• Title/Summary/Keyword: Adiponectin

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Cord Blood Adiponectin and Insulin-like Growth Factor-I in Term Neonates of Gestational Diabetes Mellitus Mothers: Relationship to Fetal Growth

  • Sohn, Jin-A;Park, Eun-Ae;Cho, Su-Jin;Kim, Young-Ju;Park, Hye-Sook
    • Neonatal Medicine
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    • v.18 no.1
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    • pp.49-58
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    • 2011
  • Purpose: The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM). Methods: Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data. Results: Cord adiponectin was lower in the GDM group than in the non-GDM group (P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group (P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group (P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different (P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity. Conclusion: Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.

Adiponectin Induces Growth Arrest and Apoptosis of MDA-MB­231 Breast Cancer Cell

  • Kang Jee Hyun;Lee Yoon Young;Yu Byung Yeon;Yang Beom-Seok;Cho Kyung-Hwan;Yoon Do Kyoung;Roh Yong Kyun
    • Archives of Pharmacal Research
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    • v.28 no.11
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    • pp.1263-1269
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    • 2005
  • Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.

The analysis of Research about Adiponectin (아디포넥틴(adiponectin) 관련 연구논문 분석)

  • Byeon, Young-Soon
    • Journal of Korean Biological Nursing Science
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    • v.12 no.3
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    • pp.175-185
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    • 2010
  • Purpose: The purpose of this study is to analyze the trend of research on intervention using adiponectin and to find the utilization in nursing. Methods: A systematic literature review was conducted. From 2005 to 2009, the articles were searched electronically using the data base with the key words of adiponectin. The criteria for inclusion in review were 1) an randomized clinical trial (RCT), 2) human, 3) English or Korean language. Finally, 89 articles (41 domestic studies, 48 foreign studies) were included in the review. Results: The major findings of this study were as follows: 1) In domestic studies, subjects of obesity were 80.5%, and the most frequently used intervention were exercise (95.1%). 2) In foreign studies, there were interventions for subjects of obesity (55.1%), and diabetes (25.0%). 66.7% of studies were in medicine including 56.3% on medicine/hormone therapy. 3) Adiponectin was significantly increased in 31 domestic studies and 33 foreign studies. Conclusion: It needs to understand the influence of Adiponectin in nursing research and practice. The practical use of Adiponectin has to be considered in a sense that it may help determining the direction of the nursing research to provide more objective evidence for nursing practice.

Regulatory Role of Autophagy in Globular Adiponectin-Induced Apoptosis in Cancer Cells

  • Nepal, Saroj;Park, Pil-Hoon
    • Biomolecules & Therapeutics
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    • v.22 no.5
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    • pp.384-389
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    • 2014
  • Adiponectin, an adipokine predominantly secreted from adipose tissue, exhibits diverse biological responses, including metabolism of glucose and lipid, and apoptosis in cancer cells. Recently, adiponectin has been shown to modulate autophagy as well. While emerging evidence has demonstrated that autophagy plays a role in the modulation of proliferation and apoptosis of cancer cells, the role of autophagy in apoptosis of cancer cell caused by adiponectin has not been explored. In the present study, we demonstrated that globular adiponectin (gAcrp) induces both apoptosis and autophagy in human hepatoma cell line (HepG2 cells) and breast cancer cells (MCF-7), as evidenced by increase in caspase-3 activity, Bax, microtubule-associated protein light chain 3-II (LC3 II) protein levels, and autophagosome formation. Interestingly, gene silencing of LC3B, an autophagy marker, significantly enhanced gAcrp-induced apoptosis in both HepG2 and MCF-7 cell lines, whereas induction of autophagy by rapamycin, an mTOR inhibitor, significantly prevented gAcrp-induced apoptosis in hepatoma cells HepG2. Furthermore, modulation of autophagy produced similar effects on gAcrp-induced Bax expression in HepG2 cells. These results implicate that induction of autophagy plays a regulatory role in adiponectin-induced apoptosis of cancer cells, and thus inhibition of autophagy would be a novel promising target to enhance the efficiency of cancer cell apoptosis by adiponectin.

