• Journal of Pharmaceutical Investigation
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• 제27권1호
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• pp.15-22
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• 1997

The mucosal route of administration(nasal, buccal, conjunctival and vaginal) has recently been considered as an alternative to parenteral delivery for many peptide drugs because enzymatic degradation of these agents may be partly avoided. The objective of these study was to establish the optimal mucosal administration dosage form of $LHRH/[D-Ala^6]LHRH$, based on presystemic metabolism. We reported previously the peptidase inhibition effect of medium chain fatty acid salts(sodium caprylate, soadium caprate and sodium laurate), EDTA and STDHF on the proteolysis of $LHRH/[D-Ala^6]LHRH$ in rabbit mucosal homgenates. We also reported that EDTA, STDHF and sodium laurate markedly increased the potency of $LHRH/[D-Ala^6]LHRH$ solution applied vaginally. In the present study, by administration of polycarbophil hydrogel containing LHRH the ovulation inducing activity was 3.3 times greater than solution. These results indicate not only peptidase inhibitor but also polycarbophil hydrogel significantly improved the absorption of this drug. The results of this study would provide the feasibility as a rational dosage form for improving bioavailability and self administration of this hydrogel by the vaginal application.

• Journal of Nutrition and Health
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• 제32권5호
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• pp.533-539
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• 1999

The effects of capsaicin, a pungent principle of hot red pepper, on body fat gain, balance serum lipid values were investigated in rats fed a high-fat(30%) diet. Administration of capsaicin by dietary administration caused a complete cessation of increased in body weight and fat gain induced by the high-fat diet. However, energy intake and body protein gain were not affected by capsaicin. Therefore, the suppression of body fat gain by capsaicn was believed due to an increased in energy expenditure. Simultaneous administration of capsaicin and a $\beta$-adrenergic blocker, propranolo, resulted in the inhibition of changes in body fat gain by capsaicin without remained unchanged, indicating an increase in the number of mitochondria in brown adipose tissue. Therefore, it appears that capsaicin possesses potent body fat suppressive effects mediated by $\beta$-adrenergic stimulation in which brown adipose tissue may be involved. On the other hand, capsaicin had no effects on serum triglyceride, total cholesterol or HDL-cholesterol levels. These results are in contrast to those reported by other investigators. Perhaps expression of the effects of capsaicin on plasma lipids is a rather complicated process, dependent on the type of diet administered, fat content of the diet, period and route of capsaicin administration, and species and strain of animals used.

• Archives of Pharmacal Research
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• 제7권2호
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• pp.141-143
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• 1984

A metabolic study was performed in order to characterize the in vivo MAO-inhibitory activity of benzyl trans-2-phenylcylopropanecarbamate which was reported to be twice as potent as the tranylcypromine. In the rat urine which was obtained after the administration of the benzyl trans-2-pheny-lcyclopropanecarbamate (40mg/kg) through oral route, a metabolic product, tranylcypromine as well as the intact drug was detected by GC/MS.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.171-172
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• 2002

Immune responses to infectious microbes and foreign antigens are regulated by a series of interactions among T cells, B cells, and antigen-presenting cells (APCs) such as macrophages (M$\square$) and dendritic cells (DCs). The inverse relationship between antibody production and cell-mediated immune responses such as delayed type hypersensitivity (DTH) was experimentally manipulated by varying the dose, route of administration, and form of antigen used to immunize animals. (omitted)

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2004년도 춘계학술발표대회
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• pp.1609-1612
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• 2004

Ad hoc network is a kind of new wireless network paradigm for mobile hosts. Ad Hoc wireless networks consist of wireless mobile hosts forming a temporary network without the aid of any established infrastructure or centralized administration. Mobile hosts rely on each other to keep the network connected. Each host is not only mobile hosts but also router. So how to design a routing protocol is the most important problem. Dynamic source routing is a kind of routing protocol. In this paper we suggest a new automatic route shortening method and an energy-aware routing mechanism based on DSR.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.236.1-236.1
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• 2002

Mucosal administration of drug or therapeutic gene is emerging as a new route of delivery for systemic and local therapeutics. Previously. in situ gelling system has been applied to chemical drug such as acetaminophen. insulin. prostaglandin E1. and clotrimazole. Plasmid DNA has not been delivered in form of in situ gelling vehicles. To improve the intranasal absorption of plasmid DNA. we designed delivery systems composed of provide of in 냐셔 gelling and mucoadhesive polymers. (omitted)

