• 환경위생공학
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• 제21권2호
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• pp.47-56
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• 2006

This study was to investigate relationship between osteoporosis and various factors. We compared the result in 390 women with under -2.5 bone mineral density (BMD, T-scores) with those in 370 women with over -1.0 BMD. According to WHO criteria, women with -2.5 BMD are regarded as patient with osteoporosis, while with above -1.0 BMD are healthy. We obtained the BMD(T-scores) data of 9.704 adult women over 20 year old. The following are the results of this study: The mean age of interviewed women was 45.7 years and their menopausal age was 48.6 years. Means of height and weight were 157.3cm and 56.9Kg respectively. The BMD was the highest in 30-34 year-old women, an average ranges were in the 35-44 year old group. The BMD decreased after 45 year-old. The early sixties women began to experience thiness of the BMD and the mid-sixties showed symptoms of osteoporosis. The formular showing the relationship between age and BMD can be represented as $Y=9.71X^2-2.71X+0.06$ (p<0.001). The bone mineral density decreased significantly with increases of age(p<0.001) and decreases of weight(p<0.001) in multiple regression analysis using age, weight, menopause age, height, number of pregnancies, number of children, and age as independent variables.

• Journal of Chest Surgery
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• 제22권2호
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• pp.191-201
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• 1989

Nowadays, in spite of the remarkable development of the results of open heart surgery, the incidence of postoperative acute renal failure [ARF] has been increased due to the expansion of the candidates and prolonged operation time for complicated cases. It is also well known that ARF after open heart surgery, if once occurred, is a critical complication, therefore early diagnosis and treatment about it are very important for prognosis. Recently a low molecular weight [2 * microglobulin [[2* MG]has been used as a indicator of renal function. Because of the properties of [2 * MG, serum concentration of it is increased in glomerular dysfunction and urine excretion of it is increased in tubular dysfunction. Author studied about the perioperative changes of serum [2* MG and BUN concentration in 25 children and 30 adults for evaluation of significances of [2* MG as a parameter of postoperative renal function in open heart surgery, and the results were obtained as follows. l. In open heart surgery, the serum [2* MG concentration was elevated postoperatively in the all cases from the first postoperative day. 2. There were a significant correlation between the preoperative BUN and [2* MG concentration [P< 0.01]. The correlation factor[r] in child group was 0.8512, and in adults 0.8636. 3. The maximum level of serum [2* MG in the both child and adult groups were noticed in 4th postoperative day as 2.61*0.80mg/ 1 in child group and 3.39*1.47 mg/ 4 in adult group, and there was a significant difference between the two groups statistically[P < 0.05]. 4. The pattern of changes of serum concentration of [2* MG with time was very similar with the changes of BUN, but in a case of ARF [expired with it] the changes of [2* MG was more remarkable. 5. There was a significant differences in the maximum level of [2* MG between the 2 group according to the ECC time [groups of below and above 60 minutes] [P< 0.01].

• 치과방사선
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• 제7권1호
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• pp.31-38
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• 1977

A study was performed to investigate the size of tongue area and intermaxillary space area, and compare the sexual differences between normal Korean children and adults by introducing planimetric and linear analysis of the lateral cephalograms. The cephalograms were composed of 41 child male aged 10.8, 40 child female aged 10.5, 38 adult male aged 21.3 and 40 adult female aged 20.8 respectively. In order to study and measure the intermaxillary space area, the followings were selected, as reference items: occlusal plane, anterior intermaxillary space height, posterior intermaxillary space height, length of intermaxillary space. Among those reference items anterior intermaxillary space height and posterior intermaxillary space height were perpendicular to the maxillary plane. An. index, (equation omitted) While the tongue area was plotted by outline of tongue shadow, above a line extending from the vallecula to the most anterior point on the hyoid body, and above a line from the most anterior point of the hyoid body to the menton. The obtained results were as follows: 1. In general the measurements of male were larger than those of female in intermaxillary space area in childhood and adulthood group. but intermaxillary space area of childhood group showed no significant sexual difference, and that of adulthood group showed significant sexual difference when evaluated statistically. 2. In both groups the measurements of male were larger than those of female in tongue area and there are also statistical significance of sexual differences in both age groups. 3. Considerable growh changes between the childhood and adulthood groups were revealed in intermaxillary space area and tongue area, and the tongue had tendency to become relatively smaller when compared with the intermaxillary space in both sex.

