• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권3호
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• pp.295-305
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• 2021

Purpose: Hepcidin levels have previously been reported to be correlated with liver damage. However, the association between hepcidin levels and liver fibrosis in children with fatty liver disease remains unclear. This study therefore aimed to investigate the pathophysiology of fibrosis in children with fatty liver disease and its association with hepcidin levels. Methods: This retrospective case series included 12 boys aged 6-17 years who were diagnosed with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) at the Tokyo Medical University Hospital. Sixteen liver biopsy samples from 12 subjects were analyzed. Serum hepcidin levels were assayed using enzyme-linked immunosorbent assay. Immunostaining for hepcidin was performed, and the samples were stratified by staining intensity. Results: Serum hepcidin levels were higher in pediatric NAFLD/NASH patients than in controls. Conversely, a significant inverse correlation was observed between hepcidin immunostaining and Brunt grade scores and between hepcidin scores and gamma-glutamyltranspeptidase, hyaluronic acid, and leukocyte levels. We observed inverse correlations with a high correlation coefficient of >0.4 between hepcidin immunostaining and aspartate aminotransferase, alanine aminotransferase, total bile acid, and platelet count. Conclusion: There was a significant inverse correlation between hepcidin immunoreactivity and fibrosis in pediatric NAFLD patients; however, serum hepcidin levels were significantly higher, suggesting that these patients experienced a reduction in the hepcidin-producing ability of the liver in response to iron levels, leading to subsequent fibrosis. Therefore, hepcidin levels can be used as markers to identify the progression of fibrosis in patients with NAFLD.

• 농촌지도와개발
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• 제18권1호
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• pp.35-72
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• 2011

Study on children from international marriage so far has been conducted focusing on the school-aged children, and it uniformly presents those children as a mere being with problem, overlooking regional variables of rural area. Hence, this study aims to seek various means of adaptation of children from international marriage by considering both variables rural area and adolescence. For this study, six children from international marriage living in the rural area of H county in Jeonlanamdo were chosen, in-dept interview were conducted, and Giorgi(1985) was used to analyze qualitative data. The results shows that these adolescences appear to have extensive experiences in the areas of learning, personal relationship, home and identity. Level of academic achievement was influenced by what school they attend to, and personal relationship aspect was affected by prejudice and discriminative perception from people around them. In addition, in home environment, hatred toward father, sympathy for mother, comparison with mothers who have great cultural adaptation skills, and pressure as the firstborn appear to be on the increase. Adolescent children tend to be addicted to internet games in order to escape from anxiety, experiencing identity crisis. They tend to be negative about international marriage of their parents, and exhibit behaviors refusing values and religious view of their parents. At the conclusion, limitation of the study and suggestion for further study are presented.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제19권3호
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• pp.182-189
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• 2008

Objectives: This study aimed to evaluate preliminarily the clinical effects of cognitive-behavioral treatment in children with anxiety disorders. Methods: Subjects were 11 children between 2nd and 6th grade with anxiety disorder. All subjects were diagnosed through Kiddie-Schedule for Affective Disorder and Schizophrenia Present and Lifetime Version (K-SADS-PL) interview. The CBT program consisted of sessions once a week (60min/session) for 14 weeks with parent education. Results: Children and parents reported significantly improved social skills, social competence and decreased anxiety. However, there were no significant changes in children's negative thoughts and subjective depressive symptoms. Conclusion: Cognitive-behavioral treatment is expected to be effective in children with anxiety disorders such as generalized anxiety disorder, phobia, separation anxiety disorder, and obsessive-compulsive disorder.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제8권2호
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• pp.242-255
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• 1997

본 연구는 비엔나 검사총집의 전산화된 검사를 포함한 다양한 주의력검사도구를 통해 주의력결핍/과잉운동장애의 특징적인 주의력결핍유형을 알아보기 위해 시행되었다. 총 9가지의 검사를 실시하여 얻어진 결과를 통해 다음과 같은 사실을 알 수 있었다. 주의력결핍/과잉운동장애아동들이 정상대조군에 비해 전반적인 경계도가 낮으며 시간이 흐름에 따른 경계도의 저하가 심하며 반응에 대한 준비도 역시 감퇴되어 있었다. 또한 감시력 검사를 통해 주의력결핍/과잉운동장애아동이 선택적 주의력의 결함을 가짐을 알 수 있었으나 지속적 주의력의 결함은 관찰되지 않았다. 이들은 정보처리용량을 초과하는 자극이 주어지는 상황에서 정상 아동들에 비해 충동적으로 반응하여 오경보오류수가 증가하였다. 전두엽기능부전에 민감한 세 가지 신경심리검사를 통하여 주의력결핍/과잉운동장애아동들의 실행능력에 결함이 있음을 알 수 있었다. 주의력결핍/과잉운동장애아동에서 나타나는 다양한 주의력의 측면에서의 결함은 이 장애가 뇌간 망상체 형성및 전두엽을 포함한 뇌의 여러 부위의 통합적인 기능이상에 의한 것이라는 가설을 지지하는 것이라고 하겠다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제10권1호
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• pp.43-49
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• 1999

