• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2001.10b
• /
• pp.116-117
• /
• 2001

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2002.05a
• /
• pp.98-98
• /
• 2002

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2001.10b
• /
• pp.191-192
• /
• 2001

• Proceedings of the Korean Society of Developmental Biology Conference
• /
• 2002.02a
• /
• pp.51-51
• /
• 2002

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.11b
• /
• pp.190-190
• /
• 2002

Methamphetamine (META) is a psychostimulant and has become popular recreational drug of abuse in many countries. The neurotoxic damage caused by METH is characterized by degeneration of the dopaminergic and serotonergic systems in striatum and hippocampus.(omitted)

• Proceedings of the PSK Conference
• /
• 2000.04a
• /
• pp.128.1-128.1
• /
• 2000

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2021.10a
• /
• pp.190-190
• /
• 2021

• Atmosphere
• /
• v.20 no.2
• /
• pp.187-194
• /
• 2010

We estimate the economic benefit of weather modification (precipitation enhancement and fog dissipation) by assuming its operation for the considered regions. Based on the statistical data, the economic benefit of the virtually operational precipitation enhancement experiments for the Andong and Imha basins, where the natural precipitation is relatively lack in South Korea, is calculated 348 for the water resources, 22,458 for forest fire prevention, and 28,458 million won/year for the drought relief. The benefit of the fog dissipation operation for the Incheon International Airport is estimated 7,365 million won/year for the flight delay due to fog. The calculated ratio of benefit to cost for precipitation enhancement operation for the basins is 14.07, which is comparable to that conducted in other countries.

• Molecular & Cellular Toxicology
• /
• v.2 no.4
• /
• pp.236-243
• /
• 2006

Microarray analysis of gene expression has become a powerful approach for exploring the biological effects of drugs, particularly at the stage of toxicology and safety assessment. Acetaminophen (APAP) has been known to induce necrosis in liver, but the molecular mechanism involved has not been fully understood. In this study, we investigated gene expression changes of APAP using microarray technology. APAP was orally administered with a single dose of 50 mg/kg or 500 mg/kg into ICR mice and the animals were sacrificed at 6, 24 and 72 h of APAP administration. Serum biochemical markers for liver toxicity were measured to estimate the maximal toxic time and hepatic gene expression was assessed using high-density oligonucleotide microarrays capable of determining the expression profile of >30,000 well-substantiated mouse genes. Significant alterations in gene expression were noted in the liver of APAP-administered mice. The most notable changes in APAP-administered mice were the expression of genes involved in apoptosis, cell cycle, and calcium signaling pathway, cystein metabolism, glutatione metabolism, and MAPK pathway. The majority of the genes upregulated included insulin-like growth factor binding protein 1, heme oxygenase 1, metallothionein 1, S100 calcium binding protein, caspase 4, and P21. The upregulation of apoptosis and cell cycle-related genes were paralleled to response to APAP. Most of the affected gene expressions were returned to control levels after 72 hr. In conclusion, we identified potential hepatotoxicity makers, and these expressions profiling lead to a better understanding of the molecular basis of APAP-induced hapatotoxicity.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2001.05a
• /
• pp.154-154
• /
• 2001

2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin(TCDD), a prototype of many halogenated aromatic hydrocarbons, is a ubiquitous, persistent environmental contaminant and the most powerful carcinogen categorized by IARC. Despite extensive research, the mechanisms of TCDD-induced carcinogenesis are poorly understood, and its carcinogenic potential in human is not clear.(omitted)