• Journal of Genetic Medicine
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• 제13권2호
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• pp.59-64
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• 2016

Gaucher disease type 1 (GD1) is an inherited lysosomal storage disorder caused by deficiency of acid ${\beta}$-glucosidase. The diminished enzyme activity leads to the accumulation of substrates and results in multi-systemic manifestations including hepatosplenomegaly, anemia, thrombocytopenia, and bone diseases. Enzyme replacement therapy (ERT) by infusion of recombinant protein has been the standard treatment for over 20 years. Despite the successful long-term treatment with ERT, several unmet needs remain in the treatment of GD1 such as severe pulmonary and skeletal manifestations. Substrate reduction therapy (SRT) reduces the accumulation of substrates by inhibiting their biosynthesis. Eliglustat, a new oral SRT, was approved in United States and Europe as a first-line therapy for treating adult patients with GD1 who have compatible CYP2D6 metabolism phenotypes. Although eliglustat is not yet available in Korea, introduction and summary of this new treatment modality are provided in this paper by review of literatures. Despite the fact that there are only limited studies to draw resolute conclusions, the current data demonstrated that eliglustat is not inferior to ERT in terms of its clinical efficacy. The approval of eligustat enables eligible adult GD1 patients to have the option of oral therapy although it still needs further studies on long-term outcomes. The individual patient should be assessed carefully for the choice of treatment modality when eliglustat becomes available in Korea. Furthermore, the clinical guidelines for Korean patients with GD1 regarding the use of eliglustat needs to be developed in near future.

• 농촌계획
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• 제27권2호
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• pp.35-42
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• 2021

This study was to analyze the Life-Cycle Physical Activity Therapy Programs (PATPs) in Hoseo Region and to suggest the Activation of the program. The subjects were the 81 PATPs performed in 36 of the Community Health Centers in the region. The basic data was collected by Official Documents, the Homepage of the Centers, Telephone Interview, and e-mail with the person in charge of the programs. All the data were classified to the administrative districts (Rural, Urban-Rural Intergration and Urban Region), the Life Cycles (Children, Youth, Adult and Old Adult) and the Health-related Fitness Variables (Strength/Muscle endurance, Flexibility and Aerobics). The ACSM's (American College Sports Medicine) Guidelines for Exercise Testing and Prescription were used to evaluate the PATPs. In the results, the number of the PATPs was too low compared to the population. Also, the PATPs were not considered to the Life-Cycle proportion of the population. The management of the PATPs was principally inadequate. The frequency and duration of the PATPs were deficient in order to improve the Health-related Fitness. In conclusion, the number of the PATPs should be increased proportionally compared to the population, operated and developed on the Specificity of the Life-Cycle Population in the administrative districts. Further, the PATPs should be managed on the scientific knowledge of physical activity therapy.

• 한국과학예술포럼
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• 제35권
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• pp.461-471
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• 2018

