• Annals of Clinical Neurophysiology
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• 제11권2호
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• pp.74-77
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• 2009

We report a 23-year-old woman with adult Sandhoff disease, who presented with motor neuron disease phenotype. The patient had experienced progressive motor weakness in four extremities since 1 year prior to admission. Electrophysiological study revealed wide-spread denervation potentials, and the assay of total hexosaminidase involving A and B activities showed decreased levels of these activities, which was consistent with Sandoff disease. This is the first Korean case of adult Sanhoff disease presented as a motor neuron disease phenotype.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권1호
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• pp.28-40
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• 2019

The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Furthermore, successful transition facilitates appropriate development and psychosocial well-being among patients, as well as comprehensive and harmonious healthcare delivery amongst stakeholders. However, there are various obstacles related to patients, family, providers, and organizations that interfere with successful transition. Successful transition requires a flexible and tailored plan that is made according to the patient's developmental abilities and situation. This plan should be established through periodic interviews with the patient and family and through close collaboration with other care providers. Through a stepwise approach to the transition process, patients' knowledge and self-management skills can be improved. After preparation for the transition is completed and the obstacles are overcome, patients can be gradually moved to adult care. Finally, successful transition can increase patients' adherence to therapy, maintain the appropriate health status, improve patients' self-management, and promote self-reliance among patients.

• The Journal of Korean Physical Therapy
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• 제13권2호
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• pp.453-458
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• 2001

The aim of this study is to present the basic reference data of age and specific gait parameters for Parkinson's Disease Patients. The basic gait parameters were extracted from 5 patients, 5 men and 65 years of age using VICON 512 Motion Analyzer. The temporal gait parameters and kinematic parameters is data of Parkinson's Disease Patients. The results were as follows; 1. The cadence, velocity, stride length decreased and single limb support period, double limb support period increased than normal adult in the temporal parameters. 2. The mean angles of joint pelvic tilt and hip, knee, ankle joint decreased than normal adult at kinematic characteristics on sagittal plane. 3. The mean angles of joint pelvic tilt and hip, knee joint has no difference than normal adult at kinematic characteristics on coronal plane. 4. The mean angles of joint pelvic tilt, hip joint no difference and internal, external rotation in ankle joint significantly decreased than normal adult at kinematic characteristics on transverse plane.

• Toxicological Research
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• 제20권4호
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• pp.299-305
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• 2004

Adult periodontitis (AP) is a chronic inflammatory disease whose etiology is not well defined. Some studies suggested that the clinical characteristics of this disease may be in part explained by genetic factors, and some attempts to find genetic markers for this disease were successful. The interleukin-1 (IL-1) gene family as one of genetic factors may influence the expression of adult periodontitis. The aim of present study is to investigate the frequencies of genetic polymorphisms in the IL-1 gene family encoding three genes (IL-1A, IL-1B and IL-1RN) in Korean AP patients and periodontically healthy controls. There were no significant differences in genotype and allele frequencies of these polymorph isms between two groups, respectively. However, -511 polymorphism of IL-1 B gene was significantly associated with mean pocket depth (MPD, mm) value in AP patients (P<0.05). Therefore, our results suggest that -511 polymorphism in the IL-1B gene may be useful as a genetic marker for the severity of AP in Koreans.

• BMB Reports
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• 제42권5호
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• pp.239-244
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• 2009

New neurons are continually generated in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles of the adult brain. These neurons proliferate, differentiate, and become integrated into neuronal circuits, but how they are involved in brain function remains unknown. A deficit of adult hippocampal neurogenesis leads to defective spatial learning and memory, and the hippocampi in neuropsychiatric diseases show altered neurogenic patterns. Adult hippocampal neurogenesis is not only affected by external stimuli but also regulated by internal growth factors including BDNF, VEGF and IGF-1. These factors are implicated in a broad spectrum of pathophysiological changes in the human brain. Elucidation of the roles of such neurotropic factors should provide insight into how adult hippocampal neurogenesis is related to psychiatric disease and synaptic plasticity.

• Clinical and Experimental Pediatrics
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• 제49권9호
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• pp.937-945
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• 2006

The population of adult patients with congenital heart disease(CHD) has increased dramatically because of improved survival of infants and children with CHD. There are still a substantial number of adults with unrepaired CHD. Many adult patients do not know the possible problems of their disease such as ventricular dysfunction, arrhythmia, and what they should pay attention to. They often consider themselves "cured" or "healthy" if only they don't have overt symptoms, and visit hospitals only after deterioration of their problems. Some patients are neglected because they cannot be corrected surgically although careful medical support can improve their survival and quality of life. It is, therefore, essential that the patients, their families, and physicians understand the potential problems of CHD and need for regular follow-up. In this paper we will take a brief review for common medical problems of repaired or unrepaired CHD and also mention a few specific diseases which are common in adults.