연구 목적：소아를 다루는 임상의들에게 관찰되는 가장 흔한 발달상의 문제 중 하나는 언어 지연이다. 언어 발달은 주변 환경의 자극에 영향을 받게 되는데, 환경과의 상호 작용에는 아동 자신의 기질 또한 중요한 요소로 작용한다. 기질 연구의 가설에 의하면 아동의 고유한 행동 양식은 상당 부분 타고난 것이며, 이것이 향후 발달에 큰 영향을 미친다고 알려져 있는데, 아동의 기질과 언어 지연과의 관계에 대한 연구는 활발치 않아, 본 연구는 한국에서 의사 소통 장애를 가진 아동에서 어떤 기질 특성이 있는지를 밝히고자 했다. 방 법：환자군은 DSM-IV 진단 기준에 의해 의사 소통 장애라고 진단되고, 전반적 발달 장애, 정신 지체, 언어 운동 장애 혹은 감각 장애를 갖지 않은 세 살에서 일곱 살 사이의 아동 20명을 대상으로 하고 정상대조군은 상기 장애를 갖지 않는 50명을 대상으로 하여 어머니에게 한국판 '부모 기질 설문(Parental Temperamental Questionnaire)'을 완성하도록 하여 기질을 측정하였다. 기질의 9가지 범주 및 요인 A점수를 비교하기 위하여 비모수적 통계법을 사용하였으며, 아동들의 기질 진단을 비교하기 위하여 Chi-square통계법을 사용하였다. 결 과：의사 소통 장애를 가진 아동들에서 정상 아동들에 비해 기분의 범주는 통계적으로 유의하게 낮았고, 반응의 강도의 범주는 통계적으로 유의하게 높았다. 기질 진단 면에서는 두 집단은 통계적으로 유의한 차이를 보이지 않았지만 의사 소통 장애를 가진 아동들이 양육 곤란형에 가까운 집단에 더 많이 포함되었다. 결 론：이와 같은 결과는 의사 소통 장애를 가진 아동들에 특징적인 기질 양상이 있음을 시사한다. 기질양상의 조기 발견은 부모들에게 의사 소통 장애 아동들의 발달학적 특성을 이해하고 이들에게 적절한 양육을 제공하는데 도움을 줄 것이다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제17권2호
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• pp.124-130
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• 2006

Objectives : The objective of this study was to evaluate the differences in patterns of temperament and character, as assessed by the Junior Temperament and Character Inventory (JTCI), between the children with attention-deficit/hyperactivity disorder (ADHD) and the control group in a community sample. In addition, we examined the potential differences on JTCI profiles according to the ADHD subtypes. Methods : Parents of 185 ADHD subjects (mean age $9.0{\pm}1.7$ years), as diagnosed by the DISC-IV, and 185 age- and gender-matched comparison children have completed the parent's version of the JTCI. Results : The ADHD group scored significantly higher in Novelty Seeking and lower in Persistence than the comparison group on JTCI. However, there were no significant differences in the temperament or character profiles by the ADHD subtypes. Conclusion : The results of this study suggest that the temperamental factors of higher Novelty Seeking and lower Persistence are related to ADHD. The temperament or character profiles in this study do not provide support for the distinctiveness of the ADHD subtypes.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권3호
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• pp.216-225
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• 2016

Objectives: The purposes of this study are to evaluate the effect of a school-based social skills training program on the emotional regulation of children and adolescents and to assess the plan for effective school-based mental health services. Methods: The Child and Adolescent Mental health promotion team of Bugok National Hospital conducted school-based social skills training (N=90, 7 sessions) for elementary and middle school students. Evaluations were conducted before and after the application of the program using a prosocial behavior questionnaire, a cohesiveness questionnaire, the Korean version of the 20-item Toronto Alexithymia Scale, a self-esteem scale, and the Novaco anger scale, in order to identify any changes. Results: The social skills training program increased the prosocial behavior and cohesiveness of the children and adolescents and decreased their alexithymic tendency and degree of anger, but did not significantly change their self-esteem. Conclusion: The social skills training program positively influences the emotional and behavioral levels of children and adolescents. The emotional regulation program based on a social skills training program is expected to have positive results in school-based mental health services. Future investigations are needed to validate the long term effects of this program.

• 대한간호학회지
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• 제24권1호
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• pp.85-95
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• 1994