Insulin Inhibits the Expression of Adiponectin and AdipoR2 mRNA in Cultured Bovine Adipocytes

  • Sun, Y.G.;Zan, L.S.;Wang, H.B.;Guo, H.F.;Yang, D.P.;Zhao, X.L.;Gui, L.S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.10
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    • pp.1429-1436
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    • 2009
  • Adiponectin is an adipocyte-derived protein that has a regulatory role in energy homeostasis and influences insulin sensitivity. Its effects on glucose utilization and lipid metabolism are mediated by AdipoR1 and AdipoR2. How insulin affects adiponectin gene expression and secretion is still controversial. This study was conducted to determine the expression of adiponectin, AdipRs and $PPAR-\gamma$ during the differentiation of bovine preadipocytes and the effect of insulin on expression of these genes in bovine adipocytes. The bovine preadipocytes started to accumulate lipids three days after differentiation was induced, with increased expression of adiponectin, AdipoR2 and $PPAR-\gamma$ mRNAs. Insulin decreased the expression of adiponectin mRNA in a dose- and time-dependent fashion, and the inhibition was detectable at insulin concentrations as low as 10 nM and as early as 2 h after addition of 100 nM insulin. Insulin also inhibited the expression of AdipoR2 mRNA at concentrations from 1 to 1,000 nM or 24 h after addition of 100 nM insulin, but did not affect the expression of AdipoR1 in bovine adipocytes. Inhibition of PI3K with LY294002 reversed the inhibition of adiponectin and AdipoR2 mRNA expression by insulin. These results suggest that insulin suppresses the expression of adiponectin and AdipoR2 at least partially via the PI3K signal pathway.

The Effect of 12-week Music Rope Skipping Exercise on Serum Adiponectin Concentration and Abdominal Fat in Obese Boys Student in Present Middle School (12주간의 음악 줄넘기 운동이 비만 남자 중학생의 혈청 Adiponectin 농도와 복부지방에 미치는 영향)

  • Lee, Hye-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.7
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    • pp.4432-4438
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    • 2014
  • The aim of this study was to provide basic programs for addressing the growing problem of adolescent obesity by considering the effects of a music rope skipping-based exercise program to increase the student athletic ability on obesity, adiponectin and abdominal fat. The subjects were 23 male middle school students, 14-year-old to 16 years old, with a BMI of more than $25kg/m^2$ (experimental group 11, control group 12), who lack basic physical fitness physical health related fitness. The subjects received a 12 weeks music rope skipping exercise program. The program was carried out before and after the 12 weeks group music rope skipping exercise program. The adiponectin and abdominal fat measurements were compared with the degree of improvement. The BMI and adiponectin levels decreased significantly after the program. In addition, the visceral fat, subcutaneous adipose fat and total abdominal fat in summer decreased significantly.

Changes of Serum Adiponectin Levels in Murine Experimental Sparganosis

  • Yang, Hyun-Jong
    • The Korean Journal of Parasitology
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    • v.46 no.2
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    • pp.91-93
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    • 2008
  • The weight gain phenomenon associated with sparganosis has been well documented and was first recognized in the 1960s. Many studies have been conducted regarding the plerocercoid growth factor in the larva of Spirometra mansoni. In the present study, we hypothesized that the weight gain may be affected by the adipocyte secreted hormones, i.e., adiponectin, which is secreted from the adipose tissues in case of tissue migrating parasitic infections. Specifically, we attempted to ascertain whether the serum levels of adiponectin change in murine sparganosis. However, serum adiponectin levels assayed by ELISA evidenced no significant changes after an experimental infection (P > 0.05). Finally, the weight gain phenomenon in mouse sparganosis is not associated with changes in adiponectin levels, and further investigations involving parasitic infection-induced weight gain remain necessary.

Association of Serum Lipids and Dietary Intakes with Serum Adiponectin Level in Overweight and Obese Korean Women (과체중 및 비만 여성의 혈청지질 및 식이섭취실태와 혈청 Adiponectin 농도와의 상관성 연구)

  • Lee, Mi-Young;Kim, Jung-Hee
    • Korean Journal of Community Nutrition
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    • v.15 no.1
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    • pp.27-35
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    • 2010
  • This study was done to investigate the association of blood clinical parameters and dietary intakes with serum adiponectin level. Athropometric measurement, dietary intakes, serum lipids and adiponectin levels were examined in 160 overweight and obese women. The subjects were divided into 5 groups by quintile according to serum adiponectin level. Weight, BMI, waist circumferences and waist/hip ratio of the highest quintile group were significantly lower than those of the lowest quintile group. Serum lipid analysis showed a significant higher level of TG, LDL-cholesterol, LDL/HDL ratio, AI, and serum hs-CRP in the lowest quintile group. Similarly, correlation data also showed that serum adiponectin level was positively correlated with serum HDL-cholesterol level (p < 0.01) and was negatively correlated with BMI (p < 0.01), waist circumferences (p < 0.01), waist/hip ratio (p<0.01), systolic (p < 0.01) and diastolic blood pressure (p < 0.05), TG (p < 0.01), LDL-cholesterol (p < 0.05), LDL/HDL ratio (p < 0.05), AI (p < 0.01), Homa-IR (p < 0.01), hs-CRP (p < 0.05) and leptin (p < 0.05). Dietary intake data showed that protein intake was significantly lower in the highest quintile group compared to the lower quintile groups while intakes of vitamin C was significantly higher in highest quintile group after adjustment by BMI, waist and energy intake, In addition, the highest quintile group had higher fiber intakes than the lower quintile groups. These results might suggest that a diet high in fiber and vitamin C and low in protein for obese patients would better be recommended to improve adiponectin level. However, further research is needed to elucidate the association of dietary intakes or dietary patterns and serum adiponectin level.