본 연구의 목적은 국립과학관 상설전시관 입장료에 대해 관람객이 지불할 수 있는 수준을 조사하여 입장료의 가치를 추정하는 것이다. 이러한 추정은 국립과학관의 경영 효율성을 높이기 위해 입장 수익을 증대하는 것이 합리적인지 아닌지를 판단하는데 있어서 중요한 논거를 제시할 수 있다. 국립과천과학관을 방문한 관람객 250명을 대상으로 조건부가치추정법(CVM)을 활용하여 입장료에 대한 지불의사(WTP)를 분석한 결과, 평균 지불의사 금액은 성인 요금 8,447원, 어린이·청소년 요금 6,535원으로 현재의 국립과천과학관 상설전시관 입장요금 4,000원과 2,000원보다 각각 2배와 3배 이상 높게 추정되었다. 이러한 추정은 국립과학관 입장료를 체계화하고 국립과학관의 재정 자생력을 확보하는 기초 자료로 활용될 수 있을 뿐만 아니라, 나아가 양질의 공공전시서비스(국공립 과학관, 미술관, 박물관 등)를 효율적이고 효과적으로 국민에게 전달할 수 있는 방안을 모색하는데 도움이 될 수 있을 것이다.

• 감성과학
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• 제25권4호
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• pp.107-118
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• 2022

Human can rapidly detect and deal with dangerous elements in their environment, and they generally manifest as attentional bias toward threat. Past studies have reported that this attentional bias is affected by anxiety level. Other studies, however, have argued that children and adolescents show attentional bias to threatening stimuli, regardless of their anxiety levels. Few studies directly have compared the two age groups in terms of attentional bias to threat, and furthermore, most previous studies have focused on attentional capture and the early stages of attention, without investigating further attentional holding by the stimuli. In this study, we investigated both attentional bias patterns (attentional capture and holding) with respect to negative emotional stimulus in neurotypical adults and adolescents. The effects of anxiety level on attentional bias were also examined. The results obtained for adult participants showed that abrupt onset of a distractor delayed attentional capture to the target, regardless of distractor type (angry or neutral faces), while it had no effect on attention holding. In adolescents, on the other hand, only the angry face distractor resulted in longer reaction time for detecting a target. Regarding anxiety, state anxiety revealed a significant positive correlation with attentional capture to a face distractor in adult participants but not in adolescents. Overall, this is the first study to investigate developmental tendencies of attentional bias to negative facial emotion in both adults and adolescents, providing novel evidence on attentional bias to threats at different ages. Our results can be applied to understanding the attentional mechanisms in people with emotion-related developmental disorders, as well as typical development.

• Clinical and Experimental Reproductive Medicine
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• 제51권3호
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• pp.192-204
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• 2024

Objective: Cisplatin (CP) is a widely used chemotherapeutic agent, but its severe side effects impact testicular function. We investigated the potential protective effects of bilberry extract against CP-induced testicular toxicity. Methods: Forty adult male albino rats were divided into four groups. Control animals received a single oral dose of 0.9% saline. Bilberry-treated rats received oral bilberry extract (200 mg/kg body weight [BW] dissolved in 1 mL of saline) daily for 10 consecutive days. CP-treated animals were administered a single intraperitoneal dose (7.5 mg/kg BW). Finally, a bilberry+CP group received oral bilberry extract (200 mg/kg BW) daily for 10 consecutive days, with one intraperitoneal dose of CP (7.5 mg/kg BW) on day 2. We assessed sperm count, motility, viability, and abnormalities, along with testis weight, testis weight-to-BW ratio, antioxidant activity, levels of oxidative stress markers (malondialdehyde [MDA] and hydrogen peroxide [H₂O₂]), sex hormones (follicle-stimulating hormone [FSH], luteinizing hormone [LH], and testosterone), and apoptotic and anti-apoptotic markers, and DNA damage. Testicular tissue underwent histopathological examination. Results: Among CP-treated rats, significantly lower values were observed for testis weight; testis weight-to-BW ratio; levels of FSH, LH, testosterone, superoxide dismutase, catalase, glutathione S-transferase, glutathione, and B-cell lymphoma 2; and sperm count, motility, and proportion of normal sperm. CP administration was associated with higher MDA, H₂O₂, p53, Bax, cytochrome c, caspase 9, and caspase 3 levels, along with elevated tail moment. However, bilberry extract administration significantly improved all altered parameters. Conclusion: Bilberry treatment demonstrated protective effects and reduced CP-induced testicular toxicity via antioxidant activity and cytoprotection.

