopy (EGD). Response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) Committee classification. Result : The tumor was disappeared after the treatment during 13 months (Complete Response (CR)). As treatment was performed, chemoradiation therapy induced complication was alleviated. Conclusion : This case provides us a possibility that Korean Medicine Treatment offers potential benefits for advanced gastric carcinoma patient.