• 한국사회정책
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• 제23권3호
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• pp.79-108
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• 2016

'저복지 국가인 미국에서, 여성들의 일-가정양립은 어떠한 역사적 과정을 거쳐 이루어져 왔을까?' 이 질문에 답을 하고자, 미국 여성 일-가정양립경로의 형성과정에 대한 역사적 인과관계를 4단계시기로 나누어 살펴보았다. 과거 전업주부에 머물렀던 중산층 기혼여성을 대상으로 하여, 여성 일-가정 양립모델에 대한 역사적 제도주의적 접근을 시도함으로써 기존연구들과의 차별성을 두었다. 주요 연구결과는 다음과 같다. 제1단계는 여성의 고등교육이 확대되고, 산업변화로 미혼여성들의 사회진출이 시작된 시기였다. 제2단계는 중산층 여성들의 사회진출이 뉴딜, 소비자본주의, 제2차 세계대전을 통해 확대된 시기이다. 제3단계는 여성해방운동으로 정부의 적극적 조치에 대한 '적극적' 시행이 요구되어 전문화된 직업영역으로 여성의 일자리가 확대된 시기였다. 제4단계에서는 더 나은 정규직 일자리로 진입하려는 여성 근로자의 공급 측면과, 양질의 근로자를 얻고자 하는 사용자의 수요 부분이 개별고용관계를 통해 노동시장 제도 내에서 맞물렸다. 이로써 맞벌이의 규범화가 이루어졌다. 즉, 저복지국가인 미국에서는 여성의 개별적 노력(학업을 통한 능력향상과 여성운동)과 개별고용관계가 발달된 노동시장 특징으로 인하여, 고학력 중산층 여성의 '고(高)고용-고출산'이 가능하며, 정규직 일자리로의 재복귀가 비교적 용이한 여성 일-가정양립 패턴이 완성될 수 있었다.

• The Korean Journal of Pain
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• 제22권2호
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• pp.117-123
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• 2009

The intrathecal drug administration system (ITDAS) has recently been introduced for treating chronic intractable pain patients who have failed with conservative pain treatments. The obvious advantages of its use are the direct intrathecal delivery of drugs, which yields reduced adverse effects and the increased strength of drugs, as compared to its oral or intravenous route. This article offers a review of the ITDAS with a brief review of its evidence-based effectiveness, the technical approach, and the complications.

• Journal of Dental Anesthesia and Pain Medicine
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• 제16권2호
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• pp.89-94
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• 2016

Anxiety and phobia in dental procedures are common deterrents for patients visiting the dental care unit. For these individuals, procedural sedation may aid in completion of dental treatments. In most cases, the patients are conscious during sedation, thereby allowing spontaneous ventilation. Intravenous sedation (IVS) is widely used during dental treatment to relieve patient anxiety. IVS is the most effective route of administration to achieve this goal, but it requires advanced training, more than that provided during undergraduate education. During IVS, rapid onset, repetitive drug administration, easy titration, and rapid recovery from sedation can be achieved. However, conscious sedation during IVS can result in deep sedation that can cause respiratory and cardiovascular depression. Therefore, the characteristics of intravenous sedatives should be known. The purpose of this review is to discuss the characteristics and usage of intravenous sedatives currently used for dental procedures.

• Journal of Preventive Medicine and Public Health
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• 제9권1호
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• pp.87-94
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• 1976

In order to study the chelating action of d-penicillamine on lead and the possibility of its application to the provocation test for diagnosis of lead poisoning, urinary excretion of lead was measured from 24-hour urine samples before, during and after administration of d-penicillamine by oral route for 5 days on 18 lead workers. The results were as follows: 1. Oral d-penicillamine 600 mg/day raised the excretion of urinary lead by approximately 3 times as compared with initial urinary lead level. 2. Initial urinary lead level was the better indicator of urinary lead excretion in d-penicillamine administration than initial blood lead ${\delta}-ALA$ and hemoglobin level. 3. Oral d-penicillamine may be quite useful in provocation test for lead poisoning.