• 한국콘텐츠학회논문지
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• 제16권8호
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• pp.257-267
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• 2016

본 연구는 장애아동을 그룹홈에 입소시킨 어머니의 양육경험 과정에 관한 질적연구이다. 연구 대상은 장애아동을 그룹홈에 입소시킨 어머니 8명이며, 연구방법으로는 심층면접 조사를 실시하였다. 개방코딩 결과 총 34개의 개념과 28개의 하위범주, 13개의 범주가 도출되었다. 이러한 범주들을 종합하여 '양육한계 봉착에 처한 후 그룹홈 입소로 관계 회복'을 핵심범주로 선택하였다. 실천 전략은 어머니의 양육단계에 따른 심리상담을 제공해야 하고, 장애아동 아버지들을 위한 프로그램을 제안하며, 학령기 비장애자녀에 대한 지원 방안이 모색되어야 하고, 대상자의 욕구에 적합한 차별화된 장애인시설이 필요하다. 정책적 차원에서는 돌봄 크레딧을 통해 장애아동 가족의 빈곤 문제의 최소화, 고운맘카드의 활용과 초기 의료사회복지적인 개입 필요, 시설순회학급 설치 확대, 성년후견제도 활용과 소득분위에 따른 장애아동 양육수당의 차등적 지급 등이 고려되어야 함을 제언하였다.

• Child Health Nursing Research
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• 제6권2호
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• pp.119-131
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• 2000

The purpose of this study was to identify the trends and contents of intervention towards children using meta analysis, to support the basis for using in the field and research method about nursing intervention. We used 27 materials which was reported from 1970 to August, 1999 : dissertation study and Korean Nurses' Academic society Journals, the Journal of Korean Academic society of Adult Nursing, The Korea Journal of Maternal and Child Health Nursing. The types of intervention we used came from 3 different researchers. Snyder showed cognitive, movement, social sensory intervention. McCloskey & Bulechek categorized as the following : self-care assistance, acute care management, life-style alteration, health promotion, life support intervention, Craft & Denehy classified psychosocial intervention and biophysiological intervention. Some findings are summarized as follow : Out of the 27 researches sensory intervention had the most in there thesis, recently cognitive intervention research has a tendency to increase. 18 researches has acute care management in there theses, and health promotion was found the least. Out of the 27 thesis 15 thesis was classified as biophysiological intervention and 12 had psychosocial. 27 thesis had 11 types of interventions which originally was categorized by Snyder, therefore sensory intervention thesis had the most. 11 types of intervention which originally was classified by McClosky & Bulechek, teaching and information had the most out of acute care management. Out of 27 thesis, 14 had dealt with newborns, especially newborns with sensory intervention. Therefore school age and above had cognitive intervention which was used for teaching and information. Infants, preschool, schoolage children received acute care management the most, health promotion intervention was used towards adolescences. Depending on the characteristics of dependent variables, it was analysed using meta however 17 thesis are possible except primary experimental research. Mean effect size comparison by Snyder classification, cognitive intervention was the largest mean(1.51), sensory intervention was larger(0.71) also, movement intervention was in the middle(0.56) as shown. Comparison done by McClosky & Bulechek, the intervention leading to life style alteration was the largest mean(1.97), teaching was used the most. Comparison by Craft & Denehy classification, psychosocial intervention was larger(1.15) than biophysiological intervention (0.67). The result of nursing intervention through age classification, the largest weighted mean effect size in the research was towards infants and neonates. The research which was focused on nursing intervention, has important meaning in nursing practice and knowledge development. When we know that children's nursing intervention is necessary and overcome our biased view, efficiency of children's nursing intervention are increased and professionalized. Therefore results will be important basic data to guide a development of child nursing intervention & classification.