• 대한한방소아과학회지
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• 제17권2호
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• pp.15-26
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• 2003

저자는 류마티스 관절염의 일종인 성인형 스틸병으로 치료받던 16세 환아의 치료 과정 중 발생한 미만성 뇌피질 손상 1예(例)에 대하여 초기 양방 병원에서의 치료에도 변화가 없었던 운동마비와 정신신경계통의 제반 증상에 대하여 한방적 치료한 결과 호전도가 있었기에 증예보고(證例報告)하는 바이다. 특히 경계정충(驚悸??)을 동반한 불면(不眠)에 대하여 자하차(紫河車) 약철(藥鍼)과 녹용(鹿茸) 약철(藥鍼)을 시술한 것에 대하여서는 지견을 얻었으며 가미온담탕(加味溫膽湯), 양심탕류(養心湯類)의 처방이 유용한 효과가 있다는 결론을 얻었다. 하지만 150일이라는 장기입원 치료에 비해서 전실어(全失語)는 거의 호전을 보지 못했으며 Mental Grade가 GCS 상 12점까지 상승하였으나 일상생활에서의 능동적인 운동능력의 호전에는 한계가 있었다는데서 아쉬움이 남는다. 아직까지 한방 분야에서 성인형 스틸병과 미만성 뇌피질 손상에 대한 연구는 별로 보고된 것이 없었으며, 특히 장기간의 관리가 필요한 마비 질환의 경우 그 평가 척도나 정신계통의 회복에 있어서 연구 및 치료방법이 부족한 듯하며 차후 지속적인 연구가 필요하리라 사료된다.

• 대한가정학회지
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• 제40권10호
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• pp.123-139
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• 2002

The purpose of this study was to understand the adult day care center as a place for the elders and adults and to develop an initial understanding of the services and activity programs for adult day care for the cognitively-impaired in the U.S.A. The data were collected from 12 Adult Day Care Centers(ADC) from 2001 to 2002 by personal interview and the documents about the programs. ADC programs provided primarily social, recreational, and health activities and services in a group setting. Centers offered participants to socialize, enjoy peer support, and receive health and social services in a stimulating and supportive environment that promotes better physical and mental health. For this purpose those centers offered not only professional health care, occupational.speech.physical therapies but also socio-recreation and therapeutic-recreation services.

• 한국동물위생학회지
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• 제43권3호
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• pp.181-187
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• 2020

On a farm with 6 Korean beef cattle, an adult cow and a calf suddenly died while eating. At that time, hair was pressed upon the stanchion facilities where the adult cow was fed. Two dead cattle were submitted to the Animal and Plant Quarantine Agency for disease diagnosis. Grossly, the mouth of the adult cow was full of feed that had been eaten before death, and there was a foamy fluid in the calf's trachea. Both hemorrhages were observed in the muscles, as well as in the internal organs such as the liver, lungs, and heart. Ruminal mucosa was easily peeled off. Histopathologically, both muscles and internal organs showed severe hemorrhages. In particular, affected muscles were shown segmental and band-like patterns of myonecrosis, disappeared some myocytes, burned hair follicles, and irregular surface of skin. Severe hemorrhages of muscles and internal organs were consistent with previous reports. Easily separated mucosa of rumen and muscle lesions were very characteristic. We determined electrocution according to the pathological findings, laboratory results, and traces of accidents. This report will help to understand of pathological lesions of electrocution. Furthermore, this case suggests that the electrical wires and devices must be installed and handled carefully during the construction of the cowsheds care.

• 대한한방소아과학회지
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• 제14권2호
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• pp.141-147
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• 2000

Moyamoya is a chronic cerebrovascular disease chracterized by progressive stenosis or occlusion of the terminal parts of both internal carotid arteries with telangiectatic vascular network of collateral circuration at the base of the brain and leptomeningeal arteries. The etiology and pathophysiology of this disease are still unknown. The clinical course in those whose first symptoms occur in childhood is different from those in whom symptoms develop in adult life. The term moyamoya disease should be resserved for those cases in which the chracteristic angiographic pattern is idiopathic; moayamoya syndrome is used when the underlying condition is known. we have experienced a case of moyamoya syndrome in a 5-year-2-month-old boy who presented right-sided hemiparesis. A cerebral angiogram revealed occlusion of abnomal collateral network. Moyamoya disease is applicable to stroke of an infant from oriental medicine point of view, and The symptoms is similar to adult stroke, we have treated adult stroke patint with herb medicine and acupuncutre and physical treatment. The acute stage of stroke is applied to the external treatment(標治), and The recovery stage is applied to the basic treament(本治).