Effects of Obesity on the Physiological Levels of Adiponectin, Leptin and Diagnostic Indices of Metabolic Syndrome in Male Workers (남성 근로자의 비만이 adiponectin과 leptin의 생리적 농도와 대사증후군 진단지표에 미치는 영향)

  • Heo, Kyung-Hwa;Won, Yong-Lim;Ko, Kyung-Sun;Kim, Ki-Woong
    • Korean Journal of Occupational Health Nursing
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    • v.18 no.1
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    • pp.44-54
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    • 2009
  • Purpose: The aim of this study was to examine the effects of obesity on the physiological levels of adiponectin, leptin and components of metabolic syndrome (MS) in male workers, aged 30-40 years. Methods: Body mass index (BMI) was measured with Anthropometric equipment. Blood pressure and serum parameters were measured with an automatic digital sphygmomanometer and autochemical analyzer, respectively. Adiponectin and leptin were analysed by ELISA kits and MS was defined based on the NCEP-ATP III. Results: Body fat mass of waist and hip, systolic and diastolic blood pressure were significantly higher, as expected, in the BMI>25kg/$m^2$ in comparison with the $BMI{\leq}25kg/m^2$. While fasting glucose, insulin, HOMA-IR and leptin in the BMI>25kg/$m^2$ were also significantly higher compared with $BMI{\leq}25kg/m^2$, HDL-cholesterol and adiponectin were significantly higher in $BMI{\leq}25kg/m^2$. On multiple logistic regression analysis for the components of MS, exercise, adiponectin and leptin were an only independent factor for MS in non-obese male workers($BMI{\leq}25kg/m^2$) after adjustment for age, cigarette smoking and drinking habits. Conclusion: These results suggested that the obesity in men was associated with physiological levels of adiponectin and leptin contributing to feedback control of MS and that dysfunction and/or declination in feedback control system associated with changes in physiological levels of neurptrophics: adiponectin and leptin might ultimately induce MS.

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Relationship between follicular fluid adipocytokines and the quality of the oocyte and corresponding embryo development from a single dominant follicle in in vitro fertilization/intracytoplasmic sperm injection cycles

  • Chang, Hye Jin;Lee, Ji Hyun;Lee, Jung Ryeol;Jee, Byung Chul;Suh, Chang Suk;Kim, Seok Hyun
    • Clinical and Experimental Reproductive Medicine
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    • v.41 no.1
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    • pp.21-28
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    • 2014
  • Objective: To investigate the association of individual follicular fluid (FF) leptin and adiponectin levels with the quality of the corresponding oocyte and embryo. Methods: We prospectively enrolled 67 women who underwent controlled ovarian hyperstimulation with 89 FF samples. FF and the corresponding oocyte was obtained from a single dominant preovulatory follicle at the time of oocyte retrieval. Concentrations of leptin and adiponectin were measured by enzyme-linked immunosorbent assay in an individual follicle. The oocyte quality, fertilization rate, and corresponding embryo development were assessed. Results: The FF level of leptin was significantly associated with body mass index (r=0.334, p<0.01). The FF adiponectin level was significantly higher in the normal fertilization group than the abnormal fertilization group (p=0.009) in the non-obese women. A lower FF leptin level was associated with a trend toward mature oocytes, normal fertilization, and good embryo quality, although these relationships were not statistically significant. The leptin:adiponectin ratio of FF did not differ significantly according to oocyte and embryo quality. The quality of the oocyte and embryo was not associated with the FF leptin level tertile. However, the normal fertilization rate was positively associated with FF adiponectin level tertile. There was a trend towards improved oocytes and normal fertilization rates with the lowest tertile of the FF leptin:adiponectin ratio, but this difference was not statistically significant. Conclusion: Our results suggest that a high FF adiponectin concentration could be a predictor of normal fertilization. However, the FF leptin concentration and leptin:adiponectin ratio is not significantly related to oocyte maturity and corresponding embryo development.