The effects of media violence on the delinquent behavior and violence of children and adolescent are controversial. However, a small but genuine association appears to exist between media violence and aggression or violence. At the present, for a considerable proportion of the population of children and adolescent, delinquent behavior and violence has become a major problem and a way of life. One factor contributing to this problem has been assumed to be the negative influence of mass media including television, drama, videotapes and fiction magazines and so on. Therefore, this paper is intended to discriminate the causal relationship of influence of mass media and juvenile delinquent behavior and violence and to provide nine hypotheses derived from reviewing the literature related to mass media and delinquent behavior. The nine hypotheses are as follows : 1. The presence of modeling mass media crime themes and the extent of interest in and exposure of children and adolescent to media violence themes will be positively correlated to their delinquent(aggressive) behavior. 2. A higher positive correlation will be revealed between interest in and exposure to media violence themes and aggressive behavior among adolescent having parental rejection than among adolescent not experiencing parental rejection. 3. A higher positive relationship will be found between interest in and exposure to mass media crime themes and delinquent behavior among youth having need deprivation than among youth not having need frustration. 4. A higher positive relationship will be presented between the presence of imitating mass media crime themes and interest in and exposure to media violence themes and delinquent or aggressive behavior among youth dysplaying their maladaptive character tendency than among those adolescent dysplaying adaptive character tendency. 5. A higher positively correlating relationship will be shown between interest in and exposure to mass media crime themes and delinquent behavior among youth with a higher scores of depressive trend than among those youth having few or no depression. 6. A higher positive relationship will be found between interest in and exposure to media violence themes and aggressive behavior among adolescent complaining of a high degree of psychosomatic complaints than among those youth having few or no psychosomatic complaints. 7. A higher positive correlation will be appeared between interest in and exposure to mass media crime themes and delinquent behavior among youth displaying aggressive impulsiveness than among those youth having few or no aggressive impulsiveness. 8. A higher positive relationship will be found between interest in and exposure to media violence themes and aggressive behavior among youth having antisocial character or neurotic character with weak ego functioning than among those adolescent not having antisocial character or neurotic character with weak ego functioning. 9. A higher positive correlation will be existed between interest in and exposure to mass media crime themes and delinquent behavior among adolescent displaying the lack of sociality than among those youth not having the lack of sociality. The above nine hypotheses will be tested by statistical methods including Chi-square test, simple correlation, principal component analysis, principal component regression analysis and LISREL path analysis.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권1호
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• pp.37-44
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• 2023

Objectives: Tic disorders are highly heritable; however, growing evidence suggests that environmental factors play a significant role in their pathogenesis. Studies on these factors have been inconsistent, with conflicting results. Therefore, this study aimed to examine the associations of pre- and perinatal exposure to Tourette syndrome (TS) or chronic tic disorders (CTD) in Korean school-aged children. Methods: This case-control study used data from a large prospective cohort study. The primary outcome was TS/CTD diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria and Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version. Demographic, pre-, and perinatal information was obtained from the maternal questionnaires. Data between the TS/CTD and control groups were compared using the chi-squared or Student's t-test, as appropriate. Two-step logistic regression analyses were used to test the association between TS/CTD and pre- and perinatal risk factors. Results: We included of 223 children (78 with TS/CTD and 145 controls). Significant differences in the demographic data between the two groups were observed. The male sex ratio, mean parental age, parental final education level, and family history of tics were included as confounders. In the final adjusted multivariable model, TS/CTD was significantly associated with antiemetic exposure during pregnancy (odds ratio [OR]=16.61, 95% confidence interval [CI] 1.49-185.22, p=0.02) and medically assisted reproduction (OR=7.89, 95% CI 2.28-27.28, p=0.01). Conclusion: Antiemetic exposure and medically assisted reproduction are significantly associated with the risk of TS/CTD. These results should be replicated in future prospective and gene-by-environment studies.

• 재활치료과학
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• 제12권4호
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• pp.67-80
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• 2023

목적 : 본 연구는 장애 소아 청소년을 치료 중인 물리치료사를 대상으로 소아 청소년 물리치료 실태, 만족도, 수가 체계, 대상, 시행, 평가 활용에 대해 알아보기 위해 진행되었다. 연구방법 : 서울 경기 지역 소아 청소년 물리치료사 60명을 대상으로 설문지를 활용하여 소아 청소년 물리치료 실태, 대상자, 만족도, 치료 시행 및 평가 활용 등을 조사하였다. 실태, 대상자, 만족도 등은 빈도 및 기초 통계 분석을 활용하여 분석하였으며, 물리치료 참여도-난이도, 소아 청소년 물리치료 주요 요소의 중요도-본인의 능력, 주요 치료 목표-사용 빈도 차이는 대응 표본 T 검정을 통하여 그 차이를 확인하였다. 결과 : 소아 청소년 물리치료 실태는 대부분 독립된 공간(95.0%)에서 하루 11~15건(66.7%), 1대 1 치료(95.0%)로 진행되는 것으로 조사되었다. 대상자의 주요 연령은 학령기, 학령전기, 진단은 뇌병변, 발달지연이 많았으며 20대 이상까지 치료하였다. 소아 청소년 물리치료 만족도는 높았으나(70.0%) 업무강도 역시 높았다(71.7%). 주요 치료법으로는 신경발달치료, 보행치료, 목표지향적 재활이 있으며, 평가는 대동작기능검사 88과 66, 대동작기능분류검사 사용이 많았다. 현 수가 체계는 부적합하다고 하였으며(66.1%), 적정 수가 체계가 필요하다고 하였다. 결론 : 본 연구를 통하여 소아 청소년 물리치료와 관련된 광범위한 내용과 요소를 확인하였다. 현 실태조사연구를 바탕으로 소아 청소년 물리치료사의 전문성 및 지속성 향상, 최신 치료법 적용을 위한 노력이 필요할 것이다.